Effects of acute prednisolone intake on substrate utilization during submaximal exercise

International Journal of Sports Medicine

Volumn 29, Issue 1, 2008, Pages 21-26

  Arlettaz, Alexandre ^a   Portier, H ^a   Lecoq, A M ^a,b   Labsy, Z ^c   De Ceaurriz, J ^d   Collomp, K ^a,d  

^a UNIVERSITÉ D'ORLÉANS   (France)

^b CENTRE HOSPITALIER RÉGIONAL D ORLÉANS   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d LNDD   (France)

Author keywords

Acute intake; Energy expenditure; Fat oxidation; Glucocorticoid; Hormones

Indexed keywords

CARBOHYDRATE; CORTICOTROPIN; FAT; GLUCOCORTICOID; GLUCOSE; INSULIN; INTERLEUKIN 6; LACTIC ACID; PREDNISOLONE;

ADULT; ANALYTIC METHOD; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; ENERGY EXPENDITURE; ENERGY YIELD; EXERCISE; HUMAN; MALE; NORMAL HUMAN; OXIDATION; RESPIRATORY FUNCTION; TRAINING;

ADRENOCORTICOTROPIC HORMONE; ADULT; BLOOD GLUCOSE; CARBOHYDRATE METABOLISM; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; ENERGY METABOLISM; EXERCISE; FATS; GLUCOCORTICOIDS; GROWTH HORMONE; HUMANS; INSULIN; INTERLEUKIN-6; LACTIC ACID; MALE; MIDDLE AGED; OXIDATION-REDUCTION; PREDNISOLONE;

EID: 38749115089     PISSN: 01724622     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2007-964994     Document Type: Article

References (33)

