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Volumn 11, Issue 7, 2011, Pages 575-581

Possible role of BDNF-induced microglial intracellular ca2+ elevation in the pathophysiology of neuropsychiatric disorders

Author keywords

BDNF; Calcium; Depression; Inflammation; Microglia; Schizophrenia; TRP channels

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CALCIUM; NITRIC OXIDE; PAROXETINE; SERTRALINE; TRANSIENT RECEPTOR POTENTIAL CHANNEL;

EID: 79959981701     PISSN: 13895575     EISSN: 18755607     Source Type: Journal    
DOI: 10.2174/138955711795906932     Document Type: Article
Times cited : (15)

References (78)
  • 1
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block, M. L.; Zecca, L.; Hong, J.S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat. Rev. Neurosci., 2007, 8, 57-69.
    • (2007) Nat. Rev. Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 2
    • 35548986304 scopus 로고    scopus 로고
    • Microglia: Active sensor and versatile effector cells in the normal and pathologic brain
    • Hanisch, U. K.; Kettenmann, H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat. Neurosci., 2007, 10, 1387-1394.
    • (2007) Nat. Neurosci , vol.10 , pp. 1387-1394
    • Hanisch, U.K.1    Kettenmann, H.2
  • 3
    • 66449130960 scopus 로고    scopus 로고
    • Regulation of innate immune responses in the brain
    • Rivest, S. Regulation of innate immune responses in the brain. Nat. Rev. Immunol., 2009, 9, 429-439.
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 429-439
    • Rivest, S.1
  • 4
    • 78149322599 scopus 로고    scopus 로고
    • Changing face of microglia
    • Graeber, M.B. Changing face of microglia. Science, 2010, 330, 783-788.
    • (2010) Science , vol.330 , pp. 783-788
    • Graeber, M.B.1
  • 5
    • 19744380563 scopus 로고    scopus 로고
    • Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo
    • Nimmerjahn, A.; Kirchhoff, F.; Helmchen, F. Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo. Science, 2005, 308, 1314-1318.
    • (2005) Science , vol.308 , pp. 1314-1318
    • Nimmerjahn, A.1    Kirchhoff, F.2    Helmchen, F.3
  • 6
    • 65249157852 scopus 로고    scopus 로고
    • Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals
    • Wake, H.; Moorhouse, A. J.; Jinno, S.; Kohsaka, S.; Nabekura, J. Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals. J. Neurosci., 2009, 29, 3974-3980.
    • (2009) J. Neurosci , vol.29 , pp. 3974-3980
    • Wake, H.1    Moorhouse, A.J.2    Jinno, S.3    Kohsaka, S.4    Nabekura, J.5
  • 8
    • 37249094173 scopus 로고    scopus 로고
    • From inflammation to sickness and depression: When the immune system subjugates the brain
    • Dantzer, R.; O'Connor, J.C.; Freund, G.G.; Johnson, R.W.; Kelley, K.W. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat. Rev. Neurosci., 2008, 9, 46-56.
    • (2008) Nat. Rev. Neurosci , vol.9 , pp. 46-56
    • Dantzer, R.1    O'Connor, J.C.2    Freund, G.G.3    Johnson, R.W.4    Kelley, K.W.5
  • 9
    • 44449179296 scopus 로고    scopus 로고
    • A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: Schizophrenia and major depression as inflammatory CNS disorders
    • Müller, N.; Schwarz, M.J. A psychoneuroimmunological perspective to Emil Kraepelins dichotomy: schizophrenia and major depression as inflammatory CNS disorders. Eur. Arch. Psychiatry Clin. Neurosci., 2008, 258, Suppl., 2, 97-106.
    • (2008) Eur. Arch. Psychiatry Clin. Neurosci , vol.258 , Issue.SUPPL. 2 , pp. 97-106
    • Müller, N.1    Schwarz, M.J.2
  • 10
    • 70450196195 scopus 로고    scopus 로고
    • TrkB signalling pathways in LTP and learning
    • Minichiello, L. TrkB signalling pathways in LTP and learning. Nat. Rev. Neurosci., 2009, 10, 850-860.
