Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with D-galactose-induced aging

FEBS Journal

Volumn 278, Issue 14, 2011, Pages 2500-2510

  Zhong, Yi ^a   Hu, Yu Juan ^a   Chen, Bei ^a,b   Peng, Wei ^a   Sun, Yu ^a   Yang, Yang ^a   Zhao, Xue Yan ^a   Fan, Guo Run ^a   Huang, Xiang ^a   Kong, Wei Jia ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

Author keywords

age related hearing loss; DNA repair; mitochondrial common deletion; mitochondrial transcription factor A; oxidative damage

Indexed keywords

8 HYDROXYGUANINE; DNA DIRECTED DNA POLYMERASE GAMMA; GALACTOSE; MITOCHONDRIAL DNA; MITOCHONDRIAL TRANSCRIPTION FACTOR A; POLYDEOXYRIBONUCLEOTIDE SYNTHASE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUDITORY MEMORY; CELL PROLIFERATION; CONTROLLED STUDY; DNA REPLICATION; EXCISION REPAIR; GENE DELETION; GENE DOSAGE; GENE OVEREXPRESSION; HAIR CELL; HEARING LOSS; INNER EAR; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRESBYACUSIS; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; RAT; WESTERN BLOTTING;

AGING; ANIMALS; DNA GLYCOSYLASES; DNA REPAIR; DNA REPLICATION; DNA, MITOCHONDRIAL; DNA-BINDING PROTEINS; DNA-DIRECTED DNA POLYMERASE; EAR, INNER; GALACTOSE; GENE DELETION; GENE DOSAGE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HAIR CELLS, AUDITORY; MALE; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; PRESBYCUSIS; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; RNA; TRANSCRIPTION FACTORS;

RATTUS;

EID: 79959981721     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/j.1742-4658.2011.08176.x     Document Type: Article

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