Serotonin transporter genotype moderates the link between children's reports of overprotective parenting and their behavioral inhibition

Journal of Abnormal Child Psychology

Volumn 39, Issue 6, 2011, Pages 783-790

  Burkhouse, Katie L ^a   Gibb, Brandon E ^a   Coles, Meredith E ^a   Knopik, Valerie S ^b,c   McGeary, John E ^b,c,d  

^a BINGHAMTON UNIVERSITY   (United States)

^b RHODE ISLAND HOSPITAL   (United States)

^c BROWN UNIVERSITY   (United States)

^d PROVIDENCE VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

5 HTTLPR; Behavioral inhibition; G E; Parenting

Indexed keywords

SEROTONIN TRANSPORTER;

ALLELE; ARTICLE; CHILD; CHILD PARENT RELATION; FEMALE; GENETICS; GENOTYPE; HUMAN; INHIBITION (PSYCHOLOGY); MAJOR DEPRESSION; MALE; MOTHER CHILD RELATION; PSYCHOLOGICAL ASPECT;

ALLELES; CHILD; DEPRESSIVE DISORDER, MAJOR; FEMALE; GENOTYPE; HUMANS; INHIBITION (PSYCHOLOGY); MALE; MOTHER-CHILD RELATIONS; PARENTING; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS;

EID: 79959851874     PISSN: 00910627     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10802-011-9526-2     Document Type: Article

References (67)

