Micro RNAS of epstein-barr virus promote cell cycle progression and prevent apoptosis of primary human B cells

PLoS Pathogens

Volumn 6, Issue 8, 2010, Pages 69-70

  Seto, Eri ^a   Moosmann, Andreas ^b   Grömminger, Sebastian ^a   Walz, Nicole ^c   Grundhoff, Adam ^c   Hammerschmidt, Wolfgang ^a  

^a INSTITUTE OF EPIDEMIOLOGY   (Germany)

^b UNIVERSITY OF MUNICH   (Germany)

^c LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; PROTEIN BHRF1; UNCLASSIFIED DRUG; VIRUS PROTEIN; BHRF1 PROTEIN, HUMAN HERPESVIRUS 4; VIRUS RNA;

APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL SURVIVAL; EPSTEIN BARR VIRUS; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOBLASTOID CELL LINE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; RNA PROCESSING; RNA SEQUENCE; RNA TRANSCRIPTION; VIRUS LATENCY; CELL CYCLE; EPSTEIN BARR VIRUS INFECTION; GENETICS; MOLECULAR GENETICS; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIROLOGY; VIRUS CELL TRANSFORMATION; VIRUS GENE;

HEXAPODA; HUMAN HERPESVIRUS 4; MAMMALIA;

APOPTOSIS; B-LYMPHOCYTES; BASE SEQUENCE; CELL CYCLE; CELL TRANSFORMATION, VIRAL; EPSTEIN-BARR VIRUS INFECTIONS; GENES, VIRAL; HERPESVIRUS 4, HUMAN; HUMANS; MICRORNAS; MOLECULAR SEQUENCE DATA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, VIRAL; VIRAL PROTEINS; VIRUS LATENCY;

EID: 77958141684     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001063     Document Type: Article

References (53)

