The new kappa-KTx 2.5 from the scorpion Opisthacanthus cayaporum

Peptides

Volumn 32, Issue 7, 2011, Pages 1509-1517

  Camargos, Thalita Soares ^a   Restano Cassulini, Rita ^b   Possani, Lourival Domingos ^b   Peigneur, Steve ^c   Tytgat, Jan ^c   Schwartz, Carlos Alberto ^a   Alves, Erica Maria C ^a   De Freitas, Sonia Maria ^a   Schwartz, Elisabeth Ferroni ^a  

^a UNIVERSITY OF BRASILIA   (Brazil)

^b INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

kappa KTx; Liochelidae; Potassium channel blocker; Scorpion; Venom

Indexed keywords

BRADYKININ; KAPPA KTXC 2.5 PEPTIDE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SCORPION VENOM; SODIUM CHANNEL; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIAL GROWTH; BINDING AFFINITY; CONTROLLED STUDY; ENZYME STABILITY; ESCHERICHIA COLI; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPISTHACANTHUS CAYAPORUM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; SCORPION; SMOOTH MUSCLE; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; ANIMALS; CHO CELLS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CIRCULAR DICHROISM; CRICETINAE; CRICETULUS; ESCHERICHIA COLI; FEMALE; GUINEA PIGS; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MYOCYTES, SMOOTH MUSCLE; OOCYTES; PEPTIDES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; PROTEIN PRECURSORS; PROTEIN STRUCTURE, SECONDARY; SCORPION VENOMS; SCORPIONS; SEQUENCE ALIGNMENT; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; XENOPUS;

BACTERIA (MICROORGANISMS); CRICETULUS GRISEUS; LIOCHELIDAE; OPISTHACANTHUS; SCORPIONES; SCORPIONIDAE;

EID: 79960309903     PISSN: 01969781     EISSN: 18735169     Source Type: Journal    
DOI: 10.1016/j.peptides.2011.05.017     Document Type: Article

References (38)