    • (2009) Nat. Rev. Neurosci , vol.10 , pp. 850-860
    • Minichiello, L.1
  • 11
    • 0035234670 scopus 로고    scopus 로고
    • Neurotrophins as synaptic modulators
    • Poo, M. M. Neurotrophins as synaptic modulators. Nat. Rev. Neurosci., 2001, 2, 24-32.
    • (2001) Nat. Rev. Neurosci , vol.2 , pp. 24-32
    • Poo, M.M.1
  • 12
    • 23044488902 scopus 로고    scopus 로고
    • The yin and yang of neurotrophin action
    • Lu, B.; Pang, P. T.; Woo, N. H. The yin and yang of neurotrophin action. Nat. Rev. Neurosci., 2005, 6, 603-614.
    • (2005) Nat. Rev. Neurosci , vol.6 , pp. 603-614
    • Lu, B.1    Pang, P.T.2    Woo, N.H.3
  • 13
    • 0242498364 scopus 로고    scopus 로고
    • A rapid increase in the total number of cell surface functional GABAA receptors induced by brain-derived neurotrophic factor in rat visual cortex
    • Mizoguchi, Y.; Kanematsu, T.; Hirata, M.; Nabekura, J. A rapid increase in the total number of cell surface functional GABAA receptors induced by brain-derived neurotrophic factor in rat visual cortex. J. Biol. Chem., 2003, 278, 44097-44102.
    • (2003) J. Biol. Chem , vol.278 , pp. 44097-44102
    • Mizoguchi, Y.1    Kanematsu, T.2    Hirata, M.3    Nabekura, J.4
  • 14
    • 0038662967 scopus 로고    scopus 로고
    • The action of BDNF on GABA(A) currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons
    • Mizoguchi, Y.; Ishibashi, H.; Nabekura, J. The action of BDNF on GABA(A) currents changes from potentiating to suppressing during maturation of rat hippocampal CA1 pyramidal neurons. J. Physiol., 2003, 548, 703-709.
    • (2003) J. Physiol , vol.548 , pp. 703-709
    • Mizoguchi, Y.1    Ishibashi, H.2    Nabekura, J.3
  • 15
    • 33750365175 scopus 로고    scopus 로고
    • BDNF occludes GABA receptormediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons
    • Mizoguchi, Y.; Kitamura, A.; Wake, H.; Ishibashi, H.; Watanabe, M.; Nishimaki, T.; Nabekura, J. BDNF occludes GABA receptormediated inhibition of GABA release in rat hippocampal CA1 pyramidal neurons. Eur. J. Neurosci., 2006, 24, 2135-2144.
    • (2006) Eur. J. Neurosci , vol.24 , pp. 2135-2144
    • Mizoguchi, Y.1    Kitamura, A.2    Wake, H.3    Ishibashi, H.4    Watanabe, M.5    Nishimaki, T.6    Nabekura, J.7
  • 17
    • 33846838739 scopus 로고    scopus 로고
    • Endogenous brain-derived neurotrophic factor triggers fast calcium transients at synapses in developing dendrites
    • Lang, S.B.; Stein, V.; Bonhoeffer, T.; Lohmann, C. Endogenous brain-derived neurotrophic factor triggers fast calcium transients at synapses in developing dendrites. J. Neurosci., 2007, 27, 1097- 1105.
    • (2007) J. Neurosci , vol.27 , pp. 1097-1105
    • Lang, S.B.1    Stein, V.2    Bonhoeffer, T.3    Lohmann, C.4
  • 18
    • 0242544035 scopus 로고    scopus 로고
    • Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells
    • Rose, C. R.; Blum, R.; Pichler, B.; Lepier, A.; Kafitz, K. W.; Konnerth, A. Truncated TrkB-T1 mediates neurotrophin-evoked calcium signalling in glia cells. Nature, 2003, 426, 74-78.
    • (2003) Nature , vol.426 , pp. 74-78
    • Rose, C.R.1    Blum, R.2    Pichler, B.3    Lepier, A.4    Kafitz, K.W.5    Konnerth, A.6
  • 19
    • 16844382943 scopus 로고    scopus 로고
    • BDNF in schizophrenia, depression and corresponding animal models
    • Angelucci, F.; Brenè, S.; Mathé, A. A. BDNF in schizophrenia, depression and corresponding animal models. Mol.Psychiatry, 2005, 10, 345-352.
