Distribution and tumor necrosis factor-alpha isoform binding specificity of locally administered etanercept into injured and uninjured rat sciatic nerve

Neuroscience

Volumn 160, Issue 2, 2009, Pages 492-500

  Kato, K ^a,b   Kikuchi, S ^b   Shubayev, V I ^a   Myers, R R ^a  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

etanercept; neuropathic pain; peripheral nerve injury; tumor necrosis factor

Indexed keywords

ETANERCEPT; IMMUNOGLOBULIN G; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL STRUCTURE; CONTROLLED STUDY; DRUG BINDING; DRUG DISTRIBUTION; DRUG INHIBITION; DRUG UPTAKE; ENDONEURIUM; FEMALE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MACROPHAGE; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE;

ANALYSIS OF VARIANCE; ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; FOLLOW-UP STUDIES; IMMUNOGLOBULIN G; IMMUNOHISTOCHEMISTRY; IMMUNOLOGIC FACTORS; NERVE CRUSH; PAIN THRESHOLD; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TUMOR NECROSIS FACTOR; SCIATIC NERVE; SCIATIC NEUROPATHY; TISSUE DISTRIBUTION; TUMOR NECROSIS FACTOR-ALPHA;

EID: 64049104780     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2009.02.038     Document Type: Article

References (46)

