Elevated cleavage of human immunoglobulin gamma molecules containing a lambda light chain mediated by iron and histidine

Analytical Biochemistry

Volumn 389, Issue 2, 2009, Pages 107-117

  Ouellette, David ^a   Alessandri, Leslie ^a   Piparia, Reema ^a   Aikhoje, Aima ^a   Chin, Adam ^a   Radziejewski, Czeslaw ^a   Correia, Ivan ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Fragmentation; Histidine; Immunoglobulin; Iron; Lambda light chain

Indexed keywords

HYDROLYSIS; IRON; MOLECULES; MONOCLONAL ANTIBODIES;

CONCENTRATION-DEPENDENT; FRAGMENTATION; HISTIDINE; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN; LIGHT CHAIN; LIQUID FORMULATIONS; NONENZYMATIC HYDROLYSIS;

AMINO ACIDS;

ASPARTIC ACID; DODECYL SULFATE SODIUM; HISTIDINE; IMMUNOGLOBULIN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN FC FRAGMENT; IRON;

ARTICLE; CAPILLARY ELECTROPHORESIS; CONCENTRATION RESPONSE; HEAVY CHAIN; LIGHT CHAIN; MASS SPECTROMETRY; PRIORITY JOURNAL;

EID: 67349280131     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2009.03.027     Document Type: Article

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