    • (2005) Mol.Psychiatry , vol.10 , pp. 345-352
    • Angelucci, F.1    Brenè, S.2    Mathé, A.A.3
  • 20
    • 31444441701 scopus 로고    scopus 로고
    • J New approaches to antidepressant drug discovery: Beyond monoamines
    • Berton, O.; Nestler, E. J New approaches to antidepressant drug discovery: beyond monoamines. Nat. Rev. Neurosci., 2006, 7, 137-151.
    • (2006) Nat. Rev. Neurosci , vol.7 , pp. 137-151
    • Berton, O.1    Nestler, E.2
  • 21
    • 33745208951 scopus 로고    scopus 로고
    • A neurotrophic model for stressrelated mood disorders
    • Duman, R.S.; Monteggia, L. M. A neurotrophic model for stressrelated mood disorders. Biol. Psychiatry, 2006, 59, 1116-1127.
    • (2006) Biol. Psychiatry , vol.59 , pp. 1116-1127
    • Duman, R.S.1    Monteggia, L.M.2
  • 23
    • 49749101642 scopus 로고    scopus 로고
    • Serum brain-derived neurotrophic factor, depression, and antidepressant medications: Meta-analyses and implications
    • Sen, S.; Duman, R.; Sanacora, G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: meta-analyses and implications. Biol. Psychiatry, 2008, 64, 527-532.
    • (2008) Biol. Psychiatry , vol.64 , pp. 527-532
    • Sen, S.1    Duman, R.2    Sanacora, G.3
  • 24
    • 77955078119 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor as a biomarker for mood disorders: An historical overview and future directions
    • Hashimoto, K. Brain-derived neurotrophic factor as a biomarker for mood disorders: an historical overview and future directions. Psychiatry Clin. Neurosci., 2010, 64, 341-357.
    • (2010) Psychiatry Clin. Neurosci , vol.64 , pp. 341-357
    • Hashimoto, K.1
  • 25
    • 77957359431 scopus 로고    scopus 로고
    • Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression
    • Kunugi, H.; Hori, H.; Adachi, N.; Numakawa, T. Interface between hypothalamic-pituitary-adrenal axis and brain-derived neurotrophic factor in depression. Psychiatry Clin. Neurosci., 2010, 64, 447-459.
    • (2010) Psychiatry Clin. Neurosci , vol.64 , pp. 447-459
    • Kunugi, H.1    Hori, H.2    Adachi, N.3    Numakawa, T.4
  • 27
    • 77953572883 scopus 로고    scopus 로고
    • Depression gets old fast: Do stress and depression accelerate cell aging?
    • Wolkowitz, O. M.; Epel, E. S.; Reus, V. I.; Mellon, S. H. Depression gets old fast: do stress and depression accelerate cell aging? Depress. Anxiety, 2010, 27, 327-338.
    • (2010) Depress. Anxiety , vol.27 , pp. 327-338
    • Wolkowitz, O.M.1    Epel, E.S.2    Reus, V.I.3    Mellon, S.H.4
  • 28
    • 0029972857 scopus 로고    scopus 로고
    • Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function
    • Elkabes, S.; DiCicco-Bloom, E. M.; Black, I. B. Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J. Neurosci., 1996, 16, 2508-2521.
    • (1996) J. Neurosci , vol.16 , pp. 2508-2521
    • Elkabes, S.1    Dicicco-Bloom, E.M.2    Black, I.B.3
  • 30
    • 0141783869 scopus 로고    scopus 로고
    • Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro
    • Zhang, J.; Geula, C.; Lu, C.; Koziel, H.; Hatcher, L. M.; Roisen, F. J. Neurotrophins regulate proliferation and survival of two microglial cell lines in vitro. Exp. Neurol., 2003, 183, 469-481.
    • (2003) Exp. Neurol , vol.183 , pp. 469-481
    • Zhang, J.1    Geula, C.2    Lu, C.3    Koziel, H.4    Hatcher, L.M.5    Roisen, F.J.6
  • 31
    • 0033104019 scopus 로고    scopus 로고
    • Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor
    • Batchelor, P. E.; Liberatore, G. T.; Wong, J. Y.; Porritt, M. J.; Frerichs, F.; Donnan, G. A.; Howells, D. W. Activated macrophages and microglia induce dopaminergic sprouting in the injured striatum and express brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor. J. Neurosci., 1999, 19, 1708-1716.
