AHR2 knockdown prevents PAH-mediated cardiac toxicity and XRE- and ARE-associated gene induction in zebrafish (Danio rerio)

Toxicology and Applied Pharmacology

Volumn 254, Issue 3, 2011, Pages 280-287

  Van Tiem, Lindsey A ^a   Di Giulio, Richard T ^a  

^a DUKE UNIVERSITY   (United States)

Author keywords

Aryl hydrocarbon receptor (AHR); Morpholino; Oxidative stress; Polycyclic aromatic hydrocarbons (PAHs); Zebrafish

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; ARYL HYDROCARBON RECEPTOR 2; BENZO[K]FLUORANTHENE; CYTOCHROME P450 1A; CYTOCHROME P450 1B1; ETHOXYRESORUFIN DEETHYLASE; FLUORANTHENE; GLUTAMATE CYSTEINE LIGASE; GLUTAMATE CYSTEINE LIGASE CATALYTIC SUBUNIT; GLUTATHIONE TRANSFERASE P1; MANGANESE SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARDIOTOXICITY; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; EMBRYO; EMBRYOTOXICITY; ENZYME INHIBITION; GENE EXPRESSION; GENE INDUCTION; GENE SILENCING; HEART PROTECTION; INHIBITION KINETICS; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PERICARDIAL EFFUSION; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; XENOBIOTIC METABOLISM; ZEBRA FISH;

ANIMALS; ANTIOXIDANTS; CARDIOTOXINS; EMBRYO, NONMAMMALIAN; GENE KNOCKDOWN TECHNIQUES; POLYCYCLIC HYDROCARBONS, AROMATIC; RECEPTORS, ARYL HYDROCARBON; RESPONSE ELEMENTS; TRANSCRIPTIONAL ACTIVATION; XENOBIOTICS; ZEBRAFISH; ZEBRAFISH PROTEINS;

DANIO RERIO;

EID: 79960336007     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2011.05.002     Document Type: Article

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