Preparation and characterization of pH-independent sustained release tablet containing solid dispersion granules of a poorly water-soluble drug

International Journal of Pharmaceutics

Volumn 415, Issue 1-2, 2011, Pages 83-88

  Tran, Huyen Thi Thanh ^a   Park, Jun Bom ^a   Hong, Ki Hyuk ^a   Choi, Han Gon ^b   Han, Hyo Kyung ^c   Lee, Jaehwi ^d   Oh, Kyung Taek ^d   Lee, Beom Jin ^a  

^a Kangwon National University   (South Korea)

^b Hanyang University   (South Korea)

^c Dongguk University   (South Korea)

^d Chung Ang University   (South Korea)

Author keywords

EDS imaging; pH independent release; Solid dispersion granules; Surface adsorption; Sustained release tablet

Indexed keywords

AEROSIL; LOSARTAN POTASSIUM; MACROGOL; POLOXAMER;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG ELIMINATION; DRUG GRANULE; DRUG SOLUBILITY; DRUG STRUCTURE; HYDROPHILICITY; INTESTINE FLUID; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STOMACH JUICE; SUSTAINED DRUG RELEASE; SUSTAINED RELEASE FORMULATION; TABLET COMPRESSION; X RAY DIFFRACTION; X RAY SPECTROMETRY;

ANIMALS; ANTIHYPERTENSIVE AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; GASTRIC JUICE; HYDROGEN-ION CONCENTRATION; INTESTINAL SECRETIONS; LOSARTAN; MICROSCOPY, ELECTRON, SCANNING; POLOXAMER; SOLUBILITY; SPECTROMETRY, X-RAY EMISSION; SURFACE PROPERTIES; TABLETS; THERMOGRAPHY;

EID: 79960200912     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.05.052     Document Type: Article

References (23)

