MiRNA expression profiles in myelodysplastic syndromes reveal EpsteinBarr virus miR-BART13 dysregulation

Leukemia and Lymphoma

Volumn 52, Issue 8, 2011, Pages 1567-1573

  Borze, Ioana ^a   Scheinin, Ilari ^a   Siitonen, Sanna ^b   Elonen, Erkki ^b   Juvonen, Eeva ^c   Knuutila, Sakari ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c Finnish Red Cross   (Finland)

Author keywords

aCGH; bone marrow smear; MDS; miRNA array

Indexed keywords

EPSTEIN BARR VIRUS MIR BART13; MICRORNA 1260; MICRORNA 1268; MICRORNA 199A 3P; MICRORNA 21; MICRORNA 574 5P; MICRORNA 575; MICRORNA 671 5P; MICRORNA 720; MICRORNA K12 12; UNCLASSIFIED DRUG; VIRUS RNA;

ARTICLE; BONE MARROW CELL; CHRONIC MYELOMONOCYTIC LEUKEMIA; COHORT ANALYSIS; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; COPY NUMBER VARIATION; EPSTEIN BARR VIRUS; GENE EXPRESSION PROFILING; HUMAN; MAJOR CLINICAL STUDY; MYELODYSPLASTIC SYNDROME; NONHUMAN; PRIORITY JOURNAL; REFRACTORY ANEMIA WITH EXCESS BLASTS; REFRACTORY CYTOPENIA WITH MULTILINEAGE DYSPLASIA; UPREGULATION;

BONE MARROW CELLS; COMPARATIVE GENOMIC HYBRIDIZATION; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, VIRAL; HERPESVIRUS 4, HUMAN; HUMANS; KARYOTYPING; MICRORNAS; MYELODYSPLASTIC SYNDROMES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; UP-REGULATION;

EID: 79960392807     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2011.568652     Document Type: Article

References (47)