1. Kim VN, Han J, Siomi MC (2009) Biogenesis of small RNAs in animals. Nat Rev Mol Cell Biol 10: 126-139.
2. Bartel DP (2004) MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 116: 281-297.
3. Landgraf P, Rusu M, Sheridan R, Sewer A, Iovino N, et al. (2007) A mammalian microRNA expression atlas based on small RNA library sequencing. Cell 129: 1401-1414.
4. Bartel DP (2009) MicroRNAs: target recognition and regulatory functions. Cell 136: 215-233.
5. Ambros V (2004) The functions of animal microRNAs. Nature 431: 350-355.
6. Bushati N, Cohen SM (2007) MicroRNA functions. Annu Rev Cell Dev Biol 23: 175-205.
7. Pfeffer S, Voinnet O (2006) Viruses, microRNAs and cancer. Oncogene 25: 6211-6219.
8. Visone R, Croce CM (2009) MiRNAs and cancer. Am J Pathol 174: 1131-1138.
9. Gottwein E, Cullen BR (2008) Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 3: 375-387.
10. Xiao C, Rajewsky K (2009) MicroRNA control in the immune system: basic principles. Cell 136: 26-36.
11. Lewis BP, Burge CB, Bartel DP (2005) Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 120: 15-20.
12. Selbach M, Schwanhausser B, Thierfelder N, Fang Z, Khanin R, et al. (2008) Widespread changes in protein synthesis induced by microRNAs. Nature 455: 58-63.
13. Rajewsky N (2006) MicroRNA target predictions in animals. Nat Genet 38 Suppl: S8-13.
14. Walz N, Christalla T, Tessmer U, Grundhoff A (2010) A global analysis of evolutionary conservation among known and predicted gammaherpesvirus microRNAs. J Virol 84: 716-728.
15. Schafer A, Cai X, Bilello JP, Desrosiers RC, Cullen BR (2007) Cloning and analysis of microRNAs encoded by the primate gamma-herpesvirus rhesus monkey rhadinovirus. Virology 364: 21-27.
16. Grundhoff A, Sullivan CS, Ganem D (2006) A combined computational and microarray-based approach identifies novel microRNAs encoded by human gamma-herpesviruses. RNA 12: 733-750.
17. Samols MA, Skalsky RL, Maldonado AM, Riva A, Lopez MC, et al. (2007) Identification of cellular genes targeted by KSHV-encoded microRNAs. PLoS Pathog 3: e65.
18. Ziegelbauer JM, Sullivan CS, Ganem D (2009) Tandem array-based expression screens identify host mRNA targets of virus-encoded microRNAs. Nat Genet 41: 130-134.
19. Krutzfeldt J, Kuwajima S, Braich R, Rajeev KG, Pena J, et al. (2007) Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res 35: 2885-2892.
20. Krutzfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, et al. (2005) Silencing of microRNAs in vivo with 'antagomirs'. Nature 438: 685-689.
21. Ebert MS, Neilson JR, Sharp PA (2007) MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells. Nat Methods 4: 721-726.
22. Eis PS, Tam W, Sun L, Chadburn A, Li Z, et al. (2005) Accumulation of miR- 155 and BIC RNA in human B cell lymphomas. Proc Natl Acad Sci USA 102: 3627-3632.
23. van den Berg A, Kroesen BJ, Kooistra K, de Jong D, Briggs J, et al. (2003) High expression of B-cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma. Genes Chromosomes Cancer 37: 20-28.
24. Costinean S, Zanesi N, Pekarsky Y, Tili E, Volinia S, et al. (2006) Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic mice. Proc Natl Acad Sci USA 103: 7024-7029.
25. Gottwein E, Mukherjee N, Sachse C, Frenzel C, Majoros WH, et al. (2007) A viral microRNA functions as an orthologue of cellular miR-155. Nature 450: 1096-1099.
26. Skalsky RL, Samols MA, Plaisance KB, Boss IW, Riva A, et al. (2007) Kaposi's sarcoma-associated herpesvirus encodes an ortholog of miR-155. J Virol 81: 12836-12845.
27. David R (2010) MiRNAs help KSHV lay low. Nature Reviews Microbiology 8: 158-159.
28. Delecluse HJ, Hilsendegen T, Pich D, Zeidler R, Hammerschmidt W (1998) Propagation and recovery of intact, infectious Epstein-Barr virus from prokaryotic to human cells. Proc Natl Acad Sci USA 95: 8245-8250.
29. Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, et al. (1984) DNA sequence and expression of the B95-8 Epstein-Barr virus genome. Nature 310: 207-211.
30. Warming S, Costantino N, Court DL, Jenkins NA, Copeland NG (2005) Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Res 33: e36.
