A cyclic peptide targeted against PSD-95 blocks central sensitization and attenuates thermal hyperalgesia

Neuroscience

Volumn 167, Issue 2, 2010, Pages 490-500

  LeBlanc, B W ^a   Iwata, M ^a   Mallon, A P ^b   Rupasinghe, C N ^c   Goebel, D J ^d   Marshall, J ^b   Spaller, M R ^c   Saab, C Y ^a  

^a BROWN UNIVERSITY   (United States)

^b BROWN UNIVERSITY   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Hyperalgesia; LTP; P38; Pain; PSD 95; WDR

Indexed keywords

CN 2097; CYCLOPEPTIDE; MITOGEN ACTIVATED PROTEIN KINASE 11; POSTSYNAPTIC DENSITY PROTEIN 95; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG PROTEIN BINDING; ENZYME PHOSPHORYLATION; EVOKED SOMATOSENSORY RESPONSE; HYPERALGESIA; ISCHIALGIA; NERVE CELL PLASTICITY; NONHUMAN; PEPTIDE ANALYSIS; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN TARGETING; RAT; SENSITIZATION; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD DORSAL HORN; THERMAL HYPERALGESIA;

ACTION POTENTIALS; ANALGESICS; ANIMALS; HOT TEMPERATURE; HUMANS; HYPERALGESIA; INJECTIONS, SPINAL; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; LIGANDS; LONG-TERM POTENTIATION; LUMBOSACRAL REGION; MEMBRANE PROTEINS; NERVE FIBERS, UNMYELINATED; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PAIN; PDZ DOMAINS; PEPTIDES, CYCLIC; PERIPHERAL NERVOUS SYSTEM DISEASES; PHOSPHORYLATION; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; SCIATIC NERVE; SPINAL CORD;

EID: 77950863747     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2010.02.031     Document Type: Article

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