    • (1999) J. Neurosci , vol.19 , pp. 1708-1716
    • Batchelor, P.E.1    Liberatore, G.T.2    Wong, J.Y.3    Porritt, M.J.4    Frerichs, F.5    Donnan, G.A.6    Howells, D.W.7
  • 34
    • 25444505872 scopus 로고    scopus 로고
    • Regulation of microglial behavior by ion channel activity
    • Eder, C. Regulation of microglial behavior by ion channel activity. J. Neurosci. Res., 2005, 81, 314-321.
    • (2005) J. Neurosci. Res , vol.81 , pp. 314-321
    • Eder, C.1
  • 35
    • 33750305578 scopus 로고    scopus 로고
    • Functional role of calcium signals for microglial function
    • Färber, K.; Kettenmann, H. Functional role of calcium signals for microglial function. Glia, 2006, 54, 656-665.
    • (2006) Glia , vol.54 , pp. 656-665
    • Färber, K.1    Kettenmann, H.2
  • 36
    • 63849192564 scopus 로고    scopus 로고
    • P2X4-receptormediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation
    • Trang, T.; Beggs, S.; Wan, X.; Salter, M. W. P2X4-receptormediated synthesis and release of brain-derived neurotrophic factor in microglia is dependent on calcium and p38-mitogen-activated protein kinase activation. J. Neurosci., 2009, 29, 3518-3528.
    • (2009) J. Neurosci , vol.29 , pp. 3518-3528
    • Trang, T.1    Beggs, S.2    Wan, X.3    Salter, M.W.4
  • 37
    • 0141853757 scopus 로고    scopus 로고
    • Calcium signaling dysfunction in schizophrenia: A unifying approach
    • Lidow, M. S. Calcium signaling dysfunction in schizophrenia: a unifying approach. Brain Res. Brain Res.Rev., 2002, 43, 70-84.
    • (2002) Brain Res. Brain Res.Rev , vol.43 , pp. 70-84
    • Lidow, M.S.1
  • 38
    • 78649520021 scopus 로고    scopus 로고
    • In vitro findings of alterations in intracellular calcium homeostasis in schizophrenia
    • Bojarski, L.: Debowska, K.: Wojda, U. In vitro findings of alterations in intracellular calcium homeostasis in schizophrenia. Prog. Neuropsychopharmacol. Biol. Psychiatry, 2010, 34, 1367-1374.
    • (2010) Prog. Neuropsychopharmacol. Biol. Psychiatry , vol.34 , pp. 1367-1374
    • Bojarski, L.1    Debowska, K.2    Wojda, U.3
  • 39
    • 44749094136 scopus 로고    scopus 로고
    • Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder
    • Kato, T. Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder. Cell Calcium, 2008, 44, 92-102.
    • (2008) Cell Calcium , vol.44 , pp. 92-102
    • Kato, T.1
  • 43
    • 34250648917 scopus 로고    scopus 로고
    • Antidepressants inhibit interferongamma- induced microglial production of IL-6 and nitric oxide
    • Hashioka, S.; Klegeris, A.; Monji, A.; Kato, T.; Sawada, M.; McGeer, P. L.; Kanba, S. Antidepressants inhibit interferongamma- induced microglial production of IL-6 and nitric oxide. Exp. Neurol., 2007, 206, 33-42.
    • (2007) Exp. Neurol , vol.206 , pp. 33-42
    • Hashioka, S.1    Klegeris, A.2    Monji, A.3    Kato, T.4    Sawada, M.5    McGeer, P.L.6    Kanba, S.7
  • 45
    • 34147102249 scopus 로고    scopus 로고
    • Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro
    • Kato, T.; Monji, A.; Hashioka, S.; Kanba. S. Risperidone significantly inhibits interferon-gamma-induced microglial activation in vitro. Schizophr. Res., 2007, 92, 108-115.
    • (2007) Schizophr. Res , vol.92 , pp. 108-115
    • Kato, T.1    Monji, A.2    Hashioka, S.3    Kanba, S.4
  • 48
    • 25444444697 scopus 로고    scopus 로고
    • 2+ mobilization and functional responses in microglia: Effects of low levels of ATP
    • 2+ mobilization and functional responses in microglia: effects of low levels of ATP. J. Neurosci. Res., 2005, 81, 349-356.
