3′-UTR-mediated post-transcriptional regulation of cancer metastasis: Beginning at the end

RNA Biology

Volumn 8, Issue 4, 2011, Pages

  Chaudhury, Arindam ^a,b,c   Hussey, George S ^a,b   Howe, Philip H ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b CLEVELAND STATE UNIVERSITY   (United States)

^c BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

eEF1A1; EMT; hnRNP E1; Metastasis; Post transcriptional regulation; TGF

Indexed keywords

ELONGATION FACTOR 1ALPHA; MESSENGER RNA; PROTEIN KINASE B BETA;

3' UNTRANSLATED REGION; CARCINOGENESIS; EPITHELIAL MESENCHYMAL TRANSITION; HUMAN; METASTASIS; POSTTRANSCRIPTIONAL GENE SILENCING; REVIEW; TUMOR GROWTH;

EUKARYOTA;

EID: 79960083245     PISSN: 15476286     EISSN: 15558584     Source Type: Journal    
DOI: None     Document Type: Review

References (36)

1. Derynck R, Akhurst RJ, Balmain A. TGF-beta signaling in tumor suppression and cancer progression. Nat Genet 2001; 29:117-29; DOI: 10.1038/ng1001-117.
2. Zavadil J, Bottinger EP. TGF-beta and epithelial-tomesenchymal transitions. Oncogene 2005; 24:5764-74; DOI: 10.1038/sj.onc.1208927.
3. Thiery JP, Sleeman JP. Complex networks orchestrate epithelial- mesenchymal transitions. Nat Rev Mol Cell Biol 2006; 7:131-42; DOI: 10.1038/nrm1835.
4. Bierie B, Moses HL. TGF-beta and cancer. Cytokine Growth Factor Rev 2006; 17:29-40; DOI: 10.1016/j.cytogfr.2005.09.006.
5. Massagué J. TGFbeta in Cancer. Cell 2008; 134:215-30; DOI: 10.1016/j.cell.2008.07.001.
6. Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007; 7:415-28; DOI: 10.1038/nrc2131.
7. Savagner P, Yamada KM, Thiery JP. The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol 1997; 137:1403-19; DOI: 10.1083/jcb.137.6.1403.
8. Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, et al. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci USA 2010; 107:15449-54; DOI: 10.1073/pnas.1004900107.
9. Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, et al. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci USA 2007; 104:10069-74; DOI: 10.1073/pnas.0703900104.
10. Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004; 117:927-39; DOI: 10.1016/j.cell.2004.06.006.
11. Yang J. Exploring the molecular basis of tumor metastasis by microarray analysis. Assay Drug Dev Technol 2006; 4:483-8; DOI: 10.1089/adt.2006.4.483.
12. Weinberg RA. Leaving home early: reexamination of the canonical models of tumor progression. Cancer Cell 2008; 14:283-4; DOI: 10.1016/j.ccr.2008.09.009.
13. Van Der Kelen K, Beyaert R, Inze D, De Veylder L. Translational control of eukaryotic gene expression. Crit Rev Biochem Mol Biol 2009; 44:143-68; DOI: 10.1080/10409230902882090.
14. Evdokimova V, Tognon C, Ng T, Ruzanov P, Melynk N, Fink D, et al. Translational activation of Snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition. Cancer Cell 2009; 15:402-15; DOI: 10.1016/j.ccr.2009.03.017.
15. Chaudhury A, Hussey GS, Ray PS, Jin G, Fox PL, Howe PH. TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI. Nat Cell Biol 2010; 12:286-93; .
16. García-Martínez J, Aranda A, Perez-Ortin JE. Genomic run-on evaluates transcription rates for all yeast genes and identifies gene regulatory mechanisms. Mol Cell 2004; 15:303-13; DOI: 10.1016/j.molcel.2004.06. 004.
17. Hieronymus H, Silver PA. A systems view of mRNP biology. Genes Dev 2004; 18:2845-60; DOI: 10.1101/gad.1256904.
18. Beilharz TH, Preiss T. Translational profiling: the genome-wide measure of the nascent proteome. Brief Funct Genomics Proteomic 2004; 3:103-11; DOI: 10.1093/bfgp/3.2.103.