1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: Author.
2. Angold, A. (1989). Structured assessments of psychopathology in children and adolescents. Chichester: Wiley.
3. AT Beck N Epstein G Brown RA Steer 1988 An inventory for measuring clinical anxiety: psychometric properties Journal of Consulting and Clinical Psychology 56 893 897 3204199 10.1037/0022-006X.56.6.893 (Pubitemid 19008360)
4. Beck, A. T.; Steer, R. A.; & Brown, G. K. (1996). Beck depression inventory manual (2nd ed.). San Antonio: Psychological Corporation.
5. K Beesdo DS Pine R Lieb H Wittchen 2010 Incidence and risk patterns of anxiety and depressive disorders and categorization of generalized anxiety disorder Archives of General Psychiatry 67 47 57 20048222 10.1001/ archgenpsychiatry.2009.177
6. J Biederman JF Rosenbaum DR Hirshfeld SV Faraone EA Bolduc M Gersten, et al. 1990 Psychiatric correlates of behavioral inhibition in young children of parents with and without psychiatric disorders Archives of General Psychiatry 47 21 26 2294852 (Pubitemid 20025542)
7. J Biederman JF Rosenbaum EA Bolduc-Murphy SV Faraone J Chaloff DR Hirshfeld 1993 A 3-year follow-up of children with and without behavioral inhibition Journal of the American Academy of Child & Adolescent Psychiatry 32 814 821 10.1097/00004583-199307000-00016 (Pubitemid 23187781)
8. J Biederman DR Hirshfeld-Becker JF Rosenbaum C Herot D Friedman N Snidman 2001 Further evidence of association between behavioral inhibition and social anxiety in children American Journal of Psychiatry 158 1673 1679 11579001 10.1176/appi.ajp.158.10.1673 (Pubitemid 32923661)
9. S Bogels V Phares 2008 Fathers' role in the etiology, prevention and treatment of child anxiety: a review and new model Clinical Psychology Review 28 539 558 17854963 10.1016/j.cpr.2007.07.011 (Pubitemid 351374600)
10. A Caspi TE Moffitt DL Newman PA Silva 1996 Behavioral observations at age 3 years predict adult psychiatric disorders Archives of General Psychiatry 53 1033 1039 8911226
11. A Caspi AR Hariri A Holmes R Uher TE Moffitt 2010 Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits American Journal of Psychiatry 167 509 527 20231323 10.1176/appi.ajp.2010.09101452
12. ME Coles CA Schofield AS Pietrefesa 2006 Behavioral inhibition and obsessive-compulsive disorder Journal of Anxiety Disorders 20 1118 1132 16621440 10.1016/j.janxdis.2006.03.003 (Pubitemid 44667386)
13. M Creamer J Foran R Bell 1995 The Beck Anxiety Inventory in a non-clinical sample Behaviour Research and Therapy 33 477 485 7755538 10.1016/0005-7967(94)00082-U
14. A De Los Reyes AE Kazdin 2005 Informant discrepancies in the assessment of childhood psychopathology: a critical review, theoretical framework, and recommendations for further study Psychological Bulletin 131 483 509 16060799 10.1037/0033-2909.131.4.483 (Pubitemid 41168493)
15. L DiLalla J Kagan J Reznick 1994 Genetic etiology of behavioral inhibition among 2-year-old children Infant Behavior and Development 17 405 412 10.1016/0163-6383(94)90032-9
16. C Edelbrock AJ Costello MK Dulcan NC Conover R Kala 1986 Parent-child agreement on child psychiatric symptoms assessed via structured interview Journal of Child Psychology and Psychiatry 27 2 181 190 3958075 (Pubitemid 16142065)
17. J Endicott RL Spitzer 1978 A diagnostic interview: the schedule for affective disorders and schizophrenia Archives of General Psychiatry 35 837 844 678037 (Pubitemid 9076798)
18. NA Fox KE Nichols HA Henderson K Rubin L Schmidt D Hamer 2005 Evidence for a gene-environment interaction in predicting behavioral inhibition in middle childhood Psychological Science 16 921 926 16313653 10.1111/j.1467-9280.2005. 01637.x (Pubitemid 43060251)
19. B Freeman J Powell D Ball L Hill I Craig R Plomin 1997 DNA by mail: an inexpensive and noninvasive method for collecting DNA samples from widely dispersed populations Behavior Genetics 27 251 257 9210796 10.1023/A: 1025614231190 (Pubitemid 27278642)
20. C Garcia-Coll J Kagan JS Reznick 1984 Behavioral inhibition in young children Child Development 55 1005 1019 10.2307/1130152
21. NK Gaylord KM Kitzmann JK Coleman 2003 Parents' and children's perceptions of parental behavior: associations with children's psychosocial adjustment in the classroom Parenting: Science and Practice 3 23 47
22. BE Gibb DJ Urhlass M Grassia JS Benas J McGeary 2009 Children's inferential styles, 5-HTTLPR genotype, and maternal expressed emotion-criticism: an integrated model for the intergenerational transmission of depression Journal of Abnormal Psychology 118 734 745 19899843 10.1037/a0016765
23. GL Gladstone GB Parker PB Mitchell KA Wilhelm GS Mali 2005 Relationship between self-reported childhood behavioral inhibition and lifetime anxiety disorders in a clinical sample Depression and Anxiety 22 103 113 16149043 10.1002/da.20082 (Pubitemid 41642287)
