Food allergy: Which tests are worth doing and which are not?

Annals of Clinical Biochemistry

Volumn 48, Issue 4, 2011, Pages 300-309

  Lock, Robert J ^a,b   Unsworth, David J ^a  

^a SOUTHMEAD HOSPITAL   (United Kingdom)

^b UNIVERSITY OF THE WEST OF ENGLAND   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLERGEN; EGG WHITE; GLIADIN ANTIBODY; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN G4; LEUKOTRIENE; OVALBUMIN; OVOMUCOID; OVOTRANSFERRIN; TRYPTASE;

ABDOMINAL PAIN; ALLERGIC REACTION; ANAPHYLAXIS; ASTHMA; BASOPHIL; BEHAVIOR CHANGE; CHRONIC URTICARIA; CROSS ALLERGY; CROSS REACTION; DAIRY PRODUCT; DERMATITIS; DIARRHEA; DIET RESTRICTION; EGG ALLERGY; ENZYME LINKED IMMUNOSORBENT ASSAY; FAILURE TO THRIVE; FALSE NEGATIVE RESULT; FALSE POSITIVE RESULT; FISH; FLOW CYTOMETRY; FOOD ALLERGY; HAIR ANALYSIS; HEADACHE; HUMAN; MAST CELL DEGRANULATION; MEDICAL HISTORY; MICROARRAY ANALYSIS; MILK ALLERGY; PEANUT ALLERGY; POINT OF CARE TESTING; POLLEN ALLERGY; PREDICTIVE VALUE; PRICK TEST; PRIORITY JOURNAL; REVIEW; SENSITIVITY AND SPECIFICITY; SEROLOGY; SKIN TEST; VOMITING;

ADOLESCENT; ADULT; ALLERGENS; ANTIBODY SPECIFICITY; CHILD; CHILD, PRESCHOOL; EGG HYPERSENSITIVITY; FOOD HYPERSENSITIVITY; GREAT BRITAIN; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOASSAY; IMMUNOGLOBULIN E; MILK HYPERSENSITIVITY; PEANUT HYPERSENSITIVITY; SKIN TESTS;

EID: 79960461234     PISSN: 00045632     EISSN: 17581001     Source Type: Journal    
DOI: 10.1258/acb.2011.011011     Document Type: Review

References (79)

