Adipocytes derived from human bone marrow mesenchymal stem cells exert inhibitory effects on osteoblastogenesis

Current Molecular Medicine

Volumn 11, Issue 6, 2011, Pages 489-502

  Zhang, H ^a   Lu, W ^a,b   Zhao, Y ^a   Rong, P ^c   Cao, R ^a   Gu, W ^d   Xiao, J ^a   Miao, D ^e   Lappe, J ^a   Recker, R ^a   Xiao, G G ^a  

^a CREIGHTON UNIVERSITY MEDICAL CENTER   (United States)

^b SHANDONG UNIVERSITY   (China)

^c INSTITUTE OF CHINESE MATERIA MEDICA   (China)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^e NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Adipogenesis; Co culture; Microarray; Osteoblastogenesis; Proteomics; Wnt signaling

Indexed keywords

ALKALINE PHOSPHATASE; AMYLIN; ANGIOTENSINOGEN; BETA CATENIN; CALCYCLIN; CALRETICULIN; COLLAGEN ALPHA1 CHAIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GALECTIN 1; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 25; LIPOCORTIN 2; LIPOCORTIN 5; MESSENGER RNA; MONOCYTE CHEMOTACTIC PROTEIN 1; NERVE GROWTH FACTOR RECEPTOR; OBESTATIN; OREXIN A; OREXIN B; PEROXIREDOXIN 6; PHOSPHOGLYCERATE MUTASE 1; PROTEIN; SERPIN H1; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA; TRIOSEPHOSPHATE ISOMERASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; WNT PROTEIN;

ADIPOCYTE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE TISSUE; CELL DIFFERENTIATION; COCULTURE; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; GENE IDENTIFICATION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LYMPHOCYTE TRANSFORMATION; MESENCHYMAL STEM CELL; MOLECULAR MECHANICS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSSIFICATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN MICROARRAY; SIGNAL TRANSDUCTION; UPREGULATION;

MUS;

EID: 79960299719     PISSN: 15665240     EISSN: 18755666     Source Type: Journal    
DOI: 10.2174/156652411796268704     Document Type: Article

References (52)

