Short-course regimens of artesunate-fosmidomycin in treatment of uncomplicated Plasmodium falciparum malaria

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 9, 2005, Pages 3749-3754

  Borrmann, Steffen ^a,b,i   Adegnika, Ayola A ^a,b   Moussavou, Félicien ^a,c   Oyakhirome, Sunny ^a   Esser, Gilbert ^a,b   Matsiegui, Pierre Blaise ^a,b   Ramharter, Michael ^d   Lundgren, Ingrid ^a,e   Kombila, Maryvonne ^c   Issifou, Saadou ^a,b   Hutchinson, David ^f   Wiesner, Jochen ^g   Jomaa, Hassan ^g   Kremsner, Peter G ^a,b,h  

^a ALBERT SCHWEITZER HOSPITAL   (Gabon)

^b UNIVERSITY OF TÜBINGEN   (Germany)

^c UNIVERSITÉ DES SCIENCES DE LA SANTÉ   (Gabon)

^d MEDICAL UNIVERSITY OF VIENNA   (Austria)

^e MAYO CLINIC COLLEGE OF MEDICINE   (United States)

^f Jomaa Pharma GmbH   (Germany)

^g JUSTUS LIEBIG UNIVERSITY   (Germany)

^h Institute of Tropical Medicine   (Germany)

ⁱ KEMRI WELLCOME TRUST RESEARCH PROGRAMME   (Kenya)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTEMISININ; ARTESUNATE; FOSMIDOMYCIN;

ADOLESCENT; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; COMBINATION CHEMOTHERAPY; DISEASE COURSE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FEMALE; HUMAN; MALARIA; MALARIA FALCIPARUM; MALE; NEUTROPENIA; PARASITOSIS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL;

ANTIMALARIALS; ARTEMISININS; CHEMISTRY, PHARMACEUTICAL; CHILD; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; ENDPOINT DETERMINATION; FEMALE; FOSFOMYCIN; HUMANS; MALARIA, FALCIPARUM; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SESQUITERPENES;

EID: 24144461306     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.9.3749-3754.2005     Document Type: Article

References (22)

