Dexamethasone improves maximal exercise capacity of individuals susceptible to high altitude pulmonary edema at 4559m

High Altitude Medicine and Biology

Volumn 12, Issue 2, 2011, Pages 169-177

  Siebenmann, Christoph ^a,b   Bloch, Konrad E ^b,c   Lundby, Carsten ^b   Nussbamer Ochsner, Yvonne ^c   Schoeb, Michèle ^c   Maggiorini, Marco ^c  

^a ETH ZURICH   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

hypoxia; pulmonary circulation; Vo 2max

Indexed keywords

DEXAMETHASONE; PLACEBO;

ADULT; ARTERIAL OXYGEN SATURATION; ARTICLE; BICYCLE ERGOMETRY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; EXERCISE; FEMALE; HEART OUTPUT; HIGH ALTITUDE PULMONARY EDEMA; HUMAN; LUNG CIRCULATION; LUNG DIFFUSION; LUNG EDEMA; MALE; OXYGEN TRANSPORT; PRIORITY JOURNAL;

ADULT; ALTITUDE SICKNESS; BLOOD GAS ANALYSIS; DEXAMETHASONE; DOUBLE-BLIND METHOD; DRUG ADMINISTRATION SCHEDULE; EXERCISE; EXERCISE TEST; FEMALE; GLUCOCORTICOIDS; HUMANS; HYPERTENSION, PULMONARY; MALE; MIDDLE AGED; OXYGEN CONSUMPTION; RESPIRATORY FUNCTION TESTS; TIME FACTORS;

EID: 79959889164     PISSN: 15270297     EISSN: 15578682     Source Type: Journal    
DOI: 10.1089/ham.2010.1075     Document Type: Article

References (39)

