메뉴 건너뛰기




Volumn 55, Issue 8, 2011, Pages 3696-3702

Single mutations in HIV integrase confer high-level resistance to raltegravir in primary human macrophages

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRASE; INTEGRASE INHIBITOR; MK 2048; RALTEGRAVIR; UNCLASSIFIED DRUG;

EID: 79960319717     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00566-11     Document Type: Article
Times cited : (21)

References (49)
  • 1
    • 0036883678 scopus 로고    scopus 로고
    • Long-term survival and virus production in human primary macrophages infected by human immunodeficiency virus
    • Aquaro, S., et al. 2002. Long-term survival and virus production in human primary macrophages infected by human immunodeficiency virus. J. Med. Virol. 68:479-488.
    • (2002) J. Med. Virol. , vol.68 , pp. 479-488
    • Aquaro, S.1
  • 2
    • 0030750548 scopus 로고    scopus 로고
    • Inhibition of replication of HIV in primary monocyte/macrophages by different antiviral drugs and comparative efficacy in lymphocytes
    • Aquaro, S., et al. 1997. Inhibition of replication of HIV in primary monocyte/macrophages by different antiviral drugs and comparative efficacy in lymphocytes. J. Leukoc. Biol. 62:138-143.
    • (1997) J. Leukoc. Biol. , vol.62 , pp. 138-143
    • Aquaro, S.1
  • 3
    • 33750478020 scopus 로고    scopus 로고
    • Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: New therapeutic strategies
    • Aquaro, S., et al. 2006. Mechanisms underlying activity of antiretroviral drugs in HIV-1-infected macrophages: new therapeutic strategies. J. Leukoc. Biol. 80:1103-1110.
    • (2006) J. Leukoc. Biol. , vol.80 , pp. 1103-1110
    • Aquaro, S.1
  • 5
    • 77956017859 scopus 로고    scopus 로고
    • Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor
    • Bar-Magen, T., et al. 2010. Identification of novel mutations responsible for resistance to MK-2048, a second-generation HIV-1 integrase inhibitor. J. Virol. 84:9210-9216.
    • (2010) J. Virol. , vol.84 , pp. 9210-9216
    • Bar-Magen, T.1
  • 9
    • 47949114939 scopus 로고    scopus 로고
    • Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection
    • Cooper, D. A., et al. 2008. Subgroup and resistance analyses of raltegravir for resistant HIV-1 infection. N. Engl. J. Med. 359:355-365.
    • (2008) N. Engl. J. Med. , vol.359 , pp. 355-365
    • Cooper, D.A.1
  • 10
    • 78649676916 scopus 로고    scopus 로고
    • Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1
    • Croteau, D., et al. 2010. Total raltegravir concentrations in cerebrospinal fluid exceed the 50-percent inhibitory concentration for wild-type HIV-1. Antimicrob. Agents Chemother. 54:5156-5160.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 5156-5160
    • Croteau, D.1
  • 11
    • 0021751840 scopus 로고
    • The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus
    • DOI 10.1038/312763a0
    • Dalgleish, A. G., et al. 1984. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature 312:763-767. (Pubitemid 15195924)
    • (1984) Nature , vol.312 , Issue.5996 , pp. 763-767
    • Dalgleish, A.G.1    Beverley, P.C.L.2    Clapham, P.R.3
  • 12
    • 62149093020 scopus 로고    scopus 로고
    • The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation
    • Delelis, O., et al. 2009. The G140S mutation in HIV integrases from raltegravir-resistant patients rescues catalytic defect due to the resistance Q148H mutation. Nucleic Acids Res. 37:1193-1201.
    • (2009) Nucleic Acids Res. , vol.37 , pp. 1193-1201
    • Delelis, O.1
  • 13
    • 19944379446 scopus 로고    scopus 로고
    • Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase
    • Diamond, T. L., et al. 2004. Macrophage tropism of HIV-1 depends on efficient cellular dNTP utilization by reverse transcriptase. J. Biol. Chem. 279:51545-51553.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51545-51553
    • Diamond, T.L.1
  • 14
    • 70350156722 scopus 로고    scopus 로고
    • The dynamics of appearance and disappearance of HIV-1 integrase mutations during and after withdrawal of raltegravir therapy
    • Ferns, R. B., et al. 2009. The dynamics of appearance and disappearance of HIV-1 integrase mutations during and after withdrawal of raltegravir therapy. Aids 23:2159-2164.
