-
1
-
-
78049485263
-
Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008
-
Ferlay,J. et al. (2010) Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 127, 2893-2917.
-
(2010)
Int. J. Cancer
, vol.127
, pp. 2893-2917
-
-
Ferlay, J.1
-
2
-
-
33646568784
-
Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world
-
Kamangar,F. et al. (2006) Patterns of cancer incidence, mortality, and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic regions of the world. J. Clin. Oncol., 24, 2137-2150.
-
(2006)
J. Clin. Oncol.
, vol.24
, pp. 2137-2150
-
-
Kamangar, F.1
-
3
-
-
34249850071
-
Prognostic models in hepatocellular carcinoma (HCC) and statistical methodologies behind them
-
Dvorchik,I. et al. (2007) Prognostic models in hepatocellular carcinoma (HCC) and statistical methodologies behind them. Curr. Pharm. Des., 13, 1527-1532.
-
(2007)
Curr. Pharm. Des.
, vol.13
, pp. 1527-1532
-
-
Dvorchik, I.1
-
4
-
-
33846473749
-
Hepatitis B virus-induced oncogenesis
-
Lupberger,J. et al. (2007) Hepatitis B virus-induced oncogenesis. World J. Gastroenterol., 13, 74-81.
-
(2007)
World J. Gastroenterol.
, vol.13
, pp. 74-81
-
-
Lupberger, J.1
-
5
-
-
44649101911
-
Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis
-
Gurtsevitch,V.E. (2008) Human oncogenic viruses: hepatitis B and hepatitis C viruses and their role in hepatocarcinogenesis. Biochemistry (Mosc.), 73, 504-513.
-
(2008)
Biochemistry (Mosc.)
, vol.73
, pp. 504-513
-
-
Gurtsevitch, V.E.1
-
6
-
-
34249303417
-
Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis
-
Feitelson,M.A. et al. (2007) Hepatitis B virus integration, fragile sites, and hepatocarcinogenesis. Cancer Lett., 252, 157-170.
-
(2007)
Cancer Lett.
, vol.252
, pp. 157-170
-
-
Feitelson, M.A.1
-
7
-
-
0025907983
-
HBx gene of hepatitis B virus induces liver cancer in transgenic mice
-
Kim,C.M. et al. (1991) HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature, 351, 317-320.
-
(1991)
Nature
, vol.351
, pp. 317-320
-
-
Kim, C.M.1
-
8
-
-
0026783165
-
Hepatitis B X-gene expression in hepatocellular carcinoma
-
Diamantis,I.D. et al. (1992) Hepatitis B X-gene expression in hepatocellular carcinoma. J. Hepatol., 15, 400-403.
-
(1992)
J. Hepatol.
, vol.15
, pp. 400-403
-
-
Diamantis, I.D.1
-
9
-
-
0033176296
-
The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review)
-
Andrisani,O.M. et al. (1999) The transcriptional function of the hepatitis B virus X protein and its role in hepatocarcinogenesis (Review). Int. J. Oncol., 15, 373-379.
-
(1999)
Int. J. Oncol.
, vol.15
, pp. 373-379
-
-
Andrisani, O.M.1
-
10
-
-
0036843524
-
Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53
-
Ahn,J.Y. et al. (2002) Dual effects of hepatitis B virus X protein on the regulation of cell-cycle control depending on the status of cellular p53. J. Gen. Virol., 83, 2765-2772.
-
(2002)
J. Gen. Virol.
, vol.83
, pp. 2765-2772
-
-
Ahn, J.Y.1
-
11
-
-
0032816238
-
Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex
-
Hu,Z. et al. (1999) Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex. J. Virol., 73, 7231-7240.
-
(1999)
J. Virol.
, vol.73
, pp. 7231-7240
-
-
Hu, Z.1
-
12
-
-
51649117144
-
Caspase-3 activation as a key factor for HBx-transformed cell death
-
Kim,A. et al. (2008) Caspase-3 activation as a key factor for HBx-transformed cell death. Cell Prolif., 41, 755-774.
-
(2008)
Cell Prolif.
, vol.41
, pp. 755-774
-
-
Kim, A.1
-
13
-
-
14844307045
-
Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3
-
Yu,F.L. et al. (2005) Hepatitis B virus X protein promotes cell migration by inducing matrix metalloproteinase-3. J. Hepatol., 42, 520-527.
-
(2005)
J. Hepatol.
, vol.42
, pp. 520-527
-
-
Yu, F.L.1
-
14
-
-
0037194639
-
Increased chromosomal alterations and micronuclei formation in human hepatoma HepG2 cells transfected with the hepatitis B virus HBX gene
-
Livezey,K.W. et al. (2002) Increased chromosomal alterations and micronuclei formation in human hepatoma HepG2 cells transfected with the hepatitis B virus HBX gene. Mutat. Res., 505, 63-74.
