Lack of c-kit receptor promotes mammary tumors in N-nitrosomethylurea-treated Ws/Ws rats

Cancer Cell International

Volumn 8, Issue , 2008, Pages

  Maffini, Maricel V ^a   Soto, Ana M ^a   Sonnenschein, Carlos ^a   Papadopoulos, Nikoletta ^a   Theoharides, Theoharis C ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

METHYLNITROSOUREA; STEM CELL FACTOR RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BREAST CARCINOGENESIS; BREAST TUMOR; CANCER INCIDENCE; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; FOLLOW UP; GENE MUTATION; MAST CELL; NONHUMAN; RAT; SIGNAL TRANSDUCTION; STROMA CELL; WILD TYPE;

EID: 44349092473     PISSN: None     EISSN: 14752867     Source Type: Journal    
DOI: 10.1186/1475-2867-8-5     Document Type: Article

References (36)

1. Zsebo KM Williams DA Geissler EN Broudy VC Martin FH Atkins HL Hsu RY Birkett NC Okino KH Murdock DC Stem cell factor is encoded at the Sl locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor Cell 1990, 63:213-224 10.1016/0092-8674(90)90302-U 1698556
2. Bernex R De Sepulveda P Kress C Elbaz C Delouis C Panthier JJ Spatial and temporal patterns of c-kit-expressing cells in WlacZ/+ and WlacZ/ WlacZ mouse embryos Development 1996, 122:3023-3033 8898216
3. Kitamura Y Go S Hatanaka K Decrease of mast cells in W/Wv mice and their increase by bone marrow transplantation Blood 1978 52 447 452 352443
4. Tsujimura T Hirota S Nomura S Niwa Y Yamazaki M Tono T Morii E Kim HM Kondo K Nishimune Y Characterization of Ws mutant allele of rats: A 12-base deletion in tyrosine kinase domain of c-kit gene Blood 1991, 78:1942-1946 1912577
5. Giebel LB Spritz RA Mutation of the KIT (mast/stem cell growth factor receptor) protooncogene in human piebaldism Proceedings of the National Academy of Science of the United States of America 2007, 88:8696-8699 10.1073/pnas.88.19.8696
6. Kitamura Y Hirota S Nishida T A loss-of-function mutation of c-kit results in depletion of mast cells and interstitial cells of Cajal, while its gain-of-function mutation results in their oncogenesis Mutation Research 2001, 477:165-171 11376697
7. Niwa Y Kasugai T Ohno K Morimoto M Yamazaki M Dohmae K Nishimune Y Kondo K Kitamura Y Anemia and mast cell depletion in mutant rats that are homozygous at "white spotting (Ws)" locus Blood 1991, 78:1936-1941 1912576
8. Hirota S Isozaki K Moriyama Y Hashimoto K Nishida T Ishiguro S Kawano K Hanada M Kurata A Takeda M Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors Science 1998, 279:577-580 10.1126/ science.279.5350.577 9438854
9. Longley BG Metcalfe DD Tharp M Wang X Tyrrell L Lu S-Z Heitjan D Ma Y Activating and dominant inactivating c-KIT catalytic domain mutations in distinct clinical forms of human mastocytosis Proc Nat Acad Sci USA 1999, 96:1609-1614 15534 9990072 10.1073/pnas.96.4.1609
10. Maurer M Theoharides T Granstein RD Bischoff SC Bienenstock J Henz B Kovanen P Piliposky AM Kambe N Vliagoftis H What is the physiological function of mast cells? Exp Dermatol 2003, 12:886-910 10.1111/ j.0906-6705.2003.0109a.x 14719507
11. Szewczyk G Szukiewicz D Zaczek R Maslinska D Mast cells in the mouse mammary gland - correlation with the development of lactiferous structures Folia Biol (Krakow) 2000, 48:13-17 11080912
12. Russo J Russo IH Rogers AE Van Zwieten MJ Gusterson BA Tumours of the mammary gland Pathology of tumours in laboratory animals. Tumors of the rat Lyon: IARC Scientific Publication N 99 Turusov VS, Mohr U 2 1990, I:47-78
13. Ulivi P Zoli W Medri L Amadori D Saragoni L Barbanti F Calistri D Silvestrini R c-kit and SCF expression in normal and tumor breast tissue Breast Cancer Res Treat 2004, 1:33-42 10.1023/B:BREA.0000010694.35023.9e 14997053
14. Singh M McGinley JN Thompson HJ A comparison of the histopathology of premalignant and malignant mammary gland lesions induced in sexually immature rats with those occurring in the human Lab Invest 2000, 80:221-231 10701691
15. Russo IH Russo J Mammary gland neoplasia in long-term rodent studies Environ Health Perspect 1996, 104:938-967 1469450 8899375 10.2307/3433143
