Breaking the light and heavy chain linkage of human immunoglobulin G1 (IgG1) by radical reactions

Journal of Biological Chemistry

Volumn 286, Issue 28, 2011, Pages 24674-24684

  Yan, Boxu ^a   Boyd, Daniel ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; DEAMIDATION; DEGRADATION PATHWAYS; DEHYDROPEPTIDES; DISULFIDE BONDS; ELECTRON TRANSFER; FREE RADICAL SCAVENGERS; HEAVY CHAIN; HUMAN ANTIBODIES; HUMAN IMMUNOGLOBULIN; HYDROGEN PEROXIDE PRODUCTION; INTERCHAIN DISULFIDE BONDS; LIGHT CHAIN; PRODUCTION OF HYDROGEN; RADICAL ANIONS; RADICAL CHAIN; RADICAL REACTIONS; RADICAL SPECIES; REDOX ACTIVE METAL IONS; SIDE-CHAINS; SULFUR RADICALS; SUPER OXIDE DISMUTASE;

AMIDES; CHEMICAL PLANTS; COVALENT BONDS; DEGRADATION; ELECTRON TRANSITIONS; FREE RADICALS; HEAVY WATER; HYDROGEN; HYDROGEN PEROXIDE; HYDROGEN PRODUCTION; METAL IONS; METALS; MOLECULAR OXYGEN; OXIDATION; PHOTODISSOCIATION; REACTION KINETICS; REDOX REACTIONS; SULFUR;

FREE RADICAL REACTIONS;

AMIDE; CARBON; CARBONYL DERIVATIVE; CYSTEINE; DEHYDROALANINE; DISULFIDE; HYDROGEN PEROXIDE; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; NITROGEN; OXYGEN; SCAVENGER; SUPEROXIDE DISMUTASE; WATER;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CHEMICAL REACTION; CONTROLLED STUDY; DEAMINATION; DISULFIDE BOND; ELECTRON TRANSPORT; HYDROLYSIS; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; TEMPERATURE STRESS;

DISULFIDES; HUMANS; HYDROGEN PEROXIDE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN GAMMA-CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; OXIDATION-REDUCTION; PROTEIN STABILITY; PROTEOLYSIS;

EID: 79960115086     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.255026     Document Type: Article

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