-
(2002)
Mutat. Res.
, vol.505
, pp. 63-74
-
-
Livezey, K.W.1
-
15
-
-
33748288087
-
Molecular functions and biological roles of hepatitis B virus x protein
-
Tang,H. et al. (2006) Molecular functions and biological roles of hepatitis B virus x protein. Cancer Sci., 97, 977-983.
-
(2006)
Cancer Sci.
, vol.97
, pp. 977-983
-
-
Tang, H.1
-
16
-
-
0028949528
-
Transactivation of cellular gene expression by hepatitis B viral proteins: a possible molecular mechanism of hepatocarcinogenesis
-
Caselmann,W.H. (1995) Transactivation of cellular gene expression by hepatitis B viral proteins: a possible molecular mechanism of hepatocarcinogenesis. J. Hepatol., 22, 34-37.
-
(1995)
J. Hepatol.
, vol.22
, pp. 34-37
-
-
Caselmann, W.H.1
-
17
-
-
0031460372
-
Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis
-
Elmore,L.W. et al. (1997) Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis. Proc. Natl Acad. Sci. USA, 94, 14707-14712.
-
(1997)
Proc. Natl Acad. Sci. USA
, vol.94
, pp. 14707-14712
-
-
Elmore, L.W.1
-
18
-
-
0030724749
-
The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct
-
Lin,Y. et al. (1997) The transactivation and p53-interacting functions of hepatitis B virus X protein are mutually interfering but distinct. Cancer Res., 57, 5137-5142.
-
(1997)
Cancer Res.
, vol.57
, pp. 5137-5142
-
-
Lin, Y.1
-
19
-
-
0000066015
-
Interaction of hepatitis B viral X protein and CCAAT/ enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter
-
Choi,B.H. et al. (1999) Interaction of hepatitis B viral X protein and CCAAT/ enhancer-binding protein alpha synergistically activates the hepatitis B viral enhancer II/pregenomic promoter. J. Biol. Chem., 274, 2858-2865.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 2858-2865
-
-
Choi, B.H.1
-
20
-
-
31544457365
-
The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1
-
Tanaka,Y. et al. (2006) The hepatitis B virus X protein enhances AP-1 activation through interaction with Jab1. Oncogene, 25, 633-642.
-
(2006)
Oncogene
, vol.25
, pp. 633-642
-
-
Tanaka, Y.1
-
21
-
-
0025176474
-
Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors
-
Seto,E. et al. (1990) Transactivation by the hepatitis B virus X protein depends on AP-2 and other transcription factors. Nature, 344, 72-74.
-
(1990)
Nature
, vol.344
, pp. 72-74
-
-
Seto, E.1
-
22
-
-
0035112148
-
The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis
-
Lee,D.K. et al. (2001) The hepatitis B virus encoded oncoprotein pX amplifies TGF-beta family signaling through direct interaction with Smad4: potential mechanism of hepatitis B virus-induced liver fibrosis. Genes Dev., 15, 455-466.
-
(2001)
Genes Dev.
, vol.15
, pp. 455-466
-
-
Lee, D.K.1
-
23
-
-
0034774463
-
Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress
-
Waris,G. et al. (2001) Mitochondrially associated hepatitis B virus X protein constitutively activates transcription factors STAT-3 and NF-kappa B via oxidative stress. Mol. Cell. Biol., 21, 7721-7730.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 7721-7730
-
-
Waris, G.1
-
24
-
-
0029982621
-
Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of relrelated proteins
-
Su,F. et al. (1996) Hepatitis B virus HBx protein activates transcription factor NF-kappaB by acting on multiple cytoplasmic inhibitors of relrelated proteins. J. Virol., 70, 4558-4566.
-
(1996)
J. Virol.
, vol.70
, pp. 4558-4566
-
-
Su, F.1
-
25
-
-
0032772369
-
Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha
-
Weil,R. et al. (1999) Direct association and nuclear import of the hepatitis B virus X protein with the NF-kappaB inhibitor IkappaBalpha. Mol. Cell. Biol., 19, 6345-6354.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 6345-6354
-
-
Weil, R.1
-
26
-
-
77950023333
-
HBx-Induced hepatic steatosis and apoptosis are regulated by TNFR1- and NF-kappaB-dependent pathways
-
Kim,J.Y. et al. (2010) HBx-Induced hepatic steatosis and apoptosis are regulated by TNFR1- and NF-kappaB-dependent pathways. J. Mol. Biol., 397, 917-931.
