Systemic and spinal administration of etanercept, a tumor necrosis factor alpha inhibitor, blocks tactile allodynia in diabetic mice

Acta Diabetologica

Volumn 48, Issue 2, 2011, Pages 135-142

  Dogrul, Ahmet ^a   Gul, Husamettin ^a   Yesilyurt, Ozgur ^a   Ulas, Umit H ^a   Yildiz, Oguzhan ^a  

^a GULHANE SCHOOL OF MEDICINE   (Turkey)

Author keywords

Diabetic neuropathic pain; Etanercept; Streptozotocin; Tactile allodynia; TNF alpha

Indexed keywords

ETANERCEPT; TUMOR NECROSIS FACTOR ALPHA;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETIC NEUROPATHY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFICACY; FEMALE; HOT PLATE TEST; HYPERALGESIA; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; STREPTOZOCIN DIABETES;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HYPERALGESIA; IMMUNOGLOBULIN G; INJECTIONS, INTRAVENOUS; INJECTIONS, SPINAL; MICE; MICE, INBRED BALB C; REACTION TIME; RECEPTORS, TUMOR NECROSIS FACTOR; STREPTOZOCIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79960284294     PISSN: 09405429     EISSN: 14325233     Source Type: Journal    
DOI: 10.1007/s00592-010-0237-x     Document Type: Article

References (58)

