Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Bjornsdottir, Unnur S ^a   Holgate, Stephen T ^b   Reddy, Padmalatha S ^c   Hill, Andrew A ^c   McKee, Charlotte M ^c   Csimma, Cristina I ^c   Weaver, Amy A ^c   Legault, Holly M ^c   Small, Clayton G ^c   Ramsey, Renee C ^c   Ellis, Debra K ^c   Burke, Conor M ^d   Thompson, Philip J ^e   Howarth, Peter H ^b   Wardlaw, Andrew J ^f   Bardin, Phillip G ^g   Bernstein, David I ^h   Irving, Louis B ⁱ   Chupp, Geoffrey L ^j   Bensch, George W ^k   Bensch, Gregory W ^k   Stahlman, Jon E ^l   Karetzky, Monroe ^m   Baker, James W ⁿ   Miller, Rachel L ^o   Goodman, Brad H ^p   Raible, Donald G ^c   Goldman, Samuel J ^c   Miller, Douglas K ^c   Ryan, John L ^c   Dorner, Andrew J ^c   Immermann, Frederick W ^c   O'Toole, Margot ^c   more..

^a UNIVERSITY OF ICELAND   (Iceland)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c PFIZER INC   (United States)

^d Stroke and Hypertension Unit   (Ireland)

^e UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^f UNIVERSITY OF LEICESTER   (United Kingdom)

^g MONASH UNIVERSITY   (Australia)

^h UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

ⁱ ROYAL MELBOURNE HOSPITAL   (Australia)

^j YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^k Bensch Clinical Research   (United States)

^l Allergy and Asthma Center   (United States)

^m NEWARK BETH ISRAEL MEDICAL CENTER   (United States)

ⁿ Baker Allergy   (United States)

^o Department of Medicine   (United States)

^p Columbia University Medical Center ^*  (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 15; LYMPHOCYTE ANTIGEN RECEPTOR; MESSENGER RNA;

ADAPTIVE IMMUNITY; ADULT; ARTICLE; ASTHMA; BLOOD ANALYSIS; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DNA MICROARRAY; FEMALE; FORCED EXPIRATORY VOLUME; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE IDENTIFICATION; HUMAN; IMMUNOREGULATION; IMMUNOSTIMULATION; INNATE IMMUNITY; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; T LYMPHOCYTE ACTIVATION; BLOOD; GENETICS; METABOLISM; METHODOLOGY; MIDDLE AGED; MONONUCLEAR CELL; PHYSIOLOGY; POLYMERASE CHAIN REACTION; PRINCIPAL COMPONENT ANALYSIS; SIGNAL TRANSDUCTION;

ADULT; ASTHMA; FEMALE; GENE EXPRESSION PROFILING; HUMANS; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; PRINCIPAL COMPONENT ANALYSIS; SIGNAL TRANSDUCTION;

EID: 79960309646     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021902     Document Type: Article

References (67)

