An unusual fold for potassium channel blockers: NMR structure of three toxins from the scorpion Opisthacanthus madagascariensis

Biochemical Journal

Volumn 388, Issue 1, 2005, Pages 263-271

  Chagot, Benjamin ^a   Pimentel, Cyril ^a   Dai, Li ^b   Pil, Joost ^c   Tytgat, Jan ^c   Nakajima, Terumi ^d   Corzo, Gerardo ^d,e   Darbon, Hervé ^a   Ferrat, Gilles ^a,d  

^a AIX MARSEILLE UNIVERSITY   (France)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^e INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

Author keywords

Cystine stabilized helix loop helix structural motif; NMR; Opisthacanthus madagascariensis; Potassium channel; Scorpion toxin; Structure determination

Indexed keywords

ELECTROSTATIC ANISOTROPY; ION-CHANNEL BLOCKERS; PHARMACOLOGY; TOXINS;

ANISOTROPY; BIOCHEMISTRY; ELECTROPHYSIOLOGY; MOLECULAR DYNAMICS; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE; POTASSIUM; TOXIC MATERIALS;

AMINO ACIDS;

HELIX LOOP HELIX PROTEIN; ION CHANNEL; OM TOXIN; POTASSIUM; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; SCORPION VENOM; UNCLASSIFIED DRUG;

AMINO ACID COMPOSITION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; GEOMETRY; MOLECULAR DYNAMICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; OPISTHACANTHUS MADAGASCARIENSIS; POTASSIUM CURRENT; PRIORITY JOURNAL; SCORPION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANIMALS; MAGNETIC RESONANCE SPECTROSCOPY; POTASSIUM CHANNEL BLOCKERS; PROTEIN CONFORMATION; PROTEIN FOLDING; SCORPION VENOMS; SCORPIONS; SEQUENCE ALIGNMENT; TOXINS, BIOLOGICAL;

OPISTHACANTHUS; OPISTHACANTHUS MADAGASCARIENSIS; SCORPIONES;

EID: 19544386953     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20041705     Document Type: Article

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