Adrenomedullin expression is up-regulated by acute hypobaric hypoxia in the cerebral cortex of the adult rat

Brain Pathology

Volumn 18, Issue 3, 2008, Pages 434-442

  Serrano, Julia ^a   Fernández, Ana Patricia ^a   Sánchez, Jaime ^b   Rodrigo, José ^a   Martínez, Alfredo ^a  

^a INSTITUTO CAJAL   (Spain)

^b NBC Defense School   (Spain)

Author keywords

Adrenomedullin; Alternative splicing; Cerebral cortex; Hypobaric hypoxia; Neuroprotection; Real time PCR

Indexed keywords

ADRENOMEDULLIN; CALBINDIN; CALRETININ; MESSENGER RNA; PARVALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; GENE CONTROL; HYPOXIA; IMMUNOREACTIVITY; INTERNEURON; MACROGLIA; MALE; NONHUMAN; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN STRUCTURE; PYRAMIDAL NERVE CELL; RAT; REAL TIME POLYMERASE CHAIN REACTION; REOXYGENATION; RNA SPLICING;

ADRENOMEDULLIN; ALTITUDE SICKNESS; ANIMALS; ANOXIA; BLOTTING, WESTERN; CEREBRAL CORTEX; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; MALE; MICROSCOPY, CONFOCAL; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; UP-REGULATION;

EID: 44649126027     PISSN: 10156305     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2008.00142.x     Document Type: Article

References (42)

