A critical review of analytical methods for subvisible and visible particles

Current Pharmaceutical Biotechnology

Volumn 10, Issue 4, 2009, Pages 373-381

  Narhi, Linda O ^a   Jiang, Yijia ^a   Cao, Shawn ^a   Benedek, Kalman ^b   Shnek, Deborah ^a  

^a AMGEN INC   (United States)

^b iGORi Inc   (United States)

Author keywords

Flow imaging; Light obscuration; Particle identification; Subvisible particles; Visible particles

Indexed keywords

SILICONE OIL; MICROSPHERE; MULTIPROTEIN COMPLEX; PROTEIN;

ACCURACY; ANALYTIC METHOD; ATOMIC FORCE MICROSCOPY; AUTOMATION; CHEMICAL COMPOSITION; ELECTRIC CONDUCTIVITY; FIELD FLOW FRACTIONATION; FLOW MEASUREMENT; GEL PERMEATION CHROMATOGRAPHY; INTERMETHOD COMPARISON; LIGHT OBSCURATION METHOD; LIGHT SCATTERING; MICROBUBBLE; MICROPARTICLE ENZYME IMMUNOASSAY; MOLECULAR IMAGING; MOLECULAR WEIGHT; PARTICLE IMAGE VELOCIMETRY; PARTICLE SIZE; PROCESS DEVELOPMENT; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN STRUCTURE; QUALITY CONTROL; QUANTITATIVE ANALYSIS; REVIEW; SCANNING ELECTRON MICROSCOPY; SENSITIVITY AND SPECIFICITY; SUBVISIBLE PARTICLE; ULTRACENTRIFUGATION; CHEMISTRY; FRACTIONATION; ISOLATION AND PURIFICATION; METHODOLOGY; PHARMACEUTICS; PHOTOMETRY; SPECTROSCOPY;

CHEMICAL FRACTIONATION; MICROSPHERES; MULTIPROTEIN COMPLEXES; NEPHELOMETRY AND TURBIDIMETRY; PARTICLE SIZE; PROTEINS; SPECTRUM ANALYSIS; TECHNOLOGY, PHARMACEUTICAL;

EID: 69249215475     PISSN: 13892010     EISSN: 18734316     Source Type: Journal    
DOI: 10.2174/138920109788488905     Document Type: Review

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