Selective Inhibition of iNOS by Benzyl- and Dibenzyl Derivatives of N-(3-Aminobenzyl)acetamidine

ChemMedChem

Volumn 6, Issue 7, 2011, Pages 1203-1206

  Fantacuzzi, Marialuigia ^a   Maccallini, Cristina ^a   Lannutti, Fabio ^a   Patruno, Antonia ^a   Masella, Simona ^a   Pesce, Mirko ^a   Speranza, Lorenza ^a   Ammazzalorso, Alessandra ^a   De Filippis, Barbara ^a   Giampietro, Letizia ^a   Re, Nazzareno ^a   Amoroso, Rosa ^a  

^a UNIVERSITY OF CHIETI   (Italy)

Author keywords

Acetamidines; Inducible nitric oxide synthases (NOS); Inhibitors; Isoform selectivity; Nitric oxide

Indexed keywords

2 NITRO BENZYL DERIVATIVE; 3 NITRO BENZYL DERIVATIVE; 4 NITRO BENZYL DERIVATIVE; ACETAMIDINE DERIVATIVE; ARGININE; BENZYL DERIVATIVE; BIBENZYL DERIVATIVE; BIPHENYL DERIVATIVE; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE; CHLOROMETHYLBENZENE; CITRULLINE; DOCKING PROTEIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; ISOENZYME; METHEMOGLOBIN; N(3 AMINOBENZYL)ACETAMIDINE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; OXYHEMOGLOBIN; TRIFLUOROACETIC ACID; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ARTHRITIS; ARTICLE; ASTHMA; COLITIS; DEGENERATIVE DISEASE; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; GRAFT REJECTION; HUMAN; HYDROGEN BOND; LIVER CELL; MACROPHAGE; MULTIPLE SCLEROSIS; NERVE CELL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; SEPTIC SHOCK;

EID: 79959759467     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100125     Document Type: Article

References (22)

1. B. Brüne, Pharmacol. Res. 2010, 61, 265-268.
2. J. T. Groves, C. C.-Y. Wang, Curr. Opin. Chem. Biol. 2000, 4, 687-695;
3. W. K. Alderton, C. E. Cooper, R. G. Knowles, Biochem. J. 2001, 357, 593-615.
4. S. Mariotto, M. Menegazzi, H. Suzuki, Curr. Pharm. Des. 2004, 10, 1627-1645.
5. Q. W. Xie, H. J. Cho, J. Calaycay, R. A. Mumford, K. M. Swiderek, T. D. Lee, A. Ding, T. Troso, C. Nathan, Science 1992, 256, 225-228.
6. J. MacMicking, Q. W. Xie, C. Nathan, Annu. Rev. Immunol. 1997, 15, 323-350.
7. I. G. Charles, R. M. Palmer, M. S. Hickery, M. T. Bayliss, A. P. Chubb, V. S. Hall, Proc. Natl. Acad. Sci. USA 1993, 90, 11419-11423.
8. D. A. Geller, C. J. Lowenstein, R. A. Shapiro, A. K. Nussler, M. DiSilvio, S. C. Wang, D. K. Nakayama, R. L. Simmons, S. H. Snyder, T. R. Billiar, Proc. Natl. Acad. Sci. USA 1993, 90, 3491-3495.
9. P. Lirk, G. Hoffmann, J. Rieder, Curr. Drug Targets: Inflammation Allergy 2002, 1, 89-108.
10. A. Pautz, J. Art, S. Hahn, S. Nowag, C. Voss, H. Kleinert, Nitric Oxide Biol. Chem. 2010, 23, 75-93.
11. D. Fukumura, S. Kashiwagi, R. K. Jain, Nat. Rev. Cancer 2006, 6, 521-534.
12. B. Tunctan, S. Altug, Curr. Med. Chem.: Anti-Inflammatory Anti-Allergy Agents 2004, 3, 271-301.
13. A. C. Tinker, A. V. Wallace, Curr. Top. Med. Chem. 2006, 6, 77-92.
14. A. Tafi, L. Angeli, G. Venturini, M. Travagli, F. Corelli, M. Botta, Curr. Med. Chem. 2006, 13, 1929-1946.
15. S. Y. Proskuryakov, A. G. Konoplyannikov, V. G. Skvortsov, A. A. Mandrugin, V. M. Fedoseev, Biochemistry 2005, 70, 8-23.
16. C. Maccallini, A. Patruno, N. Besker, J. I. Alì, A. Ammazzalorso, B. DeFilippis, S. Franceschelli, L. Giampietro, M. Pesce, M. Reale, M. L. Tricca, N. Re, M. Felaco, R. Amoroso, J. Med. Chem. 2009, 52, 1481-1485.
17. E. P. Garvey, J. A. Oplinger, E. S. Furfine, R. J. Kiff, F. Laszlo, B. J. Whittle, R. G. Knowles, J. Biol. Chem. 1997, 272, 4959-4963.
18. J. M. Hevel, M. A. Marletta, Methods Enzymol. 1994, 233, 250-258.
19. H. Li, C. S. Raman, P. Martásek, B. S. Masters, T. L. Poulos, Biochemistry 2001, 40, 5399-5406.
20. R Fedorov, E. Hartmann, D. K. Ghosh, I. Schlichting, J. Biol. Chem. 2003, 278, 45818-45825.
21. M. Flinspach, H. Li, J. Jamal, W. Yang, H. Huang, R. B. Silverman, T. L. Poulos, Biochemistry 2004, 43, 5181-5187.
22. M. D. Eldridge, C. W. Murray, T. R. Auton, G. V. Paolini, R. P. Mee, J. Comput. Aided Mol. Des. 1997, 11, 425-445.