1. Berry SD, Samelson EJ, Hannan MT, et al. Second hip fracture in older men and women: the Framingham Study. Arch Intern Med 2007; 167: 1971-6.
2. Nguyen ND, Eisman JA, Center JR, Nguyen TV. Risk factors for fracture in nonosteoporotic men and women. J Clin Endocrinol Metab 2007; 92: 955-62.
3. Reid IR. Relationships between fat and bone. Osteoporos Int 2008; 19: 595-606.
4. Rosen CJ, Bouxsein ML. Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2006; 2: 35-43.
5. Meunier P, Aaron J, Edouard C, Vignon G. Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies. Clin Orthop Relat Res 1971; 80: 147-54.
6. Duque G, Troen BR. Understanding the mechanisms of senile osteoporosis: new facts for a major geriatric syndrome. J Am Geriatr Soc 2008; 56: 935-41.
7. Jee WS, Wronski TJ, Morey ER, Kimmel DB. Effects of spaceflight on trabecular bone in rats. Am J Physiol 1983; 244: R310-4.
8. Martin RB, Chow BD, Lucas PA. Bone marrow fat content in relation to bone remodeling and serum chemistry in intact and ovariectomized dogs. Calcif Tissue Int 1990; 46: 189-94.
9. Muruganandan S, Roman AA, Sinal CJ. Adipocyte differentiation of bone marrow-derived mesenchymal stem cells: cross talk with the osteoblastogenic program. Cell Mol Life Sci 2009; 66: 236-53.
10. Dorheim MA, Sullivan M, Dandapani V, et al. Osteoblastic gene expression during adipogenesis in hematopoietic supporting murine bone marrow stromal cells. J Cell Physiol 1993; 154: 317-28.
11. Prockop DJ. Marrow stromal cells as stem cells for nonhematopoietic tissues. Science 1997; 276: 71-4.
12. Akune T, Ohba S, Kamekura S, et al. PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest 2004; 113: 846-55.
13. Bennett JH, Joyner CJ, Triffitt JT, Owen ME. Adipocytic cells cultured from marrow have osteogenic potential. J Cell Sci 1991; 99 (Pt 1): 131-9.
14. Beresford JN, Bennett JH, Devlin C, Leboy PS, Owen ME. Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell cultures. J Cell Sci 1992; 102 (Pt 2): 341-51.
15. Benayahu D, Zipori D, Wientroub S. Marrow adipocytes regulate growth and differentiation of osteoblasts. Biochem Biophys Res Commun 1993; 197: 1245-52.
16. Karsenty G. Convergence between bone and energy homeostases: leptin regulation of bone mass. Cell Metab 2006; 4: 341-8.
17. Martin TJ, Quinn JM, Gillespie MT, Ng KW, Karsdal MA, Sims NA. Mechanisms involved in skeletal anabolic therapies. Ann N Y Acad Sci 2006; 1068: 458-70.
18. Elbaz A, Wu X, Rivas D, Gimble JM, Duque G. Inhibition of fatty acid biosynthesis prevents adipocyte lipotoxicity on human osteoblasts in vitro. J Cell Mol Med 2010; 14: 982-91.
19. Murdoch AD, Grady LM, Ablett MP, Katopodi T, Meadows RS, Hardingham TE. Chondrogenic differentiation of human bone marrow stem cells in transwell cultures: generation of scaffold-free cartilage. Stem Cells 2007; 25: 2786-96.
20. Zhang HW, Ding J, Jin JL, et al. Defects in mesenchymal stem cell self-renewal and cell fate determination lead to an osteopenic phenotype in Bmi-1 null mice. J Bone Miner Res 2010; 25: 640-52.
21. Miao D, He B, Karaplis AC, Goltzman D. Parathyroid hormone is essential for normal fetal bone formation. J Clin Invest 2002; 109: 1173-82.
22. Zhao Y, Lee WN, Xiao GG. Quantitative proteomics and biomarker discovery in human cancer. Expert Rev Proteomics 2009; 6: 115-8.
23. Alliston T, Choy L, Ducy P, Karsenty G, Derynck R. TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J 2001; 20: 2254-72.
24. Centrella M, Casinghino S, Kim J, Pham T, Rosen V, Wozney J, McCarthy TL. Independent changes in type I and type 2 receptors for transforming growth factor beta induced by bone morphogenetic protein 2 parallel expression of the osteoblast phenotype. Mol Cell Biol 1995; 15: 3273-81.
25. Lucas PA. Chemotactic response of osteoblast-like cells to transforming growth factor beta. Bone 1989; 10: 459-63.
26. Maeda S, Hayashi M, Komiya S, Imamura T, Miyazono K. Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells. EMBO J 2004; 23: 552-63.
