During hypoxic exercise some vasoconstriction is needed to match O2 delivery with O2 demand at the microcirculatory level

Journal of Physiology

Volumn 586, Issue 1, 2008, Pages 123-130

  Lundby, Carsten ^a,b   Boushel, Robert ^c,d   Robach, Paul ^e   Møller, Kirsten ^e   Saltin, Bengt ^a   Calbet, José A L ^a,f  

^a International Center for Research and Research Training in Endocrine Disruption of Male Reproduction and Child Health   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d Civil and Environmental Engineering   (Canada)

^e Ecole Nationale de Ski et d'Alpinisme   (France)

^f UNIVERSITY OF LAS PALMAS DE GRAN CANARIA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; HEMOGLOBIN;

ADULT; ALTITUDE ACCLIMATIZATION; ARTERIAL OXYGEN TENSION; ARTERY BLOOD FLOW; ARTICLE; CONTROLLED STUDY; EXERCISE; FEMORAL ARTERY; FEMORAL VEIN; HEART OUTPUT; HUMAN; HUMAN EXPERIMENT; HYPOXIA; MALE; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; NORMAL HUMAN; OXYGEN CONSUMPTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; SEA LEVEL; SYMPATHETIC TONE; VASOCONSTRICTION; VASODILATATION; VEIN BLOOD FLOW; VENOUS OXYGEN TENSION; ALTITUDE; ARTERIAL OXYGEN EXTRACTION FRACTION; BLOOD VESSEL PARAMETERS; BREATHING; CARDIOVASCULAR RESPONSE; HEART RATE; HEMOGLOBIN BLOOD LEVEL; LEG ARTERIOVENOUS OXYGEN DIFFERENCE; LEG BLOOD FLOW; LEG VASCULAR CONDUCTANCE; LUNG GAS EXCHANGE; METABOLISM; OXYGEN DELIVERY; VENOUS OXYGEN CONTENT;

ADENOSINE TRIPHOSPHATE; ADULT; ANOXIA; BLOOD PRESSURE; CARDIAC OUTPUT; CARDIOVASCULAR PHYSIOLOGY; EXERCISE; FEMORAL ARTERY; HUMANS; MALE; MICROCIRCULATION; OXYGEN; OXYGEN CONSUMPTION; PULMONARY GAS EXCHANGE; PULMONARY VENTILATION; VASOCONSTRICTION; VASODILATOR AGENTS;

EID: 37749006648     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.146035     Document Type: Article

References (40)

