4-Vinylcyclohexene diepoxide (VCD) inhibits mammary epithelial differentiation and induces fibroadenoma formation in female Sprague Dawley rats

Reproductive Toxicology

Volumn 32, Issue 1, 2011, Pages 26-32

  Wright, Laura E ^a   Frye, Jennifer B ^a   Lukefahr, Ashley L ^a   Marion, Samuel L ^a   Hoyer, Patricia B ^a   Besselsen, David G ^b   Funk, Janet L ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

Casein; C KIT; Fibroadenoma; Mammary epithelium; VCD

Indexed keywords

4 VINYLCYCLOHEXENE DIEPOXIDE; ANDROSTENEDIONE; BETA CASEIN; EPOXIDE; ESTRADIOL; PROLACTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREAST EPITHELIUM; BREAST FIBROADENOMA; CANCER INCIDENCE; CARCINOGENESIS; CONTROLLED STUDY; ESTRUS CYCLE; FEMALE; HISTOPATHOLOGY; NONHUMAN; OVARY; PROTEIN EXPRESSION; RAT; SENESCENCE; TISSUE DIFFERENTIATION; TUMOR GROWTH;

ANIMALS; CASEINS; CYCLOHEXENES; ENVIRONMENTAL POLLUTANTS; ESTROUS CYCLE; FEMALE; FIBROADENOMA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MAMMARY GLANDS, ANIMAL; MAMMARY NEOPLASMS, ANIMAL; PROLACTIN; PROTO-ONCOGENE PROTEINS C-KIT; RATS; RATS, SPRAGUE-DAWLEY; VINYL COMPOUNDS;

RATTUS; RODENTIA;

EID: 79960470554     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2011.05.005     Document Type: Article

References (38)