-
(2010)
J. Mol. Biol.
, vol.397
, pp. 917-931
-
-
Kim, J.Y.1
-
27
-
-
74249087871
-
The hepatitis B viral X protein activates NF-kappaB signaling pathway through the up-regulation of TBK1
-
Kim,H.R. et al. (2010) The hepatitis B viral X protein activates NF-kappaB signaling pathway through the up-regulation of TBK1. FEBS Lett., 584, 525-530.
-
(2010)
FEBS Lett.
, vol.584
, pp. 525-530
-
-
Kim, H.R.1
-
28
-
-
67650724069
-
Regulation and function of NF-kappaB transcription factors in the immune system
-
Vallabhapurapu,S. et al. (2009) Regulation and function of NF-kappaB transcription factors in the immune system. Annu. Rev. Immunol., 27, 693-733.
-
(2009)
Annu. Rev. Immunol.
, vol.27
, pp. 693-733
-
-
Vallabhapurapu, S.1
-
29
-
-
0032900439
-
New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases
-
Chen,F. et al. (1999) New insights into the role of nuclear factor-kappaB, a ubiquitous transcription factor in the initiation of diseases. Clin. Chem., 45, 7-17.
-
(1999)
Clin. Chem.
, vol.45
, pp. 7-17
-
-
Chen, F.1
-
30
-
-
0034954377
-
Expression of nuclear factor-kappa B in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus
-
Guo,S.P. et al. (2001) Expression of nuclear factor-kappa B in hepatocellular carcinoma and its relation with the X protein of hepatitis B virus. World J. Gastroenterol., 7, 340-344.
-
(2001)
World J. Gastroenterol.
, vol.7
, pp. 340-344
-
-
Guo, S.P.1
-
31
-
-
3042579870
-
Evaluation of nuclear factor-kappaB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma
-
Chan,C.F. et al. (2004) Evaluation of nuclear factor-kappaB, urokinase-type plasminogen activator, and HBx and their clinicopathological significance in hepatocellular carcinoma. Clin. Cancer Res., 10, 4140-4149.
-
(2004)
Clin. Cancer Res.
, vol.10
, pp. 4140-4149
-
-
Chan, C.F.1
-
32
-
-
1142299661
-
Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma
-
Wang,T. et al. (2004) Activating mechanism of transcriptor NF-kappaB regulated by hepatitis B virus X protein in hepatocellular carcinoma. World J. Gastroenterol., 10, 356-360.
-
(2004)
World J. Gastroenterol.
, vol.10
, pp. 356-360
-
-
Wang, T.1
-
33
-
-
46049090192
-
Tumor promoting or tumor suppressing of NF-kappa B, a matter of cell context dependency
-
Chen,F. et al. (2008) Tumor promoting or tumor suppressing of NF-kappa B, a matter of cell context dependency. Int. Rev. Immunol., 27, 183-204.
-
(2008)
Int. Rev. Immunol.
, vol.27
, pp. 183-204
-
-
Chen, F.1
-
34
-
-
67649933565
-
Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx
-
Park,S.G. et al. (2009) Tumor suppressor protein p53 induces degradation of the oncogenic protein HBx. Cancer Lett., 282, 229-237.
-
(2009)
Cancer Lett.
, vol.282
, pp. 229-237
-
-
Park, S.G.1
-
35
-
-
33947303068
-
Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis
-
Pang,R. et al. (2007) Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis. Gastroenterology, 132, 1088-1103.
-
(2007)
Gastroenterology
, vol.132
, pp. 1088-1103
-
-
Pang, R.1
-
36
-
-
0032589462
-
IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain
-
Sakurai,H. et al. (1999) IkappaB kinases phosphorylate NF-kappaB p65 subunit on serine 536 in the transactivation domain. J. Biol. Chem., 274, 30353-30356.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30353-30356
-
-
Sakurai, H.1
-
37
-
-
61649106928
-
Inflammation and liver cancer: new molecular links
-
Berasain,C. et al. (2009) Inflammation and liver cancer: new molecular links. Ann. N. Y. Acad. Sci., 1155, 206-221.
-
(2009)
Ann. N. Y. Acad. Sci.
, vol.1155
, pp. 206-221
-
-
Berasain, C.1
-
38
-
-
65649111667
-
High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B
-
Wong,V.W. et al. (2009) High serum interleukin-6 level predicts future hepatocellular carcinoma development in patients with chronic hepatitis B. Int. J. Cancer, 124, 2766-2770.
