Tityus serrulatus Hypotensins: A new family of peptides from scorpion venom

Biochemical and Biophysical Research Communications

Volumn 371, Issue 3, 2008, Pages 515-520

  Verano Braga, T ^a   Rocha Resende, C ^a   Silva, D M ^a   Ianzer, D ^a   Martin Eauclaire, M F ^b   Bougis, P E ^b   de Lima, M E ^a   Santos, R A S ^a   Pimenta, A M C ^a  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b CNRS   (France)

Author keywords

Anti hypertensive peptides; Bradykinin potentiating peptides; Hypotensins; Hypotensive peptides; Tityus serrulatus

Indexed keywords

AMINO ACID; BRADYKININ; DIPEPTIDYL CARBOXYPEPTIDASE; HYPOTENSIN I; HYPOTENSIN I 17 25; NITRIC OXIDE; PEPTIDE DERIVATIVE; SCORPION VENOM;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM; ENZYME ACTIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEOMICS; RAT; SCORPION; TITYUS SERRULATUS; VASCULAR RING; VASODILATATION; WISTAR RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIHYPERTENSIVE AGENTS; BRADYKININ; DRUG SYNERGISM; MALE; MOLECULAR SEQUENCE DATA; NITRIC OXIDE; PEPTIDES; PEPTIDYL-DIPEPTIDASE A; RATS; RATS, WISTAR; SCORPION VENOMS; VASODILATION; VASODILATOR AGENTS;

LEIURUS QUINQUESTRIATUS; RATTUS; RATTUS NORVEGICUS; SCORPIONES; TITYUS SERRULATUS;

EID: 43749100894     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2008.04.104     Document Type: Article

References (23)