1. El-Wakeel H., Umpleby H.C. Systematic review of fibroadenoma as a risk factor for breast cancer. Breast 2003, 12:302-307.
2. Glenn E.M., Richardson S.L., Bowman B.J. A method of assay of antitumor activity using a rat mammary fibroadenoma. Endocrinology 1959, 64:379-389.
3. Huggins C., Mainzer K., Torralba Y. Hormonal influences on mammary tumors of the rat. I. Acceleration of growth of transplanted fibroadenoma in ovariectomized and hypophysectomized rats. J Exp Med 1956, 104:525-538.
4. Durbin P.W., Williams M.H., Jeung N., Arnold J.S. Development of spontaneous mammary tumors over the life-span of the female Charles River (Sprague Dawley) rat: the influence of ovariectomy, thyroidectomy and adrenalectomy-ovariectomy. Cancer Res 1966, 26:400-411.
5. Chandra M., Riley M.G., Johnson D.E. Spontaneous neoplasms in aged Sprague Dawley rats. Arch Toxicol 1992, 66:496-502.
6. Brix A.E., Nyska A., Haseman J.K., Sells D.M., Jokinen M.P., Walker N.J. Incidences of selected lesions in control female Harlan Sprague Dawley rats from two-year studies performed by the National Toxicology Program. Toxicol Pathol 2005, 33:447-483.
7. Planas-Silva M.D., Rutherford T.M., Stone M.C. Prevention of age-related spontaneous mammary tumors in outbred rats by late ovariectomy. Cancer Detect Prev 2008, 32:65-71.
8. LeFevre J., McClintock M.K. Reproductive senescence in female rats: a longitudinal study of individual differences in estrous cycles and behavior. Biol Reprod 1988, 38:780-789.
9. Goldman J.M., Murr A.S., Cooper R.L. The rodent estrous cycle: characterization of vaginal cytology and its utility in toxicological studies. Birth Defects Res Part B: Dev Reprod Toxicol 2007, 80:84-97.
10. Andersen M.E., Clewell H.J., Gearhart J., Allen B.C., Barton H.A. Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors. J Toxicol Environ Health 1997, 52:189-209.
11. National Toxicology Program Toxicology and carcinogenesis studies of 4-vinyl-1-cyclohexane diepoxide in F344/N rats and B6C3F1 mice 1989, U.S. Department of Health and Human Services.
12. Hoyer P.B., Sipes I.G. Development of an animal model for ovotoxicity using 4-vinylcyclohexene: a case study. Birth Defects Res Part B: Dev Reprod Toxicol 2007, 80:113-125.
13. Fernandez S.M., Keating A.F., Christian P.J., Sen N., Hoying J.B., Brooks H.L., et al. Involvement of the KIT/KITL signaling pathway in 4-vinylcyclohexene diepoxide-induced ovarian follicle loss in rats. Biol Reprod 2008, 79:318-327.
14. Mayer L.P., Devine P.J., Dyer C.A., Hoyer P.B. The follicle-deplete mouse ovary produces androgen. Biol Reprod 2004, 71:130-138.
15. Wright L.E., Christian P.J., Rivera Z., Van Alstine W.G., Funk J.L., Bouxsein M.L., et al. Comparison of the skeletal effects of ovariectomy versus chemically induced ovarian failure in mice. J Bone Miner Res 2008, 23:1296-1303.
16. Mayer L.P., Pearsall N.A., Christian P.J., Devine P.J., Payne C.M., McCuskey M.K., et al. Long-term effects of ovarian follicular depletion in rats by 4-vinylcyclohexene diepoxide. Reprod Toxicol 2002, 16:775-781.
17. Xie B., Tsao S.W., Wong Y.C. Sex hormone-induced mammary carcinogenesis in female Noble rats: the role of androgens. Carcinogenesis 1999, 20:1597-1606.
18. Russo I.H., Russo J. Developmental stage of the rat mammary gland as determinant of its susceptibility to 7,12-dimethylbenz[α]anthracene. J Natl Cancer Inst 1978, 61:1439-1449.
19. Funk J.L., Frye J.B., Oyarzo J.N., Kuscuoglu N., Wilson J., McCaffrey G., et al. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum 2006, 54:3452-3464.
20. Maffini M.V., Soto A.M., Sonnenschein C., Papadopoulos N., Theoharides T.C. Lack of c-kit receptor promotes mammary tumor in N-nitrosomethylurea-treated Ws/Ws rats. Cancer Cell Int 2008, 8:5.
21. Ciocca D.R., Parente A., Russo J. Endocrinologic milieu and susceptibility of the rat mammary gland to carcinogenesis. Am J Pathol 1982, 109:47-56.
22. Shan L., Yu M., Synderwine E.G. Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas. Toxicol Pathol 2005, 33:768-775.
23. Shull J.D. The rat oncogenome: comparative genetics and genomics of rat models of mammary carcinogenesis. Breast Dis 2007, 28:69-86.
24. Trichopoulos D., Adami H.O., Ekbom A., Hsieh C.C., Lagiou P. Early life events and conditions and breast cancer risk: from epidemiology to etiology. Int J Cancer 2008, 122:481-485.
25. Fokerd E.J., Dowsett M. Influence of sex hormones on cancer progression. J Clin Oncol 2010, 28:4038-4044.
26. Thompson H.J., Singh M. Rat models of premalignant breast disease. J Mammary Gland Biol Neoplasia 2000, 5:409-420.
27. Gear R.B., Yan M., Schneider J., Succop P., Heffelfinger S.C., Clegg D.J. Charles River Sprague Dawley rats lack early age-dependent susceptibility to DMBA-induced mammary carcinogenesis. Int J Biol Sci 2007, 3:408-416.
28. Medina D. Chemical carcinogenesis of rat and mouse mammary glands. Breast Dis 2007, 28:63-68.
29. Russo J., Russo I.H. Role of differentiation in pathogenesis and prevention of breast cancer. Endocr Rel Cancer 1997, 4:7-21.
30. Currier N., Solomon S.E., Demicco E.G., Change D.L.F., Farago M., Ying H., et al. Oncogenic signaling pathways activated in DMBA-induced mouse mammary tumors. Toxicol Pathol 2005, 33:726-737.
31. Papacontantinon A.D., Shanmugam H., Shan L., Schroeder I.S., Qiu C., Yu M., et al. Gene expression profiling in the mammary gland of rats treated with 7,12-dimethylbenz[α]anthracene. Int J Cancer 2006, 118:17-24.
32. Natali P.G., Ricotra M.R., Sures I., Santoro E., Botti C., Ullrich A. Expression of c-kit receptor in normal and transformed human nonlymphoid tissues. Cancer Res 1992, 52:6139-6143.
33. Natali P.G., Berlingieri M.T., Nicotra M.R., Fusco A., Santoro E., Bibotti A., et al. Transformation of thyroid epithelium is associated with loss of c-kit receptor. Cancer Res 1995, 55:1787-1791.
34. Tsuura Y., Hiraki H., Watanabe K., Igarashi S., Shimamura K., Fukuda T., et al. Preferential localization of c-kit product in tissue mast cells, basal cell of skin, epithelial cells of breast, small cell lung carcinoma, and siminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues. Virchows Arch 1994, 424:135-141.
35. Natali P.G., Nicotra M.R., Sures I., Mottolese M., Botti C., Ullrich A. Breast cancer is associated with loss of the c-kit oncogene product. Int J Cancer 1992, 52:713-717.
36. Ko C.D., Kim J.S., Ko B.G., Son B.H., Kang H.J., Yoon H.S., et al. The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium. Clin Exp Metastasis 2003, 20:593-597.
37. Yared M.A., Middleton L.P., Bernstam F.M., Cristofanilli M., Sahin A.A. Expression of c-kit proto-oncogene product in breast tissue. Breast J 2004, 10:323-327.
38. Ulivi P., Zoli W., Medri L., Amadori D., Saragoni L., Barbanti F., et al. c-kit and SCF expression in normal and breast tissue. Breast Cancer Res Treat 2004, 83:33-42.