Enhanced wind-up of the C-fiber-mediated nociceptive flexor reflex movement following painful diabetic neuropathy in mice

Journal of Pharmacological Sciences

Volumn 97, Issue 2, 2005, Pages 195-202

  Kimura, Satoko ^a   Tanabe, Mitsuo ^a   Honda, Motoko ^a   Ono, Hideki ^a  

^a NAGOYA CITY UNIVERSITY   (Japan)

Author keywords

Allodynia; C fiber; Diabetes; Flexor reflex; Wind up

Indexed keywords

AFFERENT NERVE GROUP 1; ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONDITIONING; CONTROLLED STUDY; DIABETIC NEUROPATHY; FLEXOR REFLEX; HINDLIMB; LEG MOVEMENT; MOUSE; NERVE EXCITABILITY; NERVE FIBER A DELTA; NERVE FIBER C; NOCICEPTION; NONHUMAN; SPINAL CORD NERVE CELL; STREPTOZOCIN DIABETES; TOE;

EID: 15744391650     PISSN: 13478613     EISSN: None     Source Type: Journal    
DOI: 10.1254/jphs.FP0040785     Document Type: Article

References (34)

1. Said G. Diabetic neuropathy: an update. J Neurol. 1996;243:431-440.
2. Sugimoto K, Murakawa Y, Sima AA. Diabetic neuropathy - a continuing enigma. Diabetes Metab Res Rev. 2000;16:408-433.
3. Elias KA, Cronin MJ, Stewart TA, Carlsen RC. Peripheral neuropathy in transgenic diabetic mice: restoration of C-fiber function with human recombinant nerve growth factor. Diabetes. 1998;47:1637-1642.
4. Schmeichel AM, Schmelzer JD, Low PA. Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes. 2003;52:165-171.
5. Calcutt NA, Jorge MC, Yaksh TL, Chaplan SR. Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain. 1996;68:293-299.
6. Aley KO, Levine JD. Rapid onset pain induced by intravenous streptozotocin in the rat. J Pain. 2001;2:146-150.
7. Rashid MH, Inoue M, Bakoshi S, Ueda H. Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice. J Pharmacol Exp Ther. 2003;306:709-717.
8. Pertovaara A, Wei H, Kalmari J, Ruotsalainen M. Pain behavior and response properties of spinal dorsal horn neurons following experimental diabetic neuropathy in the rat: modulation by nitecapone, a COMT inhibitor with antioxidant properties. Exp Neurol. 2001;167:425-434.
9. Chen SR, Pan HL. Hypersensitivity of spinothalamic tract neurons associated with diabetic neuropathic pain in rats. J Neurophysiol. 2002;87:2726-2733.
10. Mendell LM, Wall PD. Responses of single dorsal cord cells to peripheral cutaneous unmyelinated fibers. Nature. 1965;206:97-99.
11. Herrero JF, Laird JM, Lopez-Garcia JA. Wind-up of spinal cord neurones and pain sensation: much ado about something? Prog Neurobiol. 2000;61:169-203.
12. You HJ, Dahl Morch C, Chen J, Arendt-Nielsen L. Simultaneous recordings of wind-up of paired spinal dorsal horn nociceptive neuron and nociceptive flexion reflex in rats. Brain Res. 2003;960:235-245.
13. Schouenborg J. Functional and topographical properties of field potentials evoked in rat dorsal horn by cutaneous C-fibre stimulation. J Physiol (Lond). 1984;356:169-192.
14. Herrero JF, Cervero F. Changes in nociceptive reflex facilitation during carrageenan-induced arthritis. Brain Res. 1996;717:62-68.
15. Gozariu M, Bragard D, Willer JC, Le Bars D. Temporal summation of C-fiber afferent inputs: competition between facilitatory and inhibitory effects on C-fiber reflex in the rat. J Neurophysiol. 1997;78:3165-3179.
16. Grass S, Crawley JN, Xu XJ, Wiesenfeld-Hallin Z. Reduced spinal cord sensitization to C-fibre stimulation in mice overexpressing galanin. Eur J Neurosci. 2003;17:1829-1832.
