γ-Hydroxy-1, N 2-propano-2′-deoxyguanosine DNA adduct conjugates the N-terminal amine of the KWKK peptide via a carbinolamine linkage

Chemical Research in Toxicology

Volumn 24, Issue 7, 2011, Pages 1123-1133

  Huang, Hai ^a   Wang, Hao ^a   Voehler, Markus W ^a   Kozekova, Albena ^a   Rizzo, Carmelo J ^a   McCullough, Amanda K ^b   Lloyd, R Stephen ^b   Stone, Michael P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; DEOXYGUANOSINE DERIVATIVE; DOUBLE STRANDED DNA; GAMMA HYDROXY 1 N2 PROPANO 2' DEOXYGUANOSINE; GUANINE; HYDROGEN; IMINE; IMINO ACID; LYSYLTRYPTOPHANYLLYSYL LYSINE; METHANOLAMINE; PEPTIDE; PROPIONALDEHYDE; PROTON; SCHIFF BASE; SOLVENT; UNCLASSIFIED DRUG; WATER;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONJUGATION; CROSS LINKING; DIASTEREOISOMER; DNA ADDUCT; DNA DENATURATION; DNA SEQUENCE; HYDROGEN BOND; MOLECULAR DYNAMICS; NITROGEN NUCLEAR MAGNETIC RESONANCE; RING OPENING; TAUTOMER; THERMOSTABILITY;

ACROLEIN; AMINES; AMINO ACID SEQUENCE; DEOXYGUANOSINE; DNA ADDUCTS; HYDROGEN BONDING; IMINES; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DYNAMICS SIMULATION; OLIGODEOXYRIBONUCLEOTIDES; PEPTIDES; TRANSITION TEMPERATURE;

EID: 79960552638     PISSN: 0893228X     EISSN: 15205010     Source Type: Journal    
DOI: 10.1021/tx200113n     Document Type: Article

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