Effects of cytidine 5′-diphosphocholine (CDP-choline) on the thermal nociceptive threshold in streptozotocin-induced diabetic mice

European Journal of Pharmacology

Volumn 598, Issue 1-3, 2008, Pages 32-36

  Kamei, Junzo ^a   Ohsawa, Masahiro ^a   Miyata, Shigeo ^a   Endo, Kazuki ^b   Hayakawa, Hiroyuki ^b  

^a HOSHI UNIVERSITY   (Japan)

^b YAMASA CORPORATION   (Japan)

Author keywords

Cytidine 5 diphosphocholine; Diabetes; Hyperalgesia; Hypoalgesia; Na+ K+ ATPase; Neuropathy; Tail flick test

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CITICOLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DRUG POTENCY; ENZYME ACTIVITY; HYPERALGESIA; HYPOALGESIA; MALE; MOUSE; NOCICEPTION; NONHUMAN; PAIN THRESHOLD; PRIORITY JOURNAL; STREPTOZOCIN DIABETES; TAIL FLICK TEST; THERMAL STIMULATION;

ANIMALS; CYTIDINE DIPHOSPHATE CHOLINE; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEUROPATHIES; HOT TEMPERATURE; HYPERALGESIA; MALE; MICE; MICE, INBRED ICR; NOOTROPIC AGENTS; PAIN MEASUREMENT; PAIN THRESHOLD; SCIATIC NERVE; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 54049124398     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.09.012     Document Type: Article

References (42)