1. A Doǧrul H Gül O Yildiz F Bilgin ME Güzeldemir 2004 Cannabinoids blocks tactile allodynia in diabetic mice without attenuation of its antinociceptive effect Neurosci Lett 368 1 82 86 15342139 10.1016/j.neulet.2004.06.060 (Pubitemid 39178753)
2. IG Obrosova 2009 Diabetic painful and insensate neuropathy: pathogenesis and potential treatments Neurotherapeutics 6 4 638 647 19789069 10.1016/j.nurt.2009.07.004 1:CAS:528:DC%2BC3cXitVKqu74%3D
3. SH Sindrup TS Jensen 1999 Efficacy of pharmacological treatments of neuropathic pain: an update and effect related to mechanism of drug action Pain 83 3 389 400 10568846 10.1016/S0304-3959(99)00154-2 1:CAS:528:DyaK1MXntlemu7c%3D
4. CJ Woolf RJ Mannion 1999 Neuropathic pain: aetiology, symptoms, mechanisms, and management Lancet 353 9168 1959 1964 10371588 10.1016/S0140-6736(99)01307-0 1:STN:280:DyaK1M3psl2qug%3D%3D (Pubitemid 29255720)
5. NA Calcutt 2002 Potential mechanisms of neuropathic pain in diabetes Int Rev Neurobiol 50 205 228 12198811 10.1016/S0074-7742(02)50078-7 1:CAS:528:DC%2BD38XotFaqurg%3D
6. JL Edwards AM Vincent HT Cheng EL Feldman 2008 Diabetic neuropathy: mechanisms to management Pharmacol Ther 120 1 34 18616962 10.1016/j.pharmthera. 2008.05.005 1:CAS:528:DC%2BD1cXhtFCkurvE
7. S Hong TJ Morrow PE Paulson LL Isom JW Wiley 2004 Early painful diabetic neuropathy is associated with differential changes in tetrodotoxin-sensitive and -resistant sodium channels in dorsal root ganglion neurons in the rat J Biol Chem 279 28 29341 29350 15123645 10.1074/jbc.M404167200 1:CAS:528: DC%2BD2cXlsVCmt70%3D (Pubitemid 38915812)
8. D Kapur 2003 Neuropathic pain and diabetes Diabetes Metab Res Rev 19 Suppl 1 S9 S15 12577253 10.1002/dmrr.359 1:CAS:528:DC%2BD3sXisF2nsLg%3D (Pubitemid 36285367)
9. C Quattrini S Tesfaye 2003 Understanding the impact of painful diabetic neuropathy Diabetes Metab Res Rev 19 Suppl 1 S2 S8 12577252 10.1002/dmrr.360 (Pubitemid 36285366)
10. A Veves M Backonja RA Malik 2008 Painful diabetic neuropathy: epidemiology, natural history, early diagnosis, and treatment options Pain Med 9 660 674 18828198 10.1111/j.1526-4637.2007.00347.x
11. AM Barrett MA Lucero T Le RL Robinson RH Dworkin AS Chappell 2007 Epidemiology, public health burden, and treatment of diabetic peripheral neuropathic pain: a review Pain Med 8 Suppl 2 S50 S62 17714116 10.1111/j.1526-4637.2006.00179.x (Pubitemid 47288511)
12. EJ Bastyr III KL Price V Bril 2005 MBBQ Study Group. Development and validity testing of the neuropathy total symptom score-6: questionnaire for the study of sensory symptoms of diabetic peripheral neuropathy Clin Ther 27 8 1278 1294 16199253 10.1016/j.clinthera.2005.08.002 (Pubitemid 41393921)
13. AI Vinik S Suwanwalaikorn KB Stansberry MT Holland PM McNitt LE Colen 1995 Quantitative measurement of cutaneous perception in diabetic neuropathy Muscle Nevre 18 6 574 584 10.1002/mus.880180603 1:STN:280:DyaK2M3nt1Khsw%3D%3D
14. R Baron TR Tölle U Gockel M Brosz R Freynhagen 2009 A cross-sectional cohort survey in 2100 patients with painful diabetic neuropathy and postherpetic neuralgia: differences in demographic data and sensory symptoms Pain 146 1-2 34 40 19592166 10.1016/j.pain.2009.06.001
15. S Tesfaye 2009 Advances in the management of diabetic peripheral neuropathy Curr Opin Support Palliat Care 3 2 136 143 19421063 10.1097/SPC.0b013e32832b7df5
16. A Kuhad K Chopra 2009 Tocotrienol attenuates oxidative-nitrosative stress and inflammatory cascade in experimental model of diabetic neuropathy Neuropharmacology 57 4 456 462 19555701 10.1016/j.neuropharm.2009.06.013 1:CAS:528:DC%2BD1MXhtVeis7jJ