24. IH Gotlib J Joormann KL Minor J Hallmayer 2008 HPA axis reactivity: a mechanism underlying the associations among 5-HTTLPR, stress, and depression Biological Psychiatry 63 847 851 18005940 10.1016/j.biopsych.2007.10.008 (Pubitemid 351458452)
25. SW Guo EA Thompson 1992 Performing the exact test of Hardy-Weinberg proportion for multiple alleles Biometrics 48 361 372 1637966 10.2307/2532296
26. C Hayward JD Killen HC Kraemer CB Taylor 1998 Linking self-reported childhood behavioral inhibition to adolescent social phobia Journal of the American Academy of Child & Adolescent Psychiatry 37 1308 1316 10.1097/00004583-199812000-00015 (Pubitemid 28550724)
27. DR Hirshfeld-Becker J Biederman A Henin SV Faraone S Davis K Harrington 2007 Behavioral inhibition in preschool children at risk is a specific predictor of middle childhood social anxiety: a five year follow-up Journal of Developmental and Behavioral Pediatrics 28 225 233 17565290 10.1097/01.DBP. 0000268559.34463.d0 (Pubitemid 46944233)
28. DR Hirshfeld-Becker J Micco A Henin A Bloomfield J Biederman J Rosenbaum 2008 Behavioral inhibition Depression and Anxiety 25 357 367 18412062 10.1002/da.20490 (Pubitemid 351614570)
29. DR Hirshfeld-Becker B Masek A Henin LR Blakely RA Pollock-Wurman J McQuade, et al. 2010 Journal of Consulting and Clinical Psychology 48 498 510 10.1037/a0019055
30. X Hu G Oroszi J Chun TL Smith D Goldman MA Schuckit 2005 An expanded evaluation of the relationship of four alleles to the level of response to alcohol and the alcoholism risk Alcoholism: Clinical and Experimental Research 29 8 16 10.1097/01.ALC.0000150008.68473.62 (Pubitemid 40129206)
31. SR Jaffee TE Moffitt A Caspi E Fombonne R Poulton J Martin 2002 Differences in early childhood risk factors for juvenile-onset and adult-onset depression Archives of General Psychiatry 58 215 222 10.1001/archpsyc.59.3.215 (Pubitemid 34212497)
32. J Kagan JS Reznick C Clarke N Snidman C Garcia-Coll 1984 Behavioral inhibition to the unfamiliar Child Development 55 2212 2225 10.2307/1129793
33. Kagan, J.; Snidman, N.; Arcus, D.; & Reznick, J. S. (1994). Galen's prophecy: temperament in human nature. New York: Basic Books.
34. K Karg M Burmeister K Shedden S Sen 2011 The serotonin transporter promoter variant (5-HTTLPR), stress, and depression: meta-analysis revisited Archives of General Psychiatry 68 444 454 21199959 10.1001/archgenpsychiatry. 2010.189
35. J Kaufman B Birmaher D Brent U Rao 1997 Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data Journal of the American Academy of Child & Adolescent Psychiatry 36 980 988 10.1097/00004583- 199707000-00021 (Pubitemid 27272932)
36. KS Kendler 1996 Parenting: A genetic-epidemiologic perspective American Journal of Psychiatry 153 11 20 8540566 (Pubitemid 26026152)
37. G Kochanska 1991 Patterns of inhibition to the unfamiliar in children of normal and affectively ill mothers Child Development 62 250 263 2055122 10.2307/1131001
38. M Kovacs 1981 Rating scales to assess depression in school-aged children Acta Paedopsychiatrica 46 305 315 7025571 (Pubitemid 11141283)
39. N Lench P Stanier R Williamson 1988 Simple non-invasive method to obtain DNA for gene analysis Lancet 1 1356 1358 2898042 10.1016/S0140-6736(88)92178-2
40. KP Lesch D Bengel A Heils S Sabol BD Greenberg S Petri, et al. 1996 Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region Science 274 1527 1531 8929413 10.1126/science.274.5292.1527 (Pubitemid 26403928)
41. H Lizardi DN Klein 2002 Evidence of increased sensitivity using a three-factor version of the parental bonding instrument Journal of Nervous & Mental Disease 190 619 623 10.1097/00005053-200209000-00007
42. MA Mick MJ Telch 1998 Social anxiety and history of behavioral inhibition in young adults Journal of Anxiety Disorders 12 1 20 9549606 10.1016/S0887-6185(97)00046-7 (Pubitemid 28154240)
43. MR Munafo TG Clark LR Moore E Payne R Walton J Flint 2003 Genetic polymorphism and personality in healthy adults: a systematic review and meta-analysis Molecular Psychiatry 8 471 484 12808427 10.1038/sj.mp.4001326 (Pubitemid 36829689)
44. MR Munafò SM Brown AR Hariri 2008 Serotonin transporter (5-HTTLPR) genotype and amygdala activation: a meta-analysis Biological Psychiatry 63 852 857 17949693 10.1016/j.biopsych.2007.08.016 (Pubitemid 351458448)
45. P Muris P Steerneman 2001 The revised version of the Screen for Child Anxiety Related Emotional Disorders (SCARED-R): first evidence for its reliability and validity in a clinical sample British Journal of Clinical Psychology 40 35 44 11317947 10.1348/014466501163463 (Pubitemid 32293611)
46. P Muris L Dreessen S Bogels M Weckx M van Melick 2004 A questionnaire for screening a broad range of DSM-defined anxiety disorder symptoms in clinically referred children and adolescents Journal of Child Psychology and Psychiatry 45 813 820 15056312 10.1111/j.1469-7610.2004.00274.x (Pubitemid 38559446)