1. ACCP. (2003)ATS/ACCP statement on cardiopulmonary exercise testing. Am. J. Respir. Crit. Care Med. 167:211-277.
2. Arlettaz A., Collomp K., Portier H., Lecoq A.M., Pelle A., and de Ceaurriz J. (2006)Effects of acute prednisolone intake during intense submaximal exercise. Int. J. Sports Med. 27:673-679. (Pubitemid 44369563)
3. Arlettaz A., Collomp K., Portier H., Lecoq A.M., Rieth N., Le Panse B., and De Ceaurriz J. (2008a)Effects of acute prednisolone administration on exercise endurance and metabolism. Br. J. Sports Med. 42:250-254; discussion 254. (Pubitemid 351547685)
4. Arlettaz A., Portier H., Lecoq A.M., Labsy Z., de Ceaurriz J., and Collomp K. (2008b)Effects of acute prednisolone intake on substrate utilization during submaximal exercise. Int. J. Sports Med. 29:21-26. (Pubitemid 351183235)
5. Bartsch P., Mairbaurl H., Maggiorini M., and Swenson E.R. (2005)Physiological aspects of high-altitude pulmonary edema. J. Appl. Physiol. 98:1101-1110. (Pubitemid 40283696)
6. Bartsch P., Mairbaurl H., Swenson E.R., and Maggiorini M. (2003)High altitude pulmonary oedema. Swiss Med. Weekly. 133:377-384. (Pubitemid 37087124)
7. Beidleman B.A., Rock P.B., Muza S.R., Fulco C.S., Forte V.A. Jr., and Cymerman A. (1999)Exercise VE and physical performance at altitude are not affected by menstrual cycle phase. J. Appl. Physiol. 86:1519-1526. (Pubitemid 29230294)
8. Calbet J.A., Boushel R., Radegran G., Sondergaard H., Wagner P.D., and Saltin B. (2003)Determinants of maximal oxygen uptake in severe acute hypoxia. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284:R291-R303. (Pubitemid 36120144)
9. 2 delivery during exercise at altitude. High Alt. Med. Biol. 10: 123-134.
10. Cordova Martinez A. (2006)[Glucocorticoids and sport's performance]. Rev. Clin. Esp. 206:382-384.
11. Cremona G., Asnaghi R., Baderna P., Brunetto A., Brutsaert T., Cavallaro C., Clark T.M., Cogo A., Donis R., Lanfranchi P., Luks A., Novello N., Panzetta S., Perini L., Putnam M., Spagnolatti L., Wagner H., and Wagner P.D. (2002)Pulmonary extravascular fluid accumulation in recreational climbers: a prospective study. Lancet. 359:303-309. (Pubitemid 34119294)
12. Duplain H., Vollenweider L., Delabays A., Nicod P., Bartsch P., and Scherrer U. (1999)Augmented sympathetic activation during short-term hypoxia and high-altitude exposure in subjects susceptible to high-altitude pulmonary edema. Circulation. 99:1713-1718. (Pubitemid 29162484)
13. Ellsworth A.J., Meyer E.F., and Larson E.B. (1991)Acetazolamide or dexamethasone use versus placebo to prevent acute mountain sickness on Mount Rainier. West J. Med. 154:289-293.
14. Faoro V., Boldingh S., Moreels M., Martinez S., Lamotte M., Unger P., Brimioulle S., Huez S., and Naeije R. (2009)Bosentan decreases pulmonary vascular resistance and improves exercise capacity in acute hypoxia. Chest. 135:1215-1222.
15. Faoro V., Lamotte M., Deboeck G., Pavelescu A., Huez S., Guenard H., Martinot J.B, and Naeije R. (2007)Effects of sildenafil on exercise capacity in hypoxic normal subjects. High Alt. Med. Biol. 8:155-163. (Pubitemid 47001203)
16. Fischler M., Maggiorini M., Dorschner L., Debrunner J., Bernheim A., Kiencke S., Mairbaurl H., Bloch K.E., Naeije R., and Brunner-La Rocca H.P. (2009)Dexamethasone but not tadalafil improves exercise capacity in adults prone to high-altitude pulmonary edema. Am. J. Respir. Crit. Care Med. 180:346-352.
17. Folkesson H.G., Norlin A., Wang Y., Abedinpour P., and Matthay M.A. (2000)Dexamethasone and thyroid hormone pretreatment upregulate alveolar epithelial fluid clearance in adult rats. J. Appl. Physiol. 88:416-424. (Pubitemid 30097082)
18. Fulco C.S., Rock P.B., and Cymerman A. (1998)Maximal and submaximal exercise performance at altitude. Aviat. Space Environ. Med. 69:793-801. (Pubitemid 28365793)
19. Ghofrani H.A., Reichenberger F., Kohstall M.G., Mrosek E.H., Seeger T., Olschewski H., Seeger W., and Grimminger F. (2004)Sildenafil increased exercise capacity during hypoxia at low altitudes and at Mount Everest base camp: a randomized, double-blind, placebo-controlled crossover trial. Ann. Intern. Med. 141:169-177.