    • (2009) Aids , vol.23 , pp. 2159-2164
    • Ferns, R.B.1
  • 15
    • 70350666377 scopus 로고    scopus 로고
    • Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways
    • Fransen, S., et al. 2009. Loss of raltegravir susceptibility by human immunodeficiency virus type 1 is conferred via multiple nonoverlapping genetic pathways. J. Virol. 83:11440-11446.
    • (2009) J. Virol. , vol.83 , pp. 11440-11446
    • Fransen, S.1
  • 16
    • 84944282429 scopus 로고
    • Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS
    • DOI 10.1001/jama.256.17.2365
    • Gartner, S., P. Markovits, D. M. Markovitz, R. F. Betts, and M. Popovic. 1986. Virus isolation from and identification of HTLV-III/LAV-producing cells in brain tissue from a patient with AIDS. JAMA 256:2365-2371. (Pubitemid 17174464)
    • (1986) Journal of the American Medical Association , vol.256 , Issue.17 , pp. 2365-2371
    • Gartner, S.1    Markovits, P.2    Markovitz, D.M.3
  • 17
    • 0022480641 scopus 로고
    • The role of mononuclear phagocytes in HTLV-III/LAV infection
    • Gartner, S., et al. 1986. The role of mononuclear phagocytes in HTLV-III/LAV infection. Science 233:215-219.
    • (1986) Science , vol.233 , pp. 215-219
    • Gartner, S.1
  • 18
    • 0023898273 scopus 로고
    • Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes
    • Gendelman, H. E., et al. 1988. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J. Exp. Med. 167:1428-1441.
    • (1988) J. Exp. Med. , vol.167 , pp. 1428-1441
    • Gendelman, H.E.1
  • 19
    • 77953022020 scopus 로고    scopus 로고
    • Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with second-generation resistance profiles
    • Goethals, O., et al. 2010. Primary mutations selected in vitro with raltegravir confer large fold changes in susceptibility to first-generation integrase inhibitors, but minor fold changes to inhibitors with second-generation resistance profiles. Virology 402:338-346.
    • (2010) Virology , vol.402 , pp. 338-346
    • Goethals, O.1
  • 21
    • 34147136222 scopus 로고    scopus 로고
    • Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: A phase II randomised controlled trial
    • DOI 10.1016/S0140-6736(07)60597-2, PII S0140673607605972
    • Grinsztejn, B., et al. 2007. Safety and efficacy of the HIV-1 integrase inhibitor raltegravir (MK-0518) in treatment-experienced patients with multidrug-resistant virus: a phase II randomised controlled trial. Lancet 369:1261-1269. (Pubitemid 46553846)
    • (2007) Lancet , vol.369 , Issue.9569 , pp. 1261-1269
    • Grinsztejn, B.1    Nguyen, B.-Y.2    Katlama, C.3    Gatell, J.M.4    Lazzarin, A.5    Vittecoq, D.6    Gonzalez, C.J.7    Chen, J.8    Harvey, C.M.9    Isaacs, R.D.10
  • 22
    • 0028874048 scopus 로고
    • Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection
    • Ho, D. D., et al. 1995. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373:123-126.
    • (1995) Nature , vol.373 , pp. 123-126
    • Ho, D.D.1
  • 23
    • 0035895214 scopus 로고    scopus 로고
    • Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans
    • Igarashi, T., et al. 2001. Macrophage are the principal reservoir and sustain high virus loads in rhesus macaques after the depletion of CD4+ T cells by a highly pathogenic simian immunodeficiency virus/HIV type 1 chimera (SHIV): Implications for HIV-1 infections of humans. Proc. Natl. Acad. Sci. U. S. A. 98:658-663.
    • (2001) Proc. Natl. Acad. Sci. U. S. A. , vol.98 , pp. 658-663
    • Igarashi, T.1
  • 24
    • 0022522203 scopus 로고
    • Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy
    • Koenig, S., et al. 1986. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science 233:1089-1093. (Pubitemid 16032241)
    • (1986) Science , vol.233 , Issue.4768 , pp. 1089-1093
    • Koenig, S.1    Gendelman, H.E.2    Orenstein, J.M.3
  • 25
    • 78650670855 scopus 로고    scopus 로고
    • Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity
    • Koh, Y., H. Haim, and A. Engelman. 2011. Identification and characterization of persistent intracellular human immunodeficiency virus type 1 integrase strand transfer inhibitor activity. Antimicrob. Agents Chemother. 55:42-49.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 42-49
    • Koh, Y.1    Haim, H.2    Engelman, A.3
  • 26
    • 0024310253 scopus 로고
    • Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)
    • Larder, B. A., and S. D. Kemp. 1989. Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT). Science 246:1155-1158.