27. Pfeilschifter J, Wolf O, Naumann A, Minne HW, Mundy GR, Ziegler R. Chemotactic response of osteoblastlike cells to transforming growth factor beta. J Bone Miner Res 1990; 5: 825-30.
28. Tang Y, Wu X, Lei W, et al. TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation. Nat Med 2009; 15: 757-65.
29. Fadel MP, Szewczenko-Pawlikowski M, Leclerc P, et al. Calreticulin affects beta-catenin-associated pathways. J Biol Chem 2001; 276: 27083-9.
30. Fischer L, Boland G, Tuan RS. Wnt-3A enhances bone morphogenetic protein-2-mediated chondrogenesis of murine C3H10T1/2 mesenchymal cells. J Biol Chem 2002; 277: 30870-8.
31. Nowotny M, Spiechowicz M, Jastrzebska B, Filipek A, Kitagawa K, Kuznicki J. Calcium-regulated interaction of Sgt1 with S100A6 (calcyclin) and other S100 proteins. J Biol Chem 2003; 278: 26923-8.
32. Olkku A, Mahonen A. Calreticulin mediated glucocorticoid receptor export is involved in beta-catenin translocation and Wnt signalling inhibition in human osteoblastic cells. Bone 2009; 44: 555-65.
33. Kanamoto T, Hellman U, Heldin CH, Souchelnytskyi S. Functional proteomics of transforming growth factor-beta1-stimulated Mv1Lu epithelial cells: Rad51 as a target of TGFbeta1-dependent regulation of DNA repair. EMBO J 2002; 21: 1219-30.
34. Lurton J, Soto H, Narayanan AS, Raghu G. Regulation of human lung fibroblast C1q-receptors by transforming growth factor-beta and tumor necrosis factor-alpha. Exp Lung Res 1999; 25: 151-64.
35. Gimble JM, Zvonic S, Floyd ZE, Kassem M, Nuttall ME. Playing with bone and fat. J Cell Biochem 2006; 98: 251-66.
36. Gimble JM, Robinson CE, Wu X, Kelly KA. The function of adipocytes in the bone marrow stroma: an update. Bone 1996; 19: 421-8.
37. Welsh GI, Griffiths MR, Webster KJ, Page MJ, Tavare JM. Proteome analysis of adipogenesis. Proteomics 2004; 4: 1042-51.
38. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrell MA. The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 2001; 280: E827-E47.
39. Dwyer JR, Sever N, Carlson M, Nelson SF, Beachy PA, Parhami F. Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem 2007; 282: 8959-68.
40. Wahl EC, Aronson J, Liu L, et al. Restoration of regenerative osteoblastogenesis in aged mice: modulation of TNF. J Bone Miner Res 2010; 25: 114-23.
41. Erikson E, Erikson RL. Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product. Cell 1980; 21: 829-36.
42. Zobiack N, Rescher U, Laarmann S, Michgehl S, Schmidt MA, Gerke V. Cell-surface attachment of pedestal-forming enteropathogenic E. coli induces a clustering of raft components and a recruitment of annexin 2. J Cell Sci 2002; 115: 91-8.
43. Tezuka K, Yasuda M, Watanabe N, et al. Stimulation of osteoblastic cell differentiation by Notch. J Bone Miner Res 2002; 17: 231-9.
44. Kawabata M, Inoue H, Hanyu A, Imamura T, Miyazono K. Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J 1998; 17: 4056-65.
45. Fadel MP, Szewczenko-Pawlikowski M, Leclerc P, et al. Calreticulin affects beta-catenin-associated pathways. J Biol Chem 2001; 276: 27083-9.
46. Filipek A. S100A6 and CacyBP/. Chemotherapy 2006; 52: 32-4.
47. Donato R. Functional roles of S100 proteins, calcium-binding proteins of the EF-hand type. Biochim Biophys Acta 1999; 1450: 191-231.
48. Donato R. S100: a multigenic family of calcium-modulated proteins of the EF-hand type with intracellular and extracellular functional roles. Int J Biochem Cell Biol 2001; 33: 637-68.
49. Seth A, Lee BK, Qi S, Vary CP. Coordinate expression of novel genes during osteoblast differentiation. J Bone Miner Res 2000; 15: 1683-96.
50. Hwang R, Lee EJ, Kim MH, et al. Calcyclin, a Ca2+ ion-binding protein, contributes to the anabolic effects of simvastatin on bone. J Biol Chem 2004; 279: 21239-47.
51. St-Arnaud R, Prud'homme J, Leung-Hagesteijn C, Dedhar S. Constitutive expression of calreticulin in osteoblasts inhibits mineralization. J Cell Biol 1995; 131: 1351-9.
52. Day TF, Guo X, Garrett-Beal L, Yang Y. Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis. Dev Cell 2005; 8: 739-50.