Photosensitized degradation of losartan potassium in an extemporaneous suspension formulation

Journal of Pharmaceutical and Biomedical Analysis

Volumn 42, Issue 4, 2006, Pages 411-422

  Seburg, Randal A ^a   Ballard, John M ^a   Hwang, Tsang Lin ^a   Sullivan, Caitlin M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Degradation; Formulation; Losartan; Photosensitized; Singlet oxygen; Suspension

Indexed keywords

1,4 DIAZABICYCLO[2.2.2]OCTANE; DRUG VEHICLE; FLAVORING AGENT; HYDROCHLOROTHIAZIDE PLUS LOSARTAN; LOSARTAN POTASSIUM; PHOTOSENSITIZING AGENT; SINGLET OXYGEN;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG DEGRADATION; DRUG FORMULATION; DRUG MECHANISM; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PHOTOSENSITIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SUSPENSION;

ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; EXCIPIENTS; FLAVORING AGENTS; INDICATORS AND REAGENTS; LIGHT; LOSARTAN; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MODELS, CHEMICAL; OXIDATION-REDUCTION; PHOTOLYSIS; PIPERAZINES; ROSE BENGAL; SINGLET OXYGEN; SUSPENSIONS;

EID: 33748559805     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.04.030     Document Type: Article

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