Oxidative stress in the brain following intraventricular administration of ethylcholine aziridinium (AF64A)

Brain Research

Volumn 726, Issue 1-2, 1996, Pages 174-180

  Gulyaeva, N V ^a   Lazareva, N A ^a   Libe, M L ^a   Mitrokhina, O S ^a   Onufriev, M V ^a   Stepanichev, M Yu ^a   Chernysevskaya, I A ^a   Walsh, T J ^b  

^a INSTITUTE OF HIGHER NERVOUS ACTIVITY AND NEUROPHYSIOLOGY   (Russian Federation)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

AF64A; Cholinergic degeneration; Oxidative stress; Oxygen free radical

Indexed keywords

ACETYLCHOLINESTERASE; ALPHA TOCOPHEROL; ASCORBIC ACID; CHOLINE; CHOLINE ACETYLTRANSFERASE; CHOLINE DERIVATIVE; ETHYLCHOLINE MUSTARD AZIRIDINIUM; FREE RADICAL; HYDROGEN PEROXIDE; IRON; LUMINOL; SUPEROXIDE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL TISSUE; ARTICLE; BRAIN; CHEMOLUMINESCENCE; CONTROLLED STUDY; ENZYME ACTIVITY; HISTOCHEMISTRY; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; SPECTROPHOTOMETRY;

EID: 0030575315     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(96)00330-7     Document Type: Article

References (34)

