Quantification of surviving cerebellar granule neurones and abnormal prion protein (PrPSc) deposition in sporadic Creutzfeldt-Jakob disease supports a pathogenic role for small PrPSc deposits common to the various molecular subtypes

Neuropathology and Applied Neurobiology

Volumn 37, Issue 5, 2011, Pages 500-512

  Faucheux, Baptiste A ^a,b   Morain, E ^b   Diouron, V ^a,b   Brandel, J P ^a,c   Salomon, D ^c   Sazdovitch, V ^a,b   Privat, N ^b   Laplanche, J L ^d   Hauw, J J ^a,b   Haik S ^a,b,c  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

^b INSTITUT DU CERVEAU ET DE LA MOELLE ÉPINIÈRE   (France)

^c ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^d HÔPITAL LARIBOISIÈRE   (France)

Author keywords

Cerebellum; Creutzfeldt Jakob disease; Neuronal loss; Prion protein; PRNP codon 129 polymorphism; PrP deposition

Indexed keywords

PRION PROTEIN;

ADULT; AGED; AMYLOID PLAQUE; ARTICLE; CELL SURVIVAL; CEREBELLUM; DISEASE DURATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MALE; NERVE CELL; NERVE CELL NECROSIS; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN POLYMORPHISM; QUANTITATIVE ANALYSIS; SPORADIC CREUTZFELDT JAKOB DISEASE;

CELL COUNT; CELL DEATH; CEREBELLUM; CREUTZFELDT-JAKOB SYNDROME; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; NEURONS; PRPSC PROTEINS;

EID: 79960231821     PISSN: 03051846     EISSN: 13652990     Source Type: Journal    
DOI: 10.1111/j.1365-2990.2011.01179.x     Document Type: Article

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