1. Bereta J., Bereta M., Cohen S., and Cohen M.C. Regulation of VCAM-1 expression and involvement in cell adhesion to murine microvascular endothelium. Cell Immunol 147 (1993) 313-330
2. Bester H., Beggs S., and Woolf C.J. Changes in tactile stimuli-induced behavior and c-Fos expression in the superficial dorsal horn and in parabrachial nuclei after sciatic nerve crush. J Comp Neurol 428 (2000) 45-61
3. Bongartz T., Sutton A.J., Sweeting M.J., Buchan I., Matteson E.L., and Montori V. Anti-TNF antibody therapy in rheumatoid arthritis and the risk of serious infections and malignancies: systematic review and metal-analysis of rare harmful effects in randomized controlled trials. JAMA 295 (2006) 2275-2285
4. Chaplan S.R., Bach F.W., Pogrel J.W., Chung J.M., and Yaksh T.L. Quantitative assessment of tactile allodynia in the rat paw. J Neurosci Methods 53 (1994) 55-63
5. Deland F.H. Intrathecal toxicity studies with benzyl alcohol. Toxicol Appl Pharmacol 25 (1973) 153-156
6. Dower S.K., Smith C.A., and Park L.S. Human cytokine receptors. J Clin Immunol 10 (1990) 289-299
7. Enbrel Prescribing Information (1998). Immunex Corporation, Seattle, WA, USA.
8. George A., Schmidt C., Weishaupt A., Toyka K.V., and Sommer C. Serial determination of tumor necrosis factor-a content in rat sciatic nerve after chronic constriction injury. Exp Neurol 160 (1999) 124-132
9. George A., Buehl A., and Sommer C. Wallerian degeneration after crush injury of rat sciatic nerve increases endo- and epineurial tumor necrosis factor-alpha protein. Neurosci Lett 372 (2004) 215-219
10. Grell M., Douni E., Wajant H., Löhden M., Clauss M., Maxeiner B., Georgopoulos S., Lesslauer W., Kollias G., Pfizenmaier K., and Scheurich P. The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor. Cell 83 (1995) 793-802
11. Hochberg M.C., Lebwohl M.G., Plevy S.E., Hobbs K.F., and Yocum D.E. The benefit/risk profile of TNF-blocking agents: findings of a consensus panel. Semin Arthritis Rheum 34 (2005) 819-836
12. Homma Y., Brull S.J., and Zhang J.M. A comparison of chronic pain behavior following local application of tumor necrosis factor alpha to the normal and mechanically compressed lumbar ganglia in the rat. Pain 95 (2002) 239-246
13. Igarashi T., Kikuchi S., Shubayev V., and Myers R.R. 2000 Volvo Award winner in basic science studies: exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine 25 (2000) 2975-2980
14. Kato K., Kikuchi S., Konno S., and Sekiguchi M. Participation of 5-hydroxytryptamine in pain-related behavior induced by nucleus pulposus applied on the nerve root in rats. Spine 33 (2008) 1330-1336
15. Kirchner S., Holler E., Haffner S., Andreesen R., and Eissner G. Effect of different tumor necrosis factor (TNF) reactive agents on reverse signaling of membrane integrated TNF in monocytes. Cytokine 28 (2004) 67-74
16. Kobayashi H., Chattopadhyay S., Kato K., Dolkas J., Kikuchi S.I., Myers R.R., and Shubayev V.I. MMPs initiate Schwann cell-mediated MBP degradation and mechanical nociception after nerve damage. Mol Cell Neurosci 39 (2008) 619-627
17. Lobo E.D., Hansen R.J., and Balthasar J.P. Antibody pharmacokinetics and pharmacodynamics. J Pharmacol Sci 93 (2004) 2645-2668
18. Malmgren L.T., and Olsson Y. Differences between the peripheral and the central nervous system in permeability to sodium fluorescein. J Comp Neurol 191 (1980) 103-117
19. Myers R.R., Powell H.C., Shapiro H.M., Costello M.L., and Lampert P.W. Changes in endoneurial fluid pressure, permeability, and peripheral nerve ultrastructure in experimental lead neuropathy. Ann Neurol 8 (1980) 392-401
20. Myers R.R., Kalichman M.W., Reisner L.S., and Powell H.C. Neurotoxicity of local anesthetics: altered perineurial permeability, edema, and nerve fiber injury. Anesthesiology 64 (1986) 29-35
21. Myers R.R., Rydevik B.L., Heckman H.M., and Powell H.C. Proximodistal gradient in endoneurial fluid pressure. Exp Neurol 102 (1988) 368-370
22. Myers R.R., Campana W.M., and Shubayev V.I. The role of neuroinflammation in neuropathic pain: mechanisms and therapeutic targets. Drug Discov Today 11 (2006) 8-20
23. Nedwin G.E., Naylor S.L., Sakaguchi A.Y., Smith D., Jarrett-Nedwin J., Pennica D., Goeddel D.V., and Gray P.W. Human lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization. Nucleic Acids Res 13 (1985) 6361-6373
24. Olsson Y. Studies on vascular permeability in peripheral nerves. I. Distribution of circulating fluorescent serum albumin in normal, crushed and sectioned rat sciatic nerve. Acta Neuropathol (Berl) 7 (1966) 1-15
25. Olsson Y., and Kristensson K. The perineurium as a diffusion barrier to protein tracers following trauma to nerves. Acta Neuropathol (Berl) 23 (1973) 105-111
26. Redford E.J., Hael S.M., and Smith K.J. Vascular changes and demyelination induced by the intraneural injection of tumor necrosis factor. Brain 118 (1995) 869-878
27. Scallon B., Cai A., Solowski N., Rosenberg A., Song X.Y., Shealy D., and Wagner C. Binding and functional comparisons of two types of tumor necrosis factor antagonists. J Pharmacol Exp Ther 301 (2002) 418-426
28. Schäfers M., Svensson C.I., Sommer C., and Sorkin L.S. Tumor necrosis factor-α induces mechanical allodynia after spinal nerve ligation by activation of p38 MAPK in primary sensory neurons. J Neurosci 23 (2003) 2517-2521
29. Scheinfeld N. A comprehensive review and evaluation of the side effects of the tumor necrosis factor alpha blockers etanercept, infliximab and adalimumab. J Derm 15 (2004) 280-294
30. Shamji M.F., Jing L., Chen J., Hwang P., Ghodsizadeh O., Friedman A.H., Richardson W.J., and Setton L.A. Treatment of neuroinflammation by soluble tumor necrosis factor receptor type II fused to a thermally responsive carrier. J Neurosurg Spine 9 (2008) 221-228
31. Shubayev V.I., and Myers R.R. Upregulation and interaction of TNFalpha and gelatinases A and B in painful peripheral nerve injury. Brain Res 855 (2000) 83-89
32. Shubayev V.I., Angert M., Dolkas J., Campana W.M., Palenscar K., and Myers R.R. TNF alpha-induced MMP-9 promotes macrophage recruitment into injured peripheral nerve. Mol Cell Neurosci 31 (2006) 407-415
33. Sommer C., and Schroder J.M. HLA-DR expression in peripheral neuropathies: the role of Schwann cells, resident and hematogenous macrophages, and endoneurial fibroblasts. Acta Neuropathol (Berl) 89 (1995) 63-71
34. Sommer C., Schäfers M., Marziniak M., and Toyka K.V. Etanercept reduces hyperalgesia in experimental painful neuropathy. J Peripher Nerv Syst 6 (2001) 67-72
35. Stephen E.A., Johnny Y.B.A., Andreas F., and Quinn H.H. Permeability of injured and intact peripheral nerves and dorsal root ganglia. Anesthesiology 105 (2006) 146-153
36. Stoll G., Jung S., Jander S., van der Meide P., and Hartung H.P. Tumor necrosis factor-alpha in immune-mediated demyelination and wallerian degeneration of the rat peripheral nervous system. J Neuroimmunol 45 (1993) 175-182
37. Tobinick E.L., and Britschgi-Davoodifar S. Perispinal TNF-alpha inhibition for discogenic pain. Swiss Med Wkly 133 (2003) 170-177
38. Tobinick E., and Davoodifar S. Efficacy of etanercept delivered by perispinal administration for chronic back and/or neck disc-related pain: a study of clinical observations in 143 patients. Curr Med Res Opin 20 (2004) 1075-1085
39. Tobinick E. Perispinal etanercept for neuroinflammatory disorders. Drug Discov Today 14 (2009) 168-177
40. Tracey D., Klareskog L., Sasso E.H., Salfeld J.G., and Tak P.P. Tumor necrosis factor antagonist mechanisms of action: a comprehensive review. Pharmacol Ther 117 (2008) 244-279
41. Wagner R., and Myers R.R. Schwann cells produce TNF-alpha: expression in injured and non-injured nerves. Neuroscience 73 (1996) 625-629
42. Wagner R., and Myers R.R. Endoneurial injection of TNF-a produces neuropathic pain behaviors. Neuroreport 7 (1996) 2897-2901
43. Weerasuriya A., Rapoport S.I., and Taylor R.E. Perineural permeability increases during wallerian degeneration. Brain Res 192 (1980) 581-585
44. Weerasuriya A., and Hockman C.H. Perineurial permeability to sodium during wallerian degeneration in rat sciatic nerve. Brain Res 581 (1992) 327-333
45. Zanella J.M., Burright E.N., Hildebrand K., Hobot C., Cox M., Christoferson L., and McKay W.F. Effect of etanercept, a tumor necrosis factor-alpha inhibitor, on neuropathic pain in the rat chronic constriction injury model. Spine 33 (2008) 227-234
46. Zhou H. Clinical pharmacokinetics of etanercept: a fully humanized soluble recombinant tumor necrosis factor receptor fusion protein. J Clin Pharmacol 45 (2005) 490-497