19. Beyer A, Hollunder J, Nasheuer HP, Wilhelm T. Post-transcriptional expression regulation in the yeast Saccharomyces cerevisiae on a genomic scale. Mol Cell Proteomics 2004; 3:1083-92; DOI: 10.1074/mcp.M400099-MCP200.
20. Reimann I, Huth A, Thiele H, Thiele BJ. Suppression of 15-lipoxygenase synthesis by hnRNP E1 is dependent on repetitive nature of LOX mRNA 3′-UTR control element DICE. J Mol Biol 2002; 315:965-74; DOI: 10.1006/jmbi.2001.5315.
21. Waerner T, Alacakaptan M, Tamir I, Oberauer R, Gal A, Brabletz T, et al. ILEI: a cytokine essential for EMT, tumor formation and late events in metastasis in epithelial cells. Cancer Cell 2006; 10:227-39; DOI: 10.1016/j.ccr.2006.07.020.
22. Wang H, Vardy LA, Tan CP, Loo JM, Guo K, Li J, et al. PCBP1 suppresses the translation of metastasis-associated PRL-3 phosphatase. Cancer Cell 2010; 18:52-62; DOI: 10.1016/j.ccr.2010.04.028.
23. Varani G, Nagai K. RNA recognition by RNP proteins during RNA processing. Annu Rev Biophys Biomol Struct 1998; 27:407-45; DOI: 10.1146/annurev.biophys. 27.1.407.
24. Cusack S. RNA-protein complexes. Curr Opin Struct Biol 1999; 9:66-73; DOI: 10.1016/S0959-440X(99)80009-8.
25. Hussey GS, Chaudhury A, Dawson AE, Lindner DJ, Knudsen CR, Wilce MC, et al. Identification of an mRNP Complex Regulating Tumorigenesis at the Translational Elongation Step. Mol Cell 2011; 41:419-31; DOI: 10.1016/j.molcel.2011.02.003.
26. Prunier C, Howe PH. Disabled-2 (Dab2) is required for transforming growth factor beta-induced epithelial to mesenchymal transition (EMT). J Biol Chem 2005; 280:17540-8; DOI: 10.1074/jbc.M500974200.
27. Mintz PJ, Patterson SD, Neuwald AF, Spahr CS, Spector DL. Purification and biochemical characterization of interchromatin granule clusters. EMBO J 1999; 18:4308-20; DOI: 10.1093/emboj/18.15.4308.
28. Chkheidze AN, Liebhaber SA. A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins. Mol Cell Biol 2003; 23:8405-15; DOI: 10.1128/MCB.23.23.8405-15.2003.
29. Chaudhury A, Chander P, Howe PH. Heterogeneous nuclear ribonucleoproteins (hnRNPs) in cellular processes: Focus on hnRNP E1's multifunctional regulatory roles. RNA 2010; 16:1449-62; DOI: 10.1261/rna.2254110.
30. Gamarnik AV, Andino R. Two functional complexes formed by KH domain containing proteins with the 5′ noncoding region of poliovirus RNA. RNA 1997; 3:882-92; .
31. Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR. Nuclear proteins that bind the pre-mRNA 3′ splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol 1993; 13:4301-10. (Pubitemid 23187659)
32. LaBranche H, Dupuis S, Ben-David Y, Bani MR, Wellinger RJ, Chabot B. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nat Genet 1998; 19:199-202; DOI: 10.1038/575.
33. Pillai MR, Chacko P, Kesari LA, Jayaprakash PG, Jayaram HN, Antony AC. Expression of folate receptors and heterogeneous nuclear ribonucleoprotein E1 in women with human papillomavirus mediated transformation of cervical tissue to cancer. J Clin Pathol 2003; 56:569-74; DOI: 10.1136/jcp.56.8.569.
34. de Hoog CL, Foster LJ, Mann M. RNA and RNA binding proteins participate in early stages of cell spreading through spreading initiation centers. Cell 2004; 117:649-62; DOI: 10.1016/S0092-8674(04)00456-8.
35. Cao JX, Cui YX, Long ZJ, Dai ZM, Lin JY, Liang Y, et al. Pluripotency-associated genes in human nasopharyngeal carcinoma CNE-2 cells are reactivated by a unique epigenetic sub-microenvironment. BMC Cancer 2010; 10:68; DOI: 10.1186/1471-2407-10-68.
36. Baharvand H, Fathi A, Gourabi H, Mollamohammadi S, Salekdeh GH. Identification of mouse embryonic stem cell-associated proteins. J Proteome Res 2008; 7:412-23; DOI: 10.1021/pr700560t.