Dopamine D4 receptor and serotonin transporter gene effects on the longitudinal development of infant temperament

Genes, Brain and Behavior

Volumn 10, Issue 5, 2011, Pages 513-522

  Holmboe, K ^a,b   Nemoda, Z ^c   Fearon, R M P ^d   Sasvari Szekely, M ^c   Johnson, M H ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c SEMMELWEIS UNIVERSITY   (Hungary)

^d UNIVERSITY OF READING   (United Kingdom)

Author keywords

5 HTTLPR; DRD4; Infant; Longitudinal; Temperament

Indexed keywords

DOPAMINE 4 RECEPTOR; SEROTONIN TRANSPORTER;

ALLELE; ARTICLE; EGO DEVELOPMENT; FEMALE; GENE INTERACTION; GENOTYPE; HEREDITY; HUMAN; INFANT; MALE; PRIORITY JOURNAL; PROTEIN FUNCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TEMPERAMENT; VARIABLE NUMBER OF TANDEM REPEAT;

AFFECT; ALLELES; FEMALE; GENOTYPE; HUMANS; INFANT; INFANT BEHAVIOR; LONGITUDINAL STUDIES; MALE; PERSONALITY DEVELOPMENT; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; RECEPTORS, DOPAMINE D4; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TANDEM REPEAT SEQUENCES; TEMPERAMENT;

EID: 79959921735     PISSN: 16011848     EISSN: 1601183X     Source Type: Journal    
DOI: 10.1111/j.1601-183X.2010.00669.x     Document Type: Article

References (44)

