Synthesis and evaluation of bidentate ligands designed to interact with PDZ domains

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 14, 2011, Pages 4346-4354

  Boucherle, Benjamin ^a   Vogrig, Alexandre ^a   Deokar, Hemantkumar ^a   Bouzidi, Naoual ^a   Ripoche, Isabelle ^a   Thomas, Isabelle ^a   Marin, Philippe ^b   Ducki, Sylvie ^a  

^a UNIVERSITÉ CLERMONT AUVERGNE   (France)

^b UNIV MONTPELLIER   (France)

Author keywords

Bidentate ligands; Indole; PDZ domain; Protein protein interaction

Indexed keywords

1 [(5 CARBOXY 3 METHYL 1H INDOLE 2 CARBOXAMIDO)BUTYLAMINO] 1 OXO 3 PHENYLPROPAN 2 AMINIUM; 1 [(5 CARBOXY 3 METHYL 1H INDOLE 2 CARBOXAMIDO)BUTYLAMINO] 3 METHYL 1 OXOPENTAN 2 AMINIUM CHLORIDE; 1 [2 (5 CARBOXY 3 METHYL 1H INDOLE 2 CARBOXAMIDO)ETHYLAMINO] 3 METHYL 1 OXOPENTAN 2 AMINIUM CHLORIDE; 1 [4 (5 CARBOXY 3 METHYL 1H INDOLE 2 CARBOXAMIDO)BUTYLAMINO] 3 (1H INDOL 3 YL) 1 OXOPROPAM 2 AMINIUM CHLORIDE; 2 [(2,6 DIAMINOHEXANAMIDO)BUTYLCARBAMOYL] 3 METHYL 1H INDOLE 5 CARBOXYLIC ACID; 2 [5 (BENZYLOXYCARBONYL) 3 METHYL 1H INDOLE 2 CARBOXAMIDO]ETHANAMINIUM 2,2,2 TRIFLUOROACETIC ACID; 3 METHYL 2 [4 (5 OXOPYRROLIDINE 2 CARBOXAMIDO)BUTYLAMINO] 1H INDOLE 5 CARBOXYLIC ACID; 4 (5 CARBOXY 3 METHYL 1H INDOLE 2 CARBOXAMIDO)BUTAN 1 AMINIUM CHLORIDE; 4 (5 CARBOXY 3 METHYL 1H INDOLE 2 CARBOXAMIDO)ETHAN AMINIUM CHLORIDE; 4 [5 (BENZYLOXYCARBONYL) 3 METHYL 1H INDOLE 2 CARBOXAMIDO]BUTAN 1 AMINIUM 2,2,2 TRIFLUOROACETIC ACID; 4 [5 (ETHOXYCARBONYL) 3 METHYL 1H INDOLE 2 CARBOXAMIDO]BUTAN 1 AMINIUM 2,2,2 TRIFLUOROACETIC ACID; 5 (BENZYLOXYCARBONYL) 3 METHYL 1H INDOLE 2 CARBOXYLIC ACID; 5 (ETHOXYCARBONYL) 3 METHYL 1H INODOLE 2 CARBOXYLIC ACID; 6 [2 (5 (BENZYLOXYCARBONYL) 3 METHYL 1H INDOLE 2 CARBOXAMIDO)ETHYLAMINO] 6 OXOHEXANE 1,5 DIAMINIUM CHLORIDE; 6 [4 (5 CARBOXY 3 METHYL 1H INDOLE 2 CARBOXAMIDO)BUTYLAMINO] 6 OXOHEXANE 1,5 DIAMINIUM CHLORIDE; 6 [5 (ETHOXYCARBONYL) 3 METHYL 1H INDOLE 2 CARBOXAMIDO]HEXAN 1 AMINIUM 2,2,2 TRIFLUOROACETIC ACID; 8 [5 (ETHOXYCARBONYL) 3 METHYL 1H INDOLE 2 CARBOXAMIDO]OCTAN 1 AMINIUM 2,2,2 TRIFLUOROACETIC ACID; BENZYL 4 [BIS(TERT BUTOXYCARBONYL)AMINO] 3 IODOBENZOIC ACID; BENZYL 4 AMINO 3 IODOBENZOIC ACID; PDZ PROTEIN; POSTSYNAPTIC DENSITY PROTEIN 95; PROTEIN INHIBITOR; SEROTONIN 2A RECEPTOR; SODIUM 2 (6 AMINOHEXYLCARBAMOYL) 3 METHYL 1H INDOLE 5 CARBOXYLIC ACID; SODIUM 2 [(2 AMINO 3 (1H INDOL 2 YL)PROPANAMIDO)HEXYLCARBAMOYL] 3 METHYL 1H INDOLE 5 CARBOXYLIC ACID; SODIUM 2 [(2 AMINO 3 METHYLPENTANAMIDO)HEXYL CARBAMOYL] 3 METHYL 1H INDOLE 5 CARBOXYLIC ACID; SODIUM 2 [(2 AMINO 3 PHENYLPROPANAMIDO)HEXYLCARBAMOYL] 3 METHYL 1H INDOLE 5 CARBOXYLIC ACID; SODIUM 2 [(2 AMINO 4 CARBOXYBUTANAMIDO)HEXYLCARBAMOYL] 3 METHYL 1H INDOLE 5 CARBOXYLIC ACID; SODIUM 3 METHYL 1H INDOLE 2,5 DICARBOXYLIC ACID; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICLE; BINDING SITE; DRUG DESIGN; DRUG INHIBITION; DRUG PROTEIN BINDING; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; LIGAND BINDING; NONHUMAN; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

BINDING SITES; COMPUTATIONAL BIOLOGY; DRUG DESIGN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; MEMBRANE PROTEINS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PDZ DOMAINS; RECEPTOR, SEROTONIN, 5-HT2A; SEROTONIN 5-HT2 RECEPTOR AGONISTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79959950480     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.05.036     Document Type: Article

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