1. Allen MA, Ferguson AV (1996) In vitro recordings from area postrema neurons demonstrate responsiveness to adrenomedullin. Am J Physiol 270 : R920 R925.
2. Angerer P, Nowak D (2003) Working in permanent hypoxia for fire protection-impact on health. Int Arch Occup Environ Health 76 : 87 102.
3. Bahrke MS, Shukitt-Hale B (1993) Effects of altitude on mood, behaviour and cognitive functioning. A review. Sports Med 16 : 97 125.
4. Bernaudin M, Tang Y, Reilly M, Petit E, Sharp FR (2002) Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem 277 : 39728 39738.
5. Chen L, Kis B, Busija DW, Yamashita H, Ueta Y (2005) Adrenomedullin protects rat cerebral endothelial cells from oxidant damage in vitro. Regul Pept 130 : 27 34.
6. Cueille C, Birot O, Bigard X, Hagner S, Garel JM (2005) Post-transcriptional regulation of CRLR expression during hypoxia. Biochem Biophys Res Commun 326 : 23 29.
7. Cuttitta F, Pio R, Garayoa M, Zudaire E, Julian M, Elsasser TH, Montuenga LM, Martinez A (2002) Adrenomedullin functions as an important tumor survival factor in human carcinogenesis. Microsc Res Tech 57 : 110 119.
8. Dogan A, Suzuki Y, Koketsu N, Osuka K, Saito K, Takayasu M, Shibuya M, Yoshida J (1997) Intravenous infusion of adrenomedullin and increase in regional cerebral blood flow and prevention of ischemic brain injury after middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 17 : 19 25.
9. Encinas JM, Serrano J, Alonso D, Fernandez AP, Rodrigo J (2002) Adrenomedullin over-expression in the caudate-putamen of the adult rat brain after ischaemia-reperfusion injury. Neurosci Lett 329 : 197 200.
10. Encinas JM, Serrano J, Bentura ML, Castro-Blanco S, Fernandez AP, Rodrigo J (2003) Nitric oxide system and protein nitration are modified by an acute hypobaric hypoxia in the adult rat hippocampus. J Neuropathol Exp Neurol 62 : 863 877.
11. Encinas JM, Fernandez AP, Salas E, Castro-Blanco S, Munoz P, Rodrigo J, Serrano J (2004) Nitric oxide synthase and NADPH-diaphorase after acute hypobaric hypoxia in the rat caudate putamen. Exp Neurol 186 : 33 45.
12. Feuerstein GZ, Wang X (1997) Use of differential display reverse transcription-polymerase chain reaction for discovery of induced adrenomedullin gene expression in focal stroke. Can J Physiol Pharmacol 75 : 731 734.
13. Garayoa M, Martinez A, Lee S, Pio R, An WG, Neckers L et al (2000) Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: a possible promotion mechanism of carcinogenesis. Mol Endocrinol 14 : 848 862.
14. Garcia MA, Martin-Santamaria S, Cacho M, de la Llave FM, Julian M, Martinez A et al (2005) Synthesis biological evaluation, and three-dimensional quantitative structure-activity relationship study of small-molecule positive modulators of adrenomedullin. J Med Chem 48 : 4068 4075.
15. Hof PR, Glezer II, Conde F, Flagg RA, Rubin MB, Nimchinsky EA, Vogt Weisenhorn DM (1999) Cellular distribution of the calcium-binding proteins parvalbumin, calbindin, and calretinin in the neocortex of mammals: phylogenetic and developmental patterns. J Chem Neuroanat 16 : 77 116.
16. Kanazawa H, Kurihara N, Hirata K, Kudoh S, Kawaguchi T, Takeda T (1994) Adrenomedullin, a newly discovered hypotensive peptide, is a potent bronchodilator. Biochem Biophys Res Commun 205 : 251 254.
17. Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Nakamura S, Matsuo H, Eto T (1993) Adrenomedullin: a novel hypotensive peptide isolated from human pheochromocytoma. Biochem Biophys Res Commun 192 : 553 560.
18. Loder I, Rossler A, Wurzinger G, Duncko R, Jezova D, Hinghofer-Szalkay H (2006) Adrenomedullin and elements of orthostatic competence after 41 h of voluntary submersion in water as measured in four healthy males. Eur J Appl Physiol 96 : 644 650.
19. Martinez A, Miller MJ, Unsworth EJ, Siegfried JM, Cuttitta F (1995) Expression of adrenomedullin in normal human lung and in pulmonary tumors. Endocrinology 136 : 4099 4105.
20. Martinez A, Unsworth EJ, Cuttitta F (1996) Adrenomedullin-like immunoreactivity in the nervous system of the starfish Marthasterias glacialis. Cell Tissue Res 283 : 169 172.
21. Martinez A, Weaver C, Lopez J, Bhathena SJ, Elsasser TH, Miller MJ, Moody TW, Unsworth EJ, Cuttitta F (1996) Regulation of insulin secretion and blood glucose metabolism by adrenomedullin. Endocrinology 137 : 2626 2632.
22. Martinez A, Hodge DL, Garayoa M, Young HA, Cuttitta F (2001) Alternative splicing of the proadrenomedullin gene results in differential expression of gene products. J Mol Endocrinol 27 : 31 41.
23. Martinez A, Julian M, Bregonzio C, Notari L, Moody TW, Cuttitta F (2004) Identification of vasoactive nonpeptidic positive and negative modulators of adrenomedullin using a neutralizing antibody-based screening strategy. Endocrinology 145 : 3858 3865.
24. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N et al (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393 : 333 339.
25. Miyashita K, Itoh H, Arai H, Suganami T, Sawada N, Fukunaga Y et al (2006) The neuroprotective and vasculo-neuro-regenerative roles of adrenomedullin in ischemic brain and its therapeutic potential. Endocrinology 147 : 1642 1653.
26. Montuenga LM, Martinez A, Miller MJ, Unsworth EJ, Cuttitta F (1997) Expression of adrenomedullin and its receptor during embryogenesis suggests autocrine or paracrine modes of action. Endocrinology 138 : 440 451.
27. Munoz M, Martinez A, Cuttitta F, Gonzalez A (2001) Distribution of adrenomedullin-like immunoreactivity in the central nervous system of the frog. J Chem Neuroanat 21 : 105 123.
28. Nakanishi K, Osada H, Uenoyama M, Kanazawa F, Ohrui N, Masaki Y et al (2004) Expressions of adrenomedullin mRNA and protein in rats with hypobaric hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 286 : H2159 H2168.
29. Serrano J, Uttenthal LO, Martinez A, Fernandez AP, Martinez de Velasco J, Alonso D et al (2000) Distribution of adrenomedullin-like immunoreactivity in the rat central nervous system by light and electron microscopy. Brain Res 853 : 245 268.
30. Serrano J, Alonso D, Encinas JM, Lopez JC, Fernandez AP, Castro-Blanco S et al (2002) Adrenomedullin expression is up-regulated by ischemia-reperfusion in the cerebral cortex of the adult rat. Neuroscience 109 : 717 731.
31. Serrano J, Alonso D, Fernandez AP, Encinas JM, Lopez JC, Castro-Blanco S et al (2002) Adrenomedullin in the central nervous system. Microsc Res Tech 57 : 76 90.
32. Serrano J, Encinas JM, Salas E, Fernandez AP, Castro-Blanco S, Fernandez-Vizarra P et al (2003) Hypobaric hypoxia modifies constitutive nitric oxide synthase activity and protein nitration in the rat cerebellum. Brain Res 976 : 109 119.
33. Shimosawa T, Matsui H, Xing G, Itakura K, Ando K, Fujita T (2003) Organ-protective effects of adrenomedullin. Hypertens Res 26 (Suppl. S109 S112.
34. Shu SY, Ju G, Fan LZ (1988) The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci Lett 85 : 169 171.
35. Ueta Y, Kitamura K, Isse T, Shibuya I, Kabashima N, Yamamoto S et al (1995) Adrenomedullin-immunoreactive neurons in the paraventricular and supraoptic nuclei of the rat. Neurosci Lett 202 : 37 40.
36. Wang X, Yue TL, Barone FC, White RF, Clark RK, Willette RN et al (1995) Discovery of adrenomedullin in rat ischemic cortex and evidence for its role in exacerbating focal brain ischemic damage. Proc Natl Acad Sci USA 92 : 11480 11484.
37. Wang S, Yu Z, Liu K (2001 Synthesis and release of pulmonary tissue adrenomedullin on hypoxic pulmonary hypertension in rats and its significance Zhonghua Jie He He Hu Xi Za Zhi 24 : 725 727.
38. Watanabe K, Takayasu M, Noda A, Hara M, Takagi T, Suzuki Y, Yoshia JW (2001) Adrenomedullin reduces ischemic brain injury after transient middle cerebral artery occlusion in rats. Acta Neurochir (Wien) 143 : 1157 1161.
39. Xia CF, Yin H, Borlongan CV, Chao J, Chao L (2004) Adrenomedullin gene delivery protects against cerebral ischemic injury by promoting astrocyte migration and survival. Hum Gene Ther 15 : 1243 1254.
40. Xia CF, Yin H, Borlongan CV, Chao J, Chao L (2006) Postischemic infusion of adrenomedullin protects against ischemic stroke by inhibiting apoptosis and promoting angiogenesis. Exp Neurol 197 : 521 530.
41. Zudaire E, Martinez A, Ozbun LL, Cuttitta F (2004) Characterization of adrenomedullin in non-human primates. Biochem Biophys Res Commun 321 : 859 869.
42. Zudaire E, Cuesta N, Martinez A, Cuttitta F (2005) Characterization of adrenomedullin in birds. Gen Comp Endocrinol 143 : 10 20.