Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder

Cell Calcium

Volumn 44, Issue 1, 2008, Pages 92-102

  Kato, Tadafumi ^a  

^a RIKEN BRAIN SCIENCE INSTITUTE   (Japan)

Author keywords

Bipolar disorder; Calcium; Cyclophilin D; Isolated mitochondria; Mitochondrial DNA; Polymerase gamma

Indexed keywords

CALCIUM ION; CYCLOPHILIN D; DNA POLYMERASE; MITOCHONDRIAL DNA; MITOCHONDRIAL PERMEABILITY TRANSITION PORE;

BIPOLAR DISORDER; BRAIN CELL; CALCIUM CELL LEVEL; CALCIUM SIGNALING; CALCIUM TRANSPORT; CELL ORGANELLE; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; FOREBRAIN; GENE MUTATION; GENETIC ANALYSIS; GENETIC POLYMORPHISM; HIPPOCAMPUS; HUMAN; MITOCHONDRION; MOLECULAR GENETICS; NERVE CELL; NEUROIMAGING; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REVIEW; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 44749094136     PISSN: 01434160     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceca.2007.11.005     Document Type: Review

References (90)

1. Goodwin F.K., and Jamison K.R. Manic-Depressive Illness: Bipolar Disorders and Recurrent Depression. second ed. (2007), Oxford University Press, New York
2. Wellcome Trust Case Control Consortium W. Genome-wide association study of 14,000 cases of seven common diseases and 3000 shared controls. Nature 447 (2007) 661-678
3. Shaltiel G., Chen G., and Manji H.K. Neurotrophic signaling cascades in the pathophysiology and treatment of bipolar disorder. Curr. Opin. Pharmacol. 7 (2007) 22-26
4. Chen G., Zeng W.Z., Yuan P.X., Huang L.D., Jiang Y.M., Zhao Z.H., and Manji H.K. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J. Neurochem. 72 (1999) 879-882
5. Yamawaki S., Kagaya A., Tawara Y., and Inagaki M. Intracellular calcium signaling systems in the pathophysiology of affective disorders. Life Sci. 62 (1998) 1665-1670
6. Warsh J.J., Andreopoulos S., and Li P.P. Role of intracellular calcium signaling in the pathophysiology and pharmacotherapy of bipolar disorder: current status. Clin. Neurosci. Res. 4 (2004) 201-213
7. Kato T., and Kato N. Mitochondrial dysfunction in bipolar disorder. Bipolar Disord. 2 (2000) 180-190
8. Kato T. Mitochondrial dysfunction as the molecular basis of bipolar disorder: therapeutic implications. CNS Drugs 21 (2007) 1-11
9. Stork C., and Renshaw P.F. Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Mol. Psychiatry 10 (2005) 900-919
10. Young L.T. Is bipolar disorder a mitochondrial disease?. J. Psychiatry Neurosci. 32 (2007) 160-161
11. Bachmann R.F., Schloesser R.J., Gould T.D., and Manji H.K. Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Mol. Neurobiol. 32 (2005) 173-202
12. Rizzuto R., Bernardi P., and Pozzan T. Mitochondria as all-round players of the calcium game. J. Physiol. 1 529 Pt. (2000) 37-47
13. Collins T.J., Lipp P., Berridge M.J., and Bootman M.D. Mitochondrial Ca(2+) uptake depends on the spatial and temporal profile of cytosolic Ca(2+) signals. J. Biol. Chem. 276 (2001) 26411-26420
14. Dubovsky S.L., Christiano J., Daniell L.C., Franks R.D., Murphy J., Adler L., Baker N., and Harris R.A. Increased platelet intracellular calcium concentration in patients with bipolar affective disorders. Arch. Gen. Psychiatry 46 (1989) 632-638
