Fine mapping of a major QTL influencing morphine preference in C57BL/6 and DBA/2 mice using congenic strains

Neuropsychopharmacology

Volumn 33, Issue 12, 2008, Pages 2801-2809

  Doyle, Glenn A ^a   Furlong, Patrick J ^a   Schwebel, Candice L ^a   Smith, George G ^a,b   Lohoff, Falk W ^a   Buono, Russell J ^b   Berrettini, Wade H ^a   Ferraro, Thomas N ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Behavior; Complex trait; Drinking; Mice; Opioids; Quinine

Indexed keywords

MORPHINE; QUININE; SACCHARIN;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR; C57BL MOUSE; CHROMOSOME 10; CHROMOSOME 6; CONGENIC STRAIN; CONTROLLED STUDY; DBA MOUSE; DRINKING; DRUG PREFERENCE; GENE MAPPING; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; STRAIN DIFFERENCE; SUBSTANCE ABUSE; TELOMERE;

ANALGESICS, NON-NARCOTIC; ANALGESICS, OPIOID; ANIMALS; ANIMALS, CONGENIC; BRAIN CHEMISTRY; CHROMOSOME MAPPING; DISCRIMINATION LEARNING; FOOD PREFERENCES; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; MORPHINE; MORPHINE DEPENDENCE; NERVE TISSUE PROTEINS; QUANTITATIVE TRAIT LOCI; QUININE; R-SNARE PROTEINS; SPECIES SPECIFICITY;

EID: 53949102722     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/npp.2008.14     Document Type: Article

References (58)

1. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS (2000). A novel family of mammalian taste receptors. Cell 100: 693-702.
2. Alexander RC, Heydt D, Ferraro TN, Vogel W, Berrettini WH (1996). Further evidence for a quantitative trait locus on murine chromosome 10 controlling morphine preference in inbred mice. Psychiatr Genet 6: 29-31.
3. Baumgartner A, Pinna G, Hiedra L, Bauer F, Wolf J, Eravci M et al (1998). Effects of acute administration of ethanol and the mu-opiate agonist etonitazene on thyroid hormone metabolism in rat brain. Psychopharmacology (Berl) 135: 63-69.
4. Belknap JK (1990). Physical dependence induced by the voluntary consumption of morphine in inbred mice. Pharmacol Biochem Behav 35: 311-315.
5. Belknap JK, Crabbe JC, Riggan J, O'Toole LA (1993a). Voluntary consumption of morphine in 15 inbred mouse strains. Psychopharmacology (Berl) 112: 352-358.
6. Belknap JK, Crabbe JC, Young ER (1993b). Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology (Berl) 112: 503-510.
7. Belknap JK, Mogil JS, Helms ML, Richards SP, O'Toole LA, Bergeson SE et al (1995). Localization to chromosome 10 of a locus influencing morphine analgesia in crosses derived from C57BL/6 and DBA/2 strains. Life Sci 57: PL117-PL124.
8. Bergeson SE, Helms ML, O'Toole LA, Jarvis MW, Hain HS, Mogil JS et al (2001). Quantitative trait loci influencing morphine antinociception in four mapping populations. Mamm Genome 12: 546-553.
9. Berrettini WH, Alexander R, Ferraro TN, Vogel WH (1994a). A study of oral morphine preference in inbred mouse strains. Psychiatr Genet 4: 81-86.
10. Berrettini WH, Ferraro TN, Alexander RC, Buchberg AM, Vogel WH (1994b). Quantitative trait loci mapping of three loci controlling morphine preference using inbred mouse strains. Nat Genet 7: 54-58.
11. Blizard DA, Kotlus B, Frank ME (1999). Quantitative trait loci associated with short-term intake of sucrose, saccharin and quinine solutions in laboratory mice. Chem Senses 24: 373-385.
12. Bolan EA, Pan YX, Pasternak GW (2004). Functional analysis of MOR-1 splice variants of the mouse mu opioid receptor gene Oprm. Synapse 51: 11-18.
13. Boughter Jr JD, Raghow S, Nelson TM, Munger SD (2005). Inbred mouse strains C57BL/6J and DBA/2J vary in sensitivity to a subset of bitter stimuli. BMC Genet 6: 36.
14. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W et al (2000). T2Rs function as bitter taste receptors. Cell 100: 703-711.
15. Contet C, Kieffer BL, Befort K (2004). Mu opioid receptor: a gateway to drug addiction. Curr Opin Neurobiol 14: 370-378. Review.
16. Cunningham CL, Niehus DR, Malott DH, Prather LK (1992). Genetic differences in the rewarding and activating effects of morphine and ethanol. Psychopharmacology (Berl) 107: 385-393.
17. Doyle GA, Sheng XR, Lin SS, Press DM, Grice DE, Buono RJ et al (2007a). Identification of three mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. Gene 388: 135-147, (originally published online Nov. 1, 2006, as doi:10.1016/j.gene.2006.10.017).
18. Doyle GA, Sheng XR, Lin SS, Press DM, Grice DE, Buono RJ et al (2007b). Identification of five mouse mu-opioid receptor (MOR) gene (Oprm1) splice variants containing a newly identified alternatively spliced exon. Gene 395: 98-107, (originally published online Feb. 20, 2007, as doi:10.1016/j.gene.2007.02.004).
19. Doyle GA, Sheng XR, Schwebel CL, Ferraro TN, Berrettini WH, Buono RJ (2006). Identification and functional significance of polymorphisms in the mu-opioid receptor gene (Oprm) promoter of C57BL/6 and DBA/2 mice. Neurosci Res 55: 244-254, (originally published online Apr. 27, 2006, as doi:10.1016/j.neures.2006.03.005).
20. Ferraro TN, Golden GT, Smith GG, Martin JF, Schwebel CL, Doyle GA et al (2005). Confirmation of a major QTL influencing oral morphine intake in C57 and DBA mice using reciprocal congenic strains. Neuropsychopharmacology 30: 742-746.
21. Ferraro TN, Schill JF, Ballas C, Mulholland N, Golden GT, Smith GG et al (1998). Genotyping microsatellite polymorphisms by agarose gel electrophoresis with ethidium bromide staining: application to quantitative trait loci analysis of seizure susceptibility in mice. Psychiatr Genet 8: 227-233.
22. Frank ME, Blizard DA (1999). Chorda tympani responses in two inbred strains of mice with different taste preferences. Physiol Behav 67: 287-297, review.
23. Frigeni V, Bruno F, Carenzi A, Racagni G (1981). Difference in the development of tolerance to morphine and D-ALA2-methionine-enkephalin in C57 BL/6J and DBA/2J mice. Life Sci 28: 729-736.
24. Garzon J, Rodriguez-Munoz M, Lopez-Fando A, Sanchez-Blazquez P (2005a). The RGSZ2 protein exists in a complex with mu-opioid receptors and regulates the desensitizing capacity of Gz proteins. Neuropsychopharmacology 30: 1632-1648.
25. Garzon J, Rodriguez-Munoz M, Sanchez-Blazquez P (2005b). Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter. Neuropharmacology 48: 853-868.
26. Giros B, Pohl M, Rochelle JM, Seldin MF (1995). Chromosomal localization of opioid peptide and receptor genes in the mouse. Life Sci 56: PL369-PL375.
27. Horowitz GP, Whitney G, Smith JC, Stephan FK (1977). Morphine ingestion: genetic control in mice. Psychopharmacology (Berl) 52: 119-122.
28. Iakoubova OA, Olsson CL, Dains KM, Ross DA, Andalibi A, Lau K et al (2001). Genome-tagged mice (GTM): two sets of genomewide congenic strains. Genomics 74: 89-104.