1. O. Castañeda, and A.L. Harvey Discovery and characterization of cnidarian peptide toxins that affect neuronal potassium ion channels Toxicon 54 2009 1119 1124
2. B. Chagot, C. Pimentel, L. Dai, J. Pil, J. Tytgat, and T. Nakajima An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis Biochem J 388 2005 263 271 (Pubitemid 40732954)
3. M. Dauplais, A. Lecoq, J. Song, J. Cotton, N. Jamin, and B. Gilquin On the convergent evolution of animal toxins. Conservation of a dyad of functional residues in potassium channel-blocking toxins with unrelated structures J Biol Chem 272 1997 4302 4309 (Pubitemid 27078502)
4. M. Day, and J.R. Vane An analysis of the direct and indirect actions of drugs on the isolated guinea-pig ileum Br J Pharmacol Chemother 20 1963 150 170
5. S.R. Dennison, J. Howe, L.H. Morton, K. Brandenburg, F. Harris, and D.A. Phoenix Interactions of an anionic antimicrobial peptide with Staphylococcus aureus membranes Biochem Biophys Res Commun 347 4 2006 1006 1010 (Pubitemid 44118217)
6. S. Diochot, and M. Lazdunski Sea anemone toxins affecting potassium channels Prog Mol Subcell Biol 46 2009 99 122
7. G. Estrada, E. Villegas, and G. Corzo Spider venoms: a rich source of acylpolyamines and peptides as new leads for CNS drugs Nat Prod Rep 24 1 2007 145 161 (Pubitemid 46238593)
8. S.H. Ferreira, D.C. Bartelt, and L.J. Greene Isolation of bradykinin potentiating peptides from Bothrops jararaca venom Biochemistry 9 1970 2583 2593
9. + channels Toxicon 36 1998 1641 1650 (Pubitemid 28511079)
10. J. Gasteiger, and M. Marsili Iterative partial equalization of orbital electronegativity - a rapid access to atomic charges Tetrahedron 36 22 1980 3219 3228
11. T.S. Han, R.W. Teichert, B.M. Olivera, and G. Bulaj Conus venoms - a rich source of peptide-based therapeutics Curr Pharm Des 14 24 2008 2462 2479
12. A.L. Harvey Recent studies on dendrotoxins and potassium ion channels Gen Pharmacol 28 1 1997 7 12 (Pubitemid 27016052)
13. D. Ianzer, K. Konno, R. Marques-Porto, F.C.V. Portaro, R. Stöcklin, and A.C.M. Camargo Identification of five new bradykinin potentiating peptides (BPPs) from Bothrops jararaca crude venom by using electrospray ionization tandem mass spectrometry after a two-step liquid chromatography Peptides 25 2004 1085 1092 (Pubitemid 38881647)
14. B. Jouirou, S. Mouhat, N. Andreotti, M. De Waard, and J.M. Sabatier Toxin determinants required for interaction with voltage-gated K-channels Toxicon 43 2004 909 914 (Pubitemid 38781026)
15. F. Jungo, and A. Bairoch Tox-Prot, the toxin protein annotation program of the Swiss-Prot protein knowledgebase Toxicon 45 3 2005 293 301 (Pubitemid 40431273)
16. + channels involved in contractility of rabbit small intestine J Physiol Biochem 62 4 2006 227 236 (Pubitemid 46938951)
17. + channels J Membr Biol 158 3 1997 187 196 (Pubitemid 27348564)
18. S. Marqusee, and R.L. Baldwin Helix stabilization by Glu-.Lys+ salt bridges in short peptides of de novo design Proc Natl Acad Sci USA 84 1987 8898 8902
19. C. Möller, S. Rahmankhah, J. Lauer-Fields, J. Bubis, G.B. Fields, and F. Marí A novel conotoxin framework with a helix-loop-helix (Cs alpha/alpha) fold Biochemistry 44 49 2005 15986 15996 (Pubitemid 41785796)
20. G.M. Morris, D.S. Goodsell, R.S. Halliday, R. Huey, W.E. Hart, and R.K. Belew Automated docking using a lamarckian genetic algorithm and empirical binding free energy function J Comput Chem 19 1998 1639 1662 (Pubitemid 128590223)
21. J.D. Morrisett, J.S. David, H.J. Pownall, and A.M. Gotto Jr. Interaction of an apolipoprotein (apoLP-alanine) with phosphatidylcholine Biochemistry 12 1973 1290 1299
22. S. Mouhat, N. Andreotti, B. Jouirou, and J.M. Sabatier Animal toxins acting on voltage-gated potassium channels Curr Pharm Des 14 24 2008 2503 2518
23. S. Mouhat, B. Jouirou, A. Mosbah, M. De Waard, and J.M. Sabatier Diversity of folds in animal toxins acting on ion channels Biochem J 378 2004 717 726 (Pubitemid 38406846)
24. S. Nirthanan, J. Pil, Y. Abdel-Mottaleb, Y. Sugahara, P. Gopalakrishnakone, and J.S. Joseph Assignment of voltage-gated potassium channel blocking activity to kappa-KTx1.3, a non-toxic homologue of kappa-hefutoxin-1, from Heterometrus spinifer venom Biochem Pharmacol 69 2005 669 678
25. A. Pal, J.E. Debreczeni, M. Sevvana, T. Gruene, B. Kahle, and A. Zeeck Structures of viscotoxins A1 and B2 from European mistletoe solved using native data alone Acta Crystallogr D Biol Crystallogr 64 Pt 9 2008 985 992
26. R.W. Ransom, C.B. Goodman, and G.S. Young Bradykinin stimulation of phosphoinositide hydrolysis in guinea-pig ileum longitudinal muscle Br J Pharmacol 105 4 1992 919 924
27. + ion channels J Biol Chem 285 2010 4130 4142
28. + channels and scorpion toxins Trends Pharmacol Sci 24 2003 222 227 (Pubitemid 36588869)
29. +-channels Toxicon 43 2004 865 875 (Pubitemid 38781021)
30. E.F. Schwartz, T.S. Camargos, F.Z. Zamudio, L.P. Silva, C. Bloch Jr., and F. Caixeta Mass spectrometry analysis, amino acid sequence and biological activity of venom components from the Brazilian scorpion Opisthacanthus cayaporum Toxicon 51 8 2008 1499 1508
31. E.C. Silva, T.S. Camargos, A.Q. Maranhão, I. Silva-Pereira, L.P. Silva, and L.D. Possani Cloning and characterization of cDNA sequences encoding for new venom peptides of the Brazilian scorpion Opisthacanthus cayaporum Toxicon 54 3 2009 252 261
32. K.N. Srinivasan, V. Sivaraja, I. Huys, T. Sasaki, B. Cheng, and T.K.S. Kumar Kappa-hefutoxin1, a novel toxin from the scorpion Heterometrus fulvipes with unique structure and function. Importance of the functional diad in potassium channel selectivity J Biol Chem 277 2002 30040 30047
33. H. Steffen, S. Rieg, I. Wiedemann, H. Kallbacher, A. Peschel, and C. Garbe Structural requirements and mechanism of antimicrobial activity of dermcidin-derived peptides Exp Dermatol 15 2006 204
34. K.J. Swartz Tarantula toxins interacting with voltage sensors in potassium channels Toxicon 49 2007 213 230 (Pubitemid 46148995)
35. + channels Toxicon 140 2000 135 185
36. V.D. Twede, G. Miljanich, B.M. Olivera, and G. Bulaj Neuroprotective and cardioprotective conopeptides: an emerging class of drug leads Curr Opin Drug Discov Dev 12 2 2009 231 239
37. J. Tytgat, K.G. Chandy, M.L. Garcia, G.A. Gutman, M.F. Martin-Eauclaire, and J.J. van der Walt A unified nomenclature for short-chain peptides isolated from scorpion venoms: alpha-KTx molecular subfamilies Trends Pharmacol Sci 20 1999 444 447 (Pubitemid 29528214)
38. T. Verano-Braga, C. Rocha-Resende, D.M. Silva, D. Ianzer, M.F. Martin-Eauclaire, and P.E. Bougis Tityus serrulatus hypotensins: a new family of peptides from scorpion venom Biochem Biophys Res Commun 371 2008 515 520