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Volumn 17, Issue 12, 2001, Pages 712-718

Genetics of lifespan in C. elegans: Molecular diversity, physiological complexity, mechanistic simplicity

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BACTERIAL PROTEIN; MITOCHONDRIAL ENZYME; TRANSCRIPTION FACTOR;

EID: 0035577351     PISSN: 01689525     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-9525(01)02523-9     Document Type: Review
Times cited : (63)

References (51)
  • 1
    • 0021056471 scopus 로고
    • A method for the isolation of longevity mutants in the nematode Caenorhabditis elegans and initial results
    • (1983) Mech. Ageing Dev. , vol.22 , pp. 279-286
    • Klass, M.R.1
  • 2
    • 0023831256 scopus 로고
    • A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility
    • (1988) Genetics , vol.118 , pp. 75-86
    • Friedman, D.B.1    Johnson, T.E.2
  • 3
    • 0030007767 scopus 로고    scopus 로고
    • Genetic analysis of the roles of daf-28 and age-1 in regulating Caenorhabditis elegans dauer formation
    • (1996) Genetics , vol.143 , pp. 1193-1205
    • Malone, E.A.1
  • 4
    • 0027771804 scopus 로고
    • A C. elegans mutant that lives twice as long as wild type
    • (1993) Nature , vol.366 , pp. 461-464
    • Kenyon, C.1
  • 5
    • 0028807085 scopus 로고
    • The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans
    • (1995) Genetics , vol.141 , pp. 1399-1406
    • Dorman, J.B.1
  • 8
    • 0033551325 scopus 로고    scopus 로고
    • A cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants
    • (1999) Nature , vol.399 , pp. 162-166
    • Taub, J.1
  • 9
    • 0028786075 scopus 로고
    • Viable maternal-effect mutations that affect the development of the nematode Caenorhabditis elegans
    • (1995) Genetics , vol.141 , pp. 1351-1364
    • Hekimi, S.1
  • 10
  • 11
    • 0028950419 scopus 로고
    • Mutations in the clk-1 gene of Caenorhabditis elegans affect developmental and behavioral timing
    • (1995) Genetics , vol.139 , pp. 1247-1259
    • Wong, A.1
  • 15
    • 0034967720 scopus 로고    scopus 로고
    • Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling
    • (2001) Nat. Genet. , vol.28 , pp. 139-145
    • Lin, K.1
  • 16
    • 0032529189 scopus 로고    scopus 로고
    • Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor
    • (1998) Genes Dev. , vol.12 , pp. 2488-2498
    • Paradis, S.1    Ruvkun, G.2
  • 18
    • 0028171313 scopus 로고
    • A possible role for the 60-kD Ro autoantigen in a discard pathway for defective 5S rRNA precursors
    • (1994) Genes Dev. , vol.8 , pp. 2891-2903
    • O'Brien, C.A.1    Wolin, S.L.2
  • 19
    • 0034175553 scopus 로고    scopus 로고
    • Ro ribonucleoproteins contribute to the resistance of Deinococcus radiodurans to ultraviolet irradiation
    • (2000) Genes Dev. , vol.14 , pp. 777-782
    • Chen, X.1
  • 22
    • 0033738362 scopus 로고    scopus 로고
    • An intervention resembling caloric restriction prolongs life span and retards aging in yeast
    • (2000) Faseb J. , vol.14 , pp. 2135-2137
    • Jiang, J.C.1
  • 23
    • 0034703217 scopus 로고    scopus 로고
    • Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae
    • (2000) Science , vol.289 , pp. 2126-2128
    • Lin, S.J.1
  • 24
    • 0034677535 scopus 로고    scopus 로고
    • Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
    • (2000) Nature , vol.403 , pp. 795-800
    • Imai, S.1
  • 26
    • 0034805496 scopus 로고    scopus 로고
    • Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria
    • (2001) Genetics , vol.159 , pp. 147-157
    • Lemieux, J.1
  • 28
    • 0001715071 scopus 로고    scopus 로고
    • A new member of the family of di-iron carboxylate proteins: Coq7 (clk-1), a membrane-bound hydroxylase involved in ubiquinone biosynthesis
    • (2001) J. Biol. Chem. , vol.2 , pp. 2