15. Kusumi I., Koyama T., and Yamashita I. Thrombin-induced platelet calcium mobilization is enhanced in bipolar disorders. Biol. Psychiatry 32 (1992) 731-734
16. Kusumi I., Koyama T., and Yamashita I. Serotonin-induced platelet intracellular calcium mobilization in depressed patients. Psychopharmacology (Berl) 113 (1994) 322-327
17. Okamoto Y., Kagaya A., Shinno H., Motohashi N., and Yamawaki S. Serotonin-induced platelet calcium mobilization is enhanced in mania. Life Sci. 56 (1995) 327-332
18. Tan C.H., Javors M.A., Seleshi E., Lowrimore P.A., and Bowden C.L. Effects of lithium on platelet ionic intracellular calcium concentration in patients with bipolar (manic-depressive) disorder and healthy controls. Life Sci. 46 (1990) 1175-1180
19. Tan C.H., Lee H.S., Kua E.H., and Peh L.H. Resting and thrombin-stimulated cytosolic calcium in platelets of patients with alcoholic withdrawal, bipolar manic disorder and chronic schizophrenia. Life Sci. 56 (1995) 1817-1823
20. Dubovsky S.L., Lee C., Christiano J., and Murphy J. Elevated platelet intracellular calcium concentration in bipolar depression. Biol. Psychiatry 29 (1991) 441-450
21. Dubovsky S.L., Murphy J., Thomas M., and Rademacher J. Abnormal intracellular calcium ion concentration in platelets and lymphocytes of bipolar patients. Am. J. Psychiatry 149 (1992) 118-120
22. Yamawaki S., Kagaya A., Okamoto Y., Shimizu M., Nishida A., and Uchitomi Y. Enhanced calcium response to serotonin in platelets from patients with affective disorders. J. Psychiatry Neurosci. 21 (1996) 321-324
23. Hough C., Lu S.J., Davis C.L., Chuang D.M., and Post R.M. Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay. Biol. Psychiatry 46 (1999) 247-255
24. Bowden C.L., Huang L.G., Javors M.A., Johnson J.M., Seleshi E., McIntyre K., Contreras S., and Maas J.W. Calcium function in affective disorders and healthy controls. Biol. Psychiatry 23 (1988) 367-376
25. Bothwell R.A., Eccleston D., and Marshall E. Platelet intracellular calcium in patients with recurrent affective disorders. Psychopharmacology (Berl) 114 (1994) 375-381
26. Eckert A., Gann H., Riemann D., Aldenhoff J., and Muller W.E. Platelet and lymphocyte free intracellular calcium in affective disorders. Eur. Arch. Psychiatry Clin. Neurosci. 243 (1994) 235-239
27. Berk M., Bodemer W., van Oudenhove T., and Butkow N. Dopamine increases platelet intracellular calcium in bipolar affective disorder and controls. Int. Clin. Psychopharmacol. 9 (1994) 291-293
28. Emamghoreishi M., Schlichter L., Li P.P., Parikh S., Sen J., Kamble A., and Warsh J.J. High intracellular calcium concentrations in transformed lymphoblasts from subjects with bipolar I disorder. Am. J. Psychiatry 154 (1997) 976-982
29. Corson T.W., Li P.P., Kennedy J.L., Macciardi F., Cooke R.G., Parikh S.V., and Warsh J.J. Association analysis of G-protein beta 3 subunit gene with altered Ca(2+) homeostasis in bipolar disorder. Mol. Psychiatry 6 (2001) 125-126
30. Hahn C.G., Gomez G., Restrepo D., Friedman E., Josiassen R., Pribitkin E.A., Lowry L.D., Gallop R.J., and Rawson N.E. Aberrant intracellular calcium signaling in olfactory neurons from patients with bipolar disorder. Am. J. Psychiatry 162 (2005) 616-618
