Turnover of hepatitis B virus X protein is regulated by damaged DNA-binding complex

Journal of Virology

Volumn 76, Issue 13, 2002, Pages 6495-6501

  Bergametti, Françoise ^a   Sitterlin, Delphine ^a   Transy, Catherine ^a  

^a INSTITUT PASTEUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN X; VIRUS DNA; VIRUS PROTEIN;

ARTICLE; COMPLEX FORMATION; CONTROLLED STUDY; DNA BINDING; GENETIC CODE; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STABILITY; VIRUS GENE; WOODCHUCK;

CELL LINE; CYSTEINE ENDOPEPTIDASES; DIMERIZATION; DNA-BINDING PROTEINS; GENE EXPRESSION REGULATION, VIRAL; HALF-LIFE; HEPATITIS B VIRUS; HUMANS; IMMUNOBLOTTING; MULTIENZYME COMPLEXES; MUTATION; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; TRANS-ACTIVATORS; TRANSFECTION;

EID: 0036278326     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.13.6495-6501.2002     Document Type: Article

References (49)

1. Purification of an ultraviolet-inducible, damage-specific DNA-binding protein from primate cells
2. Putative role of hepatitis B virus X protein in hepatocarcinogenesis: Effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways
3. Hepatitis B virus and hepatocellular carcinoma
4. Hepatocellular carcinoma and hepatitis B virus. A prospective study of 22 707 men in Taiwan
5. The proapoptotic effect of hepatitis B virus HBx protein correlates with its transactivation activity in stably transfected cell lines
6. The woodchuck hepatitis virus X gene is important for establishment of virus infection in woodchucks
7. Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA
8. Transcriptional activation of homologous and heterologous genes by the hepatitis B virus X gene product in cells permissive for viral replication
9. Metabolic labeling of woodchuck hepatitis B virus X protein in naturally infected hepatocytes reveals a bimodal half-life and association with the nuclear framework
10. SCF and Cullin/Ring H2-based ubiquitin ligases
11. X protein of hepatitis B virus modulates cytokine and growth factor related signal transduction path-ways during the course of viral infections and hepatocarcinogenesis
12. Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein
13. HBx protein of hepatitis B virus interacts with the C-terminal portion of a novel human proteasome alpha-subunit
14. Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway
15. DDB, a putative DNA repair protein, can function as a transcriptional partner of E2F1
16. Hepatitis B virus X protein is both a substrate and a potential inhibitor of the proteasome complex
17. p48 activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity
18. Characterization of a human DNA damage binding protein implicated in xeroderma pigmentosum E
19. Substrate targeting in the ubiquitin system
20. The V protein of the paramyxovirus SV5 interacts with damage-specific DNA binding protein
21. Hepatitis B virus X protein interferes with cell viability through interaction with the p127-kDa UV-damaged DNA-binding protein
22. Nuclear transport of human DDB protein induced by ultraviolet light
23. Management of hepatitis B: 2000 - Summary of a workshop
24. Hepatitis B virus X protein: A multifunctional viral regulator
25. The xeroderma pigmentosum group e gene product DDB2 is a specific target of cullin 4A in mammalian cells
26. DDB2 induces nuclear accumulation of the hepatitis b virus x protein independently of binding to DDB1
27. Hepatitis B virus replication - An update
28. Human damage-specific DNA-binding protein p48. Characterization of XPE mutations and regulation following UV irradiation
29. Mutations specific to the xeroderma pigmentosum group E Ddb-phenotype
30. ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity
31. Mechanisms underlying ubiquitination
32. More than one way to skin a catenin
33. The hsp90-based chaperone system: Involvement in signal transduction from a variety of hormone and growth factor receptors
34. Steroid receptor interactions with heat shock protein and immunophilin chaperones
35. Hepatitis B virus X-gene product: A promiscuous transcriptional activator
36. Stabilization of beta-catenin by genetic defects in melanoma cell lines
37. Phosphorylation and rapid turnover of hepatitis B virus X-protein expressed in HepG2 cells from a recombinant vaccinia virus
38. Animal hepatitis B viruses
39. The naturally occurring mutants of DDB are impaired in stimulating nuclear import of the p125 subunit and E2F1-activated transcription
40. Cullin 4A associates with the UV-damaged DNA-binding protein DDB
41. Cytosol is the prime compartment of hepatitis B virus X protein where it colocalizes with the proteasome
42. Correct binding of viral X protein to UVDDB-p127 cellular protein is critical for efficient infection by hepatitis B viruses
43. UVDDB p127-binding modulates activities and intracellular distribution of hepatitis B virus X protein
44. Interaction of the UV-damaged DNA-binding protein with hepatitis B virus X protein is conserved among mammalian hepadnaviruses and restricted to transactivation-proficient X-insertion mutants
45. Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis
46. The eukaryotic response regulator Skn7p regulates calcineurin signaling through stabilization of Crzlp
47. The corepressor mSin3a interacts with the proline-rich domain of p53 and protects p53 from proteasome-mediated degradation
48. Studies of the murine DDB1 and DDB2 genes
49. Woodchuck hepatitis virus X protein is required for viral infection in vivo