    • (2005) J. Neurosci. Res , vol.81 , pp. 349-356
    • McLarnon, J.G.1
  • 49
    • 0035076192 scopus 로고    scopus 로고
    • Sustained signaling by phospholipase C-γ mediates nerve growth factortriggered gene expression
    • Choi, D.Y.; Toledo-Aral, J. J.; Segal, R.; Halegoua, S. Sustained signaling by phospholipase C-γ mediates nerve growth factortriggered gene expression. Mol. Cell. Biol., 2001, 21, 2695-2705.
    • (2001) Mol. Cell. Biol , vol.21 , pp. 2695-2705
    • Choi, D.Y.1    Toledo-Aral, J.J.2    Segal, R.3    Halegoua, S.4
  • 50
    • 0035369840 scopus 로고    scopus 로고
    • Trk receptors: Mediators of neurotrophin action
    • Patapoutian, A.; Reichardt, L. F. Trk receptors: mediators of neurotrophin action. Curr. Opin. Neurobiol., 2001, 11, 272-280.
    • (2001) Curr. Opin. Neurobiol , vol.11 , pp. 272-280
    • Patapoutian, A.1    Reichardt, L.F.2
  • 51
    • 8844266876 scopus 로고    scopus 로고
    • From modulator to mediator: Rapid effects of BDNF on ion channels
    • Rose, C. R.; Blum, R.; Kafitz, K. W.; Kovalchuk, Y.; Konnerth, A. From modulator to mediator: rapid effects of BDNF on ion channels. Bioessays, 2004, 26, 1185-1194.
    • (2004) Bioessays , vol.26 , pp. 1185-1194
    • Rose, C.R.1    Blum, R.2    Kafitz, K.W.3    Kovalchuk, Y.4    Konnerth, A.5
  • 52
    • 13844297410 scopus 로고    scopus 로고
    • A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1
    • Ohira, K.; Kumanogoh, H.; Sahara, Y.; Homma, K. J.; Hirai, H.; Nakamura, S.; Hayashi, M. A truncated tropomyosin-related kinase B receptor, T1, regulates glial cell morphology via Rho GDP dissociation inhibitor 1. J. Neurosci., 2005, 25, 1343-1353.
    • (2005) J. Neurosci , vol.25 , pp. 1343-1353
    • Ohira, K.1    Kumanogoh, H.2    Sahara, Y.3    Homma, K.J.4    Hirai, H.5    Nakamura, S.6    Hayashi, M.7
  • 53
    • 0034617476 scopus 로고    scopus 로고
    • Astrocytes in culture express the full-length Trk-B receptor and respond to brain derived neurotrophic factor by changing intracellular calcium levels: Effect of ethanol exposure in rats
    • Climent, E.; Sancho-Tello, M.; Miñana, R.; Barettino, D.; Guerri, C. Astrocytes in culture express the full-length Trk-B receptor and respond to brain derived neurotrophic factor by changing intracellular calcium levels: effect of ethanol exposure in rats. Neurosci. Lett., 2000, 288, 53-56.
    • (2000) Neurosci. Lett , vol.288 , pp. 53-56
    • Climent, E.1    Sancho-Tello, M.2    Miñana, R.3    Barettino, D.4    Guerri, C.5
  • 56
    • 0036847845 scopus 로고    scopus 로고
    • Calcium signaling in microglial cells
    • Möller, T. Calcium signaling in microglial cells. Glia, 2002, 40, 184-194.
    • (2002) Glia , vol.40 , pp. 184-194
    • Möller, T.1
  • 57
    • 34248342249 scopus 로고    scopus 로고
    • TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation
    • Amaral, M. D.; Pozzo-Miller, L. TRPC3 channels are necessary for brain-derived neurotrophic factor to activate a nonselective cationic current and to induce dendritic spine formation. J. Neurosci., 2007, 27, 5179-5189.
    • (2007) J. Neurosci , vol.27 , pp. 5179-5189
    • Amaral, M.D.1    Pozzo-Miller, L.2
  • 58
    • 17244377058 scopus 로고    scopus 로고
    • Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor
    • Li, Y.; Jia, Y. C.; Cui, K.; Li, N.; Zheng, Z. Y.; Wang, Y. Z.; Yuan, X. B. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature, 2005, 434, 894-898.