1. J. Barra, F.F. Rieg, and E. Doelker Modified drug release from inert matrix tablets prepared from formulation of identical composition but different organizations J. Control. Release 65 2000 419 428 (Pubitemid 30122943)
2. Q.-R. Cao, H.-G. Choi, D.-C. Kim, and B.-J. Lee Release behavior and photo-image of nifedipine tablet coated with high viscosity grade hydroxypropylmethylcellulose: effect of coating conditions Int. J. Pharm. 274 2004 107 117 (Pubitemid 38460963)
3. B. Chauhan, S. Shimpi, and A. Paradkar Preparation and evaluation of glibenclamide-polyglycolized glycerides solid dispersions with silicon dioxide by spray drying technique Eur. J. Pharm. Sci. 26 2005 219 230 (Pubitemid 41169805)
4. S. Chopra, G.V. Patil, and S.K. Motwani Release modulating hydrophilic matrix systems of losartan potassium: optimization of formulation using statistical experiment design Eur. J. Pharm. Biopharm. 66 2007 73 82 (Pubitemid 46412965)
5. M. Fujii, H. Okada, Y. Shibata, H. Teramachi, M. Kondoh, and Y. Watanabe Preparation, characterization, and tableting of a solid dispersion of indomethacin with crospovidone Int. J. Pharm. 293 2005 145 153 (Pubitemid 40381088)
6. M.K. Gupta, D. Goldman, R.H. Bogner, and Y.C. Tseng Enhanced drug dissolution and bulk properties of solid dispersions granulated with a surface adsorbent Pharm. Dev. Technol. 6 2001 563 572 (Pubitemid 34014964)
7. N. Hirasawa, S. Ishise, H. Miyata, and K. Danjo Physicochemical characterization and drug release studies of nilvadipine solid dispersion using water-insoluble polymer as a carrier Drug Dev. Ind. Pharm. 29 2003 339 344 (Pubitemid 36528623)
8. E. Horisawa, K. Danjo, and M. Haruna Physical properties of solid dispersion of a nonsteroidal anti-inflammatory drug (M-5011) with Eudragit E Drug Dev. Ind. Pharm. 26 2000 1271 1278 (Pubitemid 32037423)
9. E. Karavas, M. Georgarakis, A. Docoslis, and D. Bikiaris Combining SEM, TEM, and micro-Raman techniques to differentiate between the amorphous molecular level dispersions and nanodispersions of a poorly water-soluble drug within a polymer matrix Int. J. Pharm. 340 2007 76 83 (Pubitemid 47044963)
10. D. Leonardi, M.G. Barrera, M.C. Lamas, and C.J. Salomon Development of prednisone:polyethylene glycol 6000 fast-release tablets from solid dispersions: solid-state characterization, dissolution behavior, and formulation parameters AAPS PharmSciTech. 8 2007 E1 E8
11. L. Maggi, R. Bruni, and U. Conte High molecular weight polyethylene oxides (PEOs) as an alternative to HPMC in controlled release dosage forms Int. J. Pharm. 195 2000 229 238 (Pubitemid 30089507)
12. L. Maggi, L. Segale, M.L. Torre, E.O. Machiste, and U. Conte Dissolution behaviour of hydrophilic matrix tablets containing two different polyethylene oxides (PEOs) for the controlled release of a water-soluble drug. Dimension study Biomaterials 23 2002 1113 1119 (Pubitemid 33109042)
13. V.M. Rao, K. Engh, and Y. Qiu Design of pH-independent controlled release matrix tablets for acidic drugs Int. J. Pharm. 252 2003 81 86 (Pubitemid 36126616)
14. ® SR AAPS PharmSciTech. 10 2009 27 33
15. R.A. Seburg, J.M. Ballard, T.-L. Hwang, and C.M. Sullivan Photosensitized degradation of losartan potassium in an extemporaneous suspension formulation J. Pharm. Biomed. Anal. 42 4 2006 411 422 (Pubitemid 44375099)
16. H. Takeuchi, S. Nagira, H. Yamamoto, and Y. Kawashima Solid dispersion particles of tolbutamide prepared with fine silica particles by the spray-drying method Powder Technol. 141 2004 187 195 (Pubitemid 38726136)
17. N. Tanaka, K. Imai, K. Okimoto, S. Ueda, Y. Tokunaga, A. Ohike, R. Ibuki, K. Higaki, and T. Kimura Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine J. Control. Release 108 2005 386 395 (Pubitemid 41608670)
18. P.H.L. Tran, H.T.T. Tran, and B.-J. Lee Modulation of microenvironmental pH and crystallinity of ionizable telmisartan using alkalizers in solid dispersions for controlled release J. Control. Release 129 2008 59 65
19. T.T.D. Tran, P.H.L. Tran, and B.-J. Lee Dissolution-modulating mechanism of alkalizers and polymers in nanoemulsifying solid dispersion containing acidic drug Eur. J. Pharm. Biopharm. 72 2009 83 90
20. P.H. Tran, T.T. Tran, K.-H. Lee, D.-J. Kim, and B.-J. Lee Dissolution-modulating mechanism of pH modifiers in solid dispersion containing weakly acidic or basic drugs with poor water solubility Expert Opin. Drug Deliv. 7 2010 647 661
21. T.T. Tran, P.H. Tran, J. Lim, J.B. Park, S.-K. Choi, and B.-J. Lee Physicochemical principles of controlled release solid dispersion containing a poorly water-soluble drug Ther. Deliv. 1 2010 51 62
22. H.G. Yi, M.H. Chi, Y.I. Kim, J.S. Woo, and E.S. Park Formulation of a extended release tablet containing dexibuprofen Arch. Pharm. Res. 31 2008 1637 1643
23. T. Yi, J. Wan, H. Xu, and X. Yang Controlled poorly soluble drug release from solid self-microemulsifying formulations with high viscosity hydroxypropylmethylcellulose Eur. J. Pharm. Sci. 34 2008 274 280