20. Guney S., Schuler A., Ott A., Hoschele S., Zugel S., Baloglu E., Bartsch P., and Mairbaurl H. (2007)Dexamethasone prevents transport inhibition by hypoxia in rat lung and alveolar epithelial cells by stimulating activity and expression of Nap- Kp-ATPase and epithelial Napchannels. Am. J. Physiol. Lung Cell Mol. Physiol. 293:L1332-L1338. (Pubitemid 350159418)
21. Hopkins S.R., Belzberg A.S., Wiggs B.R., and McKenzie D.C. (1996)Pulmonary transit time and diffusion limitation during heavy exercise in athletes. Respir. Physiol. 103:67-73. (Pubitemid 26049036)
22. Hultgren H.N. (1996)High-altitude pulmonary edema: current concepts. Annu. Rev. Med. 47:267-284. (Pubitemid 26138891)
23. Johnson T.S., Rock P.B., Fulco C.S., Trad L.A., Spark R.F., and Maher J.T. (1984)Prevention of acute mountain sickness by dexamethasone. N. Engl. J. Med. 10:683-686. (Pubitemid 14164643)
24. 2 demand at the microcirculatory level. J. Physiol. 586:123-130.
25. Lundby C., Calbet J.A., Sander M., van Hall G., Mazzeo R.S., Stray-Gundersen J., Stager J.M., Chapman R.F., Saltin B., and Levine B.D. (2007)Exercise economy does not change after acclimatization to moderate to very high altitude. Scand. J. Med. Sci. Sports 17:281-291.
26. Lundby C., Moller P., Kanstrup I.L., and Olsen N.V. (2001). Heart rate response to hypoxic exercise: role of dopamine D2- receptors and effect of oxygen supplementation. Clin. Sci. (Lond)101:377-383. (Pubitemid 32929853)
27. Lundby C., Sander M., van Hall G., Saltin B., and Calbet J.A. (2006)Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude natives. J. Physiol. 573:535-547. (Pubitemid 43878566)
28. Maggiorini M., Brunner-La Rocca H.P., Peth S., Fischler M., Bohm T., Bernheim A., Kiencke S., Bloch K.E., Dehnert C., Naeije R., Lehmann T., Bartsch P., and Mairbaurl H. (2006). Both tadalafil and dexamethasone may reduce the incidence of high-altitude pulmonary edema: a randomized trial. Ann. Intern. Med. 145:497-506. (Pubitemid 46780953)
29. Maggiorini M., Muller A., Hofstetter D., Bartsch P., and Oelz O. (1998)Assessment of acute mountain sickness by different score protocols in the Swiss Alps. Aviat. Space Environ. Med. 69:1186-1192. (Pubitemid 28544217)
30. Marquet P., Lac G., Chassain A.P., Habrioux G., and Galen F.X. (1999)Dexamethasone in resting and exercising men. I. effects on bioenergetics, minerals, and related hormones. J. Appl. Physiol. 87:175-182. (Pubitemid 29330678)
31. Noda M., Suzuki S., Tsubochi H., Sugita M., Maeda S., Kobayashi S., Kubo H., and Kondo T. (2003)Single dexamethasone injection increases alveolar fluid clearance in adult rats. Crit. Care Med. 31:1183-1189. (Pubitemid 36444431)
32. 2 saturation during supine exercise in highly trained cyclists. Acta Physiol. Scand. 158:325-331. (Pubitemid 26426962)
33. Podolsky A., Eldridge M.W., Richardson R.S., Knight D.R., Johnson E.C., Hopkins S.R., Johnson D.H., Michimata H., Grassi B., Feiner J., Kurdak S.S., Bickler P.E., Severinghaus J.W., and Wagner P.D. (1996)Exercise-induced VA/Q inequality in subjects with prior high-altitude pulmonary edema. J. Appl. Physiol. 81:922-932. (Pubitemid 26303249)
34. Richalet J.P., Gratadour P., Robach P., Pham I., Dechaux M., Joncquiert-Latarjet A., Mollard P., Brugniaux J., and Cornolo J. (2005)Sildenafil inhibits altitude-induced hypoxemia and pulmonary hypertension. Am. J. Respir. Crit. Care. Med. 171:275-281.
35. Steinacker J.M., Tobias P., Menold E., Reissnecker S., Hohenhaus E., Liu Y., Lehmann M., Bartsch P., and Swenson E.R. (1998)Lung diffusing capacity and exercise in subjects with previous high altitude pulmonary oedema. Eur. Respir. J. 11:643-650. (Pubitemid 28194857)
36. Viru A., and Smirnova T. (1982)Independence of physical working capacity from increased glucocorticoid level during short-term exercises. Int. J. Sports Med. 3:80-83. (Pubitemid 12059840)
37. Vogel J.A., and Harris C.W. (1967)Cardiopulmonary responses of resting man during early exposure to high altitude. J. Appl. Physiol. 22:1124-1128.
38. 2max. Exerc. Sport Sci. Rev. 28:10-14.
39. West J.B., Schoene R.B., and Milledge J.S. (2007)Women at altitude. In: High Altitude Medicine and Physiology, 4th ed. P. Shaw, ed. Hodder Arnold, London; pp. 349-352.