1. Adibhatla R.M., Hatcher J.F., and Dempsey R.J. Citicoline: neuroprotective mechanisms in cerebral ischemia. J. Neurochem. 80 (2002) 12-23
2. Agut J., Font E., Sacristan A., and Ortiz J.A. Bioavailability of methyl-14C CDP-choline by oral route. Arzneim. Forsch/Drug Res. 33 (1983) 1045-1047
3. Apfel S.C., Arezzo J.C., Brownlee M., Federoff H., and Kessler J.A. Nerve growth factor administration protects against experimental diabetic sensory neuropathy. Brain Res. 634 (1994) 7-12
4. Aubel B., Kayser V., Mauborgne A., Farré A., Hamon M., and Bourgoin S. Antihyperalgesic effects of cizolirtine in diabetic rats: behavioral and biochemical studies. Pain 110 (2004) 22-32
5. Bays H.E., and Pfeifer M. Diabetes mellitus. Peripheral diabetic neuropathy. Med. Clin. North Am. 72 (1988) 1439-1464
6. Burchiel K.J., Russell L.C., Lee R.P., and Sima A.A. Spontaneous activity of primary afferent neurons in diabetic BB/Wistar rats. A possible mechanism of chronic diabetic neuropathic pain. Diabetes 34 (1985) 1210-1213
7. Calcutt N.A., Jorge M.C., Yaksh T.L., and Chaplan S.R. Tactile allodynia and formalin hyperalgesia in streptozotocin-diabetic rats: effects of insulin, aldose reductase inhibition and lidocaine. Pain 68 (1996) 293-299
8. Courteix C., Eschalier A., and Lavarenne J. Streptozotocin-induced diabetic rats: behavioural evidence for a model of chronic pain. Pain 53 (1993) 81-88
9. Dickenson A.H., Matthews E.A., and Suzuki R. Neurobiology of neuropathic pain: mode of action of anticonvulsants. Eur. J. Pain 6 (2002) (A:51-A60)
10. Dixon C.E., Ma X., and Marion D.W. Effects of CDP-choline treatment on neurobehavioral deficits after TBI and on hippocampal and neocortical acetylcholine release. J. Neurotrauma 14 (1997) 161-169
11. D'Orlando K.J., and Sandage Jr. B.W. Citicoline (CDP-choline): mechanisms of action and effects in ischemic brain injury. Neurol. Res. 17 (1995) 281-284
12. Drel V.R., Pacher P., Vareniuk I., Pavlov I., Ilnytska O., Lyzogubov V.V., Tibrewala J., Groves J.T., and Obrosova I.G. A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice. Eur. J. Pharmacol. 569 (2007) 48-58
13. Dyck P.J., and Giannini C. Pathologic alterations in the diabetic neuropathies of humans: a review. J. Neuropathol. Exp. Neurol. 55 (1996) 1181-1193
14. Dyck P.J., Dyck P.J., Larson T.S., O'Brien P.C., and Velosa J.A. Patterns of quantitative sensation testing of hypoesthesia and hyperalgesia are predictive of diabetic polyneuropathy: a study of three cohorts. Nerve growth factor study group. Diabetes Care 23 (2000) 510-517
15. Forman L.J., Lewis S.E.M., and Vasilenko P. Streptozotocin diabetes alters immunoreactive β-endorphin levels and pain perception after 8 weeks in female rats. Diabetes 35 (1986) 1309-1313
16. Greene D.A., Sima A.A.F., Pfeifer M.A., and Albers J.W. Diabetic neuropathy. Annu. Rev. Med. 41 (1990) 303-317
17. Guy R.J.C., Clark C.A., Malcolm P.N., and Watkins P.J. Evaluation of thermal and vibration sensation in diabetic neuropathy. Diabetologia 28 (1985) 131-137
18. Hazama T., Hasegawa T., Ueda S., and Sakuma A. Evaluation of the effect of CDP-choline of poststroke hemiplegia employing a double-blind controlled trial, Assessed by a New Rating Scale for Recovery in Hemiplegia. Int. J. Neurosci. 11 (1980) 211-225
19. +-ATPase activity in sciatic nerve of diabetic mice by administration of H7 or Calphostin C, inhibitors of PKC. Diabetes 42 (1993) 257-262
20. Hirade M., Yasuda H., Omatsu-Kanbe M., Kikkawa R., and Kitasato H. Tetrodotoxin-resistant sodium channels of dorsal root ganglion neurons are readily activated in diabetic rats. Neuroscience 90 (1999) 933-939
21. Horrobin D.F. The roles of essential fatty acids in the development of diabetic neuropathy and other complications of diabetic mellitus. Prostaglandins Leukot. Essent. Fat. Acids 31 (1998) 181-197
22. Julio J., and Guillermo F. CDP-choline: pharmacological and clinical review. Methods Find. Exp. Clin. Pharmacol. 17 (Suppl. B) (1995) 1-54
23. Kamei J., Ogawa Y., Ohhashi Y., and Kasuya Y. Alterations in the potassium-evoked release of substance P from the spinal cord of streptozotocin-induced diabetic rats in vitro. Gen. Pharmacol. 22 (1991) 1093-1096
24. Kamei J., Ohhashi Y., Aoki T., and Kasuya Y. Streptozotocin-induced diabetes in mice reduces the nociceptive threshold, as recognized after application of noxious mechanical stimuli but not for thermal stimuli. Pharmacol. Biochem. Behav. 39 (1991) 541-544
25. Kapur D. Neuropathic pain and diabetes. Diabetes Metab. Res. Rev. 19 (2003) S9-S15
26. Kennedy W.R., Wendelschafer-Crabb G., and Johnson T. Quantitation of epidermal nerves in diabetic neuropathy. Neurology 47 (1996) 1042-1048
27. Le Quesne P.M., and Fowler C.J. A study of pain threshold in diabetics with neuropathic foot lesions. J. Neurol. Neurosurg. Psychiatry 49 (1986) 1191-1194
28. Lee J.H., and McCarty R. Glycemic control of pain threshold in diabetic and control rats. Physiol. Behav. 47 (1990) 225-230
29. Lee J.H., and McCarty R. Pain threshold in diabetic rats: effects of good versus poor diabetic control. Pain 50 (1992) 231-236
30. Levine A.S., Wilcox G.L., Grace M., and Morley J.E. Tail pinch-induced consummatory behaviors are associated with analgesia. Physiol. Behav. 28 (1982) 959-962
31. Levy D.M., Karanth S.S., Springall D.R., and Polak J.M. Depletion of cutaneous nerves and neuropeptides in diabetes mellitus: an immunocytochemical study. Diabetologia 32 (1989) 427-433
32. Low P.A., Lagerlund T.D., and McManis P.G. Nerve blood flow and oxygen delivery in normal, diabetic, and ischemic neuropathy. Int. Rev. Neurobiol. 31 (1990) 355-438
33. Morley G.K., Mooradian A.K., Levine A.D., and Morley J.E. Mechanisms of pain in diabetic peripheral neuropathy: effect of glucose on pain perception in humans. Am. J. Med. 77 (1984) 79-82
34. Ohsawa M., Miyata S., Carlsson A., and Kamei J. Preventive effect of acetyl-L-carnitine on the thermal hypoalgesia in streptozotocin-induced diabetic mice. Eur. J. Pharmacol. 588 (2008) 213-216
35. Pabbidi R.M., Yu S.-Q., Peng S., Khardori R., Pauza M.E., and Premkumar L.S. Influence of TRPV1 on diabetes-induced alterations in thermal pain sensitivity. Mol. Pain 4 (2008) 9
36. Schmeichel A.M., Schmelzer J.D., and Low P.A. Oxidative injury and apoptosis of dorsal root ganglion neurons in chronic experimental diabetic neuropathy. Diabetes 52 (2003) 165-171
37. Shimamoto K., and Aramaki Y. Therapeutic mechanisms of cytidine diphosphate choline (CDP-choline). J. Takeda Res. Lab. 34 (1975) 189-201
38. Tesfaye S., Malik R., and Ward J.D. Vascular factors in diabetic neuropathy. Diabetologia 37 (1994) 847-854
39. Watanabe S., Kono S., Nakashima Y., Mitsunobu K., and Otsuki S. Effects of various cerebral metabolic activators on glucose metabolism of brain. Folia Psychiatr. Neurol. Jpn. 29 (1975) 67-76
40. Watkins, J., 1990. Natural history of the diabetic neuropathy. Q. J. Med. New Series 77, 1209-1218.
41. Williamson J.R., Chang K., Frangos M., Hasan K.S., Ido Y., Kawamura T., Nyengaard J.R., Enden M.V.D., Kilo C., and Tilton R.G. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes 42 (1993) 801-813
42. Ziegler D., Mayer P., Wiefels K., and Gries F.A. Assessment of small and large fiber function in long-term type 1 (insulin-dependent) diabetic patients with and without painful neuropathy. Pain 34 (1988) 1-10