Phosphorylation of SMC1 by ATR is required for desferrioxamine (DFO)-induced apoptosis

Cell Death and Disease

Volumn 2, Issue 3, 2011, Pages

  So, E Y ^a   Ausman, M ^a   Saeki, T ^b   Ouchi, T ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b SAITAMA MEDICAL UNIVERSITY INTERNATIONAL MEDICAL CENTER   (Japan)

Author keywords

ATR; Hypoxia; SMC1

Indexed keywords

ATM PROTEIN; ATR PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; DEFEROXAMINE; DEOXYRIBONUCLEOPROTEIN; DNA; HYPOXIA INDUCIBLE FACTOR 1ALPHA; NIBRIN; PROTEIN KINASE C; PROTEIN P53; SERINE; STRUCTURAL MAINTENANCE OF CHROMOSOME 1; UNCLASSIFIED DRUG; ATR PROTEIN, HUMAN; CELL CYCLE PROTEIN; NONHISTONE PROTEIN; PROTEIN SERINE THREONINE KINASE; STRUCTURAL MAINTENANCE OF CHROMOSOME PROTEIN 1;

APOPTOSIS; ARTICLE; CANCER CELL; CELL CYCLE ARREST; COLON CANCER; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; CELL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETICS; METABOLISM; PHOSPHORYLATION; PROTEIN MOTIF; TUMOR CELL LINE;

AMINO ACID MOTIFS; APOPTOSIS; CELL CYCLE PROTEINS; CELL LINE, TUMOR; CELLS; CHROMOSOMAL PROTEINS, NON-HISTONE; DEFEROXAMINE; HUMANS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 79960029703     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.9     Document Type: Article

References (30)

1. Mahaney BL, Meek K, Lees-Miller SP. Repair of ionizing radiation-induced DNA doublestrand breaks by non-homologous end-joining. Biochem J 2009; 417: 639-650.
2. Lamarche BJ, Orazio NI, Weitzman MD. The MRN complex in double-strand break repair and telomere maintenance. FEBS Lett 2010; 584: 3682-3695.
3. Moynahan ME, Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nat Rev Mol Cell Biol 2010; 11: 196-207.
4. Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat Rev Cancer 2003; 3: 155-168. (Pubitemid 37328868)
5. Uziel T, Lerenthal Y, Moyal L, Andegeko Y, Mittelman L, Shiloh Y. Requirement of the MRN complex for ATM activation by DNA damage. EMBO J 2003; 22: 5612-5621. (Pubitemid 37279970)
6. Lin Q, Yun Z. Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics. Cancer Biol Thr 2010; 9: 949-956.
7. Yuan J, Narayanan L, Rockwell S, Glazer PM. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res 2000; 60: 4372-4376. (Pubitemid 32103614)
8. Bristow RG, Hill RP. Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability. Nat Rev Cancer 2008; 8: 180-192. (Pubitemid 351301853)
9. Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol 2002; 22: 1834-1843. (Pubitemid 34174999)
10. Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem 2003; 278: 12207-12213. (Pubitemid 36800201)
11. Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM. ATM activation and signaling under hypoxic conditions. Mol Cell Biol 2009; 29: 526-537.
12. Strunnikov AV, Jessberger R. Structural maintenance of chromosomes (SMC) proteins: conserved molecular properties for multiple biological functions. Eur J Biochem 1999; 263: 6-13. (Pubitemid 29313831)
13. Watrin E, Peters JM. The cohesin complex is required for the DNA damage-induced G2/M checkpoint in mammalian cells. EMBO J 2009; 28: 2625-2635.
14. Kim ST, Xu B, Kastan MB. Involvement of the cohesin protein, Smc1, in ATM-dependent and independent responses to DNA damage. Genes Dev 2002; 16: 560-570. (Pubitemid 34212489)
15. Tomimatsu N, Mukherjee B, Burma S. Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells. EMBO Rep 2009; 10: 629-635.
16. Kim BM, Choi JY, Kim YJ, Woo HD, Chung HW. Reoxygenation following hypoxia activates DNA-damage checkpoint signaling pathways that suppress cell-cycle progression in cultured human lymphocytes. FEBS Lett 2007; 581: 3005-3012. (Pubitemid 46899042)
17. Kim BM, Choi JY, Kim YJ, Woo HD, Chung HW. Desferrioxamine (DFX) has genotoxic effects on cultured human lymphocytes and induces the p53-mediated damage response. Toxicology 2007; 229: 226-235. (Pubitemid 44937491)
18. Bakkenist CJ, Kastan MB. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 2003; 421: 499-506. (Pubitemid 36168436)
19. Cliby WA, Roberts CJ, Cimprich KA, Stringer CM, Lamb JR, Schreiber SL et al. Overexpression of a kinase-inactive ATR protein causes sensitivity to DNA-damaging agents and defects in cell cycle checkpoints. EMBO J 1998; 17: 159-169. (Pubitemid 28041057)
20. Weterings E, Chen DJ. DNA-dependent protein kinase in nonhomologous end joining: a lock with multiple keys? J Cell Biol 2007; 179: 183-186. (Pubitemid 350004882)
21. Bunz F, Dutriaux A, Lengauer C, Waldman T, Zhou S, Brown JP et al. Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science 1998; 282: 1497-1501. (Pubitemid 28538613)
22. Cortez D, Guntuku S, Qin J, Elledge SJ. ATR and ATRIP: partners in checkpoint signaling. Science 2001; 294: 1713-1716. (Pubitemid 33104841)
23. Ruis BL, Fattah KR, Hendrickson EA. The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells. Mol Cell Biol 2008; 28: 6182-6195.
24. Kim BM, Chung HW. Desferrioxamine (DFX) induces apoptosis through the p38-caspase8- Bid-Bax pathway in PHA-stimulated human lymphocytes. Toxicol Appl Pharmacol 2008; 228: 24-31.
25. Ambrosini G, Nath AK, Sierra-Honigmann MR, Flores-Riveros J. Transcriptional activation of the human leptin gene in response to hypoxia. Involvement of hypoxia-inducible factor 1. J Biol Chem 2002; 277: 34601-34609.
26. Ertabak A, Kutluay T, Unlu A, Turkozkan N, Cimen B, Yaman H. The effect of desferrioxamine on peroxynitrite-induced oxidative damage in erythrocytes. Cell Biochem Funct 2004; 22: 149-152. (Pubitemid 38649470)
27. Yazdi PT, Wang Y, Zhao S, Patel N, Lee EY, Qin J. SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint. Genes Dev 2002; 16: 571-582. (Pubitemid 34212490)
28. Shang ZF, Huang B, Xu QZ, Zhang SM, Fan R, Liu XD et al. Inactivation of DNAdependent protein kinase leads to spindle disruption and mitotic catastrophe with attenuated checkpoint protein 2 phosphorylation in response to DNA damage. Cancer Res 2010; 70: 3657-3666.
29. Wong RW, Blobel G. Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole. Proc Natl Acad Sci USA 2008; 105: 15441-15445.
30. Ongusaha PP, Ouchi T, Kim KT, Nytko E, Kwak JC, Duda RB et al. BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest. Oncogene 2003; 22: 3749-3758. (Pubitemid 36760737)