Transport systems of serine at the brain barriers and in brain parenchymal cells

Journal of Neurochemistry

Volumn 118, Issue 2, 2011, Pages 304-313

  Kasai, Yasuyuki ^a   Tachikawa, Masanori ^a   Hirose, Shirou ^a   Akanuma, Shin Ichi ^a   Hosoya, Ken Ichi ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

Author keywords

alanine serine cysteine transporter; asc 1; blood brain barrier; blood CSF barrier; clearance; d serine

Indexed keywords

AMINO ACID TRANSPORTER; DEXTRO SERINE; MANNITOL; SODIUM DEPENDENT ALANINE SERINE CYSTEINE TRANSPORTER 1; SODIUM INDEPENDENT ALANINE SERINE CYSTEINE TRANSPORTER 1; UNCLASSIFIED DRUG;

AMINO ACID METABOLISM; AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CELL; BRAIN CIRCULATION; BRAIN TISSUE; CEREBROSPINAL FLUID; CEREBROSPINAL FLUID FLOW; CONTROLLED STUDY; INTERSTITIAL FLUID; MALE; MEMBRANE TRANSPORT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

ANIMALS; BIOLOGICAL TRANSPORT, ACTIVE; BLOOD-BRAIN BARRIER; CHOROID PLEXUS; INJECTIONS, INTRAVENTRICULAR; MALE; MICE; MICE, INBRED STRAINS; RATS; RATS, WISTAR; SERINE;

EID: 79960015046     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07313.x     Document Type: Article

References (51)