    • (1989) Science , vol.246 , pp. 1155-1158
    • Larder, B.A.1    Kemp, S.D.2
  • 27
    • 0033928524 scopus 로고    scopus 로고
    • Indinavir population pharmacokinetics in plasma and cerebrospinal fluid
    • The HIV Neurobehavioral Research Center Group
    • Letendre, S. L., E. V. Capparelli, R. J. Ellis, and J. A. McCutchan. 2000. Indinavir population pharmacokinetics in plasma and cerebrospinal fluid. The HIV Neurobehavioral Research Center Group. Antimicrob. Agents Chemother. 44:2173-2175.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2173-2175
    • Letendre, S.L.1    Capparelli, E.V.2    Ellis, R.J.3    McCutchan, J.A.4
  • 28
    • 42049119625 scopus 로고    scopus 로고
    • Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro
    • Malet, I., et al. 2008. Mutations associated with failure of raltegravir treatment affect integrase sensitivity to the inhibitor in vitro. Antimicrob. Agents Chemother. 52:1351-1358.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 1351-1358
    • Malet, I.1
  • 29
    • 34748860363 scopus 로고    scopus 로고
    • Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: Results of a 48-week controlled study
    • Markowitz, M., et al. 2007. Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J. Acquir. Immune Defic. Syndr. 46:125-133.
    • (2007) J. Acquir. Immune Defic. Syndr. , vol.46 , pp. 125-133
    • Markowitz, M.1
  • 30
    • 34249810943 scopus 로고    scopus 로고
    • Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo
    • Marsden, M. D., and J. A. Zack. 2007. Human immunodeficiency virus bearing a disrupted central DNA flap is pathogenic in vivo. J. Virol. 81:6146-6150.
    • (2007) J. Virol. , vol.81 , pp. 6146-6150
    • Marsden, M.D.1    Zack, J.A.2
  • 31
    • 0022226349 scopus 로고
    • Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen
    • McDougal, J. S., et al. 1985. Cellular tropism of the human retrovirus HTLV-III/LAV. I. Role of T cell activation and expression of the T4 antigen. J. Immunol. 135:3151-3162.
    • (1985) J. Immunol. , vol.135 , pp. 3151-3162
    • McDougal, J.S.1
  • 32
    • 0005015528 scopus 로고
    • Mononuclear phagocytes of blood and bone marrow: Comparative roles as viral reservoirs in human immunodeficiency virus type 1 infections
    • McElrath, M. J., J. E. Pruett, and Z. A. Cohn. 1989. Mononuclear phagocytes of blood and bone marrow: comparative roles as viral reservoirs in human immunodeficiency virus type 1 infections. Proc. Natl. Acad. Sci. U. S. A. 86:675-679.
    • (1989) Proc. Natl. Acad. Sci. U. S. A. , vol.86 , pp. 675-679
    • McElrath, M.J.1    Pruett, J.E.2    Cohn, Z.A.3
  • 34
    • 77955092239 scopus 로고    scopus 로고
    • Evaluation of HIV-1 integrase inhibitors on human primary macrophages using a luciferase-based single-cycle phenotypic assay
    • Michelini, Z., et al. Evaluation of HIV-1 integrase inhibitors on human primary macrophages using a luciferase-based single-cycle phenotypic assay. J. Virol. Methods 168:272-276.
    • J. Virol. Methods , vol.168 , pp. 272-276
    • Michelini, Z.1
  • 35
    • 78650673812 scopus 로고    scopus 로고
    • Plasma and intracellular (peripheral blood mononuclear cells) pharmacokinetics of once-daily raltegravir (800 milligrams) in HIV-infected patients
    • Moltó, J., et al. 2011. Plasma and intracellular (peripheral blood mononuclear cells) pharmacokinetics of once-daily raltegravir (800 milligrams) in HIV-infected patients. Antimicrob. Agents Chemother. 55:72-75.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 72-75
    • Moltó, J.1
  • 36
    • 37349120701 scopus 로고    scopus 로고
    • Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase
    • DOI 10.1097/QAD.0b013e3282f12377, PII 0000203020071112000008
    • Murray, J. M., et al. 2007. Antiretroviral therapy with the integrase inhibitor raltegravir alters decay kinetics of HIV, significantly reducing the second phase. AIDS 21:2315-2321. (Pubitemid 350287458)
    • (2007) AIDS , vol.21 , Issue.17 , pp. 2315-2321
    • Murray, J.M.1    Emery, S.2    Kelleher, A.D.3    Law, M.4    Chen, J.5    Hazuda, D.J.6    Nguyen, B.-Y.T.7    Teppler, H.8    Cooper, D.A.9
  • 37
    • 0023678515 scopus 로고
    • Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: An ultrastructural study
    • Orenstein, J. M., M. S. Meltzer, T. Phipps, and H. E. Gendelman. 1988. Cytoplasmic assembly and accumulation of human immunodeficiency virus types 1 and 2 in recombinant human colony-stimulating factor-1-treated human monocytes: an ultrastructural study. J. Virol. 62:2578-2586.