31. Duszynski J., Koziel R., Brutkowski W., Szczepanowska J., and Zablocki K. The regulatory role of mitochondria in capacitative calcium entry. Biochim. Biophys. Acta 1757 (2006) 380-387
32. Kusumi I., Suzuki K., Sasaki Y., Kameda K., and Koyama T. Treatment response in depressed patients with enhanced Ca mobilization stimulated by serotonin. Neuropsychopharmacology 23 (2000) 690-696
33. Kato T., Ishiwata M., Mori K., Washizuka S., Tajima O., Akiyama T., and Kato N. Mechanisms of altered Ca2+ signalling in transformed lymphoblastoid cells from patients with bipolar disorder. Int. J. Neuropsychopharmacol. 6 (2003) 379-389
34. Perova T., Wasserman M.J., Li P.P., and Warsh J.J. Hyperactive intracellular calcium dynamics in B lymphoblasts from patients with bipolar I disorder. Int. J. Neuropsychopharmacol. (2007) 1-12
35. Brzustowicz L.M., Gardner J.P., Hopp L., Jeanclos E., Ott J., Yang X.Y., Fekete Z., and Aviv A. Linkage analysis using platelet-activating factor Ca2+ response in transformed lymphoblasts. Hypertension 29 (1997) 158-164
36. Mikoshiba K. The IP3 receptor/Ca2+ channel and its cellular function. Biochem. Soc. Symp. (2007) 9-22
37. Mikuni M., Kusumi I., Kagaya A., Kuroda Y., Mori H., and Takahashi K. Increased 5-HT-2 receptor function as measured by serotonin-stimulated phosphoinositide hydrolysis in platelets of depressed patients. Prog. Neuropsychopharmacol. Biol. Psychiatry 15 (1991) 49-61
38. Mikoshiba K., and Hattori M. IP3 receptor-operated calcium entry. Sci. STKE 2000 (2000) PE1
39. Yoon I.S., Li P.P., Siu K.P., Kennedy J.L., Macciardi F., Cooke R.G., Parikh S.V., and Warsh J.J. Altered TRPC7 gene expression in bipolar-I disorder. Biol. Psychiatry 50 (2001) 620-626
40. Wasserman M.J., Corson T.W., Sibony D., Cooke R.G., Parikh S.V., Pennefather P.S., Li P.P., and Warsh J.J. Chronic lithium treatment attenuates intracellular calcium mobilization. Neuropsychopharmacology 29 (2004) 759-769
41. Suzuki K., Kusumi I., Akimoto T., Sasaki Y., and Koyama T. Altered 5-HT-induced calcium response in the presence of staurosporine in blood platelets from bipolar disorder patients. Neuropsychopharmacology 28 (2003) 1210-1214
42. Kato T., Takahashi S., Shioiri T., and Inubushi T. Brain phosphorous metabolism in depressive disorders detected by phosphorus-31 magnetic resonance spectroscopy. J. Affect. Disord. 26 (1992) 223-230
43. Kato T., Takahashi S., Shioiri T., Murashita J., Hamakawa H., and Inubushi T. Reduction of brain phosphocreatine in bipolar II disorder detected by phosphorus-31 magnetic resonance spectroscopy. J. Affect. Disord. 31 (1994) 125-133
44. Kato T., Takahashi S., Shioiri T., and Inubushi T. Alterations in brain phosphorous metabolism in bipolar disorder detected by in vivo 31P and 7Li magnetic resonance spectroscopy. J. Affect. Disord. 27 (1993) 53-59
45. Kato T., Murashita J., Kamiya A., Shioiri T., Kato N., and Inubushi T. Decreased brain intracellular pH measured by 31P-MRS in bipolar disorder: a confirmation in drug-free patients and correlation with white matter hyperintensity. Eur. Arch. Psychiatry Clin. Neurosci. 248 (1998) 301-306
46. Hamakawa H., Murashita J., Yamada N., Inubushi T., Kato N., and Kato T. Reduced intracellular pH in the basal ganglia and whole brain measured by 31P-MRS in bipolar disorder. Psychiatry Clin. Neurosci. 58 (2004) 82-88