    • (2005) Nature , vol.434 , pp. 894-898
    • Li, Y.1    Jia, Y.C.2    Cui, K.3    Li, N.4    Zheng, Z.Y.5    Wang, Y.Z.6    Yuan, X.B.7
  • 59
    • 77957371582 scopus 로고    scopus 로고
    • Transient receptor potential canonical 3 (TRPC3) mediates thrombin-induced astrocyte activation and upregulates its own expression in cortical astrocytes
    • Shirakawa, H.; Sakimoto, S.; Nakao, K.; Sugishita, A.; Konno, M.; Iida, S.; Kusano, A.; Hashimoto, E.; Nakagawa, T.; Kaneko, S. Transient receptor potential canonical 3 (TRPC3) mediates thrombin-induced astrocyte activation and upregulates its own expression in cortical astrocytes. J. Neurosci., 2010, 30, 13116-13129.
    • (2010) J. Neurosci , vol.30 , pp. 13116-13129
    • Shirakawa, H.1    Sakimoto, S.2    Nakao, K.3    Sugishita, A.4    Konno, M.5    Iida, S.6    Kusano, A.7    Hashimoto, E.8    Nakagawa, T.9    Kaneko, S.10
  • 60
    • 33846807748 scopus 로고    scopus 로고
    • Transient receptor potential cation channels in disease
    • Nilius, B.; Owsianik, G.; Voets, T.; Peters, J. A. Transient receptor potential cation channels in disease. Physiol. Rev., 2007, 87, 165-217.
    • (2007) Physiol. Rev , vol.87 , pp. 165-217
    • Nilius, B.1    Owsianik, G.2    Voets, T.3    Peters, J.A.4
  • 64
    • 0038795206 scopus 로고    scopus 로고
    • Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): Suppression of receptor-evoked calcium signaling and control of release function
    • Hoffmann, A.; Kann, O.; Ohlemeyer, C.; Hanisch, U. K.; Kettenmann, H. Elevation of basal intracellular calcium as a central element in the activation of brain macrophages (microglia): suppression of receptor-evoked calcium signaling and control of release function. J. Neurosci., 2003, 23, 4410-4419.
    • (2003) J. Neurosci , vol.23 , pp. 4410-4419
    • Hoffmann, A.1    Kann, O.2    Ohlemeyer, C.3    Hanisch, U.K.4    Kettenmann, H.5
  • 65
    • 66249137770 scopus 로고    scopus 로고
    • Sigma receptors suppress multiple aspects of microglial activation
    • Hall, A. A.; Herrera, Y.; Ajmo, C. T. Jr.; Cuevas, J.; Pennypacker, K. R. Sigma receptors suppress multiple aspects of microglial activation. Glia, 2009, 57, 744-754.
    • (2009) Glia , vol.57 , pp. 744-754
    • Hall, A.A.1    Herrera, Y.2    Ajmo Jr., C.T.3    Cuevas, J.4    Pennypacker, K.R.5
  • 66
    • 33744957162 scopus 로고    scopus 로고
    • Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release
    • Yagasaki, Y.; Numakawa, T.; Kumamaru, E.; Hayashi, T.; Su, T. P.; Kunugi, H. Chronic antidepressants potentiate via sigma-1 receptors the brain-derived neurotrophic factor-induced signaling for glutamate release. J. Biol. Chem., 2006, 281, 12941-12949.
    • (2006) J. Biol. Chem , vol.281 , pp. 12941-12949
    • Yagasaki, Y.1    Numakawa, T.2    Kumamaru, E.3    Hayashi, T.4    Su, T.P.5    Kunugi, H.6
  • 67
    • 49749117054 scopus 로고    scopus 로고
    • Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: Role of sigma-1 receptors, IP3 receptors and cellular signaling pathways
    • Nishimura, T.; Ishima, T.; Iyo, M.; Hashimoto, K. Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways. PLoS One, 2008, 3, e2558.
    • (2008) PLoS One , vol.3
    • Nishimura, T.1    Ishima, T.2    Iyo, M.3    Hashimoto, K.4
  • 68
    • 33646110490 scopus 로고    scopus 로고
    • Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1
    • Gekker, G.; Hu, S.; Sheng, W. S.; Rock, R. B.; Lokensgard, J. R.; Peterson, P. K. Cocaine-induced HIV-1 expression in microglia involves sigma-1 receptors and transforming growth factor-beta1. Int. Immunopharmacol., 2006, 6, 1029-1033.