    • (1988) J. Virol. , vol.62 , pp. 2578-2586
    • Orenstein, J.M.1    Meltzer, M.S.2    Phipps, T.3    Gendelman, H.E.4
  • 39
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson, A. S., A. U. Neumann, M. Markowitz, J. M. Leonard, and D. D. Ho. 1996. HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span, and viral generation time. Science 271:1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 40
    • 0031848314 scopus 로고    scopus 로고
    • Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus
    • Perno, C. F., et al. 1998. Relative potency of protease inhibitors in monocytes/macrophages acutely and chronically infected with human immunodeficiency virus. J. Infect. Dis. 178:413-422.
    • (1998) J. Infect. Dis. , vol.178 , pp. 413-422
    • Perno, C.F.1
  • 42
    • 0023785829 scopus 로고
    • Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2′,3′-dideoxynucleosides
    • Perno, C. F., et al. 1988. Inhibition of human immunodeficiency virus (HIV-1/HTLV-IIIBa-L) replication in fresh and cultured human peripheral blood monocytes/macrophages by azidothymidine and related 2′,3′- dideoxynucleosides. J. Exp. Med. 168:1111-1125.
    • (1988) J. Exp. Med. , vol.168 , pp. 1111-1125
    • Perno, C.F.1
  • 43
    • 70349272200 scopus 로고    scopus 로고
    • Selective-advantage profile of human immunodeficiency virus type 1 integrase mutants explains in vivo evolution of raltegravir resistance genotypes
    • Quercia, R., E. Dam, D. Perez-Bercoff, and F. Clavel. 2009. Selective-advantage profile of human immunodeficiency virus type 1 integrase mutants explains in vivo evolution of raltegravir resistance genotypes. J. Virol. 83:10245-10249.
    • (2009) J. Virol. , vol.83 , pp. 10245-10249
    • Quercia, R.1    Dam, E.2    Perez-Bercoff, D.3    Clavel, F.4
  • 45
    • 0032845027 scopus 로고    scopus 로고
    • HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages
    • Swingler, S., et al. 1999. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nat. Med. 5:997-1003.
    • (1999) Nat. Med. , vol.5 , pp. 997-1003
    • Swingler, S.1
  • 46
    • 78650640149 scopus 로고    scopus 로고
    • Cross-resistance profile determination of two second-generation HIV-1 integrase inhibitors using a panel of recombinant viruses derived from raltegravir-treated clinical isolates
    • Van Wesenbeeck, L., et al. 2011. Cross-resistance profile determination of two second-generation HIV-1 integrase inhibitors using a panel of recombinant viruses derived from raltegravir-treated clinical isolates. Antimicrob. Agents Chemother. 55:321-325.
    • (2011) Antimicrob. Agents Chemother. , vol.55 , pp. 321-325
    • Van Wesenbeeck, L.1
  • 47
    • 0000969952 scopus 로고
    • Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients
    • Wiley, C. A., R. D. Schrier, J. A. Nelson, P. W. Lampert, and M. B. Oldstone. 1986. Cellular localization of human immunodeficiency virus infection within the brains of acquired immune deficiency syndrome patients. Proc. Natl. Acad. Sci. U. S. A. 83:7089-7093.
    • (1986) Proc. Natl. Acad. Sci. U. S. A. , vol.83 , pp. 7089-7093
    • Wiley, C.A.1    Schrier, R.D.2    Nelson, J.A.3    Lampert, P.W.4    Oldstone, M.B.5
  • 48
    • 70149119217 scopus 로고    scopus 로고
    • Raltegravir cerebrospinal fluid concentrations in HIV-1 infection
    • Yilmaz, A., et al. 2009. Raltegravir cerebrospinal fluid concentrations in HIV-1 infection. PLoS One 4:e6877.
    • (2009) PLoS One , vol.4
    • Yilmaz, A.1
  • 49
    • 0025342694 scopus 로고
    • HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure
    • Zack, J. A., et al. 1990. HIV-1 entry into quiescent primary lymphocytes: molecular analysis reveals a labile, latent viral structure. Cell 61:213-222.
    • (1990) Cell , vol.61 , pp. 213-222
    • Zack, J.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.