1. Anguelova, M., Benkelfat, C. & Turecki, G. (2003) A systematic review of association studies investigating genes coding for serotonin receptors and the serotonin transporter: I. Affective disorders. Mol Psychiatry 8, 574-591.
2. Antypa, N. & Van der Does, A.J.W. (2010) Serotonin transporter gene, childhood emotional abuse and cognitive vulnerability to depression. Genes Brain Behav 9, 615-620.
3. Arbelle, S., Benjamin, J., Golin, M., Kremer, I., Belmaker, R.H. & Ebstein, R.P. (2003) Relation of shyness in grade school children to the genotype for the long form of the serotonin transporter promoter region polymorphism. Am J Psychiatry 160, 671-676.
4. Auerbach, J., Geller, V., Lezer, S., Shinwell, E., Belmaker, R.H., Levine, J. & Ebstein, R.P. (1999) Dopamine D4 receptor (D4DR) and serotonin transporter promoter (5-HTTLPR) polymorphisms in the determination of temperament in 2-month-old infants. Mol Psychiatry 4, 369-373.
5. Auerbach, J.G., Benjamin, J., Faroy, M., Geller, V. & Ebstein, R. (2001a) DRD4 related to infant attention and information processing: a developmental link to ADHD? Psychiatr Genet 11, 31-35.
6. Auerbach, J.G., Faroy, M., Ebstein, R., Kahana, M. & Levine, J. (2001b) The association of the dopamine D4 receptor gene (DRD4) and the serotonin transporter promoter gene (5-HTTLPR) with temperament in 12-month-old infants. J Child Psychol Psychiatry 42, 777-783.
7. Battaglia, M., Ogliari, A., Zanoni, A., Citterio, A., Pozzoli, U., Giorda, R., Maffei, C. & Marino, C. (2005) Influence of the serotonin transporter promoter gene and shyness on children's cerebral responses to facial expressions. Arch Gen Psychiatry 62, 85-94.
8. Becker, K., El-Faddagh, M., Schmidt, M.H. & Laucht, M. (2007) Dopaminergic polymorphisms and regulatory problems in infancy. Z Kinder Jugendpsychiatr Psychother 35, 145-151 (in German).
9. Becker, K., Blomeyer, D., El-Faddagh, M., Esser, G., Schmidt, M.H., Banaschewski, T. & Laucht, M. (2010) From regulatory problems in infancy to attention-deficit/hyperactivity disorder in childhood: a moderating role for the dopamine D4 receptor gene? J Pediatr 156, 798-803.
10. Bloch, M.H., Landeros-Weisenberger, A., Sen, S., Dombrowski, P., Kelmendi, B., Coric, V., Pittenger, C. & Leckman, J.F. (2008) Association of the serotonin transporter polymorphism and obsessive-compulsive disorder: systematic review. Am J Med Genet 147B, 850-858.
11. Caspi, A., Hariri, A.R., Holmes, A., Uher, R. & Moffitt, T.E. (2010) Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry 167, 509-527.
12. Congdon, E., Lesch, K.P. & Canli, T. (2008) Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: implications for impulsivity. Am J Med Genet 147B, 27-32.
13. Dannlowski, U., Ohrmann, P., Bauer, J., Kugel, H., Baune, B.T., Hohoff, C., Kersting, A., Arolt, V., Heindel, W., Deckert, J. & Suslow, T. (2007) Serotonergic genes modulate amygdala activity in major depression. Genes Brain Behav 6, 672-676.
14. De Luca, A., Rizzardi, M., Torrente, I., Alessandroni, R., Salvioli, G.P., Filograsso, N., Dallapiccola, B. & Novelli, G. (2001) Dopamine D4 receptor (DRD4) polymorphism and adaptability trait during infancy: a longitudinal study in 1- to 5-month-old neonates. Neurogenetics 3, 79-82.
15. De Luca, A., Rizzardi, M., Buccino, A., Alessandroni, R., Salvioli, G.P., Filograsso, N., Novelli, G. & Dallapiccola, B. (2003) Association of dopamine D4 receptor (DRD4) exon III repeat polymorphism with temperament in 3-year-old infants. Neurogenetics 4, 207-212.
16. 4 gene (DRD4) is associated with financial risk taking in men. Evol Hum Behav 30, 85-92.
17. Ebstein, R.P., Levine, J., Geller, V., Auerbach, J., Gritsenko, I. & Belmaker, R.H. (1998) Dopamine D4 receptor and serotonin transporter promoter in the determination of neonatal temperament. Mol Psychiatry 3, 238-246.
18. Eisenberg, D.T.A., MacKillop, J., Modi, M., Beauchemin, J., Dang, D., Lisman, S.A., Lum, J.K. & Wilson, D.S. (2007) Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study. Behav Brain Funct 3.
19. Faraone, S.V., Perlis, R.H., Doyle, A.E., Smoller, J.W., Goralnick, J.J., Holmgren, M.A. & Sklar, P. (2005) Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry 57, 1313-1323.
20. Gartstein, M.A. & Rothbart, M.K. (2003) Studying infant temperament via the Revised Infant Behavior Questionnaire. Infant Behav Dev 26, 64-86.
21. Hayden, E.P., Dougherty, L.R., Maloney, B., Durbin, C.E., Olino, T.M., Nurnberger, J.I. Jr, Lahiri, D.K. & Klein, D.N. (2007) Temperamental fearfulness in childhood and the serotonin transporter promoter region polymorphism: a multimethod association study. Psychiatr Genet 17, 135-142.