1. American College of Allergy Asthma and Immunology. Food allergy: a practice parameter. Ann Allergy Asthma Immunol 2006;96(Suppl 3):S1-68
2. Coombs RRA, Gell PGH. Classification of allergic reactions responsible for hypersensitivity and disease. In: Gell PGH, Coombs RRA, eds. Clinical Aspects of Immunology. Oxford, UK: Blackwell, 1975
3. Monti G, Bonfante G, Muratore MC, et al. Kiss-induced facial urticaria and angioedema in a child allergic to fish. Allergy 2003;58:684-5
4. Hill PG, McMillan SA. Anti-tissue transglutaminase antibodies and their role in the investigation of coeliac disease. Ann Clin Biochem 2006;43:105-17
5. Royal College of Pathologists Working Party. Allergy: The Unmet Need. A Blueprint for Better Patient Care. A Report of the Royal College of Physicians Working Party on the Provision of Allergy Services in the UK. London: The Royal College of Physicians, 2003
6. Johansson SG, Hourihane JO, Bousquet J, et al. A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 2001;56:813-24
7. American Academy of Allergy Asthma & Immunology. Consultation and referral guidelines citing the evidence: how the allergist-immunologist can help. J Allergy Clin Immunol 2006;117(Suppl):S495-523
8. El-Shanawany TM, Arnold H, Carne E, et al. Survey of clinical allergy services provided by clinical immunologists in the UK. J Clin Pathol 2005;58:1283-9
9. Royal College of Physicians. Allergy Services; Still not Meeting the Unmet Need. London: Royal College of Physicians, 2010
10. Sicherer SH, Sampson HA. Food allergy. J Allergy Clin Immunol 2006;117:S470-5
11. Sicherer SH, Leung DY. Advances in allergic skin disease, anaphylaxis, and hypersensitivity reactions to foods, drugs, and insects in 2009. J Allergy Clin Immunol 2010;125:85-97
12. Tariq SM, Stevens M, Matthews SM, Ridout S, Twiselton R, Hide DW. Cohort study of peanut and nut sensitisation by age of 4 years. BMJ 1996;313:514-7
13. Grundy J, Matthews S, Bateman B, Dean T, Arshad SH. Rising prevalence of allergy to peanut in children: data from 2 sequential cohorts. J Allergy Clin Immunol 2002;110:784-9
14. WHO Expert Committee on Biological Standardization. Human Serum Immunoglobulin E. 658, 21. Technical Report Series. Geneva: World Health Organization, 1981
15. Immunoglobulins and immunodeficiency. In: Milford Ward A, Sheldon J, Rowbottom A, Wild GD, eds. Handbook of Clinical Immunochemistry. Sheffield: PRU Publications, 2007
16. Zetterstrom O, Johansson SGO. IgE concentrations measured by PRIST, in serum of healthy adults and in patients with respiratory allergy. Allergy 1981;36:537-47
17. Carosso A, Bugiani M, Migliore E, Antò JM, DeMarco R. Reference values of total serum IgE and their significance in the diagnosis of allergy in young European adults. Int Arch Allergy Immunol 2007;142:230-8
18. Campos A, Reyes J, Blanquer A, Liñares T, Torres M. Total serum IgE: adult reference values in Valencia (1981-2004). Usefulness in the diagnosis of allergic asthma and rhinitis. Allergol Immunopathol (Madr) 2005;33:303-6
19. Sears MR, Chow CM, Morseth DJ. Serum total IgE in normal subjects and the influence of a family history of allergy. Clin Exp Allergy 1979;10:423-31
20. Croner S, Kjellman NI, Eriksson B, Roth A. IgE screening in 1701 newborn infants and the development of atopic disease during infancy. Arch Dis Child 1982;57:364-8
21. Perkin MR, Strachan DP, Ho W, Lack G, ALSPAC Study Team. The predictive value of early life total immunoglobulin E measurement in identifying atopic children in a population-based birth cohort study. Paediatr Allergy Immunol 2006;17:118-24
22. Sinclair D, Peters SA. The predictive value of total serum IgE for a positive allergen specific IgE result. J Clin Pathol 2004;57:956-9
23. Prausnitz C, Küstner H. Studien über die Überempfindlichkeit. Zentrl Bakteriol 1921;86:160-90
24. Oppenheimer J, Nelson HS. Skin testing. Ann Allergy Asthma Immunol 2006;96(Suppl 1):S6-12
25. Yunginger JW, Ahlstedt S, Eggleston PA, et al. Quantitative IgE antibody assays in allergic diseases. J Allergy Clin Immunol 2000;105: 1077-84
26. Roberts G, Lack G. Diagnosing peanut allergy with skin prick testing and specific IgE testing. J Allergy Clin Immunol 2005;115:1291-6
27. Hill DJ, Heine RG, Hosking CS. The diagnostic value of skin prick testing in children with food allergy. Pediatr Allergy Immunol 2004;15:435-41
28. Sporik R, Hill DJ, Hosking CS. Specificity of allergen skin testing in predicting positive open food challenges to milk, egg and peanut in children. Clin Exp Allergy 2000;30:1540-6