47. Murashita J., Kato T., Shioiri T., Inubushi T., and Kato N. Altered brain energy metabolism in lithium-resistant bipolar disorder detected by photic stimulated 31P-MR spectroscopy. Psychol. Med. 30 (2000) 107-115
48. Dager S.R., Friedman S.D., Parow A., Demopulos C., Stoll A.L., Lyoo I.K., Dunner D.L., and Renshaw P.F. Brain metabolic alterations in medication-free patients with bipolar disorder. Arch. Gen. Psychiatry 61 (2004) 450-458
49. Bertolino A., Frye M., Callicott J.H., Mattay V.S., Rakow R., Shelton-Repella J., Post R., and Weinberger D.R. Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging. Biol. Psychiatry 53 (2003) 906-913
50. Winsberg M.E., Sachs N., Tate D.L., Adalsteinsson E., Spielman D., and Ketter T.A. Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder. Biol. Psychiatry 47 (2000) 475-481
51. Cecil K.M., DelBello M.P., Morey R., and Strakowski S.M. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disord. 4 (2002) 357-365
52. Altshuler L.L., Curran J.G., Hauser P., Mintz J., Denicoff K., and Post R. T2 hyperintensities in bipolar disorder: magnetic resonance imaging comparison and literature meta-analysis. Am. J. Psychiatry 152 (1995) 1139-1144
53. Kato T., Stine O.C., McMahon F.J., and Crowe R.R. Increased levels of a mitochondrial DNA deletion in the brain of patients with bipolar disorder. Biol. Psychiatry 42 (1997) 871-875
54. Munakata K., Iwamoto K., Bundo M., and Kato T. Mitochondrial DNA 3243A > G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia. Biol. Psychiatry 57 (2005) 525-532
55. Kato T., Kunugi H., Nanko S., and Kato N. Mitochondrial DNA polymorphisms in bipolar disorder. J. Affect. Disord. 62 (2001) 151-164
56. Munakata K., Tanaka M., Mori K., Washizuka S., Yoneda M., Tajima O., Akiyama T., Nanko S., Kunugi H., Tadokoro K., Ozaki N., Inada T., Sakamoto K., Fukunaga T., Iijima Y., Iwata N., Tatsumi M., Yamada K., Yoshikawa T., and Kato T. Mitochondrial DNA 3644T- > C mutation associated with bipolar disorder. Genomics 84 (2004) 1041-1050
57. Konradi C., Eaton M., MacDonald M.L., Walsh J., Benes F.M., and Heckers S. Molecular evidence for mitochondrial dysfunction in bipolar disorder. Arch. Gen. Psychiatry 61 (2004) 300-308
58. Sun X., Wang J.F., Tseng M., and Young L.T. Downregulation in components of the mitochondrial electron transport chain in the postmortem frontal cortex of subjects with bipolar disorder. J. Psychiatry Neurosci. 31 (2006) 189-196
59. Naydenov A.V., MacDonald M.L., Ongur D., and Konradi C. Differences in lymphocyte electron transport gene expression levels between subjects with bipolar disorder and normal controls in response to glucose deprivation stress. Arch. Gen. Psychiatry 64 (2007) 555-564
60. Washizuka S., Kakiuchi C., Mori K., Kunugi H., Tajima O., Akiyama T., Nanko S., and Kato T. Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder. Am. J. Med. Genet. 120B (2003) 72-78
61. Washizuka S., Iwamoto K., Kazuno A.A., Kakiuchi C., Mori K., Kametani M., Yamada K., Kunugi H., Tajima O., Akiyama T., Nanko S., Yoshikawa T., and Kato T. Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees. Biol. Psychiatry 56 (2004) 483-489