1. Sykes A, Seemungal T, (2008) Recent advances in exacerbations of asthma. Thorax 63: 758-760.
2. Harrison TW, Oborne J, Newton S, Tattersfield AE, (2004) Doubling the dose of inhaled corticosteroid to prevent asthma exacerbations: randomised controlled trial. Lancet 363: 271-275.
3. Rice-McDonald G, Bowler S, Staines G, Mitchell C, (2005) Doubling daily inhaled corticosteroid dose is ineffective in mild to moderately severe attacks of asthma in adults. Intern Med J 35: 693-698.
4. Belda J, Margarit G, Martinez C, Bellido-Casado J, Casan P, et al. (2007) Anti-inflammatory effects of high-dose inhaled fluticasone versus oral prednisone in asthma exacerbations. Eur Respir J 30: 1143-1149.
5. Barnes PJ, (2007) Scientific rationale for using a single inhaler for asthma control. Eur Respir J 29: 587-595.
6. Boyce JA, Broide D, Matsumoto K, Bochner BS, (2009) Advances in mechanisms of asthma, allergy, and immunology in 2008. J Allergy Clin Immunol 123: 569-574.
7. Wenzel SE, (2009) Eosinophils in asthma-closing the loop or opening the door? N Engl J Med 360: 1026-1028.
8. Sykes A, Johnston SL, (2008) Etiology of asthma exacerbations. J Allergy Clin Immunol 122: 685-688.
9. Qiu Y, Zhu J, Bandi V, Guntupalli KK, Jeffery PK, (2007) Bronchial mucosal inflammation and upregulation of CXC chemoattractants and receptors in severe exacerbations of asthma. Thorax 62: 475-482.
10. O'Toole M, Bjornsdottir U, Holgate ST, Reddy PS, Hill AA, et al. (2009) Biological Mechanism Associated with Asthma Exacerbation Attack as Revealed By Gene Expression Patterns of Peripheral Blood Mononuclear Cells. Journal of Allergy and Clinical Immunology 123: S154.
11. Murphy S, Bleecher E, Bousey H, Buist A, Busse WW, et al. (1997) Guidelines for the Diagnosis and Management of Asthma.
12. Benjamini Y, Hochberg Y, (1995) Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc pp. 289-300.
13. Hartigan JA, Wong MA, (1979) A K-means clustering algorithm. Applied Statistics 28: 100-108.
14. Rousseeuw PJ, (1987) Silhouettes: A graphical aid to the interpretation and validation of cluster analysis. J Comput Appl Math 20: 53-65.
15. McShane LM, Radmacher MD, Freidlin B, Yu R, Li MC, et al. (2002) Methods for assessing reproducibility of clustering patterns observed in analyses of microarray data. Bioinformatics 18: 1462-1469.
16. Baldi P, Long AD, (2001) A Bayesian framework for the analysis of microarray expression data: regularized t-test and statistical inferences of gene changes. Bioinformatics 17: 509-519.
17. Mariani TJ, Budhraja V, Mecham BH, Gu CC, Watson MA, et al. (2003) A variable fold change threshold determines significance for expression microarrays. Faseb J 17: 321-323.
18. McCarthy DJ, Smyth GK, (2009) Testing significance relative to a fold-change threshold is a TREAT. Bioinformatics 25: 765-771.
19. Peart MJ, Smyth GK, van Laar RK, Bowtell DD, Richon VM, et al. (2005) Identification and functional significance of genes regulated by structurally different histone deacetylase inhibitors. Proc Natl Acad Sci U S A 102: 3697-3702.
20. Whalen KA, Legault H, Hang C, Hill A, Kasaian M, et al. (2008) In vitro allergen challenge of peripheral blood induces differential gene expression in mononuclear cells of asthmatic patients: inhibition of cytosolic phospholipase A2alpha overcomes the asthma-associated response. Clin Exp Allergy 38: 1590-1605.
21. Liu K, Catalfamo M, Li Y, Henkart PA, Weng NP, (2002) IL-15 mimics T cell receptor crosslinking in the induction of cellular proliferation, gene expression, and cytotoxicity in CD8+ memory T cells. Proc Natl Acad Sci U S A 99: 6192-6197.
22. Deng J, Dekruyff RH, Freeman GJ, Umetsu DT, Levy S, (2002) Critical role of CD81 in cognate T-B cell interactions leading to Th2 responses. Int Immunol 14: 513-523.
23. Kasprowicz DJ, Kohm AP, Berton MT, Chruscinski AJ, Sharpe A, et al. (2000) Stimulation of the B cell receptor, CD86 (B7-2), and the beta 2-adrenergic receptor intrinsically modulates the level of IgG1 and IgE produced per B cell. J Immunol 165: 680-690.