17. Hopra K, Tiwari V, Arora V, Kuhad A (2010) Sesamol suppresses neuro-Inflammatory cascade in experimental model of diabetic neuropathy. J Pain Apr 23. [Epub ahead of print]
18. JL Edwards AM Vincent HT Cheng EL Feldman 2008 Diabetic neuropathy: mechanisms to management Pharmacol Ther 120 1 1 34 18616962 10.1016/j. pharmthera.2008.05.005 1:CAS:528:DC%2BD1cXhtFCkurvE
19. VK Kolla G Madhavi B Pulla Reddy BM Srikanth Babu J Yashovanthi VL Valluri J Ramesh J Akka 2009 Association of tumor necrosis factor alpha, interferon gamma and interleukin 10 gene polymorphisms with peripheral neuropathy in South Indian patients with type 2 diabetes Cytokine 47 3 173 177 19608431 10.1016/j.cyto.2009.06.007 1:CAS:528:DC%2BD1MXhtVensbzF
20. N Bariş M Erdoǧan E Sezer F Saygili A Mert Ozgönül N Turgan B Ersöz 2009 Alterations in L-arginine and inflammatory markers in type 2 diabetic patients with and without microalbuminuria Acta Diabetol 46 4 309 316 19183843 10.1007/s00592-008-0089-9
21. Nerla R, Pitocco D, Zaccardi F, Scalone G, Coviello I, Mollo R, Ghirlanda G, Lanza GA, Crea F (2009) Effect of pioglitazone on systemic inflammation is independent of metabolic control and cardiac autonomic function in patients with type 2 diabetes. Acta Diabetol 29 Sep 2009 [Epub ahead of print]
22. YJ Gao RR Ji 2010 Chemokines, neuronal-glial interactions, and central processing of neuropathic pain Pharmacol Ther 126 1 56 68 20117131 10.1016/j.pharmthera.2010.01.002 1:CAS:528:DC%2BC3cXjt1Kgs7Y%3D
23. S Kimura H Kontani 2009 Demonstration of antiallodynic effects of the cyclooxygenase-2 inhibitor meloxicam on established diabetic neuropathic pain in mice J Pharmacol Sci 110 2 213 217 19498273 10.1254/jphs.09006SC 1:CAS:528:DC%2BD1MXotFKhsb8%3D
24. LS Sorkin CM Doom 2000 Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat J Peripher Nerv Syst 5 2 96 100 10905468 10.1046/j.1529-8027.2000.00012.x 1:CAS:528:DC%2BD3cXlsFSitro%3D (Pubitemid 30451711)
25. X Jin RW Gereau 2006 Acute p38-mediated modulation of tetrodotoxin-resistant sodium channels in mouse sensory neurons by tumor necrosis factor-alpha J Neurosci 26 1 246 255 16399694 10.1523/JNEUROSCI.3858- 05.2006 1:CAS:528:DC%2BD28XmtV2mtQ%3D%3D (Pubitemid 43089538)
26. MS Kwon EJ Shim YJ Seo SS Choi JY Lee HK Lee HW Suh 2005 Effect of aspirin and acetaminophen on proinflammatory cytokine-induced pain behavior in mice Pharmacology 74 3 152 156 15775706 10.1159/000084548 1:CAS:528: DC%2BD2MXkvVOntrs%3D (Pubitemid 40981101)
27. F Marchand C Tsantoulas D Singh J Grist AK Clark EJ Bradbury SB McMahon 2009 Effects of Etanercept and Minocycline in a rat model of spinal cord injury Eur J Pain 13 7 673 681 18849175 10.1016/j.ejpain.2008.08.001 1:CAS:528:DC%2BD1MXnslyqtL8%3D
28. DH Youn H Wang SJ Jeong 2008 Exogenous tumor necrosis factor-alpha rapidly alters synaptic and sensory transmission in the adult rat spinal cord dorsal horn J Neurosci Res 86 13 2867 2875 18543334 10.1002/jnr.21726 1:CAS:528:DC%2BD1cXht1GmtLfN
29. M Schäfers DH Lee D Brors TL Yaksh LS Sorkin 2003 Increased sensitivity of injured and adjacent uninjured rat primary sensory neurons to exogenous tumor necrosis factor-alpha after spinal nerve ligation J Neurosci 23 7 3028 3038 12684490 (Pubitemid 36418639)
30. C Sommer M Schäfers M Marziniak KV Toyka 2001 Etanercept reduces hyperalgesia in experimental painful neuropathy J Peripher Nerv Syst 6 2 67 72 11446385 10.1046/j.1529-8027.2001.01010.x 1:CAS:528:DC%2BD3MXltleit7w%3D (Pubitemid 32606886)
