Protective role of PI3-kinase/Akt/eNOS signaling in mechanical stress through inhibition of p38 mitogen-activated protein kinase in mouse lung

Acta Pharmacologica Sinica

Volumn 31, Issue 2, 2010, Pages 175-183

  Peng, Xin Qi ^a   Damarla, Mahendra ^b   Skirball, Jarrett ^b   Nonas, Stephanie ^d   Wang, Xiao Ying ^f   Han, Eugenia J ^b   Hasan, Emile J ^b   Cao, Xuan ^b   Boueiz, Adel ^b   Damico, Rachel ^b   Tuder, Rubin M ^c   Sciuto, Alfred M ^a   Anderson, Dana R ^a   Garcia, Joe Gn ^e   Kass, David A ^b   Hassoun, Paul M ^b   Zhang, Jun Tian ^f  

^a US ARMY MEDICAL RESEARCH INSTITUTE OF CHEMICAL DEFENSE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^e UNIVERSITY OF CHICAGO   (United States)

^f INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Mechanical stress; P38 MAPK signalings; PI3K Akt eNOS; Pulmonary capillary leakage; Pulmonary edema; Signals cross talk; Ventilator associated lung injury; Wortmannin

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; WORTMANNIN;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CAPILLARY LEAK SYNDROME; CELL LYSATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; ENZYME PHOSPHORYLATION; EXTRAVASATION; HISTOLOGY; HYPOTHESIS; IN VIVO STUDY; LUNG; LUNG ALVEOLUS EPITHELIUM; LUNG EDEMA; LUNG INJURY; LUNG LAVAGE; MALE; MECHANICAL STRESS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TIDAL VOLUME; WILD TYPE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENZYME INHIBITORS; LUNG; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRIC OXIDE SYNTHASE TYPE III; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; STRESS, MECHANICAL;

EID: 76949092145     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2009.190     Document Type: Article

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