1. Agulhon C., Rostaing P., Ravassard P., Sagné C., Triller A., and, Giros B., (2003) Lysosomal amino acid transporter LYAAT-1 in the rat central nervous system: an in situ hybridization and immunohistochemical study. J. Comp. Neurol. 462, 71-89. (Pubitemid 36693567)
2. Akanuma S., Ohtsuki S., Doi Y., et al. (2008) ATP-binding cassette transporter A1 (ABCA1) deficiency does not attenuate the brain-to-blood efflux transport of human amyloid-β peptide (1-40) at the blood-brain barrier. Neurochem. Int. 52, 956-961.
3. Arriza J. L., Kavanaugh M. P., Fairman W. A., Wu Y. N., Murdoch G. H., North R. A., and, Amara S. G., (1993) Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. J. Biol. Chem. 268, 15329-15332. (Pubitemid 23222014)
4. Burnet P. W., Hutchinson L., von Hesling M., Gilbert E. J., Brandon N. J., Rutter A. R., Hutson P. H., and, Harrison P. J., (2008) Expression of d-serine and glycine transporters in the prefrontal cortex and cerebellum in schizophrenia. Schizophr. Res. 102, 283-294.
5. Chairoungdua A., Kanai Y., Matsuo H., Inatomi J., Kim D. K., and, Endou H., (2001) Identification and characterization of a novel member of the heterodimeric amino acid transporter family presumed to be associated with an unknown heavy chain. J. Biol. Chem. 276, 49390-49399.
6. Chen Z., Fei Y. J., Anderson C. M., Wake K. A., Miyauchi S., Huang W., Thwaites D. T., and, Ganapathy V., (2003) Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2. J. Physiol. 546, 349-361. (Pubitemid 36175972)
7. Ciriacks C. M., and, Bowser M. T., (2004) Monitoring d-serine dynamics in the rat brain using online microdialysis-capillary electrophoresis. Anal. Chem. 76, 6582-6587. (Pubitemid 39507247)
8. Cserr H. F., and, Berman B. J., (1978) Iodide and thiocyanate efflux from brain following injection into rat caudate nucleus. Am. J. Physiol. 235, F331-F337. (Pubitemid 9180972)
9. Fisher G., Lorenzo N., Abe H., Fujita E., Frey W. H., Emory C., Di Fiore M. M., and, D'Aniello A., (1998) Free d- and l-amino acids in ventricular cerebrospinal fluid from Alzheimer and normal subjects. Amino Acids 15, 263-269. (Pubitemid 28515570)
10. Foltyn V. N., Bendikov I., De Miranda J., Panizzutti R., Dumin E., Shleper M., Li P., Toney M. D., Kartvelishvily E., and, Wolosker H., (2005) Serine racemase modulates intracellular d-serine levels through an alpha,beta-elimination activity. J. Biol. Chem. 280, 1754-1763.
11. +-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral d- and l-amino acids. J. Biol. Chem. 275, 9690-9698. (Pubitemid 30185202)
12. Gliddon C. M., Shao Z., LeMaistre J. L., and, Anderson C. M., (2009) Cellular distribution of the neutral amino acid transporter subtype ASCT2 in mouse brain. J. Neurochem. 108, 372-383.
13. Hashimoto A., and, Chiba S., (2004) Effect of systemic administration of d-serine on the levels of d- and l-serine in several brain areas and periphery of rat. Eur. J. Pharmacol. 495, 153-158. (Pubitemid 38891872)
14. Hashimoto A., Oka T., and, Nishikawa T., (1995) Extracellular concentration of endogenous free d-serine in the rat brain as revealed by in vivo microdialysis. Neuroscience 66, 635-643.
15. Hashimoto K., Fukushima T., Shimizu E., et al. (2003) Decreased serum levels of d-serine in patients with schizophrenia: evidence in support of the N-methyl-d-aspartate receptor hypofunction hypothesis of schizophrenia. Arch. Gen. Psychiatry 60, 572-576. (Pubitemid 36682314)
16. Hashimoto K., Engberg G., Shimizu E., Nordin C., Lindström L. H., and, Iyo M., (2005) Reduced d-serine to total serine ratio in the cerebrospinal fluid of drug naive schizophrenic patients. Prog. Neuropsychopharmacol. Biol. Psychiatry 29, 767-769. (Pubitemid 40897791)
17. Hatanaka T., Huang W., Nakanishi T., Bridges C. C., Smith S. B., Prasad P. D., Ganapathy M. E., and, Ganapathy V., (2002) Transport of d-serine via the amino acid transporter ATB(0,+) expressed in the colon. Biochem. Biophys. Res. Commun. 291, 291-295. (Pubitemid 34694403)
18. Helboe L., Egebjerg J., MÁller M., and, Thomsen C., (2003) Distribution and pharmacology of alanine-serine-cysteine transporter 1 (asc-1) in rodent brain. Eur. J. Neurosci. 18, 2227-2238. (Pubitemid 38117396)
19. Horiike K., Tojo H., Arai R., Nozaki M., and, Maeda T., (1994) d-Amino-acid oxidase is confined to the lower brain stem and cerebellum in rat brain: regional differentiation of astrocytes. Brain Res. 652, 297-303.
20. Kakee A., Terasaki T., and, Sugiyama Y., (1996) Brain efflux index as a novel method of analyzing efflux transport at the blood-brain barrier. J. Pharmacol. Exp. Ther. 277, 1550-1559. (Pubitemid 27167171)
21. Kitazawa T., Hosoya K., Takahashi T., Sugiyama Y., and, Terasaki T., (2000) In-vivo and in-vitro evidence of a carrier-mediated efflux transport system for oestrone-3-sulphate across the blood-cerebrospinal fluid barrier. J. Pharm. Pharmacol. 52, 281-288. (Pubitemid 30189382)
22. Kleckner N. W., and, Dingledine R., (1988) Requirement for glycine in activation of NMDA-receptors expressed in Xenopus oocytes. Science 241, 835-837.
23. Miya K., Inoue R., Takata Y., Abe M., Natsume R., Sakimura K., Hongou K., Miyawaki T., and, Mori H., (2008) Serine racemase is predominantly localized in neurons in mouse brain. J. Comp. Neurol. 510, 641-654.
24. Ogawa M., Suzuki H., Sawada Y., Hanano M., and, Sugiyama Y., (1994) Kinetics of active efflux via choroid plexus of beta-lactam antibiotics from the CSF into the circulation. Am. J. Physiol. 266, R392-R399.
25. Ohtsuki S., and, Terasaki T., (2007) Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm. Res. 24, 1745-1758. (Pubitemid 47206624)