1. Pimenta A.M.C., and De Lima M.E. Small peptides, big world: biotechnological potential in neglected bioactive peptides from arthropod venoms. J. Pept. Sci. 11 (2005) 670-676
2. Fernandez J.H., Neshich G., and Camargo A.C. Using bradykinin-potentiating peptide structures to develop new antihypertensive drugs. Genet. Mol. Res. 3 (2004) 554-563
3. Ferreira S.H., Bartelt D.C., and Greene L.J. Isolation of bradykinin-potentiating peptides from Bothrops jararaca venom. Biochemistry 9 (1970) 2583-2593
4. Kato H., and Suzuki T. Bradykinin-potentiating peptides from the venom of Agkistrodon halys blomhoffi. Isolation of five bradykinin potentiators and the amino acid sequences of two of them, potentiators B and C. Biochemistry 10 (1971) 972-980
5. Cheng-Wu C., Mao-Ying W., Shan-Shan L., and Ting-Hwo C. Structure-function studies on the bradykinin-potentiating peptide from Chinese snake venom (Agkistrodon halys palls). Agents Actions 9 (1982) 283-288
6. Ferreira L.A., Henriques O.B., Lebrun I., Batista M.B., Prezoto B.C., Andreoni A.S., Zelnik R., and Habermehl G. A new bradykinin-potentiating peptide (peptide P) isolated from the venom of Bothrops jararacussu (jararacucu tapete, urutu dourado). Toxicon 30 (1992) 33-40
7. Ianzer D., Konno K., Marques-Porto R., Vieira Portaro F.C., Stöcklin R., Camargo A.C., and Pimenta D.C. Identification of five new bradykinin potentiating peptides (BPPs) from Bothrops jararaca crude venom by using electrospray ionization tandem mass spectrometry after a two-step liquid chromatography. Peptides 25 (2004) 1085-1092
8. Sosnina N.A., Golubenko Z., Akhunov A.A., Kugaevskaia E.V., Eliseeva Iu E., and Orekhovich V.N. Bradykinin-potentiating peptides from the spider Latrodectus tredecimguttatus inhibitors of carboxycathepsin and of a preparation of karakurt venom kininase. Dokl. Akad. Nauk. SSSR 315 (1990) 236-239
9. Ferreira L.A., Alves W.E., Lucas M.S., and Habermehl G.G. Isolation and characterization of a bradykinin potentiating peptide (BPP-S) isolated from Scaptocosa raptoria venom. Toxicon 34 (1996) 599-603
10. Ferreira L.A., Alves E.W., and Henriques O.B. Peptide T, a novel bradykinin potentiator isolated from Tityus serrulatus scorpion venom. Toxicon 31 (1993) 941-947
11. Meki A.R., Nassar A.Y., and Rochat H. A bradykinin-potentiating peptide (peptide K12) isolated from the venom of Egyptian scorpion Buthus occitanus. Peptides 16 (1995) 1359-1365
12. Pimenta A.M.C., Stöcklin R., Favreau P., Bougis P.E., and Martin-Eauclaire M.F. Moving pieces in a proteomic puzzle: mass fingerprinting of toxic fractions from the venom of Tityus serrulatus (Scorpiones, Buthidae). Rapid Commun. Mass Spectrom. 15 (2001) 1562-1572
13. Pimenta A.M.C., Legros C., Almeida F.M., Mansuelle P., De Lima M.E., Bougis P.E., and Martin-Eauclaire M.F. Novel structural class of four disulfide-bridged peptides from Tityus serrulatus venom. Biochem. Biophys. Res. Commun. 301 (2003) 1086-1092
14. Pimenta A.M.C., Rates B., Bloch Jr. C., Gomes P.C., Santoro M.M., De Lima M.E., Richardson M., and Cordeiro M.N. Electrospray ionization quadrupole time-of-flight and matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometric analyses to solve micro-heterogeneity in post-translationally modified peptides from Phoneutria nigriventer (Aranea, Ctenidae) venom. Rapid Commun. Mass Spectrom. 19 (2005) 31-37
15. Paula R.D., Lima C.V., Khosla M.C., and Santos R.A.S. Angiotensin-(1-7) potentiates the hypotensive effect of bradykinin in conscious rats. Hypertension 26 (1995) 1154-1159
16. 7-Angiotensin-(1-7). Hypertension 41 (2003) 737-743
17. Nascimento D.G., Rates B., Santos D.M., Verano-Braga T., Barbosa-Silva A., Dutra A.A.A., Biondi I., Martin-Eauclaire M.F., De Lima M.E., and Pimenta A.M.C. Moving pieces in a taxonomic puzzle: Venom 2D-LC/MS and data clustering analyses to infer phylogenetic relationships in some scorpions from the Buthidae family (Scorpiones). Toxicon 47 (2006) 628-639
18. Soares M.R., Oliveira-Carvalho A.L., Wermelinger L.S., Zingali R.B., Ho P.L., Junqueira-de-Azevedo L., and Diniz M.R. Identification of novel bradykinin-potentiating peptides and C-type natriuretic peptide from Lachesis muta venom. Toxicon 46 (2005) 31-38
19. Wermelinger L.S., Dutra D.L., Oliveira-Carvalho A.L., Soares M.R., Bloch Jr. C., and Zingali R.B. Fast analysis of low molecular mass compounds present in snake venom: identification of ten new pyroglutamate-containing peptides. Rapid Commun. Mass Spectrom. 19 (2005) 1703-1708
20. Conceição K., Konno K., de Melo R.L., Antoniazzi M.M., Jared C., Sciani J.M., Conceição I.M., Prezoto B.C., Camargo A.C., and Pimenta D.C. Isolation and characterization of a novel bradykinin potentiating peptide (BPP) from the skin secretion of Phyllomedusa hypochondrialis. Peptides 28 (2007) 515-523
21. Erdös E.G. Angiotensin I converting enzyme and the changes in our concepts through the years. Hypertension 16 (1990) 363-370
22. Chan W.C., and White P.D. Fmoc Solid-Phase Peptide Synthesis: A Practical Approach (2000), Oxford University Press, Oxford
23. Ianzer D., Santos R.A.S., Etelvino G.M., Xavier C.H., Santos J.A., Mendes E.P., Machado L.T., Prezoto B.C., Dive V., and Camargo A.C. Do the cardiovascular effects of angiotensin-converting enzyme (ACE) I involve ACE-independent mechanisms? New insights from proline-rich peptides of Bothrops jararaca. J. Pharmacol. Exp. Ther. 322 (2007) 795-805