29. Wang J, Godbold JH, Sampson HA. Correlation of serum allergy (IgE) tests performed by different assay systems. J Allergy Clin Immunol 2008;121:1219-24
30. Nicolaou N, Poorafshar M, Murray C, et al. Allergy or tolerance in children sensitized to peanut: prevalence and differentiation using component-resolved diagnostics. J Allergy Clin Immunol 2010;125:191-7
31. Hiller R, Laffer S, Harwanegg C, et al. Microarrayed allergen molecules: diagnostic gatekeepers for allergy treatment. FASEB J 2002;16:414-6
32. Jahn-Schmid B, Harwanegg C, Hiller R, et al. Allergen microarray: comparison of microarray using recombinant allergens with conventional diagnostic methods to detect allergen-specific serum immunoglobulin E. Clin Exp Allergy 2003;33:1443-9
33. The Royal College of Pathologists Lay Advisory Committee. Allergy and Allergy Tests; A Guide for Patients and Relatives. London: Royal College of Pathologists, 2005
34. Sampson HA. Utility of food-specific IgE concentrations in predicting symptomatic food allergy. J Allergy Clin Immunol 2001;107:891-6
35. Moneret-Vautrin DA, Halpen GM, Brignon JJ, Nicolas KP, Kanny G. Food allergen specific IgE antibodies: a comparative study of AlaSTAT and Pharmacia RAST Phadebas CAP systems in 49 patients with food allergies. Ann Allergy 1993;71:107-14
36. Ricci R, Capelli M, Miniero R, Menna G, Dillon P, Masi M. A comparison of different allergometric tests, skin prick test, Pharmacia UniCAP̊ and ADVIA Centaur̊, for diagnosis of allergic diseases in children. Allergy 2003;58:38-45
37. Venter C, Hasan Arshad G, Grundy J, et al. Time trends in the prevalence of peanut allergy: three cohorts of children from the same geographical location in the UK. Allergy 2010;65:103-8
38. Niggemann B, Celik-Bilgili S, Ziegert M, Reibel S, Sommerfeld C, Wahn U. Specific IgE levels do not indicate persistence or transience of food allergy in children with atopic dermatitis. J Investig Allergol Clin Immunol 2004;14:98-103
39. Pumphrey RS. Lessons for management of anaphylaxis from a study of fatal reactions. Clin Exp Allergy 2000;30:1144-50
40. Macdougall CF, Cant AJ, Colver AF. How dangerous is food allergy in childhood? The incidence of severe and fatal allergic reactions across the UK and Ireland. Arch Dis Child 2002;86:236-9
41. Sampson HA, Ho DG. Relationship between food-specific IgE concentrations and the risk of positive food challenges in children and adolescents. J Allergy Clin Immunol 1997;100:444-51
42. Skolnick H, Conover-Walker MK, Koerner CB, Sampson HA, Burks W, Wood RA. The natural history of peanut allergy. J Allergy Clin Immunol 2001;107:367-74
43. Celik-Bilgili S, Mehl A, Verstege A, et al. The predictive value of specific immunoglobulin E levels in serum for the outcome of oral food challenges. Clin Exp Allergy 2005;35:268-73
44. Osterballe M, Bindslev-Jensen C. Threshold levels in food challenge and specific IgE in patients with egg allergy: is there a relationship. J Allergy Clin Immunol 2003;112:196-201
45. Järvinen K-M, Beyer K, Vila L, Bardina L, Mishoe M, Sampson HA. Specificity of IgE antibodies to sequential epitopes of hen's egg ovomucoid as a marker of persistence of egg allergy. Allergy 2007;62:758-65
46. Garcia-Ara MC, Boyano-Martinez MT, Diaz-Pena JM, Martin-Munoz MF, Martin-Estaban M. Cow's milk-specific immunoglobulin E levels as predictors of clinical reactivity in the follow-up of the cow's milk allergy in infants. Clin Exp Allergy 2004;34:866-70
47. Vandenplas Y, Koletzko S, Isolauri E, et al. Guidelines for the diagnosis and management of cow's milk protein allergy in infants. Arch Dis Child 2007;92:902-8
48. Shek LP, Soderstrom L, Ahlstedt S, Beyer K, Sampson HA. Determination of food specific IgE levels over time can predict the development of tolerance in cow's milk and hen's egg allergy. J Allergy Clin Immunol 2004;114:387-91
49. Sampson HA. Food allergy. Part 2: diagnosis and management. J Allergy Clin Immunol 1999;103:981-99
50. Ortolani C, Ballmer-Weber BK, Hansen KS. Hazelnut allergy: a double-blind, placebo-controlled food challenge multicentre study. J Allergy Clin Immunol 2000;105:577-81
51. Ballmer-Weber BK, Vieths S, Luttkopf D. Celery allergy confirmed by double-blind, placebo-controlled food challenge: a clinical study in 32 subjects with a history of adverse reactions to celery root. J Allergy Clin Immunol 2000;106:373-8
52. Guilloux L, Morisset M, Codreanu F, Parisot L, Moneret-Vautrin DA. Peanut allergy diagnosis in the context of grass pollen sensitization for 125 patients: roles of peanut and cross-reactive carbohydrate determinants specific IgE. Int Arch Allergy Immunol 2009;149:91-7