1. [1] Andra, J., Lachmann, J. and Luppa, H., A comparison of the localization of acetylcholinesterae in the brain as demonstrated by enzyme histochemistry and immunocytochemistry, Histochemistry, 88 (1988) 595-601.
2. [2] Barlow, P. and Marchbanks, R.M., Effect of ethylcholine mustard on choline dehydrogenase and other enzymes of choline metabolism, J. Neurochem., 43 (1984) 1568-1573.
3. [3] Betts, W.H., Detection of radicals by chemiluminescence. In R.A. Greenwald (Ed.), CRC Handbook of Methods for Oxygen Radical Research, CRC Press, Boca Raton, FL, 1987, pp. 197-201.
4. [4] Bondy, S.C., Reactive oxygen species: relation to aging and neurotoxic damage, Neurotoxicology, 13 (1992) 87-100.
5. [5] Bradford M.M., A rapid and sensitive method for the quantitation of microgram quantities of protein using the principle of protein binding, Anal. Biochem., 72 (1976), 248-254.
6. [6] Burt A.M. and Silver A., Histochemistry of choline acetyl transferase: a critical analysis, Brain Res., 62 (1973) 509-516.
7. [7] Chrobak, J.J., Hanin, I., Schmechel, D.E. and Walsh, T.J., AF64A-induced working memory impairment: behavioral, neurochemical and histological correlates, Brain Res., 463 (1988) 107-117.
8. [8] Chrobak J.J., Spates M.J., Stackman R.W. and Walsh, T.J., Hemicholinium-3 prevents the working memory impairments and the cholinergic hypofunction induced by ethylcholine aziridinium ion (AF64A), Brain Res., (1989) 269-275.
9. [9] El Tamer A., Corey, J., Wulfert, E. and Hanin I., Reversible cholinergic changes induced by AF64A in rat hippocampus and possible septal compensatory effect, Neuropharmacology, 31 (1992) 397-402.
10. [10] Emerich, D.F. and Walsh, T.J., Ganglioside AGF2 promotes task-specific recovery and attenuates the cholinergic hypofunction induced by AF64A, Brain Res., 572 (1990) 299-307.
11. [11] Emerich, D.F., Black, B.A., Kesslak, J.P., Cotman, C.W. and Walsh, T.J., Transplantation of fetal cholinergic neurons into the hippocampus attenuates the cognitive and neurochemical deficits induced by AF64A, Brain Res. Bull., 28 (1992) 219-226.
12. [12] Ermakova, I.V., Loseva, E.V. and Gulyaeva, N.V., Behavioral, morphologic and biochemical correlates of the early effect of a neural transplant into the damaged brain of adult rats, Zh. Vyssh. Nerv. Deiat., 38 (1988) 922-930 (Published in Russian).
13. [13] Fariello, R.G., Ghilardi, O., Peschechera, A., Amacci, M.T. and Angelucci, L., Regional distribution of ubiquinones and tocopherols in the mouse brain, Neuropharmacology, 21 (1988) 1077-1080.
14. [14] Gotz, M.E., Kunig, G., Riederer, P. and Youdim, M.B., Oxidative stress: free radical production in neural degeneration, Pharmacol. Ther., 63 (1994) 37-122.
15. [15] Gulyaeva, N.V., Levshina, I.P. and Obidin, A.B., Indices of free-radical oxidation of lipids and antiradical protection of the brain -neurochemical correlates of development of the general adaptation syndrome, Neurosci. Behav. Physiol., 19 (1989) 376-82.
16. [16] Gulyaeva, N.V., Onufriev, M.V. and Stepanichev, M.Yu., NO synthase and free radical generation in brain regions of old rats: correlations with individual behaviour, Neuroreport, 6 (1994) 94-96.
17. [17] Gulyaeva N.V., Bikbulatova L.S., Obidin A.B., Airapetyanz M.G. and Kruglikov R.I., Neuropeptide administration induces a long-lasting decrease of lipid peroxidation in rat brain, Neurochemistry (Nejrokhimja), 8 (1989) 95-100.
18. [18] Gulyaeva N., Ermakova, I.V., Kurbatova, M.B., Loseva E.V., Lushchekina E.A., Obidin A.B. and Khonicheva, N.M., Lipid peroxidation decrease induced by the damage of amygdala and transplantation of embryonic brain tissue into the damaged area, Neurochemistry (Nejrokhimija), 8 (1990) 95-100.
19. [19] Hanin, I., Fisher, A., Hortnagl, H., Leventer, S., Potter, P.E. and Walsh, T.J., Ethylcholine aziridinium (AF64A; ECMA) and other potential cholinergic neuron-specific neurotoxins. In H.Y. Meltzer (Ed.), Psychopharmacology: The Third Generation of Progress, Raven Press, New York, 1987, pp. 341-349.
20. [20] Jeandel, C., Nicolas, M.B., Dubois, F., Nabet-Belleville, F., Penin, F. and Cuny, G. Lipid peroxidation and free radical scavengers in Alzheimer's disease, Gerontology, 35, 1989 275-282.
21. [21] Johnson, G.V.W., Simonato, M. and Jope, R.S., Dose-and time-dependent hippocampal cholinergic lesions induced by ethylcholine mustard aziridinium ion: effects of nerve growth factor, GM1 ganglioside, and Vitamin E, Neurochem. Res., 13 (1988) 685-692.
22. [22] Kagan, V.E., Prilipko, L.L., Savov, V.M., Pisarev, V.A., Eluashvili, I.A. and Kozlov, Yu.P., Participation of free active forms of oxygen in enzymatic peroxidation of lipids in biomembranes, Biochemistry (Biokhimija), 44 (1979) 379-385.
23. [23] Khonicheva, N.M., Lushchekina, E.A., Kurbatyova, M.B., Gulyaeva, N.V. and Obidin, A.B., Can the function of the extirpated amygdaloid complex be compensated for by the transplantation of embryonic nerve tissue?, Zh. Vyssh. Nerv. Deiat., 39 (1989) 869-76 (Published in Russian).
24. [24] Leventer, S.M., Wulfert, E. and Hanin, I., Time course of ethylcholine mustard aziridinium ion (AF64A)-induced cholinotoxicity in vivo, Neuropharmacology, 26 (1987) 351-356.
25. [25] Lorens, S.K., Kindel, G, Dong, X.W., Lee, J.M. and Hanin, I., Septal choline acetyltransferase immunoreactive neurons: dose-dependent effects of AF64A, Brain Res. Bull., 26 (1991) 965-971.
26. [26] Motavkin, P.A. and Okhotion, V.E., Histochemical evaluation of neurons with cholinergic synaptic transmission, Bull. Exp. Biol. Med., 94 (1982), 89-90.
27. [27] Nishikimi, M., Rao, N.A, and Yagi, K., The occurrence of superoxide anion in the reaction of reduced phenasine methosulfate and molecular oxygen, Biochem. Biophys. Res. Commun., 46 (1972) 849-855.
28. [28] Ravindranath, V., Shivakumar, B.R. and Anandatheerthavarada, H.K., Low glutathione levels in brain regions of aged rats, Neurosci. Lett., 101 (1989) 187-190.
29. [29] Sandberg, K., Schnaar, R.L., McKinney, M., Hanin, I., Fisher, A. and Coyle, J.T., AF64A: an active site directed irreversible inhibitor of choline acetyltransferase, J. Neurochem., 44 (1985) 439-445.
30. [30] Subbarao, K.V., Richardson, J.S. and Ang, L.C., Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro, J. Neurochem., 55 (1990) 342-345.
31. [31] Tyurin, V.A., Tyurina, Y.Yu. and Avrova, N.F., Ganglioside dependent factor, inhibiting lipid peroxidation in rat brain synaptosomes, Neurochem. Int., 20 (1992) 401-407.
32. [32] Tjurin, V.A., Bagrov, AIa., Fedorova, O.V., Zhabko, E.P., Tiurina IuIu, Avrova, N.F., Das, D.K. and Kagan, V.E., Ganglioside protection of the erythrocyte membranes in myocardial ischemia, Biull. Eksp. Biol. Med., 114 (1992) 366-368.
33. [33] Walsh, T.J. and Opello, K.D. The use of AF64A to model Alzheimer's disease. In M. Woodruff and A. Nonneman (Eds.), Animal Models of Toxin-Induced Neurological Disorders, Plenum Press, New York, 1994, pp. 259-279.
34. [34] Wortwein, G., Stackman, R.W. and Walsh, T.J., Vitamin E prevents the place learning deficit and the cholinergic hypofunction induced by AF64A, Exp. Neurol., 125 (1994) 15-21.