24. Kasaian MT, Donaldson DD, Tchistiakova L, Marquette K, Tan XY, et al. (2007) Efficacy of IL-13 neutralization in a sheep model of experimental asthma. Am J Respir Cell Mol Biol 36: 368-376.
25. Wills-Karp M, (2004) Interleukin-13 in asthma pathogenesis. Curr Allergy Asthma Rep 4: 123-131.
26. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, et al. (1998) Interleukin-13: central mediator of allergic asthma. Science 282: 2258-2261.
27. Wynn TA, (2003) IL-13 effector functions. Annu Rev Immunol 21: 425-456.
28. Haldar P, Pavord ID, Shaw DE, Berry MA, Thomas M, et al. (2008) Cluster analysis and clinical asthma phenotypes. Am J Respir Crit Care Med 178: 218-224.
29. Groskreutz DJ, Monick MM, Powers LS, Yarovinsky TO, Look DC, et al. (2006) Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J Immunol 176: 1733-1740.
30. Iwamura C, Nakayama T, (2008) Toll-like receptors in the respiratory system: their roles in inflammation. Curr Allergy Asthma Rep 8: 7-13.
31. Sears MR, Johnston NW, (2007) Understanding the September asthma epidemic. J Allergy Clin Immunol 120: 526-529.
32. Makela MJ, Halminen M, Ruuskanen O, Puhakka T, Pirhonen J, et al. (1999) Lack of induction by rhinoviruses of systemic type I interferon production or enhanced MxA protein expression during the common cold. Eur J Clin Microbiol Infect Dis 18: 665-668.
33. Xatzipsalti M, Kyrana S, Tsolia M, Psarras S, Bossios A, et al. (2005) Rhinovirus viremia in children with respiratory infections. Am J Respir Crit Care Med 172: 1037-1040.
34. Aoki T, Matsumoto Y, Hirata K, Ochiai K, Okada M, et al. (2009) Expression profiling of genes related to asthma exacerbations. Clin Exp Allergy 39: 213-221.
35. Sutherland ER, Martin RJ, (2007) Asthma and atypical bacterial infection. Chest 132: 1962-1966.
36. Wos M, Sanak M, Soja J, Olechnowicz H, Busse WW, et al. (2008) The presence of rhinovirus in lower airways of patients with bronchial asthma. Am J Respir Crit Care Med 177: 1082-1089.
37. Trompette A, Divanovic S, Visintin A, Blanchard C, Hegde RS, et al. (2009) Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein. Nature 457: 585-588.
38. Becker S, Dailey L, Soukup JM, Silbajoris R, Devlin RB, (2005) TLR-2 is involved in airway epithelial cell response to air pollution particles. Toxicol Appl Pharmacol 203: 45-52.
39. Williams AS, Leung SY, Nath P, Khorasani NM, Bhavsar P, et al. (2007) Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. J Appl Physiol 103: 1189-1195.
40. Asea A, Rehli M, Kabingu E, Boch JA, Bare O, et al. (2002) Novel signal transduction pathway utilized by extracellular HSP70: role of toll-like receptor (TLR) 2 and TLR4. J Biol Chem 277: 15028-15034.
41. Biragyn A, Ruffini PA, Leifer CA, Klyushnenkova E, Shakhov A, et al. (2002) Toll-like receptor 4-dependent activation of dendritic cells by beta-defensin 2. Science 298: 1025-1029.
42. Okamura Y, Watari M, Jerud ES, Young DW, Ishizaka ST, et al. (2001) The extra domain A of fibronectin activates Toll-like receptor 4. J Biol Chem 276: 10229-10233.
43. Saemann MD, Weichhart T, Zeyda M, Staffler G, Schunn M, et al. (2005) Tamm-Horsfall glycoprotein links innate immune cell activation with adaptive immunity via a Toll-like receptor-4-dependent mechanism. J Clin Invest 115: 468-475.
44. Smiley ST, King JA, Hancock WW, (2001) Fibrinogen stimulates macrophage chemokine secretion through toll-like receptor 4. J Immunol 167: 2887-2894.
45. Guillot L, Balloy V, McCormack FX, Golenbock DT, Chignard M, et al. (2002) Cutting edge: the immunostimulatory activity of the lung surfactant protein-A involves Toll-like receptor 4. J Immunol 168: 5989-5992.
46. Burgel PR, Nadel JA, (2008) Epidermal growth factor receptor-mediated innate immune responses and their roles in airway diseases. Eur Respir J 32: 1068-1081.