31. JM Zanella EN Burright K Hildebrand C Hobot M Cox L Christoferson WF McKay 2008 Effect of etanercept, a tumor necrosis factor-alpha inhibitor, on neuropathic pain in the rat chronic constriction injury model Spine 33 3 227 234 18303453 10.1097/BRS.0b013e318162340a (Pubitemid 351322926)
32. VR Drel S Lupachyk H Shevalye I Vareniuk W Xu J Zhang NA Delamere M Shahidullah B Slusher IG Obrosova 2010 New therapeutic and biomarker discovery for peripheral diabetic neuropathy: PARP inhibitor, nitrotyrosine, and tumor necrosis factor-{alpha} Endocrinology 151 6 2547 2555 20357221 10.1210/en.2009-1342 1:CAS:528:DC%2BC3cXnsVyqtr0%3D
33. J Kamei Y Ohhashi T Aoki Y Kasuya 1991 Streptozotocin-induced diabetes in mice reduces the nociceptive threshold, as recognized after application of noxious mechanical stimuli but not of thermal stimuli Pharmacol Biochem Behav 39 2 541 544 1719570 10.1016/0091-3057(91)90224-P 1:CAS:528:DyaK3MXltlehsb4%3D
34. M Zimmermann 1983 Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 2 109 110 6877845 10.1016/0304-3959(83)90201-4 1:STN:280:DyaL3s3nt1GqsQ%3D%3D (Pubitemid 13058546)
35. SR Chaplan FW Bach JW Pogrel JM Chung TL Yaksh 1994 Quantitative assessment of tactile allodynia in the rat paw J Neurosci Methods 53 1 55 63 7990513 10.1016/0165-0270(94)90144-9 1:STN:280:DyaK2M%2Fot1Cjug%3D%3D (Pubitemid 24238751)
36. WJ Dixon 1980 Efficient analysis of experimental observations Annu Rev Pharmacol Toxicol 20 441 462 7387124 10.1146/annurev.pa.20.040180.002301 1:STN:280:DyaL3c3hvVylsg%3D%3D
37. JL Hylden GL Wilcox 1980 Intrathecal morphine in mice: a new technique Eur J Pharmacol 67 2-3 313 316 6893963 10.1016/0014-2999(80)90515-4 1:CAS:528:DyaL3MXhtVyhsA%3D%3D (Pubitemid 10007057)
38. A Fox C Eastwood C Gentry D Manning L Urban 1999 Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat Pain 81 3 307 316 10431718 10.1016/S0304-3959(99)00024-X 1:CAS:528:DyaK1MXkvVGmur0%3D (Pubitemid 29257901)
39. S Kimura M Tanabe M Honda H Ono 2005 Enhanced wind-up of the C-fiber-mediated nociceptive flexor reflex movement following painful diabetic neuropathy in mice J Pharmacol Sci 97 2 195 202 15684569 10.1254/jphs.FP0040785 1:CAS:528:DC%2BD2MXhvFKlsbg%3D (Pubitemid 40410259)
40. O Ilnytska VV Lyzogubov MJ Stevens VR Drel N Mashtalir P Pacher MA Yorek IG Obrosova 2006 Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy Diabetes 55 6 1686 1694 16731831 10.2337/db06-0067 1:CAS:528:DC%2BD28XlsF2rur8%3D (Pubitemid 44324121)
41. JS Shaw JD Rourke KM Burns 1988 Differential sensitivity of antinociceptive tests to opioid agonists and partial agonists Br J Pharmacol 95 2 578 584 2852526 1:CAS:528:DyaL1cXlvVentLY%3D
42. J Kamei M Ohsawa S Miyata K Endo H Hayakawa 2008 Effects of cytidine 5′-diphosphocholine (CDP-choline) on the thermal nociceptive threshold in streptozotocin-induced diabetic mice Eur J Pharmacol 598 1-3 32 36 18834878 10.1016/j.ejphar.2008.09.012 1:CAS:528:DC%2BD1cXht12rsLnO
43. RM Pabbidi SQ Yu S Peng R Khardori ME Pauza LS Premkumar 2008 Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity Mol Pain 4 9 18312687 10.1186/1744-8069-4-9 (Pubitemid 351467877)
44. SE Abram J Yi A Fuchs QH Hogan 2006 Permeability of injured and intact peripheral nerves and dorsal root ganglia Anesthesiology 105 1 146 153 16810006 10.1097/00000542-200607000-00024 (Pubitemid 44305203)