62. Siciliano G., Tessa A., Petrini S., Mancuso M., Bruno C., Grieco G.S., Malandrini A., DeFlorio L., Martini B., Federico A., Nappi G., Santorelli F.M., and Murri L. Autosomal dominant external ophthalmoplegia and bipolar affective disorder associated with a mutation in the ANT1 gene. Neuromuscul. Disord. 13 (2003) 162-165
63. Fattal O., Link J., Quinn K., Cohen B.H., and Franco K. Psychiatric comorbidity in 36 adults with mitochondrial cytopathies. CNS Spectr. 12 (2007) 429-438
64. Kazuno A.A., Munakata K., Nagai T., Shimozono S., Tanaka M., Yoneda M., Kato N., Miyawaki A., and Kato T. Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix pH and intracellular calcium dynamics. PLoS Genet. 2 e128 (2006) 1167-1176
65. Kasahara T., Kubota M., Miyauchi T., Noda Y., Mouri A., Nabeshima T., and Kato T. Mice with neuron-specific accumulation of mitochondrial DNA mutations show mood disorder-like phenotypes. Mol. Psychiatry 11 577-93 (2006) 523
66. Kubota M., Kasahara T., Nakamura T., Ishiwata M., Miyauchi T., and Kato T. Abnormal Ca2+ dynamics in transgenic mice with neuron-specific mitochondrial DNA defects. J. Neurosci. 26 (2006) 12314-12324
67. Hamakawa H., Kato T., Murashita J., and Kato N. Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders. Eur. Arch. Psychiatry Clin. Neurosci. 248 (1998) 53-58
68. Kato T., and Takahashi Y. Deletion of leukocyte mitochondrial DNA in bipolar disorder. J. Affect. Disord. 37 (1996) 67-73
69. Kato T., Winokur G., McMahon F.J., DePaulo J.R., and Crowe R.R. Quantitative analysis of leukocyte mitochondrial DNA deletion in affective disorders. Biol. Psychiatry 42 (1997) 311-316
70. Sabunciyan S., Kirches E., Krause G., Bogerts B., Mawrin C., Llenos I.C., and Weis S. Quantification of total mitochondrial DNA and mitochondrial common deletion in the frontal cortex of patients with schizophrenia and bipolar disorder. J. Neural Transm. 114 (2007) 665-674
71. Kakiuchi C., Ishiwata M., Kametani M., Nelson C., Iwamoto K., and Kato T. Quantitative analysis of mitochondrial DNA deletions in the brains of patients with bipolar disorder and schizophrenia. Int. J. Neuropsychopharmacol. 8 (2005) 515-522
72. McMahon F.J., Stine O.C., Meyers D.A., Simpson S.G., and DePaulo J.R. Patterns of maternal transmission in bipolar affective disorder. Am. J. Hum. Genet. 56 (1995) 1277-1286
73. Nakatani N., Hattori E., Ohnishi T., Dean B., Iwayama Y., Matsumoto I., Kato T., Osumi N., Higuchi T., Niwa S., and Yoshikawa T. Genome-wide expression analysis detects eight genes with robust alterations specific to bipolar I disorder: relevance to neuronal network perturbation. Hum. Mol. Genet. 15 (2006) 1949-1962
74. Kato T., Winokur G., Coryell W., Keller M.B., Endicott J., and Rice J. Parent-of-origin effect in transmission of bipolar disorder. Am. J. Med. Genet. 67 (1996) 546-550
75. Iwamoto K., Bundo M., and Kato T. Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis. Hum. Mol. Genet. 14 (2005) 241-253
76. Vawter M.P., Tomita H., Meng F., Bolstad B., Li J., Evans S., Choudary P., Atz M., Shao L., Neal C., Walsh D.M., Burmeister M., Speed T., Myers R., Jones E.G., Watson S.J., Akil H., and Bunney W.E. Mitochondria-related gene expression changes are sensitive to agonal-pH state: implications for brain disorders. Mol. Psychiatry 11 615 (2006) 663-679