29. Kest B, Palmese CA, Hopkins E, Adler M, Juni A, Mogil JS (2002). Naloxone-precipitated withdrawal jumping in 11 inbred mouse strains: evidence for common genetic mechanisms in acute and chronic morphine physical dependence. Neuroscience 115: 463-469.
30. Kozak CA, Filie J, Adamson MC, Chen Y, Yu L (1994). Murine chromosomal location of the mu and kappa opioid receptor genes. Genomics 21: 659-661.
31. Liu NJ, Chakrabarti S, Gintzler AR (2004). Chronic morphine-induced loss of the facilitative interaction between vasoactive intestinal polypeptide and delta-opioid: involvement of protein kinase C and phospholipase C betas. Brain Res 1010: 1-9.
32. Liu QR, Zhang PW, Zhen Q, Walther D, Wang XB, Uhl GR (2002). KEPI, a PKC-dependent protein phosphatase 1 inhibitor regulated by morphine. J Biol Chem 277: 13312-13320, (originally published online Jan. 25, 2002, as doi:10.1074/jbc.M107558200).
33. Loh HH, Liu HC, Cavalli A, Yang W, Chen YF, Wei LN (1998). Mu opioid receptor knockout in mice: effects on ligand-induced analgesia and morphine lethality. Brain Res Mol Brain Res 54: 321-326.
34. Lush IE (1984). The genetics of tasting in mice. III. Quinine. Genet Res 44: 151-160.
35. Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I et al (1996). Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 383: 819-823.
36. Muraki T, Kato R (1987). Genetic analysis of hypothermia induced by morphine in two strains of inbred mice. Pharmacol Biochem Behav 27: 87-91.
37. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJP, Zuker CS (2001). Mammalian sweet taste receptors. Cell 106: 381-390.
38. Nelson TM, Munger SD, Boughter Jr JD (2005). Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice. BMC Genet 6: 32.
39. Orsini C, Bonito-Oliva A, Conversi D, Cabib S (2005). Susceptibility to conditioned place preference induced by addictive drugs in mice of the C57BL/6 and DBA/2 inbred strains. Psychopharmacology (Berl) 181: 327-336, (originally published online Oct. 14, 2005, as doi:10.1007/s00213-005-2259-6).
40. Pan YX (2005). Diversity and complexity of the mu opioid receptor gene: alternative pre-mRNA splicing and promoters. DNA Cell Biol 24: 736-750, review.
41. Pan YX, Xu J, Bolan E, Abbadie C, Chang A, Zuckerman A et al (1999). Identification and characterization of three new alternatively spliced mu-opioid receptor isoforms. Mol Pharmacol 56: 396-403.
42. Pan YX, Xu J, Bolan E, Chang A, Mahurter L, Rossi G et al (2000). Isolation and expression of a novel alternatively spliced mu opioid receptor isoform, MOR-1F. FEBS Lett 466: 337-340.
43. Pan YX, Xu J, Bolan E, Moskowitz HS, Xu M, Pasternak GW (2005). Identification of four novel exon 5 splice variants of the mouse mu-opioid receptor gene: functional consequences of C-terminal splicing. Mol Pharmacol 68: 866-875, (originally published online Jun. 6, 2005, as doi:10.1124/mol.105.011858).
44. Pan YX, Xu J, Mahurter L, Bolan E, Xu M, Pasternak GW (2001). Generation of the mu opioid receptor (MOR-1) protein by three new splice variants of the Oprm gene. Proc Natl Acad Sci USA 98: 14084-14089.
45. Pasternak GW (2001a). The pharmacology of mu analgesics: from patients to genes. Neuroscientist 7: 220-231, review.
46. Pasternak GW (2001b). Insights into mu opioid pharmacology the role of mu opioid receptor subtypes. Life Sci 68: 2213-2219, review.
47. Reuveni E, Ramensky VE, Gross C (2007). Mouse SNP miner: an annotated database of mouse functional single nucleotide polymorphisms. BMC Genomics 8: 24.
48. Rodriguez-Munoz M, Bermudez D, Sanchez-Blazquez P, Garzon J (2007a). Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain. Neuropsychopharmacology 32: 842-850, (originally published online Aug. 9, 2006, as doi:10.1038/sj.npp. 1301184).
49. Rodriguez-Munoz M, de la Torre-Madrid E, Sanchez-Blazquez P, Garzon J (2007b). Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins. Mol Pain 3: 19.
50. Schuller AG, King MA, Zhang J, Bolan E, Pan YX, Morgan DJ et al (1999). Retention of heroin and morphine-6 beta-glucuronide analgesia in a new line of mice lacking exon 1 of MOR-1. Nat Neurosci 2: 151-156.
51. Snedecor GW (1950). Statistical Methods: Applied to Experiments in Agriculture and Biology, 4th edn. The Iowa State College Press: Ames, IA. pp 232-236.
52. Sora I, Takahashi N, Funada M, Ujike H, Revay RS, Donovan DM et al (1997). Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia. Proc Natl Acad Sci USA 94: 1544-1549.
53. Suzuki T, Otani K, Misawa M (1991). Differential sensitivity to physical dependence on morphine and codeine in three inbred strains of mice. Jpn J Pharmacol 57: 455-462.
54. Tian M, Broxmeyer HE, Fan Y, Lai Z, Zhang S, Aronica S et al (1997). Altered hematopoiesis, behavior, and sexual function in mu opioid receptor-deficient mice. J Exp Med 185: 1517-1522.
55. Tsuang MT, Bar JL, Harley RM, Lyons MJ (2001). The Harvard Twin Study of Substance Abuse: what we have learned. Harv Rev Psychiatry 9: 267-279, review.
56. Wang J, Williams RW, Manly KF (2003). WebQTL: web-based complex trait analysis. Neuroinformatics 1: 299-308.
57. Wood PL, Iyengar S (1988). Central actions of opiates and opioid peptides: in vivo evidence for opioid receptor multiplicity. In: Pasternak GW (ed). The Opiate Receptors. Humana Press Inc.: Clifton, NJ. pp 307-356.
58. Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJP et al (2003). The receptors for mammalian sweet and umami taste. Cell 115: 255-266.