The meaning of the c-kit proto-oncogene product in malignant transformation in human mammary epithelium

Clinical and Experimental Metastasis

Volumn 20, Issue 7, 2003, Pages 593-597

  Ko, Chang Dae ^a   Kim, Jee Soo ^a   Ko, Byung Gyun ^a   Son, Byung Ho ^a   Kang, Hee Joon ^a   Yoon, Ho Sung ^a   Cho, Eun Yoon ^a   Gong, Gyungyub ^a   Ahn, Sei Hyun ^a  

^a University of Ulsan College of Medicine   (South Korea)

Author keywords

Breast cancer; c kit proto oncogene; Immunohistochemistry; Immunoreactive score; Malignant transformation

Indexed keywords

STEM CELL FACTOR RECEPTOR;

ANTIGEN DETECTION; ANTIGEN EXPRESSION; ARTICLE; BREAST CARCINOGENESIS; BREAST EPITHELIUM; CANCER GROWTH; CELL DIFFERENTIATION; CELL GROWTH; CELL IMMORTALIZATION; CONTROLLED STUDY; EARLY CANCER; EVALUATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERMETHOD COMPARISON; LYMPH NODE METASTASIS; MALIGNANT TRANSFORMATION; PROTEIN EXPRESSION;

BREAST; BREAST DISEASES; BREAST NEOPLASMS; CELL TRANSFORMATION, NEOPLASTIC; HUMANS; LYMPHATIC METASTASIS; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-KIT;

EID: 0344873650     PISSN: 02620898     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1027323210736     Document Type: Article

References (26)

1. Qiu FH, Ray P, Brown K et al. Primary structure of c-kit: Relationship with the CSF-1/PDGF receptor kinase family-oncogenic activation of v-kit involves deletion of extracellular domain and C terminus. EMBO J 1988; 7: 1003-11.
2. Yarden Y, Kuang WJ, Yang-Feng T et al. Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 1987; 6: 3341-51.
3. Natali PG, Nicotra MR, Sures I, Breast cancer is associated with loss of the c-kit oncogene product. Int J Cancer 1992; 52: 713-7.
4. Small D, Levenstein M, Kim E et al. STK-1, the human homolog of Flk-2/Flt-3, is selectively expressed in CD34+ human bone marrow cells and is involved in the proliferation of early progenitor/stem cells. Proc Natl Sci USA 1994; 91: 459-63.
5. Besmer P, Murphy JE, George PC et al. A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 1986; 320: 415-21.
6. Flanagan JG, Chan DC, Leder P. Transmembrane form of the kit ligand growth factor is determined by alternative splicing and is missing in the Sld mutant. Cell 1991; 64: 1025-35.
7. Reith AD, Ellis C, Lyman S et al. Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J 1991; 10: 2451-9.
8. Lowry PA, Zsebo KM, Deacon DH et al. Effects of rrSCF on multiple cytokine responsive HPP CFC generated from SCA+Lin-murine hematopoietic progenitors. Exp Hematol 1991; 19: 994-6.
9. Migliaccio G, Migliaccio AR, Valinsky J et al. Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoetic cells. Proc Natl Acad Sci USA 1991; 88: 7420-4.
10. Natali PG, Nicotra MR, Winkler AB et al. Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int J Cancer 1992; 52: 197-201.
11. Dolci S, Williams DE, Ernst MK et al. Requirement for mast cell growth factor for primordial germ cell survival in culture. Nature 1991; 352: 809-11.
12. Tsai M, Takeishi T, Thompson H et al. Induction of mast cell proliferation, maturation and heparin synthesis by the rat c-kit ligand, stem cell factor. Proc Natl Acad Sci USA 1991; 88: 6382-6.
13. Ward SM, Burns AJ, Torihashi S et al. Impaired development of interstitial cells and intestinal electrical rhythmicity in steel mutants. Am J Physiol 1995; 269: C1577-85.
14. Huizinga JD, Thuneberg L, Kluppel M et al. W/kit gene required for interstitial cells of Cajal and for intestinal pace-maker activity. Nature 1995; 373: 347-9.
15. Krystal GW, Hines SJ, Organ CP. Autocrine growth of small cell lung cancer mediated by coexpression of c-kit and stem cell factor. Cancer Res 1996; 15: 370-6.
16. Timeus F, Crescenzio N, Valle P et al. Stem cell factor suppresses apoptosis in neuroblastoma cell lines. Exp Hematol 1997; 25: 1253-60.
17. DiPaola RS, Kuczynski WI, Onodera K et al. Evidence for a functional kit receptor in melanoma, breast and lung carcinoma cells. Cancer Gene Ther 1997; 4: 176-82.
18. Worobec AS, Semere T, Nagata H et al. Clinical correlates of the presence of the Asp816Val c-kit mutation in the peripheral blood mononuclear cells of patients with mastocytosis. Cancer 1998; 83: 2120-9.
19. Lasota J, Jasinski M, Sarlomo-Rikala M et al. Mutations in exon 11 of c-kit occur preferentially in malignant versus benign gastrointestinal stromal tumors and do not occur in leimyomas or leiomyosarcomas. Am J Pathol 1999; 154: 53-60.
20. Buttner C, Henz BM, Welker P et al. Identification of activating c-kit mutations in adult, but not in childhood-onset indolent mastocytosis: A possible explanation for divergent clinical behavior. J Invest Dermatol 1998; 111: 1227-31.
21. Taniguchi M, Nishida T, Hirota S et al. Effect of c-kit mutation on prognosis of gastrointestinal stromal tumors. Cancer Res 1999; 59: 4297-300.
22. Natali PG, Nicotra MR, Sures I et al. Expression of c-kit receptor in normal and transformed human nonlymphoid tissues. Cancer Res 1992; 52: 6139-6143.
23. Matsuda R, Takahashi T, Nakamura S et al. Expression of the c-kit protein in human solid tumors and in corresponding fetal and adult normal tissues. Am J Pathol 1993; 142: 339-46.
24. Keshet E, Lyman SD, Williams DE et al. Embryonic RNA expression patterns of the c-kit receptor and its cognate ligand suggest multiple functional roles in mouse development. EMBO J 1991; 10: 2425-35.
25. Wershil BK, Tsai M, Geissler W et al. The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function. J Exp Med 1992; 175: 245-55.
26. Strohmeyer T, Peter S, Hartmann M et al. Expression of the hst-1 and c-kit proto-oncogenes in human testicular germ cell tumors. Cancer Res 1991; 51: 1811-6.