77. Hajnoczky G., Robb-Gaspers L.D., Seitz M.B., and Thomas A.P. Decoding of cytosolic calcium oscillations in the mitochondria. Cell 82 (1995) 415-424
78. Kirk R., Furlong R.A., Amos W., Cooper G., Rubinsztein J.S., Walsh C., Paykel E.S., and Rubinsztein D.C. Mitochondrial genetic analyses suggest selection against maternal lineages in bipolar affective disorder. Am. J. Hum. Genet. 65 (1999) 508-518
79. McMahon F.J., Chen Y.S., Patel S., Kokoszka J., Brown M.D., Torroni A., DePaulo J.R., and Wallace D.C. Mitochondrial DNA sequence diversity in bipolar affective disorder. Am. J. Psychiatry 157 (2000) 1058-1064
80. Nagai T., Sawano A., Park E.S., and Miyawaki A. Circularly permuted green fluorescent proteins engineered to sense Ca2+. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 3197-3202
81. van der Walt J.M., Nicodemus K.K., Martin E.R., Scott W.K., Nance M.A., Watts R.L., Hubble J.P., Haines J.L., Koller W.C., Lyons K., Pahwa R., Stern M.B., Colcher A., Hiner B.C., Jankovic J., Ondo W.G., Allen Jr. F.H., Goetz C.G., Small G.W., Mastaglia F., Stajich J.M., McLaurin A.C., Middleton L.T., Scott B.L., Schmechel D.E., Pericak-Vance M.A., and Vance J.M. Mitochondrial polymorphisms significantly reduce the risk of Parkinson disease. Am. J. Hum. Genet. 72 (2003) 804-811
82. van der Walt J.M., Dementieva Y.A., Martin E.R., Scott W.K., Nicodemus K.K., Kroner C.C., Welsh-Bohmer K.A., Saunders A.M., Roses A.D., Small G.W., Schmechel D.E., Murali Doraiswamy P., Gilbert J.R., Haines J.L., Vance J.M., and Pericak-Vance M.A. Analysis of European mitochondrial haplogroups with Alzheimer disease risk. Neurosci. Lett. 365 (2004) 28-32
83. Tanaka M., Gong J.S., Zhang J., Yoneda M., and Yagi K. Mitochondrial genotype associated with longevity. Lancet 351 (1998) 185-186
84. Kazuno A.A., Munakata K., Kato N., and Kato T. Mitochondrial DNA-dependent effects of valproate on mitochondrial calcium levels in transmitochondrial cybrids. Int. J. Neuropsychopharmacol. (2007) 1-8
85. Van Goethem G., Dermaut B., Lofgren A., Martin J.J., and Van Broeckhoven C. Mutation of POLG is associated with progressive external ophthalmoplegia characterized by mtDNA deletions. Nat. Genet. 28 (2001) 211-212
86. Blehar M.C., DePaulo Jr. J.R., Gershon E.S., Reich T., Simpson S.G., and Nurnberger Jr. J.I. Women with bipolar disorder: findings from the NIMH Genetics Initiative Sample. Psychopharmacol. Bull. 34 (1998) 239-243
87. Rasgon N., Bauer M., Grof P., Gyulai L., Elman S., Glenn T., and Whybrow P.C. Sex-specific self-reported mood changes by patients with bipolar disorder. J. Psychiatr. Res. 39 (2005) 77-83
88. Ichas F., and Mazat J.P. From calcium signaling to cell death: two conformations for the mitochondrial permeability transition pore. Switching from low- to high-conductance state. Biochim. Biophys. Acta 1366 (1998) 33-50
89. Mott J.L., Zhang D., Chang S.W., and Zassenhaus H.P. Mitochondrial DNA mutations cause resistance to opening of the permeability transition pore. Biochim. Biophys. Acta 1757 (2006) 596-603
90. Mott J.L., Zhang D., and Zassenhaus H.P. Mitochondrial DNA mutations, apoptosis, and the misfolded protein response. Rejuvenation Res. 8 (2005) 216-226