17. Grass S, Jacoby AS, Iismaa TP, Crawley JN, Xu XJ, Wiesenfeld-Hallin Z. Flexor reflex excitability in mice lacking galanin receptor galanin-R1. Neurosci Lett. 2003;345:153-156.
18. Xu IS, Grass S, Xu XJ, Wiesenfeld-Hallin Z. On the role of galanin in mediating spinal flexor reflex excitability in inflammation. Neuroscience. 1998;85:827-835.
19. Kimura S, Honda M, Tanabe M, Ono H. Noxious stimuli evoke a biphasic flexor reflex composed of Aδ-fiber-mediated short-latency and C-fiber-mediated long-latency withdrawal movements in mice. J Pharmacol Sci. 2004;95:94-100.
20. Chaplan SR, Bach FW, Pogrel JW, Chung JM, Yaksh TL. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods. 1994;53:55-63.
21. Dixon WJ. Efficient analysis of experimental observations. Annu Rev Pharmacol Toxicol. 1980;20:441-462.
22. Laird JM, Bennett GJ. An electrophysiological study of dorsal horn neurons in the spinal cord of rats with an experimental peripheral neuropathy. J Neurophysiol. 1993;69:2072-2085.
23. Xu XJ, Zhang X, Hökfelt T, Wiesenfeld-Hallin Z. Plasticity in spinal nociception after peripheral nerve section: reduced effectiveness of the NMDA receptor antagonist MK-801 in blocking wind-up and central sensitization of the flexor reflex. Brain Res. 1995;670:342-346.
24. Chapman V, Suzuki R, Dickenson AH. Electrophysiological characterization of spinal neuronal response properties in anaesthetized rats after ligation of spinal nerves L5-L6. J Physiol (Lond). 1998;507:881-894.
25. Khan GM, Chen SR, Pan HL. Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats. Neuroscience. 2002;114:291-299.
26. Malcangio M, Tomlinson DR. A pharmacologic analysis of mechanical hyperalgesia in streptozotocin/diabetic rats. Pain. 1998;76:151-157.
27. Fox A, Eastwood C, Gentry C, Manning D, Urban L. Critical evaluation of the streptozotocin model of painful diabetic neuropathy in the rat. Pain. 1999;81:307-316.
28. Zurek JR, Nadeson R, Goodchild CS. Spinal and supraspinal components of opioid antinociception in streptozotocin induced diabetic neuropathy in rats. Pain. 2001;90:57-63.
29. Suzuki Y, Sato J, Kawanishi M, Mizumura K. Lowered response threshold and increased responsiveness to mechanical stimulation of cutaneous nociceptive fibers in streptozotocin - diabetic rat skin in vitro - correlates of mechanical allodynia and hyperalgesia observed in the early stage of diabetes. Neurosci Res. 2002;43:171-178.
30. Chen X, Levine JD. Hyper-responsivity in a subset of C-fiber nociceptors in a model of painful diabetic neuropathy in the rat. Neuroscience. 2001;102:185-192.
31. Chen SR, Sweigart KL, Lakoski JM, Pan HL. Functional μ opioid receptors are reduced in the spinal cord dorsal horn of diabetic rats. Anesthesiology. 2002;97:1602-1608.
32. Schouenborg J, Sjölund BH. Activity evoked by A- and C-afferent fibers in rat dorsal horn neurons and its relation to a flexion reflex. J Neurophysiol. 1983;50:1108-1121.
33. Wall PD, Woolf CJ. Muscle but not cutaneous C-afferent input produces prolonged increases in the excitability of the flexion reflex in the rat. J Physiol (Lond). 1984;356:443-458.
34. Fitzgerald M, Woolf CJ. Effects of cutaneous nerve and intraspinal conditioning on C-fibre afferent terminal excitability in decerebrate spinal rats. J Physiol (Lond). 1981;318:25-39.