Pharmacodynamic model of the rat estrus cycle in relation to endocrine disruptors

Journal of Toxicology and Environmental Health

Volumn 52, Issue 3, 1997, Pages 189-209

  Andersen, Melvin E ^a   Clewell, Harvey J ^b   Gearhart, Jeffrey ^b   Allen, Bruce C ^a   Barton, Hugh A ^a  

^a ICF Kaiser Engineers Inc   (United States)

^b ICF INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATRAZINE; CHLORDECONE; ESTRADIOL; ESTROGEN; HERBICIDE; LUTEINIZING HORMONE; METHOXYCHLOR; XENOBIOTIC AGENT;

AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST TUMOR; ENDOCRINE DISEASE; ESTROGEN ACTIVITY; ESTRUS CYCLE; FEMALE; HYPOTHALAMUS HYPOPHYSIS GONAD SYSTEM; MODEL; NONHUMAN; PHARMACODYNAMICS; PRIORITY JOURNAL; RAT;

AGING; ANIMALS; CHLORDECONE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTRUS; FEMALE; HYPOTHALAMUS; INSECTICIDES; LUTEINIZING HORMONE; MAMMARY NEOPLASMS, ANIMAL; OVARY; PITUITARY GLAND; PROLACTIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTRADIOL; REPRODUCTION; TRANSCRIPTION, GENETIC;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0030765876     PISSN: 00984108     EISSN: None     Source Type: Journal    
DOI: 10.1080/00984109708984060     Document Type: Article

References (20)

1. Andersen, M. E., Clewell, H. J., III, and Barton, H. A. 1997. A pharmacodynamic model of atrazine effects on estrus cycle characteristics in the Sprague-Dawley rat. ACS Symp. Ser., in press.
2. Andrews, W., and Ojeda, S. R. 1977. On the feedback actions of estrogen on gonadotropin and prolactin release in infantile female rats. Endocrinology 101:1517-1523.
3. Bogumil, R. J., Ferin, M., Rootenberg, J., Speroff, L., and Van de Wiele, R. L. 1972a. Mathematical studies of the human menstrual cycle. I. Formulation of a mathematical model. J. Clin. Endocrinol. Metab. 35:126-143.
4. Bogumil, R. J., Ferin, M., and Van de Wiele, R. L. 1972b. Mathematical studies of the human menstrual cycle. II. Simulation performance of a model of the human menstrual cycle. J. Clin. Endocrinol. Metab. 35:144-156.
5. Brawer, J. R., Beaudet, A., Desjardins, G. C., and Schipper, H. M. 1993. Pathologic effect of estradiol on the hypothalamus. Biol. Reprod. 49:647-652.
6. Freeman, M. E. 1994. The neuroendocrine control of the ovarian cycle of the rat. In The physiology of reproduction, 2nd ed., eds. E. Knobil and J. D. Neill, pp. 613-658. New York: Raven Press.
7. Gellert, R. J. 1978. Kepone, mirex, dieldrin, and aldrin: Estrogenic activity and the induction of persistent vaginal estrus and anovulation in rats following neonatal treatment. Environ. Res. 16:131-138.
8. Huber, J. J. 1965. Some physiological effects of the insecticide Kepone in the laboratory mouse. Toxicol. Appl. Pharmacol. 7:516-524.
9. Keefe, D., Michelson, D. S., Lee, S. H., and Naftolin, F. 1991. Astrocytes within the hypothalamic arcuate nucleus contain estrogen-sensitive peroxidase, bind fluorescein-conjugated estradiol, and may mediate synaptic plasticity in the rat. Am. J. Obstet. Gynecol. 164:959-966.
10. Keefe, D., Carcia-Segura, L. M., and Naftolin, F. 1994. New insights into estrogen action on the bra in. Neurobiol. Aging 15:495-497.
11. Lu, K. H., Hopper, B. R., Vargo, T. M., and Yen, S. S. C. 1979. Chronological changes in sex steroid, gonadotropin and prolactin secretion in aging rats displaying different reproductive states. Biol. Reprod. 21:193-203.
12. McConnell, D. R. 1989. General observations on the effects of sex steroids in rodents with emphasis on long-term oral contraceptive studies. In Safety requirements for contraceptive steroids, ed. F. Michal, pp. 211-229. Cambridge: Cambridge University Press.
13. Plouffe, L., and Luxenberg, S. N. 1992. Biological modeling on a microcomputer using standard spreadsheet and equation solver programs: The hypothalamic-pituitary-ovarian axis as an example. Comp. Biomed. Res. 25:117-130.
14. Smith, M. S., Freeman, M. E., and Neill, J. D. 1975. The control of progesterone secretion during the estrus cycle and early pseudopregnancy in the rat: Prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy. Endocrinology 96:219-226.
15. Stevens, J. T. 1994. Rat mammary tumorigenesis: Relevance of hormonal imbalance to dose selection. Toxicology Forum Annual Summer Meeting, 11-15 July, Givens Institute, Aspen, CO.
16. Stevens, J. T., Breckenridge, C. B., Wetzel, L. T., Gillis, J. H., Luempert, L. G. III, and Eldridge, J. C. 1994. Hypothesis for mammary tumorigenesis in Sprague-Dawley rats exposed to certain triazine herbicides. J. Toxicol. Environ Health 43:139-153.
17. Takewaki, K. 1962. Some aspects of hormonal mechanism involved in persistent estrus in the rat. Experientia 18:1-6.
18. Tennant, M. K., Hill, D. S., Eldridge, J. C., Wetzel, L. T., Breckenridge, C. B., and Stevens, J. T. 1994a. Chloro-s-triazine antagonism of estrogen action: Limited interaction with estrogen receptor binding. J. Toxicol. Environ. Health 43:197-211.
19. Tennant, M. K., Hill, D. S., Eldridge, J. C., Wetzel, L. T., Breckenridge, C. B., and Stevens, J. T. 1994b. Possible antiestrogenic properties of chloro-s-triazines in rat uterus. J. Toxicol. Environ. Health 43:183-196.
20. Wise, P. M., 1987. The role of the hypothalamus in aging of the female reproductive system. J. Steroid Biochem. 27:713-719.