Minor groove orientation of the KWKK peptide tethered via the N-terminal amine to the acrolein-derived 1, N 2-γ- hydroxypropanodeoxyguanosine lesion with a trimethylene linkage

Biochemistry

Volumn 49, Issue 29, 2010, Pages 6155-6164

  Huang, Hai ^a   Kozekov, Ivan D ^a   Kozekova, Albena ^a   Rizzo, Carmelo J ^a   McCullough, Amanda K ^b   Lloyd, R Stephen ^b   Stone, Michael P ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE NITROGEN; BIOLOGICAL PROCESSING; DNA-PEPTIDE CONJUGATES; INDOLYL GROUPS; MINOR GROOVES; N-TERMINALS; PROTEIN CONJUGATES; PROTEOLYTIC DIGESTION; TRANS CONFIGURATION; TRIMETHYLENE;

ALDEHYDES; AMINO ACIDS; GENE TRANSFER; GENES; ORGANIC ACIDS; PEPTIDES;

DNA;

1,N 2 GAMMA HYDROXYPROPANODEOXYGUANOSINE; ACROLEIN; AMINE; CYCLOPROPANE; DEOXYGUANOSINE DERIVATIVE; INDOLE DERIVATIVE; INDOLYL DERIVATIVE; LYSINE; LYSYLTRYPTOPHANYLLYSYLLYSINE; NITROGEN; PEPTIDE; PROTON; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; DNA PROTEIN COMPLEX; INTERCALATION COMPLEX; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN STABILITY; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; TRANS ISOMER;

ACROLEIN; AMINES; CYCLOPROPANES; DEOXYGUANOSINE; DNA ADDUCTS; DNA DAMAGE; DNA REPAIR; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; OLIGOPEPTIDES;

EID: 77954820678     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi100364f     Document Type: Article

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