53. van der Veen MJ, van Ree R, Aalberse RC, et al. Poor biologic activity of cross-reactive IgE directed to carbohydrate determinants of glycoproteins. J Allergy Clin Immunol 1997;100:327-34
54. Jones SM, Magnolfi CF, Cooke SK, Sampson HA. Immunologic cross-reactivity among cereal grains and grasses in children with food hypersensitivity. J Allergy Clin Immunol 1995;96:341-51
55. Rodríguez-Perez R, Fernández-Rivas M, González-Mancebo E, Sánchez-Monge R, Díaz-Perales A, Salcedo G. Peach profilin: cloning, heterologous expression and cross-reactivity with Bet v 2. Allergy 2003;58:635-40
56. Working Group of the Resuscitation Council (UK). Emergency Treatment of Anaphylactic Reactions. Guidelines for Healthcare Providers. London: Resuscitation Council (UK), 2008
57. Pengiran Tengah CD, Lock RJ, Unsworth DJ, Wills AJ. Multiple sclerosis and occult gluten sensitivity. Neurology 2004;62:2326-7
58. Hadjivassiliou M, Gibson A, Davies-Jones GA, Lobo AJ, Stephenson TJ, Milford-Ward A. Does cryptic gluten sensitivity play a part in neurological illnes? Lancet 1996;347:369-71
59. Lock RJ, Pengiran Tengah DSNA, Unsworth DJ, Ward JJ, Wills AJ. Ataxia, peripheral neuropathy, and anti-gliadin antibody. Guilt by association? J Neurol Neurosurg Psychiatry 2005;76:1601-3
60. Abele M, Schöls L, Schwartz S, Klockgether T. Prevalence of antigliadin antibodies in ataxia patients. Neurology 2003;60:1674-5
61. Atkinson W, Sheldon TA, Shaath N, Whorwell PJ. Food elimination based on IgG antibodies in irritable bowel syndrome: a randomised controlled trial. Gut 2004;53:1459-64
62. Kruszewski J, Rackza A, Klos M, Wiktor-Jedrzejczak W. High serum levels of allergen specific IgG-4 (asIgG-4) for common food allergens in healthy blood donors. Arch Immunol Ther Exp (Warsz) 1994;42:259-61
63. Husby S, Schultz Larsen F, Svehag SE. IgG subclass antibodies to dietary antigens in atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 1989;144:88-92
64. Rossi RE, Monasterolo G, Coco G, Silvestro L, Operti D. Evaluation of serum IgG4 antibodies specific to grass pollen allergen components in the follow up of allergic patients undergoing subcutaneous and sublingual immunotherapy. Vaccine 2007;25:957-64
65. Clark AT, Islam S, King Y, Deighton J, Anagnostou K, Ewan PW. Successful oral tolerance induction in severe peanut allergy. Allergy 2009;64:1218-20
66. Shakib F, Brown HM, Stanworth DR. Relevance of milk- and egg-specific IgG4 in atopic eczema. Int Arch Allergy Appl Immunol 1984;75:107-12
67. Garcia BE, Sanz ML, Fernandez M, Dieguez I, Oehling A. Value of IgG4 antibodies against foods in atopic dermatitis. Allergol Immunopathol (Madr) 1990;18:187-90
68. Noh G, Ahn HS, Cho NY, Lee S, Oh JW. The clinical significance of food specific IgE/IgG4 in food specific atopic dermatitis. Pediatr Allergy Immunol 2007;18:63-70
69. Norgaard A, Bindslev-Jensen C, Stahl Skov P, Poulsen LK. Specific serum IgE in the diagnosis of egg and milk allergy in adults. Allergy 1995;50:636-47
70. Moneret-Vautrin DA, Sainte-Laudy J, Kanny G, Fremont S. Human basophil activation measured by CD63 expression and LTC4 release in IgE-mediated food allergy. Ann Allergy Asthma Immunol 1999;82: 33-40
71. Erdmann SM, Heussen N, Moll-Slodowy S, Merk HF, Sachs B. CD63 expression on basophils as a tool for the diagnosis of pollen-associated food allergy: sensitivity and specificity. Clin Exp Allergy 2003;33: 607-14
72. Worm M, Vieth W, Ehlers I, Sterry W, Zuberbier T. Increased leukotriene production by food additives in patients with atopic dermatitis and proven food intolerance. Clin Exp Allergy 2001;31:265-73
73. Niggemann B, Grüber C. Unproven diagnostic procedures in IgE-mediated allergic diseases. Allergy 2004;59:806-8
74. Spergel JM, Beausoleil JL, Fiedler JM, Ginsberg J, Wagner K, Pawlowski NA. Correlation of initial food reactions to observed reactions on challenges. Ann Allergy Asthma Immunol 2004;92:217-24
75. Roesler TA, Barry PC, Bock SA. Factitious food allergy and failure to thrive. Arch Pediatr Adolesc Med 1994;148:1150-5
76. Rottem M, Shostak D, Foldi S. The predictive value of specific immunoglobulin E on the outcome of milk allergy. IMAJ 2008;10:862-4
77. Majamaa H, Moisio P, Holm K, Turjanmaa K. Wheat allergy: diagnostic accuracy of skin prick and patch tests and specific IgE. Allergy 1999;54:851-6
78. Giampietro PG, Ragno V, Daniele S, Cantani A, Ferrara M, Businco L. Soy hypersensitivity in children with food allergy. Ann Allergy 1992;69:143-6
79. Benhamou AH, Zamora S, Eigenmann PA. Correlation between specific immunoglobulin E levels and the severity of reactions in egg allergic patients. Pediatr Allergy Immunol 2008;19:173-9