45. H Zhou 2005 Clinical pharmacokinetics of etanercept: a fully humanized soluble recombinant tumor necrosis factor receptor fusion protein J Clin Pharmacol 45 5 490 497 15831771 10.1177/0091270004273321 1:CAS:528: DC%2BD2MXkvVWmsbY%3D (Pubitemid 40562938)
46. T Genovese E Mazzon C Crisafulli R Di Paola C Muià P Bramanti S Cuzzocrea 2006 Immunomodulatory effects of etanercept in an experimental model of spinal cord injury J Pharmacol Exp Ther 316 3 1006 1016 16303916 10.1124/jpet.105.097188 1:CAS:528:DC%2BD28Xit1Shu78%3D (Pubitemid 43345272)
47. McGeer PL, Tobinick E, Kornelsen R, McCormick S, Ferreira C, Lapi S, Ruth TJ (2009) PET Imaging reveals that etanercept crosses the blood-cerebrospinal fluid but not the blood-brain barrier: Implications for Alzheimer's disease. J Alzheimers Dis (in press)
48. CI Svensson M Schäfers TL Jones H Powell LS Sorkin 2005 Spinal blockade of TNF blocks spinal nerve ligation-induced increases in spinal P-p38 Neurosci Lett 379 3 209 213 15843065 10.1016/j.neulet.2004.12.064 1:CAS:528:DC%2BD2MXjsVenu78%3D (Pubitemid 40544536)
49. K Kato S Kikuchi VI Shubayev RR Myers 2009 Distribution and tumor necrosis factor-alpha isoform binding specificity of locally administered etanercept into injured and uninjured rat sciatic nerve Neuroscience 160 2 492 500 19250961 10.1016/j.neuroscience.2009.02.038 1:CAS:528:DC%2BD1MXksVSrtrk%3D
50. MK Boettger S Hensellek F Richter M Gajda R Stöckigt GS von Banchet R Bräuer HG Schaible 2008 Antinociceptive effects of tumor necrosis factor alpha neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal target Arthritis Rheum 58 8 2368 2378 18668541 10.1002/art.23608 1:CAS:528:DC%2BD1cXhtVCjtbfN
51. C Morgado I Tavares 2007 C-fos expression at the spinal dorsal horn of streptozotocin-induced diabetic rats Diabetes Metab Res Rev 23 8 644 652 17506118 10.1002/dmrr.751 1:CAS:528:DC%2BD1cXkslyhtQ%3D%3D (Pubitemid 350200405)
52. Morgado C, Terra PP, Tavares I (2009) Neuronal hyperactivity at the spinal cord and periaqueductal grey during painful diabetic neuropathy: effects of gabapentin. Eur J Pain (in press)
53. H Junger LS Sorkin 2000 Nociceptive and inflammatory effects of subcutaneous TNF alpha Pain 85 1-2 145 151 10692613 10.1016/S0304-3959(99)00262- 6 1:CAS:528:DC%2BD3cXht1Oit70%3D (Pubitemid 30110754)
54. VI Shubayev RR Myers 2002 Anterograde TNF alpha transport from rat dorsal root ganglion to spinal cord and injured sciatic nerve Neurosci Lett 320 1-2 99 101 11849773 10.1016/S0304-3940(02)00010-1 1:CAS:528:DC%2BD38Xht1ags7o%3D (Pubitemid 34159285)
55. VI Shubayev RR Myers 2001 Axonal transport of TNF-alpha in painful neuropathy: distribution of ligand tracer and TNF receptors J Neuroimmunol 114 1-2 48 56 11240015 10.1016/S0165-5728(00)00453-7 1:CAS:528:DC%2BD3MXhs1CjtLs%3D (Pubitemid 32184725)
56. ED Milligan C Twining M Chacur J Biedenkapp K O'Connor S Poole K Tracey D Martin SF Maier LR Watkins 2003 Spinal glia and proinflammatory cytokines mediate mirror-image neuropathic pain in rats J Neurosci 23 3 1026 1040 12574433 1:CAS:528:DC%2BD3sXhtlOrtLw%3D (Pubitemid 36206195)
57. L Daulhac C Mallet C Courteix M Etienne E Duroux AM Privat A Eschalier J Fialip 2006 Diabetes-induced mechanical hyperalgesia involves spinal mitogen-activated protein kinase activation in neurons and microglia via N-methyl-D-aspartate-dependent mechanisms Mol Pharmacol 70 4 1246 1254 16868181 10.1124/mol.106.025478 1:CAS:528:DC%2BD28XhtVOjt7bL (Pubitemid 44435976)
58. DJ MacEwan 2002 TNF ligands and receptors-a matter of life and death Br J Pharmacol 135 4 855 875 11861313 10.1038/sj.bjp.0704549 1:CAS:528: DC%2BD38Xit1CntL0%3D (Pubitemid 34214444)