22. Heils, A., Teufel, A., Petri, S., Stöber, G., Riederer, P., Bengel, D. & Lesch, K. (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66, 2621-2624.
23. Holmboe, K., Nemoda, Z., Fearon, R.M.P., Csibra, G., Sasvari-Szekely, M. & Johnson, M.H. (2010) Polymorphisms in dopamine system genes are associated with individual differences in attention in infancy. Dev Psychol 46, 404-416.
24. Hu, X.Z., Lipsky, R.H., Zhu, G., Akhtar, L.A., Taubman, J., Greenberg, B.D., Xu, K., Arnold, P.D., Richter, M.A. & Kennedy, J.L. (2006) Serotonin transporter promoter gain-of-function genotypes are linked to obsessive-compulsive disorder. Am J Hum Genet 78, 815-826.
25. Huisman, M. (2000) Imputation of missing item responses: some simple techniques. Qual Quant 34, 331-351.
26. Jorm, A.F., Prior, M., Sanson, A., Smart, D., Zhang, Y. & Easteal, S. (2000) Association of a functional polymorphism of the serotonin transporter gene with anxiety-related temperament and behavior problems in children: a longitudinal study from infancy to the mid-teens. Mol Psychiatry 5, 542-547.
27. Lakatos, K., Nemoda, Z., Birkas, E., Ronai, Z., Kovacs, E., Ney, K., Toth, I., Sasvari-Szekely, M. & Gervai, J. (2003) Association of D4 dopamine receptor gene and serotonin transporter promoter polymorphisms with infants' response to novelty. Mol Psychiatry 8, 90-97.
28. Lasky-Su, J.A., Faraone, S.V., Glatt, S.J. & Tsuang, M.T. (2005) Meta-analysis of the association between two polymorphisms in the serotonin transporter gene and affective disorders. Am J Med Genet 133B, 110-115.
29. Laucht, M., Becker, K. & Schmidt, M.H. (2006) Visual exploratory behaviour in infancy and novelty seeking in adolescence: two developmentally specific phenotypes of DRD4? J Child Psychol Psychiatry 47, 1143-1151.
30. Lin, P.-Y. (2007) Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry 31, 683-689.
31. Munafò, M.R., Durrant, C., Lewis, G. & Flint, J. (2009a) Gene × environment interactions at the serotonin transporter locus. Biol Psychiatry 65, 211-219.
32. Munafò, M.R., Freimer, N.B., Ng, W., Ophoff, R., Veijola, J., Miettunen, J., Järvelin, M.R., Taanila, A. & Flint, J. (2009b) 5-HTTLPR genotype and anxiety-related personality traits: a meta-analysis and new data. Am J Med Genet 150B, 271-281.
33. Nakamura, M., Ueno, S., Sano, A. & Tanabe, H. (2000) The human serotonin transporter gene linked polymorphism (5-HTTLPR) shows ten novel allelic variants. Mol Psychiatry 5, 32-38.
34. Risch, N., Herrell, R., Lehner, T., Liang, K.-Y., Eaves, L., Hoh, J., Griem, A., Kovacs, M., Ott, J. & Merikangas, K.R. (2009) Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA 301, 2462-2471.
35. Ronai, Z., Guttman, A., Nemoda, Z., Staub, M., Kalasz, H. & Sasvari-Szekely, M. (2000) Rapid and sensitive genotyping of dopamine D4 receptor tandem repeats by automated ultrathin-layer gel electrophoresis. Electrophoresis 21, 2058-2061.
36. Schinka, J., Busch, R. & Robichaux-Keene, N. (2004) A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry 9, 197-202.
37. Schmidt, L.A., Fox, N.A., Perez-Edgar, K., Hu, S. & Hamer, D.H. (2001) Association of DRD4 with attention problems in normal childhood development. Psychiatr Genet 11, 25-29.
38. Schmidt, L.A., Fox, N.A. & Hamer, D.H. (2007) Evidence for a gene-gene interaction in predicting children's behavior problems: association of serotonin transporter short and dopamine receptor D4 long genotypes with internalizing and externalizing behaviors in typically developing 7-year-olds. Dev Psychopathol 19, 1105-1116.
39. Uher, R. & McGuffin, P. (2010) The moderation by the serotonin transporter gene of environmental adversity in the etiology of depression: 2009 update. Mol Psychiatry 15, 18-22.
40. Voyiaziakis, E., Evgrafov, O., Li, D. et al. (2011) Association of SLC6A4 variants with obsessive-compulsive disorder in a large multicenter US family study. Mol Psychiatry 16, 108-120.
41. Wendland, J., Moya, P., Kruse, M., Ren-Patterson, R., Jensen, C., Timpano, K. & Murphy, D. (2008) A novel, putative gain-of-function haplotype at SLC6A4 associates with obsessive-compulsive disorder. Hum Mol Genet 17, 717-723.
42. Wendland, J.R., Martin, B.J., Kruse, M.R., Lesch, K.-P. & Murphy, D.L. (2006) Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 11, 224-226.
43. Wendland, J.R., Kruse, M.R., Cromer, K.C. & Murphy, D.L. (2007) A large case-control study of common functional SLC6A4 and BDNF variants in obsessive-compulsive disorder. Neuropsychopharmacology 32, 2543-2551.
44. Zalsman, G., Huang, Y.Y., Oquendo, M.A., Burke, A.K., Hu, X.Z., Brent, D.A., Ellis, S.P., Goldman, D. & Mann, J.J. (2006) Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression. Am J Psychiatry 163, 1588-1593.