Stereospecific formation of the (R)-γ-hydroxytrimethylene interstrand N2-dG:N2-dG cross-link arising from the γ-OH-1,N2-propano-2′-deoxyguanosine adduct in the 5′-CpG-3′ DNA sequence

Journal of the American Chemical Society

Volumn 131, Issue 24, 2009, Pages 8416-8424

  Huang, Hai ^a   Kim, Hye Young ^a   Kozekov, Ivan D ^a   Cho, Young Jin ^a   Wang, Hao ^a   Kozekova, Albena ^a   Harris, Thomas M ^a   Rizzo, Carmelo J ^a   Stone, Michael P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-CONFORMATIONS; BASE PAIRS; CROSSLINK; DIASTEREOMERIC; DUPLEX DNA; ERYTHRO; GAUCHE CONFORMATION; HETERONUCLEAR SINGLE QUANTUM CORRELATIONS; HYDROXYL GROUPS; INTERSTRAND CROSS-LINKS; MINOR GROOVES; NUCLEAR OVERHAUSER ENHANCEMENT; STEREOSPECIFIC; STERIC INTERACTIONS; STRUCTURAL PERTURBATION; STRUCTURAL REFINEMENT; THERMAL STABILITY; WATSON-CRICK HYDROGEN BONDING;

ALDEHYDES; AMINES; BINDING SITES; DNA; GENES; HYDROGEN; ISOTOPES; LABELS; NUCLEIC ACIDS; RESONANCE; THERMODYNAMIC STABILITY;

HYDROGEN BONDS;

CYCLOPROPANE DERIVATIVE; DEOXYGUANOSINE DERIVATIVE; HYDROXYL GROUP; CROSS LINKING REAGENT; CYCLOPROPANE; DEOXYGUANOSINE; DNA; DRUG DERIVATIVE; OH 1, N(2) PROPANO 2' DEOXYGUANOSINE; OH-1,-N(2)-PROPANO-2'-DEOXYGUANOSINE;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; CONFORMATION; DNA CROSS LINKING; DNA SEQUENCE; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HYDROGEN BOND; NUCLEAR OVERHAUSER EFFECT; STEREOCHEMISTRY; STEREOSPECIFICITY; BASE PAIRING; CHEMISTRY; CPG ISLAND; DNA ADDUCT; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE; STEREOISOMERISM; THERMODYNAMICS;

BASE PAIRING; CPG ISLANDS; CROSS-LINKING REAGENTS; CYCLOPROPANES; DEOXYGUANOSINE; DNA; DNA ADDUCTS; HYDROGEN BONDING; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; STEREOISOMERISM; THERMODYNAMICS;

EID: 67650545671     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja809543j     Document Type: Article

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