16. Tsuura Y Hiraki H Wantanabe K Igarashi S Shimamura K Fukuda T Suzuki T Seito T Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: Immunohistochemical study on formalin-fixed, paraffin-embedded tissues Virchows Archiv 1994, 424:135-141 10.1007/BF00193492 7514077
17. Li Q Kondoh G Inafuku S Nishimune Y Hakura A Abrogation of c-kit/Steel factor-dependent tumorigenesis by kinase defective mutants of the c-kit receptor: C-kit kinase defective mutants as candidate tools for cancer gene therapy Cancer Res 2007, 56:4343-4346
18. Chui X Egami H Yamashita J Kurizaki T Ohmachi H Yamamoto S Ogawa M Immunohistochemical expression of the c-kit proto-oncogene product in human malignant and non-malignant breast tissues Brit J Cancer 1996, 73:1233-1236 8630284
19. Natali PG Nicotra MR Sures I Mottolese M Botti C Ullrich A Breast cancer is associated with loss of the c-kit oncogene product Int J Cancer 1992, 52:713-717 10.1002/ijc.2910520508 1385336
20. Ko CD Kim JS Ko BG Son BH Kang HJ Yoon HS Cho EY Gong G Ahn SH The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium Clin Exp Metastas 2003, 20:593-597 10.1023/ A:1027323210736
21. Simon R Panussis S Maurer R Spichtin H Glatz K Tapia C Mirlacher M Rufle A Torhorst J Sauter G KIT (CD117)-positive breast cancers are infrequent and lack KIT gene mutations Clin Cancer Res 2004, 10:178-183 10.1158/ 1078-0432.CCR-0597-3 14734467
22. Samoszuk M Corwin MA Acceleration of tumor growth and peri-tumoral blood clotting by imatinib mesylate (Gleevec) Int J Cancer 2003, 106:647-652 10.1002/ijc.11282 12866022
23. Natali PG Berlingieri MT Nicotra MR Fusco A Santoro E Vecchio G Transformation of thyroid epithelium is associated with loss of c-kit receptor Cancer Research 1995, 55:1787-1791 7536131
24. de Visser KE Eichten A Coussens LM Paradoxical roles of the immune system during cancer development Nature Reviews: Cancer 2006, 6:24-37 10.1038/nrc1782 16397525
25. Theoharides TC Conti P Mast cells: The Jekyll and Hyde of tumor growth Trends in Immunology 2004, 25:235-241 10.1016/j.it.2004.02.013 15099563
26. Kashiwase Y Morioka J Inamura H Yoshizawa Y Usui R Kurosawa M Quantitative analysis of mast cells in benign and malignant breast lesions. Immunohistochemical study on formalin-fixed, paraffin-embedded tissues Int Arch Allergy Immunol 2004, 134(3):199-205 10.1159/000078766 15178888
27. Aaltomaa S Lipponen P Papinaho S Kosma VM Mast cells in breast cancer Anticancer Research 1993, 13:785-788 8317912
28. Rajput AB Turbin DA Cheang MCU Voduc DK Leung S Gelmon KA Gilks CB Huntsman DG Stromal mast cells in invasive breast cancer are a marker of favourable prognosis: A study of 4,444 cases Breast Cancer Res Treat 2137942 17431762
29. Tanooka H Kitamura Y Sado T Tanaka K Nagase M Kondo S Evidence for involvement of mast cells in tumor suppression in mice Journal of the National Cancer Institute 1982, 69:1305-1309 6982995
30. Hartveit F Mast cell association with collagen fibers in human breast stroma European Journal of Morphology 1993, 31:209-218 8217470
31. Yamamoto T Hartmann K Eckes B Krieg T Mast cells enhance contraction of three-dimensional collagen lattices by fibroblasts by cell-cell interaction: Role of stem cell factor/c-kit Immunology 2000, 99:435-439 2327175 10712674 10.1046/j.1365-2567.2000.00973.x
32. van Kempen LCL Rhee J-S Dehne K Lee J Edwards DR Coussens LM Epithelial carcinogenesis: Dynamic interplay between neoplastic cells and their microenvironment Differentiation 2002, 70:610-623 10.1046/ j.1432-0436.2002.700914.x 12492502
33. Soto AM Sonnenschein C The somatic mutation theory of cancer: Growing problems with the paradigm? BioEssays 2004, 26:1097-1107 10.1002/ bies.20087 15382143
34. Maffini MV Soto AM Calabro JM Ucci AA Sonnenschein C The stroma as a crucial target in rat mammary gland carcinogenesis J Cell Sci 2004, 117:1495-1502 10.1242/jcs.01000 14996910
35. informatics.jax.org http://informatics.jax.org
36. Maffini MV Calabro JM Soto AM Sonnenschein C Stromal regulation of neoplastic development: Age-dependent normalization of neoplastic mammary cells by mammary stroma Am J Pathol 2005, 67(5):1405-1410