    • Stenmark, P.1
  • 30
    • 0035896557 scopus 로고    scopus 로고
    • Altered quinone biosynthesis in the long-lived clk-1 mutants of Caenorhabditis elegans
    • (2001) J. Biol. Chem. , vol.276 , pp. 7713-7716
    • Miyadera, H.1
  • 31
    • 0033118981 scopus 로고    scopus 로고
    • CLK-1 controls respiration, behavior and aging in the nematode Caenorhabditis elegans
    • (1999) EMBO J. , vol.18 , pp. 1783-1792
    • Felkai, S.1
  • 32
    • 0033529032 scopus 로고    scopus 로고
    • Apparent uncoupling of energy production and consumption in long-lived Clk mutants of Caenorhabditis elegans
    • (1999) Curr. Biol. , vol.9 , pp. 493-496
    • Braeckman, B.P.1
  • 35
    • 0006760911 scopus 로고    scopus 로고
    • Phenotypic and suppressor analysis of clk-1 mutants reveals that the adaptation of the defecation rate to changes in temperature is an active process in Caenorhabditis elegans
    • in press
    • Genetics
    • Branicky, R.1
  • 36
    • 0344223281 scopus 로고    scopus 로고
    • Transfer RNA modification: Influence on translational frameshifting and metabolism
    • (1999) FEBS Lett. , vol.452 , pp. 47-51
    • Bjork, G.R.1
  • 37
    • 0026322024 scopus 로고
    • MOD5 translation initiation sites determine N6-isopentenyladenosine modification of mitochondrial and cytoplasmic tRNA
    • (1991) Mol. Cell Biol. , vol.11 , pp. 2382-2390
    • Gillman, E.C.1
  • 38
    • 0034758767 scopus 로고    scopus 로고
    • The C. elegans maternal-effect gene clk-2 is essential for embryonic development, encodes a protein homologous to yeast Tel2p, and is required for the regulation of telomere length
    • in press
    • Development
    • Benard, C.1
  • 39
    • 0029954325 scopus 로고    scopus 로고
    • TEL2, an essential gene required for telomere length regulation and telomere position effect in Saccharomyces cerevisiae
    • (1996) Mol. Cell Biol. , vol.16 , pp. 3094-3105
    • Runge, K.W.1    Zakian, V.A.2
  • 41
    • 0032829895 scopus 로고    scopus 로고
    • Tel2p, a regulator of yeast telomeric length in vivo, binds to single-stranded telomeric DNA in vitro
    • (1999) Chromosoma , vol.108 , pp. 278-290
    • Kota, R.S.1    Runge, K.W.2
  • 42
    • 0035863153 scopus 로고    scopus 로고
    • A cytosolic NAD-dependent deacetylase, Hst2p, can modulate nucleolar and telomeric silencing in yeast
    • (2001) EMBO J. , vol.20 , pp. 197-209
    • Perrod, S.1
  • 43
    • 0033960607 scopus 로고    scopus 로고
    • Telomere structure regulates the heritability of repressed subtelomeric chromatin in Saccharomyces cerevisiae
    • (2000) Genetics , vol.154 , pp. 587-598
    • Park, Y.1    Lustig, A.J.2
  • 44
    • 0035874977 scopus 로고    scopus 로고
    • Telomere position effect in human cells
    • (2001) Science , vol.292 , pp. 2075-2077
    • Baur, J.A.1
  • 45
    • 0027423154 scopus 로고
    • SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres
    • (1993) Cell , vol.75 , pp. 543-555
    • Palladino, F.1
  • 46
    • 0023340731 scopus 로고
    • Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae
    • (1987) Genetics , vol.116 , pp. 9-22
    • Rine, J.1    Herskowitz, I.2
  • 47
    • 0030916153 scopus 로고    scopus 로고
    • Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae
    • (1997) Cell , vol.89 , pp. 381-391
    • Kennedy, B.K.1
  • 48
    • 0029741576 scopus 로고    scopus 로고
    • Silencing of genes at nontelomeric sites in yeast is controlled by sequestration of silencing factors at telomeres by Rap 1 protein
    • (1996) Genes Dev. , vol.10 , pp. 1297-1309
    • Marcand, S.1
  • 50
    • 0032782364 scopus 로고    scopus 로고
    • The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans
    • (1999) FASEB J. , vol.13 , pp. 1385-1393
    • Honda, Y.1    Honda, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.