1. Amann M, Eldridge MW, Lovering AT, Stickland MK, Pegelow DF & Dempsey JA (2006). Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans. J Physiol 575, 937-952.
2. Amann M, Romer LM, Subudhi AW, Pegelow DF & Dempsey JA (2007). Severity of arterial hypoxaemia affects the relative contributions of peripheral muscle fatigue to exercise performance in healthy humans. J Physiol 581, 389-403.
3. Andersen P & Saltin B (1985). Maximal perfusion of skeletal muscle in man. J Physiol 366, 233-249.
4. Boushel R, Calbet JAL, Radegran G, Sondergaard H, Wagner PD & Saltin B (2001). Parasympathetic neural activity accounts for the lowering of exercise heart rate at high altitude. Circulation 104, 1785-1791.
5. Calbet JAL (2003). Chronic hypoxia increases blood pressure and noradrenaline spillover in healthy humans. J Physiol 551, 379-386.
6. Calbet JAL (2006). The rate of fatigue accumulation as a sensed variable. J Physiol 575, 688-689.
7. Calbet JAL, Boushel R, Radegran G, Sondergaard H, Wagner PD & Saltin B (2003a). Determinants of maximal oxygen uptake in severe acute hypoxia. Am J Physiol Regul Integr Comp Physiol 284, R291-R303.
8. 2 content? Am J Physiol Regul Integr Comp Physiol 284, R304-R316.
9. Calbet JAL, Jensen-Urstad M, van Hall G, Holmberg HC, Rosdahl H & Saltin B (2004a). Maximal muscular vascular conductances during whole body upright exercise in humans. J Physiol 558, 319-331.
10. 2 extraction during maximal exercise in humans. Am J Physiol Regul Integr Comp Physiol 291, R447-R453.
11. Calbet JAL, Radegran G, Boushel R, Sondergaard H, Saltin B & Wagner PD (2002). Effect of blood haemoglobin concentration on and cardiovascular function in lowlanders acclimatised to 5260 m. J Physiol 545, 715-728.
12. 2 max in lowlanders acclimatized to altitude. Am J Physiol Heart Circ Physiol 287, H1214-H1224.
13. Converse RL, Jacobsen TN, Toto RD, Jost CM, Cosentino F, Fouad-Tarazi F & Victor RG (1992). Sympathetic overactivity in patients with chronic renal failure. N Engl J Med 327, 1912-1918.
14. Dill DB, Myhre LG, Philips EE & Brown DK (1966). Work capacity in acute exposure to altitude. J Appl Physiol 21, 1168-1176.
15. Ekblom B & Berglund B (1991). Effect of erythropoietin administration on maximal aerobic power. Scand J Med Sci Sports 1, 88-93.
16. Gonzalez-Alonso J, Olsen DB & Saltin B (2002). Erythrocyte and the regulation of human skeletal muscle blood flow and oxygen delivery: Role of circulating ATP. Circ Res 91, 1046-1055.
17. Hansen J & Sander M (2003). Sympathetic neural overactivity in healthy humans after prolonged exposure to hypobaric hypoxia. J Physiol 546, 921-929.
18. Heindl S, Lehnert M, Criee CP, Hasenfuss G & Andreas S (2001). Marked sympathetic activation in patients with chronic respiratory failure. Am J Respir Crit Care Med 164, 597-601.
19. Hill AV, Long CNH & Lupton H (1924). Muscular exercise, lactic acid and the supply and utilization of oxygen. Proc R Soc Lond B Biol Sci 155-176.
20. Kardos A, Taylor DJ, Thompson C, Styles P, Hands L, Collin J & Casadei B (2000). Sympathetic denervation of the upper limb improves forearm exercise performance and skeletal muscle bioenergetics. Circulation 101, 2716-2720.
21. Kayser B (2003). Exercise starts and ends in the brain. Eur J Appl Physiol 90, 411-419.
22. Kjaer M, Hanel B, Worm L, Perko G, Lewis SF, Sahlin K, Galbo H & Secher NH (1999). Cardiovascular and neuroendocrine responses to exercise in hypoxia during impaired neural feedback from muscle. Am J Physiol Regul Integr Comp Physiol 277, R76-R85.
23. Lang CC, Rayos GH, Chomsky DB, Wood AJJ & Wilson JR (1997). Effect of sympathoinhibition on exercise performance in patients with heart failure. Circulation 96, 238-245.
24. Lundby C, Calbet JAL, van Hall G, Saltin B & Sander M (2004). Pulmonary gas exchange at maximal exercise in Danish lowlanders during 8 wk of acclimatization to 4,100 m and in high-altitude Aymara natives. Am J Physiol Regul Integr Comp Physiol 287, R1202-R1208.
25. Lundby C & Damsgaard R (2006). Exercise performance in hypoxia after novel erythropoiesis stimulating protein treatment. Scand J Med Sports 16, 35-40.
26. Lundby C, Sander M, van Hall G, Saltin B & Calbet JAL (2006). Maximal exercise and muscle oxygen extraction in acclimatizing lowlanders and high altitude natives. J Physiol 573, 535-547.
27. Mazzeo RS, Brooks GA, Butterfield GE, Cymerman A, Roberts AC, Selland M, Wolfel EE & Reeves JT (1994). b-Adrenergic blockade does not prevent the lactate response to exercise after acclimatization to high altitude. J Appl Physiol 76, 610-615.
28. Mazzeo RS, Dubay A, Kirsch J, Braun B, Butterfield GE, Rock PB, Wolfel EE, Zamudio S & Moore LG (2003). Influence of α-adrenergic blockade on the catecholamine response to exercise at 4,300 meters. Metabolism 52, 1471-1477.
29. 2 on maximal oxygen uptake. Acta Physiol Scand 164, 89-87.
30. Notarius CF, Ando S, Rongen GA & Floras JS (1999). Resting muscle sympathetic nerve activity and peak oxygen uptake in heart failure and normal subjects. Eur Heart J 20, 880-887.
31. Perneger TV (1998). What's wrong with Bonferroni adjustments. BMJ 316, 1236-1238.
32. Ralevic V & Burnstock G (1998). Receptors for purines and pyrimidines. Pharmacol Rev 50, 413-492.
33. Rosenmeier JB, Hansen J & Gonzalez-Alonso J (2004). Circulating ATP-induced vasodilatation overrides sympathetic vasoconstrictor activity in human skeletal muscle. J Physiol 558, 351-365.
34. Schuler B, Thomsen JJ, Gassmann M & Lundby C (2007). Timing the arrival at 2340 m altitude for aerobic performance. Scand J Med Sci Sports 17, 588-594.
35. Segal SS (2005). Regulation of blood flow in the microcirculation. Microcirculation 12, 33-45.
36. Sevre K, Bendz B, Hanko E, Nakstad AR, Hauge A, Kasin JI, Lefrandt JD, Smit AJ, Eide I & Rostrup M (2001). Reduced autonomic activity during stepwise exposure to high altitude. Acta Physiol Scand 173, 409-417.
37. Stenberg J, Ekblom B & Messin R (1966). Hemodynamic response to work at simulated altitude, 4,000 m. J Appl Physiol 21, 1589-1594.
38. Strandell T & Shepherd JT (1967). The effect in humans of increased sympathetic activity on the blood flow to active muscles. Acta Med Scand Suppl 472, 146-167.
39. van Hall G, Sander M, Calbet LAJ, Lundby C, Araoz M & Satin B (2003). Regulation of glycogenolysis during exercise at 4100 m in high altitude natives and low landers in the course of acclimatisation. Fases Jounal 17 (5), A1284-A1284.
40. 2 max at high altitude. J Appl Physiol 81, 252-259.