Anti-angiogenic effects of the receptor tyrosine kinase inhibitor, pazopanib, on choroidal neovascularization in rats

European Journal of Pharmacology

Volumn 666, Issue 1-3, 2011, Pages 12-18

  Yafai, Yousef ^a   Yang, Xiu Mei ^a,b   Niemeyer, Marc ^a   Nishiwaki, Akiko ^a,c   Lange, Johannes ^a   Wiedemann, Peter ^a   King, Andrew G ^d   Yasukawa, Tsutomu ^a,c   Eichler, Wolfram ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

^d GLAXOSMITHKLINE   (United States)

Author keywords

Age related macular degeneration; Angiogenesis; Choroidal neovascularization; Pazopanib; Receptor tyrosine kinase inhibitor; VEGF vascular endothelial growth factor

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 1; PAZOPANIB; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; BRUCH MEMBRANE; CELL MIGRATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; IN VIVO STUDY; LASER COAGULATION; MALE; NONHUMAN; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBRETINAL NEOVASCULARIZATION;

ADMINISTRATION, TOPICAL; ANGIOGENESIS INHIBITORS; ANIMALS; CELL MOVEMENT; CHOROID; DOWN-REGULATION; ENDOTHELIAL CELLS; HUMANS; INTRACELLULAR SPACE; MACULAR DEGENERATION; MALE; NEOVASCULARIZATION, PATHOLOGIC; PROTEIN KINASE INHIBITORS; PYRIMIDINES; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; SULFONAMIDES; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 79959925767     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.05.016     Document Type: Article

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