-
(2009)
Int. J. Cancer
, vol.124
, pp. 2766-2770
-
-
Wong, V.W.1
-
39
-
-
77649191716
-
NF-kappaB signaling mediates the induction of MTA1 by hepatitis B virus transactivator protein HBx
-
Bui-Nguyen,T.M. et al. (2010) NF-kappaB signaling mediates the induction of MTA1 by hepatitis B virus transactivator protein HBx. Oncogene, 29, 1179-1189.
-
(2010)
Oncogene
, vol.29
, pp. 1179-1189
-
-
Bui-Nguyen, T.M.1
-
40
-
-
0141703513
-
Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p.65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway
-
Sakurai,H. et al. (2003) Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p.65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway. J. Biol. Chem., 278, 36916-36923.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 36916-36923
-
-
Sakurai, H.1
-
41
-
-
34249060683
-
Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein
-
Zheng,Y. et al. (2007) Enhancement of gene transactivation activity of androgen receptor by hepatitis B virus X protein. Virology, 363, 454-461.
-
(2007)
Virology
, vol.363
, pp. 454-461
-
-
Zheng, Y.1
-
42
-
-
37649020435
-
Ubiquitin-dependent and -independent proteasomal degradation of hepatitis B virus X protein
-
Kim,J.H. et al. (2008) Ubiquitin-dependent and -independent proteasomal degradation of hepatitis B virus X protein. Biochem. Biophys. Res. Commun., 366, 1036-1042.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.366
, pp. 1036-1042
-
-
Kim, J.H.1
-
43
-
-
77955659895
-
p53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2
-
Xian,L. et al. (2010) p.53 Promotes proteasome-dependent degradation of oncogenic protein HBx by transcription of MDM2. Mol. Biol. Rep., 37, 2935-2940.
-
(2010)
Mol. Biol. Rep.
, vol.37
, pp. 2935-2940
-
-
Xian, L.1
-
44
-
-
49349107931
-
Id-1 induces proteasome-dependent degradation of the HBX protein
-
Ling,M.T. et al. (2008) Id-1 induces proteasome-dependent degradation of the HBX protein. J. Mol. Biol., 382, 34-43.
-
(2008)
J. Mol. Biol.
, vol.382
, pp. 34-43
-
-
Ling, M.T.1
-
45
-
-
0036278326
-
Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex
-
Bergametti,F. et al. (2002) Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex. J. Virol., 76, 6495-6501.
-
(2002)
J. Virol.
, vol.76
, pp. 6495-6501
-
-
Bergametti, F.1
-
46
-
-
58649093547
-
The RelA/p65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis
-
Dahlman,J.M. et al. (2009) The RelA/p.65 subunit of NF-kappaB specifically regulates cyclin D1 protein stability: implications for cell cycle withdrawal and skeletal myogenesis. J. Cell. Biochem., 106, 42-51.
-
(2009)
J. Cell. Biochem.
, vol.106
, pp. 42-51
-
-
Dahlman, J.M.1
-
47
-
-
0027168948
-
The p65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms
-
Scott,M.L. et al. (1993) The p.65 subunit of NF-kappa B regulates I kappa B by two distinct mechanisms. Genes Dev., 7, 1266-1276.
-
(1993)
Genes Dev.
, vol.7
, pp. 1266-1276
-
-
Scott, M.L.1
-
48
-
-
33646193810
-
Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication
-
Bouchard,M.J. et al. (2006) Activation of focal adhesion kinase by hepatitis B virus HBx protein: multiple functions in viral replication. J. Virol., 80, 4406-4414.
-
(2006)
J. Virol.
, vol.80
, pp. 4406-4414
-
-
Bouchard, M.J.1
-
49
-
-
0035515221
-
Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms
-
Kim,W.H. et al. (2001) Additive activation of hepatic NF-kappaB by ethanol and hepatitis B protein X (HBX) or HCV core protein: involvement of TNF-alpha receptor 1-independent and -dependent mechanisms. FASEB J., 15, 2551-2553.
-
(2001)
FASEB J.
, vol.15
, pp. 2551-2553
-
-
Kim, W.H.1
-
50
-
-
67349101230
-
Use of tumor necrosis factor-alpha (TNF-alpha) antagonists infliximab, etanercept, and adalimumab in patients with concurrent rheumatoid arthritis and hepatitis B or hepatitis C: a retrospective record review of 11 patients
-
Li,S. et al. (2009) Use of tumor necrosis factor-alpha (TNF-alpha) antagonists infliximab, etanercept, and adalimumab in patients with concurrent rheumatoid arthritis and hepatitis B or hepatitis C: a retrospective record review of 11 patients. Clin. Rheumatol., 28, 787-791.
-
(2009)
Clin. Rheumatol.
, vol.28
, pp. 787-791
-
-
Li, S.1
|