47. E Murphy CR Brewin L Silka 1997 The assessment of parenting using the parental bonding instrument: two or three factors Psychological Medicine 27 333 342 9089826 10.1017/S0033291796004606 (Pubitemid 27139966)
48. J Neal RJ Edelman M Glachan 2002 Behavioural inhibition and symptoms of anxiety and depression: is there a specific relationship with social phobia British Journal of Clinical Psychology 41 274 361 10.1348/014466502760387489 (Pubitemid 35439329)
49. P Noller VJ Callan 1988 Understanding parent-adolescent interactions: perceptions of family members and outsiders Developmental Psychology 24 707 714 10.1037/0012-1649.24.5.707
50. G Parker H Tupling LB Brown 1979 A parental bonding instrument British Journal of Medical Psychology 52 1 10 (Pubitemid 9171341)
51. EC Pooley K Houston K Hawton PJ Harrison 2003 Deliberate self-harm is associated with allelic variation in the tryptophan hydroxylase gene (TPH A779C), but not with polymorphisms in five other sertonergic genes Psychological Medicine 33 775 783 12877392 10.1017/S0033291703007463 (Pubitemid 36874657)
52. RM Rapee 1997 Potential role of child rearing practices in the development of anxiety and depression Clinical Psychology Review 17 47 67 9125367 10.1016/S0272-7358(96)00040-2 (Pubitemid 27164383)
53. JS Reznick IM Hegeman ER Kaufman SW Woods M Jacobs 1992 Retrospective and concurrent self-report of behavioral inhibition and their relation to adult mental health Development and Psychopathology 4 301 321 10.1017/ S095457940000016X
54. N Risch R Herrell T Lehner KY Liang L Eaves J Hoh, et al. 2009 Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis Journal of the American Medical Association 301 2462 2471 19531786 10.1001/jama.2009.878
55. JF Rosenbaum J Biederman DR Hirshfeld EA Bolduc J Chaloff 1991 Behavioral inhibition in children: a possible precursor to panic disorder or social phobia Journal of Clinical Psychiatry 52 5 9 1757458
56. KH Rubin PD Hastings SL Stewart HA Henderson X Chen 1997 The consistency and concomitants of inhibition: some of the children, all of the time Child Development 68 467 483 9249961 10.2307/1131672 (Pubitemid 127456030)
57. KH Rubin CS Cheah NA Fox 2001 Emotion regulation, parenting, and display of social reticence in preschoolers Early Education and Development 12 97 115 10.1207/s15566935eed1201-6
58. KH Rubin KB Burgess PD Hastings 2002 Stability and social-behavioral consequences of toddlers' inhibited temperament and parenting behaviors Child Development 73 483 495 11949904 10.1111/1467-8624.00419 (Pubitemid 41692459)
59. LA Schmidt NA Fox KH Rubin S Hu DH Hamer 2002 Molecular genetics of shyness and aggression in preschoolers Personality and Individual Differences 33 227 238 10.1016/S0191-8869(01)00147-7
60. CA Schofield ME Coles BE Gibb 2009 Retrospective reports of behavioral inhibition and young adults' current symptoms of social anxiety, depression, and anxious arousal Journal of Anxiety Disorders 23 884 890 19592214 10.1016/j.janxdis.2009.05.003
61. CE Schwartz N Snidman J Kagan 1999 Adolescent social anxiety as an outcome of inhibited temperament in childhood Journal of the American Academy of Child & Adolescent Psychiatry 38 1008 1015 10.1097/00004583-199908000-00017 (Pubitemid 29353036)
62. JC Schwarz ML Barton-Henry T Pruzinsky 1985 Assessing child-rearing behaviors: a comparison of ratings made by mother, father, child and sibling on the CRPBI Child Development 56 462 479 3987419 10.2307/1129734
63. MR Smucker WE Craighead LW Craighead BJ Green 1986 Normative and reliability data for the children's depression inventory Journal of Abnormal Child Psychology 14 25 39 3950219 10.1007/BF00917219 (Pubitemid 16172595)
64. M Van Ameringen C Mancini JM Oakman 1998 The relationship of behavioral inhibition and shyness to anxiety disorder Journal of Nervous & Mental Disease 186 425 431 10.1097/00005053-199807000-00007 (Pubitemid 28363359)
65. M Weissman H Orvaschel N Padian 1980 Children's symptom and social functioning self-report scales. Comparison of mothers' and children's reports The Journal of Nervous and Mental Disease 168 736 740 7452212 10.1097/00005053-198012000-00005 (Pubitemid 11209776)
66. JR Wendland BJ Martin MR Kruse K-P Lesch DL Murphy 2006 Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531 Molecular Psychiatry 11 224 226 16402131 10.1038/sj.mp.4001789
67. G Zalsman Y Huang MA Oquendo AK Burke X Hu DA Brent, et al. 2006 Association of a triallelic serotonin transporter gene promoter region (5-HTTLPR) polymorphism with stressful life events and severity of depression American Journal of Psychiatry 163 1588 1593 16946185 10.1176/appi.ajp.163.9. 1588 (Pubitemid 44465760)