1. Borrmann, S., A. A. Adegnika, P. B. Matsiegui, S. Issifou, A. Schindler, D. P. Mawili-Mboumba, T. Baranek, J. Wiesner, H. Jomaa, and P. G. Kremsner. 2004. Fosmidomycin-clindamycin for Plasmodium falciparum infections in African children. J. Infect. Dis. 189:901-908.
2. Borrmann, S., A. A. Adegnika, M. A. Missinou, R. K. Binder, S. Issifou, A. Schindler, P. B. Matsiegui, J. F. Kun, S. Krishna, B. Lell, and P. G. Kremsner. 2003. Short-course artesunate treatment of uncomplicated Plasmodium falciparum malaria in Gabon. Antimicrob. Agents Chemother. 47:901-904.
3. Borrmann, S., S. Issifou, G. Esser, A. A. Adegnika, M. Ramharter, P. B. Matsiegui, S. Oyakhirome, D. P. Mawili-Mboumba, M. A. Missinou, J. F. Kun, H. Jomaa, and P. G. Kremsner. 2004. Fosmidomycin-clindamycin for the treatment of Plasmodium falciparum malaria. J. Infect. Dis. 190:1534-1540.
4. Borrmann, S., N. Szlezàk, R. K. Binder, M. A. Missinou, B. Lell, and P. G. Kremsner. 2002. Evidence for the efficacy of artesunate in asymptomatic Plasmodium malanae infections. J. Antimicrob. Chemother. 50:751-754.
5. Fogg, C., F. Bajunirwe, P. Piola, S. Biraro, F. Checchi, J. Kiguli, P. Namiiro, J. Musabe, A. Kyomugisha, and J. P. Guthmann. 2004. Adherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Uganda. Am. J. Trop. Med. Hyg. 71:525-530.
6. Greenwood, B. M., A. M. Bradley-Moore, A. D. Bryceson, and A. Palit. 1972. Immunosuppression in children with malaria. Lancet 1:169-172.
7. Jomaa, H., J. Wiesner, S. Sanderbrand, B. Altincicek, C. Weidemeyer, M. Hintz, I. Turbachova, M. Eberl, J. Zeidler, H. K. Lichtenthaler, D. Soldati, and E. Beck. 1999. Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugs. Science 285:1573-1576.
8. Kuemmerle, H. P., T. Murakawa, and F. De Santis. 1987. Pharmacokinetic evaluation of fosmidomycin, a new phosphonic acid antibiotic. Chemioterapia 6:113-119.
9. Kun, J. F., R. J. Schmidt-Ott, L. G. Lehman, B. Lell, D. Luckner, B. Greve, P. Matousek, and P. G. Kremsner. 1998. Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambarene, Gabon. Trans. R. Soc. Trop. Med. Hyg. 92:110-114.
10. Labro, M. T., and C. Babin-Chevaye. 1988. Effects of amodiaquine, chloroquine, and mefloquine on human polymorphonuclear neutrophil function in vitro. Antimicrob. Agents Chemother. 32:1124-1130.
11. Lell, B., R. Ruangweerayut, J. Wiesner, M. A. Missinou, A. Schindler, T. Baranek, M. Hintz, D. Hutchinson, H. Jomaa, and P. G. Kremsner. 2003. Fosmidomycin, a novel chemotherapeutic agent for malaria. Antimicrob. Agents Chemother. 47:735-738.
12. Missinou, M. A., S. Borrmann, A. Schindler, S. Issifou, A. A. Adegnika, P. B. Matsiegui, R. Binder, B. Lell, J. Wiesner, T. Baranek, H. Jomaa, and P. G. Kremsner. 2002. Fosmidomycin for malaria. Lancet 360:1941-1942.
13. Missinou, M. A., O. Dangelmaier, J. F. Kun, and P. G. Kremsner. 2000. Genetic diversity of Plasmodium falciparum infections in one family in Lambarene. Trans. R. Soc. Trop. Med. Hyg. 94:376.
14. National Institute of Allergy and Infectious Diseases. May 2004, posting date. Pediatric toxicity tables. [Online.] Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md. http://www.niaid.nih.gov/dmid /clinresearch/DMIDpedtox.doc. Accessed 26 July 2005.
15. Newton, P., Y. Suputtamongkol, P. Teja-Isavadharm, S. Pukrittayakamee, V. Navaratnam, I. Bates, and N. White. 2000. Antimalarial bioavailability and disposition of artesunate in acute falciparum malaria. Antimicrob. Agents Chemother. 44:972-977.
16. Planche, T., S. Krishna, M. Kombila, K. Engel, J. F. Faucher, E. Ngou-Milama, and P. G. Kremsner. 2001. Comparison of methods for the rapid laboratory assessment of children with malaria. Am. J. Trop. Med. Hyg. 65:599-602.
17. Sylla, E. H., J. F. Kun, and P. G. Kremsner. 2000. Mosquito distribution and entomological inoculation rates in three malaria-endemic areas in Gabon. Trans. R. Soc. Trop. Med. Hyg. 94:652-656.
18. Taylor, W. R., and N. J. White. 2004. Antimalarial drug toxicity: a review. Drug Saf. 27:25-61.
19. White, N. J. 2004. Antimalarial drug resistance. J. Clin. Investig. 113:1084-1092.
20. Wiesner, J., S. Borrmann, and H. Jomaa. 2003. Fosmidomycin for the treatment of malaria. Parasitol. Res. 90(Suppl. 2):S71-S76.
21. Wiesner, J., D. Henschker, D. B. Hutchinson, E. Beck, and H. Jomaa. 2002. In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin. Antimicrob. Agents Chemother. 46:2889-2894.
22. Wildling, E., S. Winkler, P. G. Kremsner, C. Brandts, L. Jenne, and W. H. Wernsdorfer. 1995. Malaria epidemiology in the province of Moyen Ogoov, Gabon. Trop. Med. Parasitol. 46:77-82.