26. Ohtsuki S., Tachikawa M., Takanaga H., Shimizu H., Watanabe M., Hosoya K., and, Terasaki T., (2002) The blood-brain barrier creatine transporter is a major pathway for supplying creatine to the brain. J. Cereb. Blood Flow Metab. 22, 1327-1335. (Pubitemid 35285090)
27. Olney J. W., and, Farber N. B., (1995) Glutamate receptor dysfunction and schizophrenia. Arch. Gen. Psychiatry 52, 998-1007.
28. Ono K., Shishido Y., Park H. K., et al. (2009) Potential pathophysiological role of d-amino acid oxidase in schizophrenia: immunohistochemical and in situ hybridization study of the expression in human and rat brain. J. Neural Transm. 116, 1335-1347.
29. Preston J. E., and, Segal M. B., (1990) The steady-state amino acid fluxes across the perfused choroid plexus of the sheep. Brain Res. 525, 275-279. (Pubitemid 20257746)
30. Ribeiro C. S., Reis M., Panizzutti R., de Miranda J., and, Wolosker H., (2002) Glial transport of the neuromodulator d-serine. Brain Res. 929, 202-209. (Pubitemid 34178335)
31. Rutter A. R., Fradley R. L., Garrett E. M., Chapman K. L., Lawrence J. M., Rosahl T. W., and, Patel S., (2007) Evidence from gene knockout studies implicates Asc-1 as the primary transporter mediating d-serine reuptake in the mouse CNS. Eur. J. Neurosci. 25, 1757-1766. (Pubitemid 46550015)
32. Sakai K., Shimizu H., Koike T., Furuya S., and, Watanabe M., (2003) Neutral amino acid transporter ASCT1 is preferentially expressed in l-Ser-synthetic/storing glial cells in the mouse brain with transient expression in developing capillaries. J. Neurosci. 23, 550-560. (Pubitemid 36139554)
33. Schell M. J., Molliver M. E., and, Snyder S. H., (1995) d-Serine, an endogenous synaptic modulator: localization to astrocytes and glutamate-stimulated release. Proc. Natl. Acad. Sci. U S A 92, 3948-3952.
34. +/glutamate cotransporters. J. Biol. Chem. 268, 15351-15355. (Pubitemid 23222020)
35. Shao Z., Kamboj A., and, Anderson C. M., (2009) Functional and immunocytochemical characterization of d-serine transporters in cortical neuron and astrocyte cultures. J. Neurosci. Res. 87, 2520-2530.
36. Smith S. M., Uslaner J. M., Yao L., et al. (2009) The behavioral and neurochemical effects of a novel d-amino acid oxidase inhibitor compound 8 [4H-thieno [3,2-b]pyrrole-5-carboxylic acid] and d-serine. J. Pharmacol. Exp. Ther. 328, 921-930.
37. Tachikawa M., and, Hosoya K., (2011) Transport characteristics of guanidino compounds at the blood-brain barrier and blood-cerebrospinal fluid barrier: relevance to neural disorders. Fluids Barriers CNS 8, 13.
38. Tachikawa M., Kasai Y., Takahashi M., Fujinawa J., Kitaichi K., Terasaki T., and, Hosoya K., (2008a) The blood-cerebrospinal fluid barrier is a major pathway of cerebral creatinine clearance: involvement of transporter-mediated process. J. Neurochem. 107, 432-442.
39. Tachikawa M., Fujinawa J., Takahashi M., et al. (2008b) Expression and possible role of creatine transporter in the brain and at the blood-cerebrospinal fluid barrier as a transporting protein of guanidinoacetate, an endogenous convulsant. J. Neurochem. 107, 768-778.
40. Tachikawa M., Kasai Y., Yokoyama R., Fujinawa J., Ganapathy V., Terasaki T., and, Hosoya K., (2009) The blood-brain barrier transport and cerebral distribution of guanidinoacetate in rats: involvement of creatine and taurine transporters. J. Neurochem. 111, 499-509.
41. Tachikawa M., Takeda Y., Tomi M., and, Hosoya K., (2010) Involvement of OCTN2 in the transport of acetyl-l-carnitine across the inner blood-retinal barrier. Invest. Ophthalmol. Vis. Sci. 51, 430-436.
42. Tsai G., and, Coyle J. T., (2002) Glutamatergic mechanisms in schizophrenia. Annu. Rev. Pharmacol. Toxicol. 42, 165-179. (Pubitemid 34160524)
43. Tsai G., Yang P., Chung L. C., Lange N., and, Coyle J. T., (1998) d-Serine added to antipsychotics for the treatment of schizophrenia. Biol. Psychiatry 44, 1081-1089. (Pubitemid 28547143)
44. +-dependent neutral amino acid transporter. J. Biol. Chem. 271, 14883-14890.
45. Wako K., Ma N., Shiroyama T., and, Semba R., (1995) Glial uptake of intracerebroventricularly injected d-serine in the rat brain: an immunocytochemical study. Neurosci. Lett. 185, 171-174.
46. Wolosker H., Sheth K. N., Takahashi M., Mothet J. P., Brady R. O., Jr, Ferris C. D., and, Snyder S. H., (1999) Purification of serine racemase: biosynthesis of the neuromodulator d-serine. Proc. Natl Acad. Sci. USA 96, 721-725. (Pubitemid 29061275)
47. Xia M., Liu Y., Figueroa D. J., Chiu C. S., Wei N., Lawlor A. M., Lu P., Sur C., Koblan K. S., and, Connolly T. M., (2004) Characterization and localization of a human serine racemase. Brain Res. Mol. Brain Res. 125, 96-104. (Pubitemid 38757395)
48. Xie X., Dumas T., Tang L., et al. (2005) Lack of the alanine-serine- cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice. Brain Res. 1052, 212-221. (Pubitemid 41116780)
49. Yamaoka K., Tanigawara Y., Nakagawa T., and, Uno T., (1981) A pharmacokinetic analysis program (multi) for microcomputer. J. Pharmacobiodyn. 4, 879-885. (Pubitemid 12174128)
50. Yang C. R., and, Svensson K. A., (2008) Allosteric modulation of NMDA receptor via elevation of brain glycine and d-serine: the therapeutic potentials for schizophrenia. Pharmacol. Ther. 120, 317-332.
51. Yoshikawa M., Takayasu N., Hashimoto A., Sato Y., Tamaki R., Tsukamoto H., Kobayashi H., and, Noda S., (2007) The serine racemase mRNA is predominantly expressed in rat brain neurons. Arch. Histol. Cytol. 70, 127-134. (Pubitemid 47395208)