1. Arlettaz A, Collomp K, Portier H, Lecoq AM, Pellé A, De Ceaurriz J. Effect of acute prednisolone intake during intense submaximal exercise. Int J Sport Med 2006; 27: 673-679
2. Bauer A, Tronche F, Wessely O, Kellendonk C, Reichardt HM, Steinlein P, Schutz G, Beug H. The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev 1999; 13: 2996-3002
3. Brillon DH, Zheng B, Campbell RG, Matthews DE. Effect of Cortisol on energy expenditure and amino acid metabolism in humans. Am J Physiol 1995; 268: E501-E513
4. Carballo-Jane E, Pandit S, Santoro JC, Freund C, Harris G, Forrest MJ, Sitlani A. Skeletal muscle: a dual system to measure glucocorticoid- dependent transactivation and transrepression of gene regulation. J Steroid Biochem Mol Biol 2004; 88: 191-201
5. Carter SL, Rennie C, Tarnopolsky MA. Substrate utilization during endurance exercise in men and women after endurance training. Am J Physiol 2001; 280: E898-E907
6. Casanueva FF, Burguera B, Muruais C, Dieguez C. Acute administration of corticoids: a new and peculiar stimulus of growth hormone secretion in man. J Clin Endocrinol Metab 1990; 70: 234-237
7. Del Corral P, Howley ET, Hartsell M, Ashraf M, Younger MS. Metabolic effects of low Cortisol during exercise in humans. J Appl Physiol 1998; 84: 939-947
8. Deuster PA, Chrousos GP, Luger A, DeBolt JE, Bernier LL, Trostmann UH, Kyle SB, Montgomery LC, Loriaux DL. Hormonal and metabolic responses of untrained, moderately trained and highly trained men to three exercise intensities. Metabolism 1989; 38: 141-148
9. Deuster PA, Petrides JS, Singh A, Lucci EB, Chrousos GP, Gold PW. High intensity exercise promotes escape of adrenocorticotropin and Cortisol from suppression by dexamethasone : sexually dimporphic responses. J Clin Endocrinol Metab 1998; 83: 3332-3338
10. El-Khoury AE, Forslund A, Olsson R, Branth S, Sjodin A, Andersson A, Atkinson A, Selvaraj A, Hambraeus L, Young VR. Moderate exercise at energy balance does not affect 24-h leucine oxidation or nitrogen retention in healthy men. Am J Physiol 1997; 273: E394-E407
11. 2 uptake, and endurance. J Appl Physiol 1988; 64: 1098-1106
12. Green HJ, Jones S, Ball-Burnett M, Farrance B, Ranney D. Adaptations in muscle metabolism to prolonged voluntary exercise and training. J Appl Physiol 1995; 78: 138-145
13. Holloszy JO, Kohrt WM, Hansen PA. The regulation of carbohydrate and fat metabolism during and after exercise. Front Biosci 1998; 3: D1011-D1027
14. Knapik J, Meredith C, Jones B, Fielding R, Young VR, Evans W. Leucine metabolism during fasting and exercise. J Appl Physiol 1991; 70: 43-47
15. McKenzie S, Phillips SM, Carter SL, Lowther S, Gibala MJ, Tarnopolsky MA. Endurance exercise training attenuates leucine oxidation and BCOAD activation during exercise in humans. Am J Physiol 2000; 278: E580-E587
16. Malarkey WB, Lipkus IM, Cacioppo JT. The dissociation of catecholamine and hypothalamic-pituitary-adrenal responses to daily stressors using dexamethasone. J Clin Endocrinol Metab 1995; 80: 2458-2463
17. Marquet P, Lac G, Chassain AP, Habrioux G, Galen FX. Dexamethasone in resting and exercising men. I. Effects on bioenergetics, minerals, and related hormones. J Appl Physiol 1999; 87: 175-182
18. McMahon M, Gerich J, Rizza R. Effects of glucocorticoids on carbohydrate metabolism. Diabetes Metab Rev 1988; 4: 17-30
19. Papanicolaou DA, Petrides JS, Tsigos C, Bina S, Kalogeras KT, Wilder R, Gold PW, Deuster PA, Chrousos GP. Exercise stimulates interleukin-6 secretion: inhibition by glucocorticoids and correlation with catecholamines. Am J Physiol 1996; 271: E601-E605
20. Pedersen B, Steensberg A, Schjerling P. Muscle-derived interleukin-6: possible biological effects. J Physiol 2001; 536: 329-337
21. Perronet F, Massicotte D. Table of nonprotein respiratory quotient: an update. Can J Sport Sci 1991; 16: 23-29
22. Petrides JS, Gold PW, Mueller GP, Singh A, Stratakis C, Chrousos GP, Deuster PA. Marked differences in functionning of the hypothalamic- pituitary-adrenal axis between groups of men. J Appl Physiol 1997; 82: 1979-1988
23. Phillips SM, Green HJ, Tarnopolsky MA, Heigenhauser GF, Hill RE, Grant SM. Effects of training duration on substrate turnover and oxidation during exercise. J Appl Physiol 1996; 81: 2182-2191
24. Phillips SM, Atkinson SA, Tarnopolsky MA, MacDougall JD. Gender differences in leucine kinetics and nitrogen balance in endurance athletes. J Appl Physiol 1993; 75: 2134-2141
25. Qi D, Pulinilkunnil T, An D, Ghosh S, Abraham A, Pospisilik JA, Brownsey R, Wambolt R, Allard M, Rodrigues B. Single-dose dexamethasone induces whole-body insulin resistance and alters both cardiac fatty acid and carbohydrate metabolism. Diabetes 2004; 53: 1790-1797
26. Rennie MJ, Edwards RH, Krywawych S, Davies CT. Effect of exercise on protein turnover in man. Clin Sci 1981; 61: 627-639
27. Swinburn CR, Wakefield JM, Newman SP, Jones PW. Evidence of prednisolone induces mood change ('steroid euphoria') in patients with chronic obstructive airways disease. Br J Clin Pharmacol 1988; 26: 709-713
28. Tarnopolsky MA. Gender differences in substrate metabolism during endurance exercise. Can J Appl Physiol 2000; 25: 312-327
29. Tataranni P, Larson D, Snitker S, Young J, Flatt J, Ravussin E. Effects of glucocorticoids on energy metabolism and food intake in humans. Am J Physiol 1996; 271: E317-E325
30. Thakore GD, Dinan TH. Subnormal growth hormone responses to acutely administered dexamethasone in depression. Clin Endocrinol 1994; 40: 623-627
31. Viru A, Litvinova L, Viru M, Smirnova T. Glucocorticoids in metabolic control during exercise: alanine metabolism. J Appl Physiol 1994; 76: 801-805
32. Yasuda K, Kitabchi AE. Decreased insulin binding of human erythrocytes after dexamethasone or prednisone ingestion. Diabetes 1980; 29: 811-814
33. [no authors listed]. WADA list of doping classes and methods. World Anti-Doping Agency, 2006