31. Altmann M, Hammerschmidt W (2005) Epstein-Barr virus provides a new paradigm: a requirement for the immediate inhibition of apoptosis. PLoS Biol 3: e404.
32. Neuhierl B, Feederle R, Hammerschmidt W, Delecluse HJ (2002) Glycoprotein gp110 of Epstein-Barr virus determines viral tropism and efficiency of infection. Proc Natl Acad Sci USA 99: 15036-15041.
33. Pratt ZL, Kuzembayeva M, Sengupta S, Sugden B (2009) The microRNAs of Epstein-Barr Virus are expressed at dramatically differing levels among cell lines. Virology 386: 387-397.
34. Cullen BR (2009) Viral and cellular messenger RNA targets of viral microRNAs. Nature 457: 421-425.
35. Bellare P, Ganem D (2009) Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivation. Cell Host Microbe 6: 570-575.
36. Lei X, Bai Z, Ye F, Xie J, Kim CG, et al. (2010) Regulation of NF-kappaB inhibitor IkappaBalpha and viral replication by a KSHV microRNA. Nat Cell Biol 12: 193-199.
37. Lu F, Stedman W, Yousef M, Renne R, Lieberman PM (2010) Epigenetic Regulation of Kaposi's Sarcoma-Associated Herpesvirus Latency by Virus-Encoded MicroRNAs That Target Rta and the Cellular Rbl2-DNMT Pathway. J Virol 84: 2697-2706.
38. Umbach JL, Kramer MF, Jurak I, Karnowski HW, Coen DM, et al. (2008) MicroRNAs expressed by herpes simplex virus 1 during latent infection regulate viral mRNAs. Nature 454: 780-783.
39. Murphy E, Vanicek J, Robins H, Shenk T, Levine AJ (2008) Suppression of immediate-early viral gene expression by herpesvirus-coded microRNAs: implications for latency. Proc Natl Acad Sci USA 105: 5453-5458.
40. Wen W, Iwakiri D, Yamamoto K, Maruo S, Kanda T, et al. (2007) Epstein-Barr virus BZLF1 gene, a switch from latency to lytic infection, is expressed as an immediate-early gene after primary infection of B lymphocytes. J Virol 81: 1037-1042.
41. Kalla M, Schmeinck A, Bergbauer M, Pich D, Hammerschmidt W (2010) AP-1 homolog BZLF1 of Epstein-Barr virus has two essential functions dependent on the epigenetic state of the viral genome. Proc Natl Acad Sci USA 107: 850-855.
42. Kelly GL, Long HM, Stylianou J, Thomas WA, Leese A, et al. (2009) An Epstein-Barr virus anti-apoptotic protein constitutively expressed in transformed cells and implicated in burkitt lymphomagenesis: the Wp/BHRF1 link. PLoS Pathog 5: e1000341.
43. Lo AK, To KF, Lo KW, Lung RW, Hui JW, et al. (2007) Modulation of LMP1 protein expression by EBV-encoded microRNAs. Proc Natl Acad Sci USA 104: 16164-16169.
44. Lam N, Sandberg ML, Sugden B (2004) High physiological levels of LMP1 result in phosphorylation of eIF2 alpha in Epstein-Barr virus-infected cells. J Virol 78: 1657-1664.
45. Lee DY, Sugden B (2008) The LMP1 oncogene of EBV activates PERK and the unfolded protein response to drive its own synthesis. Blood 111: 2280-2289.
46. Lee DY, Sugden B (2008) The latent membrane protein 1 oncogene modifies B-cell physiology by regulating autophagy. Oncogene 27: 2833-2842.
47. Cai X, Schafer A, Lu S, Bilello JP, Desrosiers RC, et al. (2006) Epstein-Barr virus microRNAs are evolutionarily conserved and differentially expressed. PLoS Pathog 2: e23.
48. Grimson A, Farh KK, Johnston WK, Garrett-Engele P, Lim LP, et al. (2007) MicroRNA targeting specificity in mammals: determinants beyond seed pairing. Mol Cell 27: 91-105.
49. Hammerschmidt W, Sugden B (1988) Identification and characterization of oriLyt, a lytic origin of DNA replication of Epstein-Barr virus. Cell 55: 427-433.
50. Janz A, Oezel M, Kurzeder C, Mautner J, Pich D, et al. (2000) Infectious Epstein-Barr virus lacking major glycoprotein BLLF1 (gp350/220) demonstrates the existence of additional viral ligands. J Virol 74: 10142-10152.
51. Feederle R, Kost M, Baumann M, Janz A, Drouet E, et al. (2000) The Epstein- Barr virus lytic program is controlled by the co-operative functions of two transactivators. EMBO J 19: 3080-3089.
52. Varkonyi-Gasic E, Wu R, Wood M, Walton EF, Hellens RP (2007) Protocol: a highly sensitive RT-PCR method for detection and quantification of microRNAs. Plant Methods 3: 12.
53. Hofacker LL, Fontana W, Stadler PF, Bonhoeffer S, Tacker M, et al. (1994) Fast Folding and Comparison of RNA Secondary Structures. Monatshefte f Chemie 125: 167-188.