47. Hammad H, Chieppa M, Perros F, Willart MA, Germain RN, et al. (2009) House dust mite allergen induces asthma via Toll-like receptor 4 triggering of airway structural cells. Nat Med 15: 410-416.
48. Le Souef PN, (2009) Gene-environmental interaction in the development of atopic asthma: new developments. Curr Opin Allergy Clin Immunol 9: 123-127.
49. Reed CE, Milton DK, (2001) Endotoxin-stimulated innate immunity: A contributing factor for asthma. J Allergy Clin Immunol 108: 157-166.
50. Simpson JL, Brooks C, Douwes J, (2008) Innate immunity in asthma. Paediatr Respir Rev 9: 263-270.
51. Tamari M, Harada M, Hirota T, Nakamura Y, (2009) Host molecular defense mechanisms against Chlamydophila pneumoniae and genetic studies of immune-response-related genes in asthma. Recent Pat Inflamm Allergy Drug Discov 3: 17-25.
52. Eder W, Klimecki W, Yu L, von Mutius E, Riedler J, et al. (2004) Toll-like receptor 2 as a major gene for asthma in children of European farmers. J Allergy Clin Immunol 113: 482-488.
53. Fageras Bottcher M, Hmani-Aifa M, Lindstrom A, Jenmalm MC, Mai XM, et al. (2004) A TLR4 polymorphism is associated with asthma and reduced lipopolysaccharide-induced interleukin-12(p70) responses in Swedish children. J Allergy Clin Immunol 114: 561-567.
54. Lazarus R, Raby BA, Lange C, Silverman EK, Kwiatkowski DJ, et al. (2004) TOLL-like receptor 10 genetic variation is associated with asthma in two independent samples. Am J Respir Crit Care Med 170: 594-600.
55. Smit LA, Siroux V, Bouzigon E, Oryszczyn MP, Lathrop M, et al. (2009) CD14 and toll-like receptor gene polymorphisms, country living, and asthma in adults. Am J Respir Crit Care Med 179: 363-368.
56. Yang IA, Fong KM, Holgate ST, Holloway JW, (2006) The role of Toll-like receptors and related receptors of the innate immune system in asthma. Curr Opin Allergy Clin Immunol 6: 23-28.
57. Koppelman GH, Reijmerink NE, Colin Stine O, Howard TD, Whittaker PA, et al. (2001) Association of a promoter polymorphism of the CD14 gene and atopy. Am J Respir Crit Care Med 163: 965-969.
58. Nakao F, Ihara K, Kusuhara K, Sasaki Y, Kinukawa N, et al. (2001) Association of IFN-gamma and IFN regulatory factor 1 polymorphisms with childhood atopic asthma. J Allergy Clin Immunol 107: 499-504.
59. Sharma M, Batra J, Mabalirajan U, Goswami S, Ganguly D, et al. (2004) Suggestive evidence of association of C-159T functional polymorphism of the CD14 gene with atopic asthma in northern and northwestern Indian populations. Immunogenetics 56: 544-547.
60. Wang TN, Chu YT, Chen WY, Feng WW, Shih NH, et al. (2006) Association of interferon-gamma and interferon regulatory factor 1 polymorphisms with asthma in a family-based association study in Taiwan. Clin Exp Allergy 36: 1147-1152.
61. Woo JG, Assa'ad A, Heizer AB, Bernstein JA, Hershey GK, (2003) The-159 C→T polymorphism of CD14 is associated with nonatopic asthma and food allergy. J Allergy Clin Immunol 112: 438-444.
62. Boyman O, Purton JF, Surh CD, Sprent J, (2007) Cytokines and T-cell homeostasis. Curr Opin Immunol 19: 320-326.
63. Ohteki T, Yoshida H, Matsuyama T, Duncan GS, Mak TW, et al. (1998) The transcription factor interferon regulatory factor 1 (IRF-1) is important during the maturation of natural killer 1.1+ T cell receptor-alpha/beta+ (NK1+ T) cells, natural killer cells, and intestinal intraepithelial T cells. J Exp Med 187: 967-972.
64. Zhang X, Sun S, Hwang I, Tough DF, Sprent J, (1998) Potent and selective stimulation of memory-phenotype CD8+ T cells in vivo by IL-15. Immunity 8: 591-599.
65. Bierbaum S, Nickel R, Zitnik S, Ahlert I, Lau S, et al. (2006) Confirmation of association of IL-15 with pediatric asthma and comparison of different controls. Allergy 61: 576-580.
66. Kurz T, Strauch K, Dietrich H, Braun S, Hierl S, et al. (2004) Multilocus haplotype analyses reveal association between 5 novel IL-15 polymorphisms and asthma. J Allergy Clin Immunol 113: 896-901.
67. Janeway CA Jr, Medzhitov R, (2002) Innate immune recognition. Annu Rev Immunol 20: 197-216.