    • (2006) Int. Immunopharmacol , vol.6 , pp. 1029-1033
    • Gekker, G.1    Hu, S.2    Sheng, W.S.3    Rock, R.B.4    Lokensgard, J.R.5    Peterson P., K.6
  • 69
    • 0030594575 scopus 로고    scopus 로고
    • Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain
    • Narita, N.; Hashimoto, K.; Tomitaka, S.; Minabe, Y. Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain. Eur. J. Pharmacol., 1996, 307, 117-119.
    • (1996) Eur. J. Pharmacol , vol.307 , pp. 117-119
    • Narita, N.1    Hashimoto, K.2    Tomitaka, S.3    Minabe, Y.4
  • 70
    • 28644435880 scopus 로고    scopus 로고
    • Metalloproteinases: Mediators of pathology and regeneration in the CNS
    • Yong, V. W. Metalloproteinases: mediators of pathology and regeneration in the CNS. Nat. Rev. Neurosci., 2005, 6, 931-944.
    • (2005) Nat. Rev. Neurosci , vol.6 , pp. 931-944
    • Yong, V.W.1
  • 71
    • 70350446962 scopus 로고    scopus 로고
    • New insights in the biology of BDNF synthesis and release: Implications in CNS function
    • Greenberg, M. E.; Xu, B.; Lu, B.; Hempstead, B. L. New insights in the biology of BDNF synthesis and release: implications in CNS function. J. Neurosci., 2009, 29, 12764-12767.
    • (2009) J. Neurosci , vol.29 , pp. 12764-12767
    • Greenberg, M.E.1    Xu, B.2    Lu, B.3    Hempstead, B.L.4
  • 72
    • 34447643571 scopus 로고    scopus 로고
    • Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury
    • Yune, T.Y.; Lee, J. Y.; Jung, G. Y.; Kim, S. J.; Jiang, M. H.; Kim, Y. C.; Oh, Y.J.; Markelonis, G. J.; Oh, T. H. Minocycline alleviates death of oligodendrocytes by inhibiting pro-nerve growth factor production in microglia after spinal cord injury. J. Neurosci., 2007, 27, 7751-7761.
    • (2007) J. Neurosci , vol.27 , pp. 7751-7761
    • Yune, T.Y.1    Lee, J.Y.2    Jung, G.Y.3    Kim, S.J.4    Jiang, M.H.5    Kim, Y.C.6    Oh, Y.J.7    Markelonis, G.J.8    Oh, T.H.9
  • 75
    • 34548336779 scopus 로고    scopus 로고
    • New insights into BDNF function in depression and anxiety
    • Martinowich, K.; Manji, H.; Lu, B. New insights into BDNF function in depression and anxiety. Nat. Neurosci., 2007, 10, 1089- 1093.
    • (2007) Nat. Neurosci , vol.10 , pp. 1089-1093
    • Martinowich, K.1    Manji, H.2    Lu, B.3
  • 77
    • 85096762511 scopus 로고    scopus 로고
    • Effect of 7,8 Dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning
    • In press
    • Andero, R.; Heldt, S. A.; Ye, K.; Liu, X.; Armario, A.; Ressler, K.J. Effect of 7,8 Dihydroxyflavone, a small-molecule TrkB agonist, on emotional learning. Am. J. Psychiatry, 2010, In press.
    • (2010) Am. J. Psychiatry
    • Andero, R.1    Heldt, S.A.2    Ye, K.3    Liu, X.4    Armario, A.5    Ressler, K.J.6
  • 78
    • 78649955466 scopus 로고    scopus 로고
    • Inflammation, sanitation, and consternation: Loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression
    • Raison, C.L.; Lowry, C. A.; Rook, G. A. Inflammation, sanitation, and consternation: loss of contact with coevolved, tolerogenic microorganisms and the pathophysiology and treatment of major depression. Arch. Gen. Psychiatry, 2010, 67, 1211-1224.
    • (2010) Arch. Gen. Psychiatry , vol.67 , pp. 1211-1224
    • Raison, C.L.1    Lowry, C.A.2    Rook, G.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.