1. Platzbecker M, Meredyth-Stewart M, Ehninger G. The pathogenesis of myelodysplastic syndromes (MDS). Cancer Treat Rev 2007;33:S53-S58 (Pubitemid 350056323)
2. Bejar R, Ebert BL. The genetic basis of myelodysplastic syndromes. Hematol Oncol Clin North Am 2010;24:295-315
3. Borze I, Juvonen E, Ninomiya S, Jee KJ, Elonen E, Knuutila S. High-resolution oligonucleotide array comparative genomic hybridization study and methylation status of the RPS14 gene in de novo myelodysplastic syndromes. Cancer Genet Cytogenet 2010;197:166-173
4. Paulsson K, Heidenblad M, Strombeck B, et al. Highresolution genome-wide array-based comparative genome hybridization reveals cryptic chromosome changes in AML and MDS cases with trisomy 8 as the sole cytogenetic aberration. Leukemia 2006;20:840-846
5. Martinez-Ramirez A, Urioste M, Melchor L, et al. Analysis of myelodysplastic syndromes with complex karyotypes by highresolution comparative genomic hybridization and subtelomeric CGH array. Genes Chromosomes Cancer 2005;42: 287-298 (Pubitemid 40171193)
6. Vercauteren SM, Sung S, Starczynowski DT, et al. Array comparative genomic hybridization of peripheral blood granulocytes of patients with myelodysplastic syndrome detects karyotypic abnormalities. Am J Clin Pathol 2010;134:119-126
7. Langemeijer SM, Kuiper RP, Berends M, et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet 2009;41:838-842
8. Szpurka H, Jankowska AM, Makishima H, et al. Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations. Leuk Res 2010;34:969-973
9. Heinrichs S, Kulkarni RV, Bueso-Ramos CE, et al. Accurate detection of uniparental disomy and microdeletions by SNP array analysis in myelodysplastic syndromes with normal cytogenetics. Leukemia 2009;23:1605-1613
10. Mohamedali A, Gaken J, Twine NA, et al. Prevalence and prognostic significance of allelic imbalance by single-nucleotide polymorphism analysis in low-risk myelodysplastic syndromes. Blood 2007;110:3365-3373 (Pubitemid 350106331)
11. Dutta KK, Zhong Y, Liu YT, et al. Association of microRNA- 34a overexpression with proliferation is cell type-dependent. Cancer Sci 2007;98:1845-1852 (Pubitemid 350002188)
12. Raponi M, Dossey L, Jatkoe T, et al. MicroRNA classifiers for predicting prognosis of squamous cell lung cancer. Cancer Res 2009;69:5776-5783
13. Costa A, Osorio C, Dias S. MicroRNA expression profiling in bone marrow: implications in hematological malignancies. Biotechnol J 2009;4:88-97
14. Dickstein J, Senyuk V, Premanand K, et al. Methylation and silencing of miRNA-124 by EVI1 and self-renewal exhaustion of hematopoietic stem cells in murine myelodysplastic syndrome. Proc Natl Acad Sci USA 2010;107:9783-9788
15. Kumar M, Narla A, Nonami A, et al. Coordinate loss of a microRNA mir 145 and a protein-coding gene RPS14 cooperate in the pathogenesis of 5q- syndrome. Blood 2009;114(Suppl. 1): Abstract 947
16. Gaken J, Mohamedali AZ, Twine N, et al. MicroRNA expression profiling of high and low risk MDS. Blood 2008;112(Suppl. 1): Abstract 3645
17. Dostalova Merkerova M, Krejcik Z, Votavova H, Belickova M, Vasikova A, Cermak J. Distinctive microRNA expression profiles in CD34? bone marrow cells from patients with myelodysplastic syndrome. Eur J Hum Genet 2011;19:313-319
18. Jaffe ES, Harris NL, Stein H, Vardiman JW. WHO classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues. Lyon: IARC; 2001. pp 61-73
19. Borze I, Guled M, Musse S, et al. MicroRNA microarrays on archive bone marrow core biopsies of leukemias-method validation. Leuk Res 2011;35:188-195
20. R Development Core Team. R: a language and environment for statistical computing. Vienna: R Foundation for Statistical Computing; 2009
21. Gentleman RC, Carey VJ, Bates DM, et al. Bioconductor: open software development for computational biology and bioinformatics. Genome Biol 2004;5:R80
22. Lopez-Romero P, Gonzalez MA, Callejas S, Dopazo A, Irizarry RA. Processing of agilent microRNA array data. BMC Res Notes 2010;3:18
23. Irizarry RA, Hobbs B, Collin F, et al. Exploration, normalization, and summaries of high density oligonucleotide array probe level data. Biostatistics 2003;4:249-264
24. Smyth GK, Speed T. Normalization of cDNA microarray data. Methods 2003;31:265-273 (Pubitemid 37338763)
25. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B 1995;57:289-300
26. Krek A, Grun D, Poy MN, et al. Combinatorial microRNA target predictions. Nat Genet 2005;37:495-500. [Available from: http://pictar.mdc-berlin.de/] (Pubitemid 40617277)
27. Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120:15-20. [Available from: http://targetscan.org/] (Pubitemid 40094598)
28. Ritchie ME, Silver J, Oshlack A, et al. A comparison of background correction methods for two-colour microarrays. Bioinformatics 2007;23:2700-2707 (Pubitemid 350048334)
29. van de Wiel MA, Brosens R, Eilers PH, et al. Smoothing waves in array CGH tumor profiles. Bioinformatics 2009;25: 1099-1104
30. Siggberg L, Ala-Mello S, Jaakkola E, et al. Array CGH in molecular diagnosis of mental retardation - a study of 150 Finnish patients. Am J Med Genet A 2010;152A:1398-1410
31. Venkatraman ES, Olshen AB. A faster circular binary segmentation algorithm for the analysis of array CGH data. Bioinformatics 2007;23:657-663 (Pubitemid 46554715)
32. van de Wiel MA, Kim KI, Vosse SJ, van Wieringen WN, Wilting SM, Ylstra B. CGHcall: calling aberrations for array CGH tumor profiles. Bioinformatics 2007;23:892-894 (Pubitemid 47049924)
33. Scheinin I, Myllykangas S, Borze I, Bohling T, Knuutila S, Saharinen J. CanGEM: mining gene copy number changes in cancer. Nucleic Acids Res 2008;36:D830-D835 (Pubitemid 351149831)
34. Hussein K, Theophile K, Busche G, et al. Aberrant microRNA expression pattern in myelodysplastic bone marrow cells. Leuk Res 2010;34:1169-1174
35. Hussein K, Theophile K, Busche G, et al. Significant inverse correlation of microRNA-150/MYB and microRNA-222/p27 in myelodysplastic syndrome. Leuk Res 2010;34:328-334
36. Pons A, Nomdedeu B, Navarro A, et al. Hematopoiesisrelated microRNA expression in myelodysplastic syndromes. Leuk Lymphoma 2009;50:1854-1859
37. Starczynowski DT, Kuchenbauer F, Argiropoulos B, et al. Identification of miR-145 and miR-146a as mediators of the 5q- syndrome phenotype. Nat Med 2010;16:49-58
38. Bousquet M, Quelen C, Rosati R, et al. Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocation. J Exp Med 2008;205:2499-506
39. Hermeking H. The miR-34 family in cancer and apoptosis. Cell Death Differ 2010;17:193-199
40. Cazzola M. Myelodysplastic syndrome with isolated 5q deletion (5q- syndrome). A clonal stem cell disorder characterized by defective ribosome biogenesis. Haematologica 2008;93:967-972
41. Seto E, Moosmann A, Gromminger S, Walz N, Grundhoff A, Hammerschmidt W. Micro RNAs of Epstein-Barr virus promote cell cycle progression and prevent apoptosis of primary human B cells. PLoS Pathog 2010;6:pii:e1001063
42. Pfeffer S, Voinnet O. Viruses, microRNAs and cancer. Oncogene 2006;25:6211-62119
43. Raza A. Myelodysplastic syndromes may have an infectious etiology. J Toxicol Environ Health A 2000;61:387-390
44. Raza A. Hypothesis: myelodysplastic syndromes may have a viral etiology. Int J Hematol 1998;68:245-256 (Pubitemid 28522550)
45. Selcuklu SD, Donoghue MT, Spillane C. miR-21 as a key regulator of oncogenic processes. Biochem Soc Trans 2009;37:918-925
46. Kerbauy DB, Deeg HJ. Apoptosis and antiapoptotic mechanisms in the progression of myelodysplastic syndrome. Exp Hematol 2007;35:1739-1746 (Pubitemid 47633781)
47. Swerdlow SH, Campo E, Harris NL, et al.WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. Lyon: IARC; 2008